Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.8
USERS' SCORE
Moderately Good
Based on 113 Reviews
7.9
Supplement Facts
Serving Size:  3 Caplets
Amount Per Serving
%DV
Vitamin D (as D3 Cholecalciferol)
15 mcg (600 IU)
75%
Calcium  (as Calcium Carbonate and Calcium Gluconate)
1,000 mg
77%
Magnesium  (as Magnesium Oxide and Magnesium Gluconate)
400 mg
95%
Zinc (as Zinc Gluconate and Zinc Citrate)
25 mg
227%
Sodium
10 mg
<1%

Top Medical Research Studies

We explored the connection between vitamin D levels and upper respiratory tract infections (URTIs) among military recruits during their training. This observation spanned across different seasons and included over 1,600 recruits. Our aim was to understand how achieving sufficient vitamin D levels could potentially impact the frequency and severity of colds among physically active individuals.

In an additional phase of the research, we conducted a randomized controlled trial with 250 male recruits. They received either a placebo, simulated sunlight exposure, or oral vitamin D3 supplements during winter. This comparison allowed us to see if these methods effectively increased vitamin D levels to a sufficient status of 25(OH)D at 50 nmol/L or higher.

Notably, our findings showed that only 21% of recruits had adequate vitamin D during winter, yet those who did were 40% less likely to suffer from URTIs. Furthermore, both vitamin D supplementation strategies similarly helped nearly all participants achieve sufficient levels. Vitamin D supplementation notably reduced the severity of URTI symptoms by 15% and the number of days with URTIs by 36% compared to placebo.

While the supplementation strategies did not significantly alter other immune factors, such as salivary secretory immunoglobulin A, the overall reduction in respiratory infections indicates a beneficial effect of maintaining vitamin D sufficiency during military training.
Read More
8
Zinc’s effects on colds
We explored how zinc might help in treating and preventing the common cold. The study focused on zinc's effects, isolating it from other treatments to understand its true impact on cold symptoms. By doing this, the researchers aimed to clarify whether zinc could genuinely shorten the duration of a cold or alleviate its symptoms.

The findings were intriguing but showed that zinc might not yield significant benefits for everyone. While some individuals reported a slight reduction in cold symptoms, the evidence did not strongly support zinc as an effective treatment overall.

This means that, for those seeking relief from a nasty cold, zinc alone might not be the go-to solution we hoped it would be. It’s essential to consider this information when deciding on a cold treatment plan and to approach zinc with realistic expectations.
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8
MPM performance in cold environments
We examined how incorporating fly ash into magnesium phosphate repair mortar (MPM) influences its effectiveness in cold environments. Our investigation revealed that fly ash modifies the microstructure of the MPM, enhancing its performance without affecting the setting time or fluidity significantly.

We discovered that adding 10% to 15% fly ash improves the mechanical strength, adhesion, water resistance, and stability of the mortar. Notably, we found that the curing temperature plays a critical role; as the temperature rises, compressive strength increases, while properties like flexural strength decrease.

Interestingly, even when cured in icy conditions at -20°C or 0°C, MPM with fly ash retains good early strength and strong adhesion properties. This suggests magnesium phosphate repair mortar modified with fly ash is suitable for emergency repairs in cold weather, showcasing its potential for use in challenging environments.
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Most Useful Reviews

9
Effective in cold season
3 people found this helpful
A good working complex! Zinc and vitamin D3 are essential during the cold season, and I appreciate this combination because it means I don’t have to take numerous pills; just one does the job wonderfully!
Read More
9
Prevents colds
This complex of vitamins and minerals—magnesium, zinc, vitamin D, and calcium—is well-balanced in one tablet, making it very convenient to take. I use it for 1-2 months at the beginning of winter, and it effectively protects against colds and viral illnesses. I highly recommend it!
Read More
9
Fights inflammation
Very good! I've repurchased this multiple times! It effectively fights inflammation when I have a cold, fever, or cough!
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.8
  • All Researches
9
Magnesium enhances vascular preservation
We examined the effectiveness of modified Krebs-Henseleit (KH) solutions with low calcium and high magnesium levels on preserving vascular function during cold storage. Our focus was on whether adding adenosine and lidocaine could further improve the preservation of rat aortic rings after six days of cold preservation.

