Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.4
USERS' SCORE
Good
Based on 8 Reviews
8
Supplement Facts
Serving Size: 3 Caplets
Amount Per Serving
%DV
Vitamin D (as D3 Cholecalciferol)
15 mcg (600 IU)
75%
Calcium (as Calcium Carbonate and Calcium Gluconate)
1,000 mg
77%
Magnesium (as Magnesium Oxide and Magnesium Gluconate)
400 mg
95%
Zinc (as Zinc Gluconate and Zinc Citrate)
25 mg
227%
Sodium
10 mg
<1%
Top Medical Research Studies
9.5
We examined how vitamin D supplementation could help improve symptoms for those suffering from irritable bowel syndrome (IBS). This systematic review pulled together findings from four randomized, placebo-controlled trials, with a total of 335 participants, to determine the effectiveness of vitamin D on various IBS measures.
Participants with IBS often struggle with symptoms like pain and discomfort, and vitamin D deficiency has been frequently noted in these individuals. Our research indicated that taking vitamin D could lead to significant improvements in IBS severity compared to a placebo. The results showed that those receiving vitamin D reported notable changes in their IBS severity scores and quality of life scores after the supplementation.
Specifically, after taking vitamin D, participants fared much better in terms of symptom relief than those who received a placebo. While we found some variability in the overall effects on the total score of IBS, the positive outcomes in severity and quality of life were compelling. Overall, our findings suggest that vitamin D supplementation presents a promising option for managing IBS symptoms.
Participants with IBS often struggle with symptoms like pain and discomfort, and vitamin D deficiency has been frequently noted in these individuals. Our research indicated that taking vitamin D could lead to significant improvements in IBS severity compared to a placebo. The results showed that those receiving vitamin D reported notable changes in their IBS severity scores and quality of life scores after the supplementation.
Specifically, after taking vitamin D, participants fared much better in terms of symptom relief than those who received a placebo. While we found some variability in the overall effects on the total score of IBS, the positive outcomes in severity and quality of life were compelling. Overall, our findings suggest that vitamin D supplementation presents a promising option for managing IBS symptoms.
Read More
9
We aimed to find out how vitamin D supplementation might help those suffering from irritable bowel syndrome (IBS). To do this, we conducted a thorough review of nine randomized controlled trials that included a total of 780 participants.
Our findings showed that vitamin D supplementation significantly improved IBS symptoms and overall quality of life. Specifically, we observed a notable reduction in symptom severity scores and increased satisfaction with life among those taking vitamin D compared to those who did not. Additionally, we confirmed an increase in the levels of serum 25(OH)D, which is crucial for overall health.
Importantly, we also found that the risks of any adverse events while taking vitamin D were low. The results suggest that vitamin D could be a promising option for managing IBS effectively and safely.
Our findings showed that vitamin D supplementation significantly improved IBS symptoms and overall quality of life. Specifically, we observed a notable reduction in symptom severity scores and increased satisfaction with life among those taking vitamin D compared to those who did not. Additionally, we confirmed an increase in the levels of serum 25(OH)D, which is crucial for overall health.
Importantly, we also found that the risks of any adverse events while taking vitamin D were low. The results suggest that vitamin D could be a promising option for managing IBS effectively and safely.
Read More
8
We set out to investigate how vitamin D levels, particularly serum 25-hydroxyvitamin D, might affect the risk of developing irritable bowel syndrome (IBS). Using a sophisticated approach called Mendelian randomization, we analyzed data collected from large biobanks. This method allows us to draw more robust conclusions about causality, especially given the controversies surrounding previous observational studies.
Our analysis focused on a substantial number of participants and examined the genetic factors associated with both vitamin D levels and IBS. While we found no significant causal relationship between vitamin D intake and IBS, we discovered an intriguing result regarding 25-hydroxyvitamin D. Specifically, higher levels of this form of vitamin D seemed to correlate with a decreased risk of IBS. More precisely, each additional standard deviation increase in genetically determined 25-hydroxyvitamin D was linked to a 16.8% lower risk of developing IBS.
