Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 34 Researches
7.3
USERS' SCORE
Good
Based on 75 Reviews
8.7
Supplement Facts
Serving Size: 3 Caplets
Amount Per Serving
%DV
Vitamin D (as D3 Cholecalciferol)
15 mcg (600 IU)
75%
Calcium (as Calcium Carbonate and Calcium Gluconate)
1,000 mg
77%
Magnesium (as Magnesium Oxide and Magnesium Gluconate)
400 mg
95%
Zinc (as Zinc Gluconate and Zinc Citrate)
25 mg
227%
Sodium
10 mg
<1%
Top Medical Research Studies
9
Magnesium sulfate alleviates postoperative pain
We explored the impact of magnesium sulfate on managing pain following total knee arthroplasty. In a randomized, double-blind trial with 90 patients, half received a blend of analgesics that included magnesium sulfate, while the other half did not.
Following surgery, the results showed that magnesium sulfate helped prolong pain relief and reduced the need for opioids. Patients receiving it experienced less postoperative pain and moved towards recovery more effectively.
Overall, adding magnesium sulfate appears beneficial for postoperative knee pain management.
Following surgery, the results showed that magnesium sulfate helped prolong pain relief and reduced the need for opioids. Patients receiving it experienced less postoperative pain and moved towards recovery more effectively.
Overall, adding magnesium sulfate appears beneficial for postoperative knee pain management.
Read More
9
Magnesium aids postoperative pain relief
We explored the role of magnesium in reducing knee pain following total knee arthroplasty (TKA). In a study involving 119 adults, participants received either an adductor canal block with magnesium and bupivacaine or just bupivacaine.
Those who received magnesium reported significantly lower pain scores and reduced opioid usage in the days after surgery, without experiencing an uptick in nausea or dissatisfaction. This suggests that adding magnesium to local anesthesia could enhance pain management for TKA patients, promoting a smoother recovery.
Those who received magnesium reported significantly lower pain scores and reduced opioid usage in the days after surgery, without experiencing an uptick in nausea or dissatisfaction. This suggests that adding magnesium to local anesthesia could enhance pain management for TKA patients, promoting a smoother recovery.
Read More
9
Magnesium reduces postoperative knee pain
We evaluated the impact of magnesium sulphate on pain levels for 44 patients undergoing staged bilateral total knee arthroplasty.
In this study, the magnesium group received magnesium sulphate while the control group received isotonic saline during their surgeries.
Our findings showed that those who received magnesium experienced significantly lower pain scores compared to the control group, both after their first and second surgeries.
Importantly, magnesium also helped reduce the need for additional pain relief medications in the days following surgery.
In this study, the magnesium group received magnesium sulphate while the control group received isotonic saline during their surgeries.
Our findings showed that those who received magnesium experienced significantly lower pain scores compared to the control group, both after their first and second surgeries.
Importantly, magnesium also helped reduce the need for additional pain relief medications in the days following surgery.
Read More
Most Useful Reviews
9.5
Pain relief achieved
A remarkable complex of minerals! At 39, I had severe knee pain from walking, but after a month of taking this, the pain vanished completely! I continue to take courses, drinking it for a month with breaks, and I wish to help others with my honest feedback.
Read More
9.5
Joint pain eased
For the price, these vitamins are very effective. After starting my jogging routine, I experienced knee pain, but it disappeared after taking these pills, which clearly absorbed well. I'll continue to order more.
Read More
9.5
Pain management
An excellent complex! After my fracture, I was plagued by knee pain, but this complex has significantly reduced it, greatly improving my overall health.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 34 Researches
7.3
- All Researches
9
We explored how calcium phosphate (CaP) injections impact knee pain, particularly in patients suffering from osteoarthritis-related bone marrow lesions (OA-BML). In this study, we compared two groups of patients: those who received knee arthroscopy combined with CaP injections and those who had knee arthroscopy for different knee issues.
Our observations showed that patients receiving the CaP injections experienced less frequent conversions to total knee arthroplasty (TKA) when compared to the other group. Notably, within the CaP group, we noticed a significant improvement in their knee injury and functional outcome scores before and after the procedure. However, patients who only underwent knee arthroscopy did not show the same level of improvement.