In our study, we found that traditional preservation solutions often fail to maintain proper vascular function after just three days of cold storage. However, when we tested a modified KH solution with lower calcium and higher magnesium, we observed significant recovery of contraction and relaxation functions in the aortic rings. This suggests that magnesium plays a vital role in preserving these functions.

Interestingly, while adding adenosine and lidocaine did not enhance contraction, it did improve the aortic rings' ability to relax in response to a chemical called acetylcholine. Furthermore, a histological examination showed that the addition of adenosine positively affected the endothelial lining and structural integrity of the vessels, highlighting its importance in cold preservation.

Overall, our findings suggest that magnesium in combination with adenosine significantly enhances the preservation of vascular structures and functionalities during extended cold storage, making it an important consideration for vascular grafts.
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9
Magnesium improves beef storage safety
We explored the effects of incorporating hydrogen-producing magnesium into minced beef meat (MBM) to see how it affects quality and safety during cold storage. The study involved vacuum packaging the MBMs and storing them at 4°C for 12 days while comparing them with other treatments, such as gassing with hydrogen or nitrogen.

What we found was quite promising. The samples with magnesium showed the lowest browning index values, which indicates less color change and better visual quality. Additionally, these samples exhibited reduced bacterial counts, including mesophilic and psychrotrophic bacteria, as well as yeast and molds. This suggests that magnesium can help in maintaining the freshness and safety of the meat.

Interestingly, the magnesium treatment also limited the formation of potentially harmful compounds, such as thiobarbituric acid reactive substances and biogenic amines, which can negatively impact meat quality. By the end of the storage period, the control samples had the highest levels of volatile compounds, hinting at spoilage, while magnesium-enhanced and vacuum-packaged samples fared better.

Overall, we observed that using hydrogen-producing magnesium while handling minced beef could be an effective way to protect important quality attributes and safety during cold storage.
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9
CuMg alloys enhance cold working
We examined the use of copper-magnesium (CuMg) alloys, particularly focusing on those with higher magnesium content, to understand how they perform during cold metal working processes. Our testing aimed to identify the effects of magnesium on the mechanical properties and workability of these alloys, as they’re known to provide significant solid-solution hardening.

The results revealed that CuMg alloys with 2 to 4 weight percent (wt%) magnesium displayed impressive strength characteristics, outperforming commonly used materials like pure copper and aluminum. We calculated improvements in hardness and Ultimate Tensile Strength (UTS), showing increases of up to two and a half times compared to pure copper. However, we noted that while magnesium enhances strength, it also raises friction during processing, which can complicate metal forming.

We learned that increasing magnesium content could lead to brittleness when it exceeded approximately 3.6 wt%, introducing challenges for cold working. This brittleness arises from the formation of specific phases, making it challenging to use these alloys in practical applications. Our findings suggest that while magnesium can significantly boost the mechanical properties of CuMg alloys, careful consideration is needed regarding its maximum content to maintain ductility and workability.
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9
Zinc enhances rice cold resistance
We explored the impact of zinc-amino acids chelate on cold stress resistance in machine-transplanted early rice. Our investigation included other cold-resistant agents like uniconazole and abscisic acid, but we found zinc to be particularly effective. When applied during the regreening stage, zinc notably enhanced rice growth by promoting tillering and increasing the leaf area, which led to better yields.

We noted that zinc-amino acids chelate improved antioxidant enzyme activities, which are crucial for helping rice withstand cold temperatures. The yield of rice treated with zinc was approximately 9.22% higher than with uniconazole and 7.14% higher than with abscisic acid.

Additionally, we observed that using 750 g/ha of zinc-amino acids chelate during the transplanting and regreening stages yielded the best results. The timing of the application played a critical role, as spraying during these specific phases maximized both yield and cold resistance.