Nevertheless, it's important to acknowledge the complexity of these findings. Although we observed a negative causal relationship between 25-hydroxyvitamin D and IBS, the same could not be said for vitamin D intake or functional dyspepsia (FD). This study brushes against the broader conversation about the potential health benefits of vitamin D while acknowledging that further research is necessary to fully understand these dynamics.
Our analysis focused on a substantial number of participants and examined the genetic factors associated with both vitamin D levels and IBS. While we found no significant causal relationship between vitamin D intake and IBS, we discovered an intriguing result regarding 25-hydroxyvitamin D. Specifically, higher levels of this form of vitamin D seemed to correlate with a decreased risk of IBS. More precisely, each additional standard deviation increase in genetically determined 25-hydroxyvitamin D was linked to a 16.8% lower risk of developing IBS.
Nevertheless, it's important to acknowledge the complexity of these findings. Although we observed a negative causal relationship between 25-hydroxyvitamin D and IBS, the same could not be said for vitamin D intake or functional dyspepsia (FD). This study brushes against the broader conversation about the potential health benefits of vitamin D while acknowledging that further research is necessary to fully understand these dynamics.
Read More
Most Useful Reviews
9
IBS improvement
8 people found this helpful
I previously suffered from irritable bowel syndrome and tried Tsumura's Chinese medicine, which was ineffective and costly. After researching, I discovered that magnesium helps soften stools. When I switched to magnesium, my bowel movements stabilised, and both my IBS symptoms and hemorrhoids improved. Despite being larger than typical Japanese supplements, they are smooth and easy to swallow. I'm pleased that one supplement addresses two conditions and offers great value.
Read More
7.5
Constipation relief
3 people found this helpful
I began taking this supplement to help with teeth grinding at night. After a few days of taking three tablets before bed, I woke up feeling refreshed and experienced less jaw pain. Additionally, magnesium significantly improved my constipation and bowel movements. I appreciate that I can also consume vitamin D, calcium, and zinc with it. I plan to continue using it daily.
Read More
9
Neurological benefits
I take magnesium supplements due to a neurological condition, and this one is particularly effective. It quickly relaxes spasms, promotes sleep, and is suitable for my irritable bowel syndrome. My abdominal pain dissipates swiftly, and I'm very satisfied with the results, even sharing them with my mother.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.4
- All Researches
9.5
We examined how vitamin D supplementation could help improve symptoms for those suffering from irritable bowel syndrome (IBS). This systematic review pulled together findings from four randomized, placebo-controlled trials, with a total of 335 participants, to determine the effectiveness of vitamin D on various IBS measures.
Participants with IBS often struggle with symptoms like pain and discomfort, and vitamin D deficiency has been frequently noted in these individuals. Our research indicated that taking vitamin D could lead to significant improvements in IBS severity compared to a placebo. The results showed that those receiving vitamin D reported notable changes in their IBS severity scores and quality of life scores after the supplementation.
Specifically, after taking vitamin D, participants fared much better in terms of symptom relief than those who received a placebo. While we found some variability in the overall effects on the total score of IBS, the positive outcomes in severity and quality of life were compelling. Overall, our findings suggest that vitamin D supplementation presents a promising option for managing IBS symptoms.
Participants with IBS often struggle with symptoms like pain and discomfort, and vitamin D deficiency has been frequently noted in these individuals. Our research indicated that taking vitamin D could lead to significant improvements in IBS severity compared to a placebo. The results showed that those receiving vitamin D reported notable changes in their IBS severity scores and quality of life scores after the supplementation.
Specifically, after taking vitamin D, participants fared much better in terms of symptom relief than those who received a placebo. While we found some variability in the overall effects on the total score of IBS, the positive outcomes in severity and quality of life were compelling. Overall, our findings suggest that vitamin D supplementation presents a promising option for managing IBS symptoms.
Read More
9
We conducted a double-blind, randomized clinical trial involving 76 patients diagnosed with diarrhea-predominant irritable bowel syndrome (IBS) to evaluate the effectiveness of a dried extract combined with calcium treatment. Participants were split into two groups: one receiving a placebo, and the other receiving a combination of 75 mg of the dried extract and 175 mg of dibasic calcium phosphate (calcium).
