Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 27 Researches
7.7
USERS' SCORE
Good
Based on 10 Reviews
8
Supplement Facts
Serving Size: 3 Caplets
Amount Per Serving
%DV
Vitamin D (as D3 Cholecalciferol)
15 mcg (600 IU)
75%
Calcium (as Calcium Carbonate and Calcium Gluconate)
1,000 mg
77%
Magnesium (as Magnesium Oxide and Magnesium Gluconate)
400 mg
95%
Zinc (as Zinc Gluconate and Zinc Citrate)
25 mg
227%
Sodium
10 mg
<1%
Top Medical Research Studies
9
We conducted a randomized, double-blind, placebo-controlled trial to explore how zinc gluconate affects migraine symptoms in women. Sixty participants, with an average age of 35, were given either 15 mg of zinc per day or a placebo for 12 weeks, allowing us to measure the impact on headache frequency, duration, and intensity.
The results were quite promising; zinc supplementation significantly reduced how often headaches occurred, shortened their duration, and decreased the severity of the migraines reported. Participants in the zinc group experienced notable improvements, as indicated by their responses to the headache severity scale and a disability assessment questionnaire.
Furthermore, we found that zinc also had a positive effect on certain health markers. The serum levels of low-density lipoprotein (LDL), total cholesterol, and high-sensitivity C-reactive protein (hs-CRP) decreased with zinc supplementation. However, we didn’t observe significant changes in triglycerides or high-density lipoprotein (HDL) levels after adjusting for baseline values.
In conclusion, zinc supplementation appears to hold beneficial effects on migraine severity and frequency, offering a potential alternative for those who seek relief from these debilitating headaches.
The results were quite promising; zinc supplementation significantly reduced how often headaches occurred, shortened their duration, and decreased the severity of the migraines reported. Participants in the zinc group experienced notable improvements, as indicated by their responses to the headache severity scale and a disability assessment questionnaire.
Furthermore, we found that zinc also had a positive effect on certain health markers. The serum levels of low-density lipoprotein (LDL), total cholesterol, and high-sensitivity C-reactive protein (hs-CRP) decreased with zinc supplementation. However, we didn’t observe significant changes in triglycerides or high-density lipoprotein (HDL) levels after adjusting for baseline values.
In conclusion, zinc supplementation appears to hold beneficial effects on migraine severity and frequency, offering a potential alternative for those who seek relief from these debilitating headaches.
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7
We explored the impact of zinc on migraine headaches, particularly looking at its effectiveness for those who haven’t found relief from traditional preventive treatments. Our investigation involved four patients suffering from migraine attacks that were resistant to usual prophylactic therapies.
Each of these patients reported a notable improvement in the frequency and severity of their headaches after incorporating zinc supplements into their regimen. This suggests that zinc might serve as a beneficial alternative for those grappling with stubborn migraines.
While our findings are promising, it's crucial to recognize that further research is needed to firmly establish the efficacy of zinc replacement therapy in this context. Nevertheless, zinc administration could offer hope for individuals facing challenges with typical migraine treatment options.
Each of these patients reported a notable improvement in the frequency and severity of their headaches after incorporating zinc supplements into their regimen. This suggests that zinc might serve as a beneficial alternative for those grappling with stubborn migraines.
While our findings are promising, it's crucial to recognize that further research is needed to firmly establish the efficacy of zinc replacement therapy in this context. Nevertheless, zinc administration could offer hope for individuals facing challenges with typical migraine treatment options.
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9
Magnesium aids migraine management
We explored the impact of magnesium on migraine headaches, focusing on its potential benefits based on various studies. Magnesium deficiency is quite common and can arise from different factors, such as not consuming enough through diet or losing more through bodily systems.
A wealth of research, including case reports and controlled trials, suggests that magnesium supplementation can effectively alleviate migraines, both in the short term and long term. The proposed reasons for this effectiveness range from magnesium's role in preventing spreading cortical depression to its ability to manage oxidative stress and inflammation.
