Reviewed By
Overview
SCIENTIFIC SCORE
Likely Ineffective
Based on 21 Researches
4.9
USERS' SCORE
Good
Based on 84 Reviews
8.5
Supplement Facts
Serving Size: 3 Caplets
Amount Per Serving
%DV
Vitamin D (as D3 Cholecalciferol)
15 mcg (600 IU)
75%
Calcium (as Calcium Carbonate and Calcium Gluconate)
1,000 mg
77%
Magnesium (as Magnesium Oxide and Magnesium Gluconate)
400 mg
95%
Zinc (as Zinc Gluconate and Zinc Citrate)
25 mg
227%
Sodium
10 mg
<1%
Top Medical Research Studies
9
Magnesium oxide treats leg cramps
We conducted a study to evaluate how effective magnesium oxide monohydrate (MOMH) is in treating nocturnal leg cramps (NLC). This was a randomized, double-blind, placebo-controlled trial involving multiple centers in Ukraine, where participants took either MOMH or a placebo nightly for 60 days.
Our focus was on measuring the frequency and duration of cramps, the pain they caused, and how they affected sleep quality and overall life satisfaction. We used thorough statistical methods to compare the results between the two groups.
The findings indicated that MOMH is both effective and safe for individuals dealing with NLC. Participants reported improvements in their symptoms, demonstrating that this magnesium supplement can play a helpful role in managing nocturnal leg cramps.
Our focus was on measuring the frequency and duration of cramps, the pain they caused, and how they affected sleep quality and overall life satisfaction. We used thorough statistical methods to compare the results between the two groups.
The findings indicated that MOMH is both effective and safe for individuals dealing with NLC. Participants reported improvements in their symptoms, demonstrating that this magnesium supplement can play a helpful role in managing nocturnal leg cramps.
Read More
9
We sought to understand the effectiveness of oral magnesium in treating leg cramps experienced by pregnant women. Our study was well-structured, involving a double-blind, randomized, placebo-controlled design. It included 86 healthy pregnant women between 14 to 34 weeks of gestation who encountered leg cramps at least twice a week, and we followed them over a four-week period.
At the end of the study, we discovered that the women taking magnesium bisglycinate chelate (300 mg per day) reported a significant reduction in cramp frequency—86% experienced at least a 50% drop compared to only 60.5% of those taking the placebo. Additionally, those on magnesium also noted a notable decrease in cramp intensity, with 69.8% achieving a similar improvement versus just 48.8% in the placebo group.
Encouragingly, we found no major side effects reported in either group, such as nausea or diarrhea. Our findings suggest that magnesium supplements can effectively reduce both the frequency and severity of leg cramps during pregnancy, offering a potential treatment option for women dealing with this common issue.
At the end of the study, we discovered that the women taking magnesium bisglycinate chelate (300 mg per day) reported a significant reduction in cramp frequency—86% experienced at least a 50% drop compared to only 60.5% of those taking the placebo. Additionally, those on magnesium also noted a notable decrease in cramp intensity, with 69.8% achieving a similar improvement versus just 48.8% in the placebo group.
Encouragingly, we found no major side effects reported in either group, such as nausea or diarrhea. Our findings suggest that magnesium supplements can effectively reduce both the frequency and severity of leg cramps during pregnancy, offering a potential treatment option for women dealing with this common issue.
Read More
7
We set out to investigate whether magnesium citrate could be an effective remedy for those who experience bothersome leg cramps, particularly at night. In our study, we used a randomised, double-blind, cross-over, placebo-controlled design to ensure reliable results. Participants suffering from regular leg cramps were recruited and given either magnesium citrate or a matching placebo over six weeks.
Our findings revealed that those who began the trial with the placebo experienced an average reduction in cramps when taking magnesium, with a median of 5 cramps compared to 9 on the placebo. Moreover, a notable percentage of participants felt that the magnesium treatment had indeed helped them, with 78% reporting benefits, as opposed to 54% who felt the placebo was effective.
While these results suggest that magnesium may have a positive impact, it’s essential to mention that the impact on cramp severity and duration wasn’t significantly different between the two groups. Additionally, some participants did report experiencing diarrhoea as a side effect of magnesium. Overall, we believe magnesium shows promise in alleviating nocturnal leg cramps and recommend further research to fully evaluate its effectiveness.
Our findings revealed that those who began the trial with the placebo experienced an average reduction in cramps when taking magnesium, with a median of 5 cramps compared to 9 on the placebo. Moreover, a notable percentage of participants felt that the magnesium treatment had indeed helped them, with 78% reporting benefits, as opposed to 54% who felt the placebo was effective.