Overall, we found that adding CaP injections during knee surgery for OA-BML significantly enhanced functional outcomes over traditional surgery alone. This study underscores the potential benefits of CaP treatments in managing knee pain and improving quality of life for those suffering from knee OA.
Our observations showed that patients receiving the CaP injections experienced less frequent conversions to total knee arthroplasty (TKA) when compared to the other group. Notably, within the CaP group, we noticed a significant improvement in their knee injury and functional outcome scores before and after the procedure. However, patients who only underwent knee arthroscopy did not show the same level of improvement.
Overall, we found that adding CaP injections during knee surgery for OA-BML significantly enhanced functional outcomes over traditional surgery alone. This study underscores the potential benefits of CaP treatments in managing knee pain and improving quality of life for those suffering from knee OA.
Read More
9
We focused on the effects of vitamin D (VITD) in reducing knee pain linked to osteoarthritis (OA) using a study conducted on Wistar rats. The rats were induced with OA through a combination of surgical methods known as ACLT (anterior cruciate ligament transection) along with medial meniscectomy. This allowed us to closely observe the direct impact of VITD on pain levels and cartilage health.
Our investigations revealed that VITD not only alleviated pain but also minimized cartilage destruction. We measured pain severity through various tests, examined knee structure through histopathological studies, and analyzed different biological markers including inflammatory cytokines and matrix metalloproteinases (MMPs), which are linked to cartilage degradation.
The results were quite promising. Not only did VITD show a significant reduction in pain, but it also decreased inflammation and the destruction of chondrocytes, or cartilage cells. These benefits appear to stem from VITD's ability to lower the expression of MMPs, which are known contributors to cartilage breakdown in OA.
Overall, our findings strongly suggest that adding vitamin D to treatment regimens could be beneficial for those suffering from knee pain related to osteoarthritis, making it a potential ally in managing this common joint condition.
Our investigations revealed that VITD not only alleviated pain but also minimized cartilage destruction. We measured pain severity through various tests, examined knee structure through histopathological studies, and analyzed different biological markers including inflammatory cytokines and matrix metalloproteinases (MMPs), which are linked to cartilage degradation.
The results were quite promising. Not only did VITD show a significant reduction in pain, but it also decreased inflammation and the destruction of chondrocytes, or cartilage cells. These benefits appear to stem from VITD's ability to lower the expression of MMPs, which are known contributors to cartilage breakdown in OA.
Overall, our findings strongly suggest that adding vitamin D to treatment regimens could be beneficial for those suffering from knee pain related to osteoarthritis, making it a potential ally in managing this common joint condition.
Read More
9
Magnesium sulfate alleviates postoperative pain
We explored the impact of magnesium sulfate on managing pain following total knee arthroplasty. In a randomized, double-blind trial with 90 patients, half received a blend of analgesics that included magnesium sulfate, while the other half did not.
Following surgery, the results showed that magnesium sulfate helped prolong pain relief and reduced the need for opioids. Patients receiving it experienced less postoperative pain and moved towards recovery more effectively.
Overall, adding magnesium sulfate appears beneficial for postoperative knee pain management.
Following surgery, the results showed that magnesium sulfate helped prolong pain relief and reduced the need for opioids. Patients receiving it experienced less postoperative pain and moved towards recovery more effectively.
Overall, adding magnesium sulfate appears beneficial for postoperative knee pain management.
Read More
9
Magnesium aids postoperative pain relief
We explored the role of magnesium in reducing knee pain following total knee arthroplasty (TKA). In a study involving 119 adults, participants received either an adductor canal block with magnesium and bupivacaine or just bupivacaine.
Those who received magnesium reported significantly lower pain scores and reduced opioid usage in the days after surgery, without experiencing an uptick in nausea or dissatisfaction. This suggests that adding magnesium to local anesthesia could enhance pain management for TKA patients, promoting a smoother recovery.
Those who received magnesium reported significantly lower pain scores and reduced opioid usage in the days after surgery, without experiencing an uptick in nausea or dissatisfaction. This suggests that adding magnesium to local anesthesia could enhance pain management for TKA patients, promoting a smoother recovery.