Throughout the treatment period, we observed significant improvements in the quality of life, temperament, and various IBS symptoms among those who received the active treatment. Even four weeks after the treatment ended, there was a slight decrease in these benefits but still indicated some level of effectiveness.
Overall, we found that the whole extract, supplemented with calcium, helped to moderate symptoms of IBS and improve patients' overall quality of life. However, it’s important to note that due to the calcium's inclusion as part of the formulation, we can't define its isolated effect on IBS conclusively.
Throughout the treatment period, we observed significant improvements in the quality of life, temperament, and various IBS symptoms among those who received the active treatment. Even four weeks after the treatment ended, there was a slight decrease in these benefits but still indicated some level of effectiveness.
Overall, we found that the whole extract, supplemented with calcium, helped to moderate symptoms of IBS and improve patients' overall quality of life. However, it’s important to note that due to the calcium's inclusion as part of the formulation, we can't define its isolated effect on IBS conclusively.
Read More
9
We aimed to find out how vitamin D supplementation might help those suffering from irritable bowel syndrome (IBS). To do this, we conducted a thorough review of nine randomized controlled trials that included a total of 780 participants.
Our findings showed that vitamin D supplementation significantly improved IBS symptoms and overall quality of life. Specifically, we observed a notable reduction in symptom severity scores and increased satisfaction with life among those taking vitamin D compared to those who did not. Additionally, we confirmed an increase in the levels of serum 25(OH)D, which is crucial for overall health.
Importantly, we also found that the risks of any adverse events while taking vitamin D were low. The results suggest that vitamin D could be a promising option for managing IBS effectively and safely.
Our findings showed that vitamin D supplementation significantly improved IBS symptoms and overall quality of life. Specifically, we observed a notable reduction in symptom severity scores and increased satisfaction with life among those taking vitamin D compared to those who did not. Additionally, we confirmed an increase in the levels of serum 25(OH)D, which is crucial for overall health.
Importantly, we also found that the risks of any adverse events while taking vitamin D were low. The results suggest that vitamin D could be a promising option for managing IBS effectively and safely.
Read More
9
We conducted a study to understand how probiotic 35624 affects irritable bowel syndrome (IBS) in children and adolescents aged 8 to 18. This real-world study, carried out in Chile, involved 64 young participants over a span of 12 weeks, during which we closely monitored their gastrointestinal symptoms.
Throughout the study, participants showed significant improvements in various IBS symptoms measured by specific scoring systems. By week 6 and again at week 12, we saw strong positive changes with 98.3% of them experiencing improvements in three or more IBS domains. This shift was impressive, as the severity of their IBS symptoms moved from moderate or severe to mild or in remission.
Interestingly, the study also looked into vitamin D levels, as vitamin D deficiency is prevalent among children in Latin America. However, we found that low baseline serum vitamin D levels did not correlate with the severity of IBS symptoms or the response to the probiotic treatment. While the improvements were promising, they did not last after a two-week washout period, highlighting the need for more research to understand these effects fully, particularly regarding vitamin D's influence.
Throughout the study, participants showed significant improvements in various IBS symptoms measured by specific scoring systems. By week 6 and again at week 12, we saw strong positive changes with 98.3% of them experiencing improvements in three or more IBS domains. This shift was impressive, as the severity of their IBS symptoms moved from moderate or severe to mild or in remission.
Interestingly, the study also looked into vitamin D levels, as vitamin D deficiency is prevalent among children in Latin America. However, we found that low baseline serum vitamin D levels did not correlate with the severity of IBS symptoms or the response to the probiotic treatment. While the improvements were promising, they did not last after a two-week washout period, highlighting the need for more research to understand these effects fully, particularly regarding vitamin D's influence.
