' 
SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.8
USERS' SCORE
Good
Based on 113 Reviews
8.9
Supplement Facts
Serving Size: 3 Caplets
Amount Per Serving
%DV
Vitamin D (as D3 Cholecalciferol)
15 mcg (600 IU)
75%
Calcium (as Calcium Carbonate and Calcium Gluconate)
1,000 mg
77%
Magnesium (as Magnesium Oxide and Magnesium Gluconate)
400 mg
95%
Zinc (as Zinc Gluconate and Zinc Citrate)
25 mg
227%
Sodium
10 mg
<1%
Top Medical Research Studies
8
Vitamin D reduces cold severity
Influence of Vitamin D Supplementation by Simulated Sunlight or Oral D3 on Respiratory Infection during Military Training.
Strong relevance to cold health.
We explored the connection between vitamin D levels and upper respiratory tract infections (URTIs) among military recruits during their training. This observation spanned across different seasons and included over 1,600 recruits. Our aim was to understand how achieving sufficient vitamin D levels could potentially impact the frequency and severity of colds among physically active individuals.
In an additional phase of the research, we conducted a randomized controlled trial with 250 male recruits. They received either a placebo, simulated sunlight exposure, or oral vitamin D3 supplements during winter. This comparison allowed us to see if these methods effectively increased vitamin D levels to a sufficient status of 25(OH)D at 50 nmol/L or higher.
Notably, our findings showed that only 21% of recruits had adequate vitamin D during winter, yet those who did were 40% less likely to suffer from URTIs. Furthermore, both vitamin D supplementation strategies similarly helped nearly all participants achieve sufficient levels. Vitamin D supplementation notably reduced the severity of URTI symptoms by 15% and the number of days with URTIs by 36% compared to placebo.
While the supplementation strategies did not significantly alter other immune factors, such as salivary secretory immunoglobulin A, the overall reduction in respiratory infections indicates a beneficial effect of maintaining vitamin D sufficiency during military training.
In an additional phase of the research, we conducted a randomized controlled trial with 250 male recruits. They received either a placebo, simulated sunlight exposure, or oral vitamin D3 supplements during winter. This comparison allowed us to see if these methods effectively increased vitamin D levels to a sufficient status of 25(OH)D at 50 nmol/L or higher.
Notably, our findings showed that only 21% of recruits had adequate vitamin D during winter, yet those who did were 40% less likely to suffer from URTIs. Furthermore, both vitamin D supplementation strategies similarly helped nearly all participants achieve sufficient levels. Vitamin D supplementation notably reduced the severity of URTI symptoms by 15% and the number of days with URTIs by 36% compared to placebo.
While the supplementation strategies did not significantly alter other immune factors, such as salivary secretory immunoglobulin A, the overall reduction in respiratory infections indicates a beneficial effect of maintaining vitamin D sufficiency during military training.
Read More
8
Zinc’s effects on colds
Zinc for prevention and treatment of the common cold: Summary of a Cochrane review.
High relevance to cold treatment
We explored how zinc might help in treating and preventing the common cold. The study focused on zinc's effects, isolating it from other treatments to understand its true impact on cold symptoms. By doing this, the researchers aimed to clarify whether zinc could genuinely shorten the duration of a cold or alleviate its symptoms.
The findings were intriguing but showed that zinc might not yield significant benefits for everyone. While some individuals reported a slight reduction in cold symptoms, the evidence did not strongly support zinc as an effective treatment overall.
This means that, for those seeking relief from a nasty cold, zinc alone might not be the go-to solution we hoped it would be. It’s essential to consider this information when deciding on a cold treatment plan and to approach zinc with realistic expectations.
The findings were intriguing but showed that zinc might not yield significant benefits for everyone. While some individuals reported a slight reduction in cold symptoms, the evidence did not strongly support zinc as an effective treatment overall.
This means that, for those seeking relief from a nasty cold, zinc alone might not be the go-to solution we hoped it would be. It’s essential to consider this information when deciding on a cold treatment plan and to approach zinc with realistic expectations.
Read More
8
MPM performance in cold environments
Effect of fly ash and curing temperature on the properties of magnesium phosphate repair mortar.
Relevant to cold repair applications
We examined how incorporating fly ash into magnesium phosphate repair mortar (MPM) influences its effectiveness in cold environments. Our investigation revealed that fly ash modifies the microstructure of the MPM, enhancing its performance without affecting the setting time or fluidity significantly.