Overall, zinc treatments stand out as a promising option for improving cold stress resilience in early rice, making it a key consideration for farmers dealing with cold climate conditions.
Read More
We explored the connection between vitamin D levels and upper respiratory tract infections (URTIs) among military recruits during their training. This observation spanned across different seasons and included over 1,600 recruits. Our aim was to understand how achieving sufficient vitamin D levels could potentially impact the frequency and severity of colds among physically active individuals.

In an additional phase of the research, we conducted a randomized controlled trial with 250 male recruits. They received either a placebo, simulated sunlight exposure, or oral vitamin D3 supplements during winter. This comparison allowed us to see if these methods effectively increased vitamin D levels to a sufficient status of 25(OH)D at 50 nmol/L or higher.

Notably, our findings showed that only 21% of recruits had adequate vitamin D during winter, yet those who did were 40% less likely to suffer from URTIs. Furthermore, both vitamin D supplementation strategies similarly helped nearly all participants achieve sufficient levels. Vitamin D supplementation notably reduced the severity of URTI symptoms by 15% and the number of days with URTIs by 36% compared to placebo.

While the supplementation strategies did not significantly alter other immune factors, such as salivary secretory immunoglobulin A, the overall reduction in respiratory infections indicates a beneficial effect of maintaining vitamin D sufficiency during military training.
Read More

User Reviews

USERS' SCORE
Moderately Good
Based on 113 Reviews
7.9
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Effective in cold season
3 people found this helpful
A good working complex! Zinc and vitamin D3 are essential during the cold season, and I appreciate this combination because it means I don’t have to take numerous pills; just one does the job wonderfully!
Read More
9
Prevents colds
This complex of vitamins and minerals—magnesium, zinc, vitamin D, and calcium—is well-balanced in one tablet, making it very convenient to take. I use it for 1-2 months at the beginning of winter, and it effectively protects against colds and viral illnesses. I highly recommend it!
Read More
9
Fights inflammation
Very good! I've repurchased this multiple times! It effectively fights inflammation when I have a cold, fever, or cough!
Read More
9
Essential for colds
I recommend this for anyone feeling unwell; it's essential during a cold, especially since zinc levels deplete. Combining it with tree bark and black walnuts really helps you recover in two days! Please click if you find this review useful!
Read More
9
Boosts energy post-cold
I’m thoroughly impressed! This product works wonders; I can feel the difference in my body already. I began taking it after catching a cold, and it’s remarkably effective—I feel very energetic now.
Read More

Frequently Asked Questions

9
Rapid recovery
If you fall ill, I highly recommend this. When I have a cold, it’s essential to have, especially with zinc and natural extracts. It got me back on my feet in two days!
9
Mandatory for cold
This is essential for colds, as zinc levels in the body are at zero. Combining it with ant tree bark and black walnut can truly get you back on your feet in just two days!
9
Prevents colds
This complex of vitamins and minerals—magnesium, zinc, vitamin D, and calcium—is well-balanced in one tablet, making it very convenient to take. I use it for 1-2 months at the beginning of winter, and it effectively protects against colds and viral illnesses. I highly recommend it!
9
Essential for colds
I recommend this for anyone feeling unwell; it's essential during a cold, especially since zinc levels deplete. Combining it with tree bark and black walnuts really helps you recover in two days! Please click if you find this review useful!
9
Strengthens immune system
Excellent complex; I have been taking this supplement for a short time and have already noticed a strengthening of my immune system. I caught a viral infection, perhaps the most popular virus of 2020, but recovered almost unnoticed. A slight stuffy nose and general weakness were my only noticeable symptoms, which passed in just 2 days! In the past, I used to have a cold that lasted longer. I did double my daily dose of magnesium during this period. I then rushed to my favourite gym and found my strength intact, with no residual weakness! I may be lucky, but I am pleased with the supplement; the quality is excellent and the ingredients are verified. The size is convenient for consumption.
9
Reduces colds
This is not the first time I've ordered this complex for my mother. Thanks to it, she experiences far fewer colds. She takes one tablet daily throughout the cold season.
9
Prevents cold
Excellent composition and dosage. Particularly beneficial for colds in the winter season. I use preventative measures twice a year and, during illness, I take three a day. Excellent quality and reasonably priced. I recommend it to everyone.
We explored the effects of vitamin D supplementation on respiratory infections, particularly colds, in children under six years old. By examining various studies published until February 2023, we observed diverse findings, with some studies reporting benefits while others found no significant advantage. Overall, eight studies were included, with a total of 2,189 children assessed.