While these results suggest that magnesium may have a positive impact, it’s essential to mention that the impact on cramp severity and duration wasn’t significantly different between the two groups. Additionally, some participants did report experiencing diarrhoea as a side effect of magnesium. Overall, we believe magnesium shows promise in alleviating nocturnal leg cramps and recommend further research to fully evaluate its effectiveness.
Read More
Most Useful Reviews
10
Leg cramps relief
151 people found this helpful
A wonderful complex of minerals! I’m amazed by the effect! At 39, my legs often hurt and felt heavy after walking. After a month of taking this, the pain disappeared completely! I take it in cycles, drinking for a month and then resting for a month. I hope my honest feedback helps others.
Read More
9
Cramps improvement
101 people found this helpful
After two months of taking these vitamins, I'm satisfied. They have improved my muscle tone and eliminated my calf cramps, as prescribed by my doctor.
Read More
7.5
Fewer cramps
100 people found this helpful
The large pack contains 100 tablets, and I found the effect after a month. My leg cramps and knee pain have decreased, so I plan to take it again in autumn.
Read More
Medical Researches
SCIENTIFIC SCORE
Likely Ineffective
Based on 21 Researches
4.9
- All Researches
9.5
We observed an interesting case regarding the effects of calcium treatment on leg cramps related to a chemotherapy drug called oxaliplatin. In this case, a 62-year-old woman undergoing palliative treatment for stage IV colon cancer experienced acute neurotoxicity symptoms. Notably, thirty minutes after her first infusion of oxaliplatin, which she received in her left arm, she developed cramps and paresthesia in her right leg.
As part of her treatment for these symptoms, intravenous calcium gluconate was administered alongside magnesium sulfate. This combination helped alleviate her leg cramping and associated symptoms within three hours. However, while calcium was part of the treatment regimen, it is important to note that its isolated effectiveness on leg cramps is unclear due to its concurrent administration with magnesium.
Consequently, while we saw improvement in the patient's symptoms, it is difficult to attribute these results solely to calcium. Instead, it suggests that magnesium might be playing a significant role as well. Future investigations could help clarify the specific contributions of calcium in treating leg cramps related to neurotoxicity and other conditions.
As part of her treatment for these symptoms, intravenous calcium gluconate was administered alongside magnesium sulfate. This combination helped alleviate her leg cramping and associated symptoms within three hours. However, while calcium was part of the treatment regimen, it is important to note that its isolated effectiveness on leg cramps is unclear due to its concurrent administration with magnesium.
Consequently, while we saw improvement in the patient's symptoms, it is difficult to attribute these results solely to calcium. Instead, it suggests that magnesium might be playing a significant role as well. Future investigations could help clarify the specific contributions of calcium in treating leg cramps related to neurotoxicity and other conditions.
Read More
9
Calcium dobesilate reduces leg cramps
We examined the benefits of calcium dobesilate for patients suffering from chronic venous insufficiency (CVI), particularly focusing on how it impacts symptoms like leg cramps. In a systematic evaluation of ten different clinical trials involving 778 patients, we compared the effects of calcium dobesilate to a placebo.
Our analysis found that calcium dobesilate significantly reduced night cramps, helping patients nearly twice as much as those who received a placebo. The number needed to treat for this relief was calculated to be 8, indicating that for every eight patients treated with calcium dobesilate, one experienced noticeable improvement.
Moreover, patients also reported less discomfort, with a number needed to treat of 4 for that symptom. Interestingly, we noted that those with more severe symptoms experienced even greater relief, suggesting that calcium dobesilate is particularly effective for patients with advanced CVI. However, both doses tested—1,000 mg and 1,500 mg—proved equally effective, which is good news as it suggests that a lower dose might suffice.
Additionally, we found that adverse events were not significantly different from the placebo group, indicating a favorable safety profile. While calcium dobesilate shows promise, we acknowledge the need for further studies to solidify these findings and explore its efficacy in various CVI stages.
Our analysis found that calcium dobesilate significantly reduced night cramps, helping patients nearly twice as much as those who received a placebo. The number needed to treat for this relief was calculated to be 8, indicating that for every eight patients treated with calcium dobesilate, one experienced noticeable improvement.
Moreover, patients also reported less discomfort, with a number needed to treat of 4 for that symptom. Interestingly, we noted that those with more severe symptoms experienced even greater relief, suggesting that calcium dobesilate is particularly effective for patients with advanced CVI. However, both doses tested—1,000 mg and 1,500 mg—proved equally effective, which is good news as it suggests that a lower dose might suffice.