This evidence leads us to consider magnesium not just as a dietary supplement but as an important player in migraine management. Understanding these links helps us contemplate magnesium’s role in prevention and treatment, promising a potential path for those who suffer from this debilitating condition.
A wealth of research, including case reports and controlled trials, suggests that magnesium supplementation can effectively alleviate migraines, both in the short term and long term. The proposed reasons for this effectiveness range from magnesium's role in preventing spreading cortical depression to its ability to manage oxidative stress and inflammation.
This evidence leads us to consider magnesium not just as a dietary supplement but as an important player in migraine management. Understanding these links helps us contemplate magnesium’s role in prevention and treatment, promising a potential path for those who suffer from this debilitating condition.
Read More
Most Useful Reviews
9
Decreased headaches
1 people found this helpful
I've been taking this magnesium complex for two years to help with migraines, which I find effective. Although I only take one tablet a day, I have noticed reduced muscle tension and fewer headaches, alongside other therapies. I'm very satisfied with the product and highly recommend it.
Read More
9
Headache relief
I no longer experience headaches and sleep well at night. Overall, I feel much more at peace. Everything is excellent.
Read More
9
No more headaches
I’m very pleased with the fast delivery and excellent packaging. The capsules are a bit large but easy to swallow and taste pleasant. After ten days of taking one capsule daily with meals, I’ve noticed more energy, elimination of headaches, and an improved mood. I recommend it, especially for those interested in fitness.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 27 Researches
7.7
- All Researches
9.5
We explored the connection between calcium treatment and headaches, particularly in patients with reversible cerebral vasoconstriction syndrome (RCVS). In this case, we observed a healthy young woman who had been using escitalopram for a long time. She presented with bilateral neurological deficits, and after treatment with intra-arterial calcium channel blockers, her symptoms improved significantly.
However, it’s important to note that while calcium channel blockers were administered, the study does not specifically isolate calcium’s effects on headache relief. This combination of treatments makes it challenging to understand how much calcium alone contributes to alleviating headache symptoms, if at all.
As we considered the overall findings, it became clear that while calcium channel blockers can lead to symptom improvement in RCVS, the direct impact of calcium on headaches remains uncertain. Therefore, individuals experiencing thunderclap headaches, especially those on selective serotonin reuptake inhibitors, should consider RCVS as a possible diagnosis, but we cannot definitively conclude that calcium treatment is effective for headaches based on this case alone.
However, it’s important to note that while calcium channel blockers were administered, the study does not specifically isolate calcium’s effects on headache relief. This combination of treatments makes it challenging to understand how much calcium alone contributes to alleviating headache symptoms, if at all.
As we considered the overall findings, it became clear that while calcium channel blockers can lead to symptom improvement in RCVS, the direct impact of calcium on headaches remains uncertain. Therefore, individuals experiencing thunderclap headaches, especially those on selective serotonin reuptake inhibitors, should consider RCVS as a possible diagnosis, but we cannot definitively conclude that calcium treatment is effective for headaches based on this case alone.
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9
We conducted a clinical trial to investigate the effects of vitamin D supplementation alongside topiramate, a medication commonly used for migraine prevention in children aged 5 to 14. In this double-blind study, participants were divided into two groups: one received vitamin D with their topiramate treatment, while the other received a placebo.
After four months, we observed that those who took vitamin D experienced a significant reduction in the monthly frequency of headache attacks compared to the placebo group. We noted that children taking vitamin D also reported less disability from their migraines and a higher percentage showed a good response to the treatment.
Furthermore, the side effects were relatively similar between both groups, suggesting that combining vitamin D with topiramate is a safe and well-tolerated option. Overall, our findings indicate that vitamin D supplementation could enhance migraine management in pediatric patients.
After four months, we observed that those who took vitamin D experienced a significant reduction in the monthly frequency of headache attacks compared to the placebo group. We noted that children taking vitamin D also reported less disability from their migraines and a higher percentage showed a good response to the treatment.