While a few studies indicated that low vitamin D levels might be linked to an increased risk of respiratory infections, only one study specifically noted that children who took 800 IU of vitamin D daily for three months experienced fewer mild respiratory symptoms and recovered more quickly. However, a significant number of studies showed no notable differences in the rates or severity of colds when vitamin D supplementation was used.

In essence, the evidence regarding vitamin D's role in preventing or effectively treating colds in young children is still unclear. We did find some indications that certain doses, like 80 IU/kg/day, may help reduce acute respiratory infection risks, but most research highlighted only minor benefits, such as quicker recovery rather than preventing infections. Variability in study design and supplementation protocols contributed to these inconclusive results, highlighting the need for further research.
7
Vitamin D's limited cold impact
We evaluated the impact of high-dose vitamin D supplementation, specifically doses exceeding the standard 400 IU, on preventing colds and other infections in children under five years of age. Our analysis included seven studies, involving a total of 5,748 children, which looked into how effective vitamin D might be in reducing the incidence of upper respiratory tract infections.

Interestingly, while our findings showed no significant benefit of high-dose vitamin D on the prevention of upper respiratory tract infections as a whole, we did observe a noteworthy reduction in specific illness occurrences. We noted a 57% reduction in colds, a 56% reduction in coughs, and a 59% decrease in fever rates with daily doses exceeding 1,000 IU.

However, we must approach these findings with caution, as the evidence supporting the reduction in cough and fever was of lower certainty. No significant effects were observed regarding other conditions such as bronchitis or otitis media. Overall, while high-dose vitamin D may help with colds specifically, further research is needed to solidify these conclusions.
We explored the connection between vitamin D levels and upper respiratory tract infections (URTIs) among military recruits during their training. This observation spanned across different seasons and included over 1,600 recruits. Our aim was to understand how achieving sufficient vitamin D levels could potentially impact the frequency and severity of colds among physically active individuals.

In an additional phase of the research, we conducted a randomized controlled trial with 250 male recruits. They received either a placebo, simulated sunlight exposure, or oral vitamin D3 supplements during winter. This comparison allowed us to see if these methods effectively increased vitamin D levels to a sufficient status of 25(OH)D at 50 nmol/L or higher.

Notably, our findings showed that only 21% of recruits had adequate vitamin D during winter, yet those who did were 40% less likely to suffer from URTIs. Furthermore, both vitamin D supplementation strategies similarly helped nearly all participants achieve sufficient levels. Vitamin D supplementation notably reduced the severity of URTI symptoms by 15% and the number of days with URTIs by 36% compared to placebo.

While the supplementation strategies did not significantly alter other immune factors, such as salivary secretory immunoglobulin A, the overall reduction in respiratory infections indicates a beneficial effect of maintaining vitamin D sufficiency during military training.
7
Vitamin D reduces cold symptoms
We explored the effects of 25-hydroxyvitamin D (25OHD) on individuals experiencing upper respiratory tract infections (URTIs), commonly known as colds. In a well-structured study, participants with low vitamin D levels received either a daily dose of 10 micrograms of 25OHD or a placebo for a span of 16 weeks. The participants' symptoms were assessed using the Wisconsin Upper Respiratory Symptom Survey-21, focusing on how the vitamin impacted their cold symptoms.