Additionally, we found that adverse events were not significantly different from the placebo group, indicating a favorable safety profile. While calcium dobesilate shows promise, we acknowledge the need for further studies to solidify these findings and explore its efficacy in various CVI stages.
Read More
9
Magnesium oxide treats leg cramps
We conducted a study to evaluate how effective magnesium oxide monohydrate (MOMH) is in treating nocturnal leg cramps (NLC). This was a randomized, double-blind, placebo-controlled trial involving multiple centers in Ukraine, where participants took either MOMH or a placebo nightly for 60 days.
Our focus was on measuring the frequency and duration of cramps, the pain they caused, and how they affected sleep quality and overall life satisfaction. We used thorough statistical methods to compare the results between the two groups.
The findings indicated that MOMH is both effective and safe for individuals dealing with NLC. Participants reported improvements in their symptoms, demonstrating that this magnesium supplement can play a helpful role in managing nocturnal leg cramps.
Our focus was on measuring the frequency and duration of cramps, the pain they caused, and how they affected sleep quality and overall life satisfaction. We used thorough statistical methods to compare the results between the two groups.
The findings indicated that MOMH is both effective and safe for individuals dealing with NLC. Participants reported improvements in their symptoms, demonstrating that this magnesium supplement can play a helpful role in managing nocturnal leg cramps.
Read More
9
We sought to understand the effectiveness of oral magnesium in treating leg cramps experienced by pregnant women. Our study was well-structured, involving a double-blind, randomized, placebo-controlled design. It included 86 healthy pregnant women between 14 to 34 weeks of gestation who encountered leg cramps at least twice a week, and we followed them over a four-week period.
At the end of the study, we discovered that the women taking magnesium bisglycinate chelate (300 mg per day) reported a significant reduction in cramp frequency—86% experienced at least a 50% drop compared to only 60.5% of those taking the placebo. Additionally, those on magnesium also noted a notable decrease in cramp intensity, with 69.8% achieving a similar improvement versus just 48.8% in the placebo group.
Encouragingly, we found no major side effects reported in either group, such as nausea or diarrhea. Our findings suggest that magnesium supplements can effectively reduce both the frequency and severity of leg cramps during pregnancy, offering a potential treatment option for women dealing with this common issue.
At the end of the study, we discovered that the women taking magnesium bisglycinate chelate (300 mg per day) reported a significant reduction in cramp frequency—86% experienced at least a 50% drop compared to only 60.5% of those taking the placebo. Additionally, those on magnesium also noted a notable decrease in cramp intensity, with 69.8% achieving a similar improvement versus just 48.8% in the placebo group.
Encouragingly, we found no major side effects reported in either group, such as nausea or diarrhea. Our findings suggest that magnesium supplements can effectively reduce both the frequency and severity of leg cramps during pregnancy, offering a potential treatment option for women dealing with this common issue.
Read More
8
We explored the impact of calcium treatment on leg cramps in an adolescent diagnosed with pseudohypoparathyroidism type 1B. The patient experienced symptoms such as muscle cramps and leg pain during activities, with laboratory tests revealing hypocalcemia and an elevated parathyroid hormone level.
While calcium treatment was part of a combined therapy that included other medications, we observed that the muscle cramps and hypocalcemia resolved after administering calcium carbonate, ergocalciferol, and calcitriol. However, due to the combination of treatments, it is challenging to determine the isolated effect of calcium on the leg cramps specifically.
Ultimately, while calcium contributed to symptom relief, our study does not provide conclusive evidence on its effectiveness alone for alleviating leg cramps. This highlights the need for further investigation into how calcium might individually influence leg cramp symptoms in such patients.
While calcium treatment was part of a combined therapy that included other medications, we observed that the muscle cramps and hypocalcemia resolved after administering calcium carbonate, ergocalciferol, and calcitriol. However, due to the combination of treatments, it is challenging to determine the isolated effect of calcium on the leg cramps specifically.
Ultimately, while calcium contributed to symptom relief, our study does not provide conclusive evidence on its effectiveness alone for alleviating leg cramps. This highlights the need for further investigation into how calcium might individually influence leg cramp symptoms in such patients.
Read More
User Reviews
USERS' SCORE
Good
Based on 84 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
10
Leg cramps relief
151 people found this helpful
A wonderful complex of minerals! I’m amazed by the effect! At 39, my legs often hurt and felt heavy after walking. After a month of taking this, the pain disappeared completely! I take it in cycles, drinking for a month and then resting for a month. I hope my honest feedback helps others.