Read More
9
We evaluated how effective magnesium, especially when combined with bupivacaine, is for managing knee pain after arthroscopy. Our study looked at data from 78 randomized trials involving 4,425 participants.
It turns out that magnesium with bupivacaine is the top performer in easing pain right after surgery and at the 24-hour mark, outperforming other analgesics like morphine.
However, magnesium alone didn’t show significant pain relief. We found that using this combination does not lead to more side effects, making it a safe choice for recovery.
It turns out that magnesium with bupivacaine is the top performer in easing pain right after surgery and at the 24-hour mark, outperforming other analgesics like morphine.
However, magnesium alone didn’t show significant pain relief. We found that using this combination does not lead to more side effects, making it a safe choice for recovery.
Read More
User Reviews
USERS' SCORE
Good
Based on 75 Reviews
8.7
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Pain relief achieved
A remarkable complex of minerals! At 39, I had severe knee pain from walking, but after a month of taking this, the pain vanished completely! I continue to take courses, drinking it for a month with breaks, and I wish to help others with my honest feedback.
Read More
9.5
Joint pain eased
For the price, these vitamins are very effective. After starting my jogging routine, I experienced knee pain, but it disappeared after taking these pills, which clearly absorbed well. I'll continue to order more.
Read More
9.5
Pain management
An excellent complex! After my fracture, I was plagued by knee pain, but this complex has significantly reduced it, greatly improving my overall health.
Read More
9.5
Joint strength gained
At 36, I discovered knee pain and needed a calcium complex for joint strengthening. After taking this affordable solution containing essential vitamins, I feel fantastic and recommend it for anyone leading a slightly sedentary lifestyle.
Read More
9.5
Back pain alleviated
We have already finished our third bottle. My husband's knee pain and back pain have noticeably improved, and my hair has stopped falling out.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Rai S, Patel S, Chouhan DK, Jain A, Thami T, et al. Is There a Need for an Exogenous Activator Along with PRP for Early Knee Osteoarthritis? A Triple-Blinded Randomized Control Trial. Indian J Orthop. 2024;58:905. doi:10.1007/s43465-024-01159-7
- Stratton A, Wanless M, Abidi N. Total Knee Conversion Rates and Functional Outcome After Calcium Phosphate Injection for Bone Marrow Lesions of the Knee. J Knee Surg. 2024;37:341. doi:10.1055/a-2094-5724
- Montemor CN, Fernandes MTP, Marquez AS, Bignardi PR, Poli RC, et al. Impact of Reduced Vitamin D Levels on Pain, Function, and Severity in Knee or Hip Osteoarthritis. Nutrients. 2025;17. doi:10.3390/nu17030447
- Mende LK, Kuthati Y, Wong CS. Curcumin and Vitamin D Supplement Attenuates Knee Osteoarthritis Progression in ACLT + MMx Rat Model: Effect on Cartilage Protection and Pain Reduction. Nutrients. 2025;17. doi:10.3390/nu17020349
- Rajani AM, Mittal A, Kulkarni VU, Rajani KA, Rajani KA. Role of Pre-operative Correction of Vitamin D3 Deficiency in Controlling Post-operative Bone Pain after Unicompartmental Knee Arthroplasty. Malays Orthop J. 2024;18:7. doi:10.5704/MOJ.2411.002
- Gottreich JR, Katz JN, Jones MH. Nonsurgical Knee Osteoarthritis Treatments for Reducing Inflammation as Measured on MRI Scans: A Systematic Review of Randomized Controlled Trials. Orthop J Sports Med. 2024;12:23259671241272667. doi:10.1177/23259671241272667