We discovered that adding 10% to 15% fly ash improves the mechanical strength, adhesion, water resistance, and stability of the mortar. Notably, we found that the curing temperature plays a critical role; as the temperature rises, compressive strength increases, while properties like flexural strength decrease.
Interestingly, even when cured in icy conditions at -20°C or 0°C, MPM with fly ash retains good early strength and strong adhesion properties. This suggests magnesium phosphate repair mortar modified with fly ash is suitable for emergency repairs in cold weather, showcasing its potential for use in challenging environments.
We discovered that adding 10% to 15% fly ash improves the mechanical strength, adhesion, water resistance, and stability of the mortar. Notably, we found that the curing temperature plays a critical role; as the temperature rises, compressive strength increases, while properties like flexural strength decrease.
Interestingly, even when cured in icy conditions at -20°C or 0°C, MPM with fly ash retains good early strength and strong adhesion properties. This suggests magnesium phosphate repair mortar modified with fly ash is suitable for emergency repairs in cold weather, showcasing its potential for use in challenging environments.
Read More
Most Useful Reviews
9.5
Effective in cold season
A good working complex! Zinc and vitamin D3 are essential during the cold season, and I appreciate this combination because it means I don’t have to take numerous pills; just one does the job wonderfully!
Read More
9.5
Prevents colds
This complex of vitamins and minerals—magnesium, zinc, vitamin D, and calcium—is well-balanced in one tablet, making it very convenient to take. I use it for 1-2 months at the beginning of winter, and it effectively protects against colds and viral illnesses. I highly recommend it!
Read More
9.5
Fights inflammation
Very good! I've repurchased this multiple times! It effectively fights inflammation when I have a cold, fever, or cough!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.8
- All Researches
9
Magnesium enhances vascular preservation
Low Calcium-High Magnesium Krebs-Henseleit Solution Combined with Adenosine and Lidocaine Improved Rat Aortic Function and Structure Following Cold Preservation.
Combination effects complicate results
We examined the effectiveness of modified Krebs-Henseleit (KH) solutions with low calcium and high magnesium levels on preserving vascular function during cold storage. Our focus was on whether adding adenosine and lidocaine could further improve the preservation of rat aortic rings after six days of cold preservation.
In our study, we found that traditional preservation solutions often fail to maintain proper vascular function after just three days of cold storage. However, when we tested a modified KH solution with lower calcium and higher magnesium, we observed significant recovery of contraction and relaxation functions in the aortic rings. This suggests that magnesium plays a vital role in preserving these functions.
Interestingly, while adding adenosine and lidocaine did not enhance contraction, it did improve the aortic rings' ability to relax in response to a chemical called acetylcholine. Furthermore, a histological examination showed that the addition of adenosine positively affected the endothelial lining and structural integrity of the vessels, highlighting its importance in cold preservation.
Overall, our findings suggest that magnesium in combination with adenosine significantly enhances the preservation of vascular structures and functionalities during extended cold storage, making it an important consideration for vascular grafts.
In our study, we found that traditional preservation solutions often fail to maintain proper vascular function after just three days of cold storage. However, when we tested a modified KH solution with lower calcium and higher magnesium, we observed significant recovery of contraction and relaxation functions in the aortic rings. This suggests that magnesium plays a vital role in preserving these functions.
Interestingly, while adding adenosine and lidocaine did not enhance contraction, it did improve the aortic rings' ability to relax in response to a chemical called acetylcholine. Furthermore, a histological examination showed that the addition of adenosine positively affected the endothelial lining and structural integrity of the vessels, highlighting its importance in cold preservation.
Overall, our findings suggest that magnesium in combination with adenosine significantly enhances the preservation of vascular structures and functionalities during extended cold storage, making it an important consideration for vascular grafts.
Read More
9
Magnesium improves beef storage safety
Incorporation of hydrogen-producing magnesium into minced beef meat protects the quality attributes and safety of the product during cold storage.
Limited isolation of magnesium's impact
We explored the effects of incorporating hydrogen-producing magnesium into minced beef meat (MBM) to see how it affects quality and safety during cold storage. The study involved vacuum packaging the MBMs and storing them at 4°C for 12 days while comparing them with other treatments, such as gassing with hydrogen or nitrogen.