Read More
9
We investigated the impacts of a combination treatment involving probiotics and vitamin D on individuals with irritable bowel syndrome (IBS), specifically those experiencing diarrhea-predominant IBS (IBS-D) or mixed bowel movements (IBS-M). The study involved 246 adults followed by private gastroenterologists, who were given a daily dose of probiotics along with vitamin D over a period of 42 days.
At the end of this timeframe, we found that a significant number of patients—about 62.9%—reported improvements in their symptoms. In fact, there was a notable decrease in the IBS Severity Scoring System scores. This improvement also correlated with enhancements in overall quality of life related to IBS, as well as reductions in anxiety and depression symptoms.
Our findings align with earlier randomized clinical trials, reinforcing the notion that the probiotic and vitamin D combination can be beneficial. While we recognize that this study consolidates the evidence of such a combination rather than isolating the effects of vitamin D alone, the results suggest that including vitamin D in treatment plans may indeed foster better mental and gut health for those suffering from IBS.
At the end of this timeframe, we found that a significant number of patients—about 62.9%—reported improvements in their symptoms. In fact, there was a notable decrease in the IBS Severity Scoring System scores. This improvement also correlated with enhancements in overall quality of life related to IBS, as well as reductions in anxiety and depression symptoms.
Our findings align with earlier randomized clinical trials, reinforcing the notion that the probiotic and vitamin D combination can be beneficial. While we recognize that this study consolidates the evidence of such a combination rather than isolating the effects of vitamin D alone, the results suggest that including vitamin D in treatment plans may indeed foster better mental and gut health for those suffering from IBS.
Read More
User Reviews
USERS' SCORE
Good
Based on 8 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
9
IBS improvement
8 people found this helpful
I previously suffered from irritable bowel syndrome and tried Tsumura's Chinese medicine, which was ineffective and costly. After researching, I discovered that magnesium helps soften stools. When I switched to magnesium, my bowel movements stabilised, and both my IBS symptoms and hemorrhoids improved. Despite being larger than typical Japanese supplements, they are smooth and easy to swallow. I'm pleased that one supplement addresses two conditions and offers great value.
Read More
7.5
Constipation relief
3 people found this helpful
I began taking this supplement to help with teeth grinding at night. After a few days of taking three tablets before bed, I woke up feeling refreshed and experienced less jaw pain. Additionally, magnesium significantly improved my constipation and bowel movements. I appreciate that I can also consume vitamin D, calcium, and zinc with it. I plan to continue using it daily.
Read More
9
Neurological benefits
I take magnesium supplements due to a neurological condition, and this one is particularly effective. It quickly relaxes spasms, promotes sleep, and is suitable for my irritable bowel syndrome. My abdominal pain dissipates swiftly, and I'm very satisfied with the results, even sharing them with my mother.
Read More
6
Gradual improvements
Initially, I didn’t notice improvements after two weeks of taking this supplement; my hair was still falling out and I struggled with stress and sleep. However, by the third week, I began experiencing better sleep and less irritability. My hair loss reduced, and my nails became stronger. Though I’m unsure if my immunity improved, I've avoided colds, which is unusual for me this season.
Read More
6
Bowel movement enhancement
3 people found this helpful
I previously used this supplement but stopped taking vitamins and became constipated, leading me to restart my use of this product. Magnesium appears to improve bowel movements, and I benefit from taking calcium, zinc, and vitamin D simultaneously. Since using it again, my constipation has gradually diminished. Though a bit large, it's easy to swallow.
Read More
Frequently Asked Questions
9
IBS improvement
8 people found this helpful
I previously suffered from irritable bowel syndrome and tried Tsumura's Chinese medicine, which was ineffective and costly. After researching, I discovered that magnesium helps soften stools. When I switched to magnesium, my bowel movements stabilised, and both my IBS symptoms and hemorrhoids improved. Despite being larger than typical Japanese supplements, they are smooth and easy to swallow. I'm pleased that one supplement addresses two conditions and offers great value.
9
Neurological benefits
I take magnesium supplements due to a neurological condition, and this one is particularly effective. It quickly relaxes spasms, promotes sleep, and is suitable for my irritable bowel syndrome. My abdominal pain dissipates swiftly, and I'm very satisfied with the results, even sharing them with my mother.