- Zuo A, Jia Q, Zhang M, Zhou X, Li T, et al. The association of vitamin D with knee osteoarthritis pain: an analysis from the Osteoarthritis Initiative database. Sci Rep. 2024;14:30176. doi:10.1038/s41598-024-81845-6
- Wang QW, Ong MT, Man GC, Yeung YM, He X, et al. The effectiveness of vitamin D supplementation in patients with end-stage knee osteoarthritis: Study protocol for a double-blinded, randomized controlled trial. PLoS One. 2024;19:e0309610. doi:10.1371/journal.pone.0309610
- Saengsiwaritt W, Jittikoon J, Chaikledkaew U, Tawonsawatruk T, Honsawek S, et al. Effect of vitamin D supplementation on circulating level of autophagosome protein LC3A, inflammation, and physical performance in knee osteoarthritis. Clin Transl Sci. 2023;16:2543. doi:10.1111/cts.13646
- Wang Z, Zhu Z, Pan F, Zheng S, Parameswaran V, et al. Long-term effects of vitamin D supplementation and maintaining sufficient vitamin D on knee osteoarthritis over 5 years. Arthritis Res Ther. 2023;25:178. doi:10.1186/s13075-023-03167-8
- Wang R, Wang ZM, Xiang SC, Jin ZK, Zhang JJ, et al. Relationship between 25-hydroxy vitamin D and knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials. Front Med (Lausanne). 2023;10:1200592. doi:10.3389/fmed.2023.1200592
- Busa P, Huang N, Kuthati Y, Wong CS. Vitamin D reduces pain and cartilage destruction in knee osteoarthritis animals through inhibiting the matrix metalloprotease (MMPs) expression. Heliyon. 2023;9:e15268. doi:10.1016/j.heliyon.2023.e15268
- Shen J, Lin X, Lin Y, Xiao J, Wu C, et al. Supplementation of hyaluronic acid injections with vitamin D improve knee function by attenuating synovial fluid oxidative stress in osteoarthritis patients with vitamin D insufficiency. Front Nutr. 2023;10:1026722. doi:10.3389/fnut.2023.1026722
- Divjak A, Jovanovic I, Matic A, Lucic AT, Gajovic N, et al. The influence of vitamin D supplementation on the expression of mediators of inflammation in knee osteoarthritis. Immunol Res. 2023;71:442. doi:10.1007/s12026-022-09354-0
- Lin T, Peng S, Lu S, Fu S, Zeng D, et al. Prediction of knee pain improvement over two years for knee osteoarthritis using a dynamic nomogram based on MRI-derived radiomics: a proof-of-concept study. Osteoarthritis Cartilage. 2023;31:267. doi:10.1016/j.joca.2022.10.014
- Strath LJ, Hernandez PV, Nodarse CL, Johnson AJ, Edberg JD, et al. Clinical vitamin D levels are associated with insular volume and inferior temporal gyrus white matter surface area in community-dwelling individuals with knee pain. Front Neurosci. 2022;16:882322. doi:10.3389/fnins.2022.882322
- Jin X, Ding C, Hunter DJ, Gallego B. Effectiveness of vitamin D supplementation on knee osteoarthritis - A target trial emulation study using data from the Osteoarthritis Initiative cohort. Osteoarthritis Cartilage. 2022;30:1495. doi:10.1016/j.joca.2022.06.005
- Peng HM, Weng XS, Li Y, Feng B, Qian W, et al. Effect of alendronate sodium plus vitamin D tablets on knee joint structure and osteoarthritis pain: a multi-center, randomized, double-blind, placebo-controlled study protocol. BMC Musculoskelet Disord. 2022;23:584. doi:10.1186/s12891-022-05521-4
- Zhu Y, Shen S, Cui L, Wu L, Zhang B. Magnesium sulphate and sodium bicarbonate as additives for periarticular local infiltration analgesia improve pain management after unicompartmental knee arthroplasty: a prospective, double-blind, randomized controlled trial. J Orthop Surg Res. 2024;19:764. doi:10.1186/s13018-024-05233-6
- Xu H, Hao C, Wang X, Du J, Zhang T, et al. Effect of Magnesium Sulfate Infusion on Postoperative Quality of Recovery in Patients Undergoing Total Knee Arthroplasty: A Prospective, Double-Blind, Randomized Controlled Trial. Drug Des Devel Ther. 2024;18:919. doi:10.2147/DDDT.S444896