What we found was quite promising. The samples with magnesium showed the lowest browning index values, which indicates less color change and better visual quality. Additionally, these samples exhibited reduced bacterial counts, including mesophilic and psychrotrophic bacteria, as well as yeast and molds. This suggests that magnesium can help in maintaining the freshness and safety of the meat.
Interestingly, the magnesium treatment also limited the formation of potentially harmful compounds, such as thiobarbituric acid reactive substances and biogenic amines, which can negatively impact meat quality. By the end of the storage period, the control samples had the highest levels of volatile compounds, hinting at spoilage, while magnesium-enhanced and vacuum-packaged samples fared better.
Overall, we observed that using hydrogen-producing magnesium while handling minced beef could be an effective way to protect important quality attributes and safety during cold storage.
What we found was quite promising. The samples with magnesium showed the lowest browning index values, which indicates less color change and better visual quality. Additionally, these samples exhibited reduced bacterial counts, including mesophilic and psychrotrophic bacteria, as well as yeast and molds. This suggests that magnesium can help in maintaining the freshness and safety of the meat.
Interestingly, the magnesium treatment also limited the formation of potentially harmful compounds, such as thiobarbituric acid reactive substances and biogenic amines, which can negatively impact meat quality. By the end of the storage period, the control samples had the highest levels of volatile compounds, hinting at spoilage, while magnesium-enhanced and vacuum-packaged samples fared better.
Overall, we observed that using hydrogen-producing magnesium while handling minced beef could be an effective way to protect important quality attributes and safety during cold storage.
Read More
9
CuMg alloys enhance cold working
Prospective cold metal working and analysis of deformation susceptibility of CuMg alloys with high magnesium content.
Magnesium impacts alloy deformation
We examined the use of copper-magnesium (CuMg) alloys, particularly focusing on those with higher magnesium content, to understand how they perform during cold metal working processes. Our testing aimed to identify the effects of magnesium on the mechanical properties and workability of these alloys, as they’re known to provide significant solid-solution hardening.
The results revealed that CuMg alloys with 2 to 4 weight percent (wt%) magnesium displayed impressive strength characteristics, outperforming commonly used materials like pure copper and aluminum. We calculated improvements in hardness and Ultimate Tensile Strength (UTS), showing increases of up to two and a half times compared to pure copper. However, we noted that while magnesium enhances strength, it also raises friction during processing, which can complicate metal forming.
We learned that increasing magnesium content could lead to brittleness when it exceeded approximately 3.6 wt%, introducing challenges for cold working. This brittleness arises from the formation of specific phases, making it challenging to use these alloys in practical applications. Our findings suggest that while magnesium can significantly boost the mechanical properties of CuMg alloys, careful consideration is needed regarding its maximum content to maintain ductility and workability.
The results revealed that CuMg alloys with 2 to 4 weight percent (wt%) magnesium displayed impressive strength characteristics, outperforming commonly used materials like pure copper and aluminum. We calculated improvements in hardness and Ultimate Tensile Strength (UTS), showing increases of up to two and a half times compared to pure copper. However, we noted that while magnesium enhances strength, it also raises friction during processing, which can complicate metal forming.
We learned that increasing magnesium content could lead to brittleness when it exceeded approximately 3.6 wt%, introducing challenges for cold working. This brittleness arises from the formation of specific phases, making it challenging to use these alloys in practical applications. Our findings suggest that while magnesium can significantly boost the mechanical properties of CuMg alloys, careful consideration is needed regarding its maximum content to maintain ductility and workability.
Read More
9
Zinc enhances rice cold resistance
Effects of different cold-resistant agents and application methods on yield and cold-resistance of machine-transplanted early rice.
Study highlights zinc's effectiveness
We explored the impact of zinc-amino acids chelate on cold stress resistance in machine-transplanted early rice. Our investigation included other cold-resistant agents like uniconazole and abscisic acid, but we found zinc to be particularly effective. When applied during the regreening stage, zinc notably enhanced rice growth by promoting tillering and increasing the leaf area, which led to better yields.
We noted that zinc-amino acids chelate improved antioxidant enzyme activities, which are crucial for helping rice withstand cold temperatures. The yield of rice treated with zinc was approximately 9.22% higher than with uniconazole and 7.14% higher than with abscisic acid.