6
Gradual improvements
Initially, I didn’t notice improvements after two weeks of taking this supplement; my hair was still falling out and I struggled with stress and sleep. However, by the third week, I began experiencing better sleep and less irritability. My hair loss reduced, and my nails became stronger. Though I’m unsure if my immunity improved, I've avoided colds, which is unusual for me this season.
7.5
Constipation relief
3 people found this helpful
I began taking this supplement to help with teeth grinding at night. After a few days of taking three tablets before bed, I woke up feeling refreshed and experienced less jaw pain. Additionally, magnesium significantly improved my constipation and bowel movements. I appreciate that I can also consume vitamin D, calcium, and zinc with it. I plan to continue using it daily.
6
Bowel movement enhancement
3 people found this helpful
I previously used this supplement but stopped taking vitamins and became constipated, leading me to restart my use of this product. Magnesium appears to improve bowel movements, and I benefit from taking calcium, zinc, and vitamin D simultaneously. Since using it again, my constipation has gradually diminished. Though a bit large, it's easy to swallow.
9
We aimed to find out how vitamin D supplementation might help those suffering from irritable bowel syndrome (IBS). To do this, we conducted a thorough review of nine randomized controlled trials that included a total of 780 participants.
Our findings showed that vitamin D supplementation significantly improved IBS symptoms and overall quality of life. Specifically, we observed a notable reduction in symptom severity scores and increased satisfaction with life among those taking vitamin D compared to those who did not. Additionally, we confirmed an increase in the levels of serum 25(OH)D, which is crucial for overall health.
Importantly, we also found that the risks of any adverse events while taking vitamin D were low. The results suggest that vitamin D could be a promising option for managing IBS effectively and safely.
Our findings showed that vitamin D supplementation significantly improved IBS symptoms and overall quality of life. Specifically, we observed a notable reduction in symptom severity scores and increased satisfaction with life among those taking vitamin D compared to those who did not. Additionally, we confirmed an increase in the levels of serum 25(OH)D, which is crucial for overall health.
Importantly, we also found that the risks of any adverse events while taking vitamin D were low. The results suggest that vitamin D could be a promising option for managing IBS effectively and safely.
9
We investigated the impacts of a combination treatment involving probiotics and vitamin D on individuals with irritable bowel syndrome (IBS), specifically those experiencing diarrhea-predominant IBS (IBS-D) or mixed bowel movements (IBS-M). The study involved 246 adults followed by private gastroenterologists, who were given a daily dose of probiotics along with vitamin D over a period of 42 days.
At the end of this timeframe, we found that a significant number of patients—about 62.9%—reported improvements in their symptoms. In fact, there was a notable decrease in the IBS Severity Scoring System scores. This improvement also correlated with enhancements in overall quality of life related to IBS, as well as reductions in anxiety and depression symptoms.
Our findings align with earlier randomized clinical trials, reinforcing the notion that the probiotic and vitamin D combination can be beneficial. While we recognize that this study consolidates the evidence of such a combination rather than isolating the effects of vitamin D alone, the results suggest that including vitamin D in treatment plans may indeed foster better mental and gut health for those suffering from IBS.
At the end of this timeframe, we found that a significant number of patients—about 62.9%—reported improvements in their symptoms. In fact, there was a notable decrease in the IBS Severity Scoring System scores. This improvement also correlated with enhancements in overall quality of life related to IBS, as well as reductions in anxiety and depression symptoms.
Our findings align with earlier randomized clinical trials, reinforcing the notion that the probiotic and vitamin D combination can be beneficial. While we recognize that this study consolidates the evidence of such a combination rather than isolating the effects of vitamin D alone, the results suggest that including vitamin D in treatment plans may indeed foster better mental and gut health for those suffering from IBS.
8
We explored the effects of vitamin D3 (VitD3) on irritable bowel syndrome (IBS) and its role in promoting gut-brain health. By using a unique formulation that complexed VitD3 with cyclodextrin nanosponges, we aimed to enhance its biological activity.