Our findings showed that those taking 25OHD reported significant reductions in physical symptoms such as runny noses, sneezing, and head congestion compared to those on the placebo. Additionally, the quality of life scores improved for most symptoms, except for ease of breathing. However, it’s important to note that there was no significant difference in the total number of cold events or how often participants used medications like antibiotics or pain relievers.

Collectively, these results suggest that adequate intake of vitamin D can help ease cold symptoms, particularly those affecting the nose, and might enhance overall well-being when a cold strikes. This indicates that vitamin D may play a positive role in managing the discomfort associated with upper respiratory infections.

References

  1. Marusca LM, Reddy G, Blaj M, Prathipati R, Rosca O, et al. The Effects of Vitamin D Supplementation on Respiratory Infections in Children under 6 Years Old: A Systematic Review. Diseases. 2023;11. 10.3390/diseases11030104
  2. Carboo JA, Dolman-Macleod RC, Malan L, Lombard MJ. High-dose oral vitamin D supplementation for prevention of infections in children aged 0 to 59 months: a systematic review and meta-analysis. Nutr Rev. 2024;82:579. 10.1093/nutrit/nuad082
  3. Kisla Ekinci RM, Taskin Karacay IE, Celik U. Serum vitamin B12 and D levels in children with Primary Raynaud Phenomenon: a retrospective cohort study. Eur J Clin Nutr. 2022;76:1615. 10.1038/s41430-022-01151-0
  4. Harrison SE, Oliver SJ, Kashi DS, Carswell AT, Edwards JP, et al. Influence of Vitamin D Supplementation by Simulated Sunlight or Oral D3 on Respiratory Infection during Military Training. Med Sci Sports Exerc. 2021;53:1505. 10.1249/MSS.0000000000002604
  5. Shimizu Y, Ito Y, Uotsu N, Yui K. Intake of 25-Hydroxyvitamin D May Reduce the Severity of Upper Respiratory Tract Infection: Post hoc Analysis of a Randomized, Double-Blind, Placebo-Controlled, Parallel Group Comparison Study. Nutrients. 2020;12. 10.3390/nu12123769
  6. Arsyad A, Lembang GKR, Linda SL, Djabir YY, Dobson GP. Low Calcium-High Magnesium Krebs-Henseleit Solution Combined with Adenosine and Lidocaine Improved Rat Aortic Function and Structure Following Cold Preservation. Medicina (Kaunas). 2024;60. 10.3390/medicina60081284
  7. Liu J, Zhang J, Li A, Xia X, Chen J. Effect of fly ash and curing temperature on the properties of magnesium phosphate repair mortar. Sci Rep. 2024;14:15512. 10.1038/s41598-024-66581-1
  8. Çelebi Y, Kavrut E, Bulut M, Çetintaş Y, Tekin A, et al. Incorporation of hydrogen-producing magnesium into minced beef meat protects the quality attributes and safety of the product during cold storage. Food Chem. 2024;448:139185. 10.1016/j.foodchem.2024.139185
  9. Strzępek P, Zasadzińska M. Prospective cold metal working and analysis of deformation susceptibility of CuMg alloys with high magnesium content. Sci Rep. 2024;14:6447. 10.1038/s41598-024-57083-1
  10. Muniz FWMG, Casarin M, Pola NM, Rösing CK, Silveira TMD, et al. Efficacy of regular gargling with a cetylpyridinium chloride plus zinc containing mouthwash can reduce upper respiratory symptoms. PLoS One. 2025;20:e0316807. 10.1371/journal.pone.0316807
  11. Wieland LS. Zinc for prevention and treatment of the common cold: Summary of a Cochrane review. Explore (NY). 2025;21:103111. 10.1016/j.explore.2025.103111
  12. Yuan S, Qin S, Shi Q, Chen P, Tu N, et al. Effects of different cold-resistant agents and application methods on yield and cold-resistance of machine-transplanted early rice. Front Plant Sci. 2024;15:1422374. 10.3389/fpls.2024.1422374
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