Additionally, we observed that using 750 g/ha of zinc-amino acids chelate during the transplanting and regreening stages yielded the best results. The timing of the application played a critical role, as spraying during these specific phases maximized both yield and cold resistance.
Overall, zinc treatments stand out as a promising option for improving cold stress resilience in early rice, making it a key consideration for farmers dealing with cold climate conditions.
We noted that zinc-amino acids chelate improved antioxidant enzyme activities, which are crucial for helping rice withstand cold temperatures. The yield of rice treated with zinc was approximately 9.22% higher than with uniconazole and 7.14% higher than with abscisic acid.
Additionally, we observed that using 750 g/ha of zinc-amino acids chelate during the transplanting and regreening stages yielded the best results. The timing of the application played a critical role, as spraying during these specific phases maximized both yield and cold resistance.
Overall, zinc treatments stand out as a promising option for improving cold stress resilience in early rice, making it a key consideration for farmers dealing with cold climate conditions.
Read More
8
Vitamin D reduces cold severity
Influence of Vitamin D Supplementation by Simulated Sunlight or Oral D3 on Respiratory Infection during Military Training.
Strong relevance to cold health.
We explored the connection between vitamin D levels and upper respiratory tract infections (URTIs) among military recruits during their training. This observation spanned across different seasons and included over 1,600 recruits. Our aim was to understand how achieving sufficient vitamin D levels could potentially impact the frequency and severity of colds among physically active individuals.
In an additional phase of the research, we conducted a randomized controlled trial with 250 male recruits. They received either a placebo, simulated sunlight exposure, or oral vitamin D3 supplements during winter. This comparison allowed us to see if these methods effectively increased vitamin D levels to a sufficient status of 25(OH)D at 50 nmol/L or higher.
Notably, our findings showed that only 21% of recruits had adequate vitamin D during winter, yet those who did were 40% less likely to suffer from URTIs. Furthermore, both vitamin D supplementation strategies similarly helped nearly all participants achieve sufficient levels. Vitamin D supplementation notably reduced the severity of URTI symptoms by 15% and the number of days with URTIs by 36% compared to placebo.
While the supplementation strategies did not significantly alter other immune factors, such as salivary secretory immunoglobulin A, the overall reduction in respiratory infections indicates a beneficial effect of maintaining vitamin D sufficiency during military training.
In an additional phase of the research, we conducted a randomized controlled trial with 250 male recruits. They received either a placebo, simulated sunlight exposure, or oral vitamin D3 supplements during winter. This comparison allowed us to see if these methods effectively increased vitamin D levels to a sufficient status of 25(OH)D at 50 nmol/L or higher.
Notably, our findings showed that only 21% of recruits had adequate vitamin D during winter, yet those who did were 40% less likely to suffer from URTIs. Furthermore, both vitamin D supplementation strategies similarly helped nearly all participants achieve sufficient levels. Vitamin D supplementation notably reduced the severity of URTI symptoms by 15% and the number of days with URTIs by 36% compared to placebo.
While the supplementation strategies did not significantly alter other immune factors, such as salivary secretory immunoglobulin A, the overall reduction in respiratory infections indicates a beneficial effect of maintaining vitamin D sufficiency during military training.
Read More
User Reviews
USERS' SCORE
Good
Based on 113 Reviews
8.9
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Effective in cold season
A good working complex! Zinc and vitamin D3 are essential during the cold season, and I appreciate this combination because it means I don’t have to take numerous pills; just one does the job wonderfully!
9.5
Prevents colds
This complex of vitamins and minerals—magnesium, zinc, vitamin D, and calcium—is well-balanced in one tablet, making it very convenient to take. I use it for 1-2 months at the beginning of winter, and it effectively protects against colds and viral illnesses. I highly recommend it!
Read More
9.5
Fights inflammation
Very good! I've repurchased this multiple times! It effectively fights inflammation when I have a cold, fever, or cough!
9.5
Essential for colds
I recommend this for anyone feeling unwell; it's essential during a cold, especially since zinc levels deplete. Combining it with tree bark and black walnuts really helps you recover in two days! Please click if you find this review useful!
9.5
Boosts energy post-cold
I’m thoroughly impressed! This product works wonders; I can feel the difference in my body already. I began taking it after catching a cold, and it’s remarkably effective—I feel very energetic now.