Our study focused on how this improved form of vitamin D3 could impact various conditions, specifically examining two different gut-brain axes: one associated with a healthy gut and a degenerative brain, and another linked to IBS and neurodegeneration.
We found that VitD3-NS significantly alleviated damage caused by lipopolysaccharides in gut cells, helping to restore cell viability, integrity, and tight junction activity. It also reduced harmful oxidative stress and inflammation markers commonly seen in IBS.
Beyond gut benefits, we observed that VitD3-NS improved neurodegenerative conditions in both the healthy model and the IBS model, indicating its potential therapeutic value. Hence, this innovative approach to delivering vitamin D3 appears to enhance its benefits for gut and brain health, even in challenging IBS scenarios.
Our study focused on how this improved form of vitamin D3 could impact various conditions, specifically examining two different gut-brain axes: one associated with a healthy gut and a degenerative brain, and another linked to IBS and neurodegeneration.
We found that VitD3-NS significantly alleviated damage caused by lipopolysaccharides in gut cells, helping to restore cell viability, integrity, and tight junction activity. It also reduced harmful oxidative stress and inflammation markers commonly seen in IBS.
Beyond gut benefits, we observed that VitD3-NS improved neurodegenerative conditions in both the healthy model and the IBS model, indicating its potential therapeutic value. Hence, this innovative approach to delivering vitamin D3 appears to enhance its benefits for gut and brain health, even in challenging IBS scenarios.
4
We explored the connection between vitamin D and irritable bowel syndrome (IBS) by analyzing data from twelve clinical trials that included 1331 IBS patients. Our goal was to see how vitamin D levels might relate to IBS symptoms and whether vitamin D supplementation can make a difference.
The findings revealed something interesting: patients with IBS tend to have lower levels of vitamin D in their blood. While vitamin D supplementation did show an improvement in the quality of life for these patients, it did not significantly affect the overall severity of their IBS symptoms.
This indicates that while vitamin D deficiency is linked to IBS and supplementation can enhance daily living, it may not directly relieve the main symptoms that trouble patients. Therefore, vitamin D could be a valuable part of the conversation around managing IBS, but it should not be seen as a standalone treatment for symptom relief.
The findings revealed something interesting: patients with IBS tend to have lower levels of vitamin D in their blood. While vitamin D supplementation did show an improvement in the quality of life for these patients, it did not significantly affect the overall severity of their IBS symptoms.
This indicates that while vitamin D deficiency is linked to IBS and supplementation can enhance daily living, it may not directly relieve the main symptoms that trouble patients. Therefore, vitamin D could be a valuable part of the conversation around managing IBS, but it should not be seen as a standalone treatment for symptom relief.
References
- Heydari P, Ghanadian M, Asghari G, Azimi M, Babaeian M, et al. A double-blind randomized clinical trial of Boiss. in the patients with diarrhea-predominant irritable bowel syndrome. Res Pharm Sci. 2023;18:89. doi:10.4103/1735-5362.363599
- Qi S, Zhao M, Sun Y, Boro S, Arora B, et al. Impact of vitamin D supplementation on symptom severity and quality of life in patients with irritable bowel syndrome: A meta-analysis. Adv Clin Exp Med. 2025. doi:10.17219/acem/191463