Furthermore, the side effects were relatively similar between both groups, suggesting that combining vitamin D with topiramate is a safe and well-tolerated option. Overall, our findings indicate that vitamin D supplementation could enhance migraine management in pediatric patients.
Read More
9
Magnesium aids migraine management
We explored the impact of magnesium on migraine headaches, focusing on its potential benefits based on various studies. Magnesium deficiency is quite common and can arise from different factors, such as not consuming enough through diet or losing more through bodily systems.
A wealth of research, including case reports and controlled trials, suggests that magnesium supplementation can effectively alleviate migraines, both in the short term and long term. The proposed reasons for this effectiveness range from magnesium's role in preventing spreading cortical depression to its ability to manage oxidative stress and inflammation.
This evidence leads us to consider magnesium not just as a dietary supplement but as an important player in migraine management. Understanding these links helps us contemplate magnesium’s role in prevention and treatment, promising a potential path for those who suffer from this debilitating condition.
A wealth of research, including case reports and controlled trials, suggests that magnesium supplementation can effectively alleviate migraines, both in the short term and long term. The proposed reasons for this effectiveness range from magnesium's role in preventing spreading cortical depression to its ability to manage oxidative stress and inflammation.
This evidence leads us to consider magnesium not just as a dietary supplement but as an important player in migraine management. Understanding these links helps us contemplate magnesium’s role in prevention and treatment, promising a potential path for those who suffer from this debilitating condition.
Read More
9
We examined the effects of magnesium treatment on individuals suffering from episodic migraine and tension-type headache, aiming to understand its potential benefits alongside other therapeutic approaches. The study involved 104 participants, who were assessed for anxiety, depression, insomnia, and fatigue before and after receiving various treatments, including magnesium.
Our findings indicated that a significant portion of patients reported anxiety and depression, affecting their headache severity. After treatment, we noticed a marked decrease in headache intensity, along with improvements in anxiety and depressive symptoms. However, the specific impact of magnesium alone couldn’t be isolated in this study, as we looked at it alongside other medications like anxiolytics and antidepressants.
Overall, while magnesium was part of the treatment plan and showed potential benefits, we must acknowledge that its individual effectiveness cannot be clearly determined from our research. It appears to contribute to an overall improvement in managing headaches when combined with other treatments.
Our findings indicated that a significant portion of patients reported anxiety and depression, affecting their headache severity. After treatment, we noticed a marked decrease in headache intensity, along with improvements in anxiety and depressive symptoms. However, the specific impact of magnesium alone couldn’t be isolated in this study, as we looked at it alongside other medications like anxiolytics and antidepressants.
Overall, while magnesium was part of the treatment plan and showed potential benefits, we must acknowledge that its individual effectiveness cannot be clearly determined from our research. It appears to contribute to an overall improvement in managing headaches when combined with other treatments.
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9
We explored a case involving a 36-year-old woman with endometriosis suffering from frequent headaches and debilitating pain. While traditional medications didn't work for her, she started a new treatment plan that included acupuncture and supplements like magnesium and turmeric.
After this multimodal approach, her headache frequency decreased significantly, along with improvements in her lumbopelvic pain, sleep quality, and overall focus. This case indicates that integrating various alternative therapies can provide significant relief for those with challenging symptoms.
After this multimodal approach, her headache frequency decreased significantly, along with improvements in her lumbopelvic pain, sleep quality, and overall focus. This case indicates that integrating various alternative therapies can provide significant relief for those with challenging symptoms.
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User Reviews
USERS' SCORE
Good
Based on 10 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Decreased headaches
1 people found this helpful
I've been taking this magnesium complex for two years to help with migraines, which I find effective. Although I only take one tablet a day, I have noticed reduced muscle tension and fewer headaches, alongside other therapies. I'm very satisfied with the product and highly recommend it.
Read More
9
Headache relief
I no longer experience headaches and sleep well at night. Overall, I feel much more at peace. Everything is excellent.