- Zhao C, Wang L, Chen L, Wang Q, Kang P. Effects of magnesium sulfate on periarticular infiltration analgesia in total knee arthroplasty: a prospective, double-blind, randomized controlled trial. J Orthop Surg Res. 2023;18:301. doi:10.1186/s13018-023-03790-w
- Wang Q, Zhao C, Hu J, Ma T, Yang J, et al. Efficacy of a Modified Cocktail for Periarticular Local Infiltration Analgesia in Total Knee Arthroplasty: A Prospective, Double-Blinded, Randomized Controlled Trial. J Bone Joint Surg Am. 2023;105:354. doi:10.2106/JBJS.22.00614
- Choi JW, Lahori A, Merlo JA, Gill O, Ghoddoussi F, et al. Adductor Canal Blocks With Bupivacaine and Magnesium After Same-day Discharge Total Knee Arthroplasty Improve Postoperative Pain Relief and Decrease Opioid Consumption: A Prospective Randomized Controlled Trial. Clin J Pain. 2022;38:388. doi:10.1097/AJP.0000000000001036
- He Y, He H, Li X, Lei G, Xie D, et al. Intra-Articular Magnesium Plus Bupivacaine Is the Most Effective and Safe Postoperative Analgesic Option Following Knee Arthroscopy: A Network Meta-analysis. Arthroscopy. 2022;38:2897. doi:10.1016/j.arthro.2022.03.013
- Shi L, Zhu H, Ma J, Shi LL, Gao F, et al. Intra-articular magnesium to alleviate postoperative pain after arthroscopic knee surgery: a meta-analysis of randomized controlled trials. J Orthop Surg Res. 2021;16:111. doi:10.1186/s13018-021-02264-1
- Zhao Z, Zhang X, Peng H, Li W, Liu H, et al. Magnesium Sulfate Combined with a Levobupivacaine Periarticular Cocktail for Analgesia in the Early Postoperative Period after Total Knee Arthroplasty. J Knee Surg. 2021;34:1463. doi:10.1055/s-0040-1710364
- Condello V, Filardo G, Madonna V, Andriolo L, Screpis D, et al. Use of a Biomimetic Scaffold for the Treatment of Osteochondral Lesions in Early Osteoarthritis. Biomed Res Int. 2018;2018:7937089. doi:10.1155/2018/7937089
- Shmagel A, Onizuka N, Langsetmo L, Vo T, Foley R, et al. Low magnesium intake is associated with increased knee pain in subjects with radiographic knee osteoarthritis: data from the Osteoarthritis Initiative. Osteoarthritis Cartilage. 2018;26:651. doi:10.1016/j.joca.2018.02.002
- Shin HJ, Kim EY, Na HS, Kim TK, Kim MH, et al. Magnesium sulphate attenuates acute postoperative pain and increased pain intensity after surgical injury in staged bilateral total knee arthroplasty: a randomized, double-blinded, placebo-controlled trial. Br J Anaesth. 2016;117:497. doi:10.1093/bja/aew227
- Chen Y, Zhang Y, Zhu YL, Fu PL. Efficacy and safety of an intra-operative intra-articular magnesium/ropivacaine injection for pain control following total knee arthroplasty. J Int Med Res. 2012;40:2032.
- Ekmekci P, Bengisun ZK, Akan B, Kazbek BK, Ozkan KS, et al. The effect of magnesium added to levobupivacaine for femoral nerve block on postoperative analgesia in patients undergoing ACL reconstruction. Knee Surg Sports Traumatol Arthrosc. 2013;21:1119. doi:10.1007/s00167-012-2093-4
- Koltka K, Koknel-Talu G, Asik M, Ozyalcin S. Comparison of efficacy of intraarticular application of magnesium, levobupivacaine and lornoxicam with placebo in arthroscopic surgery. Knee Surg Sports Traumatol Arthrosc. 2011;19:1884. doi:10.1007/s00167-011-1497-x
- Chen Y, Zhang Y, Zhu YL, Fu PL. Efficacy and safety of an intra-operative intra-articular magnesium/ropivacaine injection for pain control following total knee arthroplasty. J Int Med Res. 2009;37:1733.
- Farouk S, Aly A. A comparison of intra-articular magnesium and/or morphine with bupivacaine for postoperative analgesia after arthroscopic knee surgery. J Anesth. 2009;23:508. doi:10.1007/s00540-009-0822-8