- Cara KC, Taylor SF, Alhmly HF, Wallace TC. The effects of vitamin D intake and status on symptom severity and quality-of-life in adults with irritable bowel syndrome (IBS): a systematic review and meta-analysis. Crit Rev Food Sci Nutr. 2024. doi:10.1080/10408398.2024.2400603
- Cruchet Muñoz S, Verbeke Palma S, Lera Marqués L, Espinosa Pizarro MN, Malig Mechasqui J, et al. Effects of 35624 in Children and Adolescents with Irritable Bowel Syndrome. Nutrients. 2024;16. doi:10.3390/nu16121967
- Jouët P, Altman C, Bruley DES Varannes S, Juhel C, Henri F. Probiotics plus vitamin D in irritable bowel syndrome: a prospective multicentric non-interventional study. Minerva Gastroenterol (Torino). 2024;70:332. doi:10.23736/S2724-5985.24.03581-2
- Uberti F, Trotta F, Cavalli R, Galla R, Caldera F, et al. Enhancing Vitamin D3 Efficacy: Insights from Complexation with Cyclodextrin Nanosponges and Its Impact on Gut-Brain Axes in Physiology and IBS Syndrome. Int J Mol Sci. 2024;25. doi:10.3390/ijms25042189
- Xu S, Luo Q, He J, Chen X, Li S, et al. Causal associations of 25-hydroxyvitamin D with functional gastrointestinal disorders: a two-sample Mendelian randomization study. Genes Nutr. 2023;18:14. doi:10.1186/s12263-023-00734-1
- Kesavan C, Das A, Goyal P, Jackson CS, Strong DD, et al. Vitamin D Deficiency (VDD) and Benefits of Supplementation in Veterans with IBS-D. Diagnostics (Basel). 2023;13. doi:10.3390/diagnostics13172807
- Yan C, Hu C, Chen X, Jia X, Zhu Z, et al. Vitamin D improves irritable bowel syndrome symptoms: A meta-analysis. Heliyon. 2023;9:e16437. doi:10.1016/j.heliyon.2023.e16437
- Yu XL, Wu QQ, He LP, Zheng YF. Role of in vitamin D in irritable bowel syndrome. World J Clin Cases. 2023;11:2677. doi:10.12998/wjcc.v11.i12.2677
- Alvi H, Ali G, Iqbal S, Ahsan MN, Siddiqui MA, et al. Role of 25-hydroxyvitamin D in irritable bowel syndrome patients. J Family Med Prim Care. 2022;11:7975. doi:10.4103/jfmpc.jfmpc_1336_22
- Abdelmalak MFL, Abdelrahim DS, George Michael TMA, Abdel-Maksoud OM, Labib JMW. Vitamin D and lactoferrin attenuate stress-induced colitis in Wistar rats via enhancing AMPK expression with inhibiting mTOR-STAT3 signaling and modulating autophagy. Cell Biochem Funct. 2023;41:211. doi:10.1002/cbf.3774
- Grozić A, Coker K, Dussik CM, Sabir MS, Sabir Z, et al. Identification of putative transcriptomic biomarkers in irritable bowel syndrome (IBS): Differential gene expression and regulation of TPH1 and SERT by vitamin D. PLoS One. 2022;17:e0275683. doi:10.1371/journal.pone.0275683
- Abuelazm M, Muhammad S, Gamal M, Labieb F, Amin MA, et al. The Effect of Vitamin D Supplementation on the Severity of Symptoms and the Quality of Life in Irritable Bowel Syndrome Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients. 2022;14. doi:10.3390/nu14132618
- Bin Y, Kang L, Lili Y. Vitamin D status in irritable bowel syndrome and the impact of supplementation on symptoms: a systematic review and meta-analysis. Nutr Hosp. 2022;39:1144. doi:10.20960/nh.04044
- Huang H, Lu L, Chen Y, Zeng Y, Xu C. The efficacy of vitamin D supplementation for irritable bowel syndrome: a systematic review with meta-analysis. Nutr J. 2022;21:24. doi:10.1186/s12937-022-00777-x
- Chong RIH, Yaow CYL, Loh CYL, Teoh SE, Masuda Y, et al. Vitamin D supplementation for irritable bowel syndrome: A systematic review and meta-analysis. J Gastroenterol Hepatol. 2022;37:993. doi:10.1111/jgh.15852
- Harvey RF, Read AE. Effects of oral magnesium sulphate on colonic motility in patients with the irritable bowel syndrome. Gut. 1973;14:983.
- Zhuang Y, Li L, Ran Y, Zhang Y, Chen J, et al. Dietary copper, zinc, copper/zinc ratio intakes and irritable bowel syndrome risk: a large-scale prospective cohort study from UK Biobank. Am J Epidemiol. 2024. doi:10.1093/aje/kwae412