Read More
9
No more headaches
I’m very pleased with the fast delivery and excellent packaging. The capsules are a bit large but easy to swallow and taste pleasant. After ten days of taking one capsule daily with meals, I’ve noticed more energy, elimination of headaches, and an improved mood. I recommend it, especially for those interested in fitness.
Read More
9
Better sleep
I take this every evening for poor sleep. When I feel tired or have a headache, it provides significant relief.
Read More
7.5
Soothed headaches
This vitamin complex is fantastic! Its calcium, magnesium, and zinc content is essential. Since starting, my headaches and dizziness have significantly reduced, my blood pressure normalised, and I feel less irritated. Overall, my health has improved, and I've stopped experiencing hair loss.
Read More
Frequently Asked Questions
9
No more headaches
I’m very pleased with the fast delivery and excellent packaging. The capsules are a bit large but easy to swallow and taste pleasant. After ten days of taking one capsule daily with meals, I’ve noticed more energy, elimination of headaches, and an improved mood. I recommend it, especially for those interested in fitness.
7.5
Resolved headaches
My family and I have been taking this vitamin for two months, and we experienced many headaches and fatigue before. Since starting the supplement, our sleep has improved, headaches have stopped, and we feel more energised. We'll continue taking it to maintain the positive effects as the composition is well-selected.
7.5
Soothed headaches
This vitamin complex is fantastic! Its calcium, magnesium, and zinc content is essential. Since starting, my headaches and dizziness have significantly reduced, my blood pressure normalised, and I feel less irritated. Overall, my health has improved, and I've stopped experiencing hair loss.
9
Headache relief
I no longer experience headaches and sleep well at night. Overall, I feel much more at peace. Everything is excellent.
9
Decreased headaches
1 people found this helpful
I've been taking this magnesium complex for two years to help with migraines, which I find effective. Although I only take one tablet a day, I have noticed reduced muscle tension and fewer headaches, alongside other therapies. I'm very satisfied with the product and highly recommend it.
9
Better sleep
I take this every evening for poor sleep. When I feel tired or have a headache, it provides significant relief.
7.5
Prevented headaches
3 people found this helpful
After advice from a headache specialist, I started taking these calcium and magnesium supplements, which also include zinc and vitamin D. Although the tablets are large, I believe they are typical for many overseas supplements. So far, they seem beneficial for preventing migraines.
0
Increased headaches
I usually order from a different brand but tried this one when my usual was unavailable. Unfortunately, I started having headaches, which I believe are due to this product.
7
We explored the impact of magnesium treatment on headaches, focusing specifically on its role in preventing migraines. The evidence suggests that magnesium may be beneficial for some individuals in managing headache frequency and intensity. It is often recommended not only for migraine prevention but also for acute treatment when given intravenously.
Importantly, we noted that magnesium tends to have a good safety profile, with any adverse effects typically being mild and related to gastrointestinal tolerance. This makes it a potentially attractive option for those seeking relief from headaches. However, it's crucial to approach magnesium use with careful consideration, recognizing that responses can vary from person to person.
Overall, our examination highlights magnesium as a valuable tool in the headache management arsenal, although it should be part of a more comprehensive treatment strategy. Knowing its benefits allows us to better inform those struggling with headache disorders.
Importantly, we noted that magnesium tends to have a good safety profile, with any adverse effects typically being mild and related to gastrointestinal tolerance. This makes it a potentially attractive option for those seeking relief from headaches. However, it's crucial to approach magnesium use with careful consideration, recognizing that responses can vary from person to person.
Overall, our examination highlights magnesium as a valuable tool in the headache management arsenal, although it should be part of a more comprehensive treatment strategy. Knowing its benefits allows us to better inform those struggling with headache disorders.
7
We examined the connection between vitamin D and headaches, particularly in children and adolescents. Although studies show a potential benefit of vitamin D supplementation, the overall effectiveness in reducing headaches isn't conclusively proven.
The research indicated that dietary supplements like vitamin D might have specific effects on lowering headache frequency or severity. However, they are often assessed alongside other treatments, such as physiotherapy or acupuncture, making it difficult to isolate their impact.
Overall, while incorporating vitamin D may be beneficial for some, we should remain cautious and not regard it as a standalone solution for headache relief.
The research indicated that dietary supplements like vitamin D might have specific effects on lowering headache frequency or severity. However, they are often assessed alongside other treatments, such as physiotherapy or acupuncture, making it difficult to isolate their impact.
Overall, while incorporating vitamin D may be beneficial for some, we should remain cautious and not regard it as a standalone solution for headache relief.
7
We aimed to explore the relationship between vitamin D levels and migraine prevalence, using data from over 9,100 participants in the National Health and Nutrition Examination Survey conducted between 2001 and 2004. Our focus was on how serum vitamin D, specifically 25OHD2 and 25OHD3, might impact headache occurrences.
Our findings indicated that about 20.5% of the adults we studied reported experiencing migraines. Notably, those with lower levels of vitamin D were more likely to suffer from migraines. In fact, participants in the highest quartile of vitamin D levels had a 16% lower likelihood of experiencing migraines compared to those in the lowest quartile. This was confirmed through various analytical methods, including logistic regression and stratified analysis.
While the results suggest a significant negative correlation between vitamin D levels and migraine prevalence, it’s important to remember that this study does not directly address whether vitamin D treatment could alleviate headaches. Rather, it highlights the need for further research to understand the role of vitamin D in migraine development.
Our findings indicated that about 20.5% of the adults we studied reported experiencing migraines. Notably, those with lower levels of vitamin D were more likely to suffer from migraines. In fact, participants in the highest quartile of vitamin D levels had a 16% lower likelihood of experiencing migraines compared to those in the lowest quartile. This was confirmed through various analytical methods, including logistic regression and stratified analysis.
While the results suggest a significant negative correlation between vitamin D levels and migraine prevalence, it’s important to remember that this study does not directly address whether vitamin D treatment could alleviate headaches. Rather, it highlights the need for further research to understand the role of vitamin D in migraine development.
8
Combined treatment benefits migraines
We conducted a randomized, triple-blinded, placebo-controlled trial focusing on the effects of vitamin D and probiotic co-supplementation on migraine headaches. This study included adult patients aged 18 to 55 diagnosed with migraines, specifically using the International Classification of Headache Disorders-3 criteria.
Over a 12-week period, participants received either 50,000 IU of vitamin D plus a daily probiotic or a placebo. We assessed their migraine symptoms through reliable questionnaires and self-reported diaries, tracking headache frequency, duration, and intensity. We also measured their mental health, daily functioning, and inflammation markers during the trial.
Our findings indicated that the combination of vitamin D and probiotics provided beneficial effects on migraine characteristics, including improved mental health outcomes. Although we did not isolate the impact of vitamin D alone, the results suggest that it may play a role in migraine management when paired with probiotics. Further studies are needed to firmly establish these effects and better understand the potential of vitamin D as a treatment option for headaches.
Over a 12-week period, participants received either 50,000 IU of vitamin D plus a daily probiotic or a placebo. We assessed their migraine symptoms through reliable questionnaires and self-reported diaries, tracking headache frequency, duration, and intensity. We also measured their mental health, daily functioning, and inflammation markers during the trial.
Our findings indicated that the combination of vitamin D and probiotics provided beneficial effects on migraine characteristics, including improved mental health outcomes. Although we did not isolate the impact of vitamin D alone, the results suggest that it may play a role in migraine management when paired with probiotics. Further studies are needed to firmly establish these effects and better understand the potential of vitamin D as a treatment option for headaches.
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- Semelka RC, Ramalho M, Jay M, Hickey L, Hickey J. Intravenous Calcium-/Zinc-Diethylene Triamine Penta-Acetic Acid in Patients With Presumed Gadolinium Deposition Disease: A Preliminary Report on 25 Patients. Invest Radiol. 2018;53:373. doi:10.1097/RLI.0000000000000453