Read More
9
Cramps improvement
101 people found this helpful
After two months of taking these vitamins, I'm satisfied. They have improved my muscle tone and eliminated my calf cramps, as prescribed by my doctor.
Read More
7.5
Fewer cramps
100 people found this helpful
The large pack contains 100 tablets, and I found the effect after a month. My leg cramps and knee pain have decreased, so I plan to take it again in autumn.
Read More
9
Reduced leg cramps
97 people found this helpful
The doctor recommended I drink this at night during a stressful period in my life. I started sleeping better, and my leg cramps have eased. It does take about 10 days to see the benefits, particularly with acne. Overall, I've noticed positive effects following two weeks of use.
Read More
10
Health improvement
26 people found this helpful
Calcium, magnesium, and zinc are essential for health, especially for bones and muscles. After taking this complex, my leg cramps have reduced significantly, and I believe my overall health has improved as well, including better sleep. I will continue taking it regularly.
Read More
Frequently Asked Questions
9
Reduced leg cramps
97 people found this helpful
The doctor recommended I drink this at night during a stressful period in my life. I started sleeping better, and my leg cramps have eased. It does take about 10 days to see the benefits, particularly with acne. Overall, I've noticed positive effects following two weeks of use.
9
Improved well-being
6 people found this helpful
There’s definitely a benefit! I sometimes suffer from leg cramps in the winter, especially when stretching in the morning. After starting these vitamins, my cramps have reduced dramatically, and I feel calmer overall. I take them in the evenings, which also seems to improve my sleep. No side effects experienced.
9
Cramps improvement
101 people found this helpful
After two months of taking these vitamins, I'm satisfied. They have improved my muscle tone and eliminated my calf cramps, as prescribed by my doctor.
9
Leg cramps relief
2 people found this helpful
I chose Nature's Bounty to rebuild my body. By the end of the second month, my leg cramps ceased, and I've enjoyed remarkable skin health. This product has been life-changing for me!
9
Cramps vanished
4 people found this helpful
After using just one bottle, my persistent night-time leg cramps disappeared completely! I can't believe how effectively this product worked for me.
7.5
Fewer cramps
100 people found this helpful
The large pack contains 100 tablets, and I found the effect after a month. My leg cramps and knee pain have decreased, so I plan to take it again in autumn.
9
Calmed leg cramps
19 people found this helpful
The effect seems cumulative, but my leg cramps have significantly improved. I sleep better now and have noticed decreased headaches and dizziness. My hair no longer breaks as much, and overall, my health feels better, leading to less irritability. Even my husband has stopped snoring!
9
Cramps reduced
4 people found this helpful
I find magnesium beneficial for bone growth and overall health. It normalises heart rate, lowers blood pressure, and alleviates muscle cramps. Since using this complex, my restless legs syndrome has disappeared and I've been sleeping better.
10
Health improvement
26 people found this helpful
Calcium, magnesium, and zinc are essential for health, especially for bones and muscles. After taking this complex, my leg cramps have reduced significantly, and I believe my overall health has improved as well, including better sleep. I will continue taking it regularly.
10
Eliminated night cramps
1 people found this helpful
Heart throbbing and painful leg cramps at night have vanished. Despite longstanding health issues, after taking this, my symptoms disappeared. It turns out a complex formula like this works best, rather than just calcium or magnesium. I love iHerb!
9
Effective for cramps
5 people found this helpful
I took these vitamins for my leg cramps, which were quite bothersome. I only take one tablet a day instead of three, and after 24 days, my cramps have reduced significantly. The price is excellent, and I will definitely repurchase these!
9
Improved sleep
3 people found this helpful
This is an excellent supplement at a promotional price. Calcium strengthens bones, magnesium supports the nervous system, and zinc is vital for various bodily functions. I take one tablet after dinner, and magnesium has really improved my sleep and reduced my leg cramps.
9
Stops cramps
1 people found this helpful
A great vitamin complex! I experienced severe hair loss and leg cramps during breastfeeding. After two weeks of taking it, my cramps disappeared, hair loss reduced, and my mood improved. Swallowing the capsules is easy.
References
- Sasidharan Pillai S, Reyes M, Jüppner H, Topor LS. Growth Hormone Deficiency in an Adolescent With Pseudohypoparathyroidism Type 1B. JCEM Case Rep. 2024;2:luae152. 10.1210/jcemcr/luae152
- Luo L, Zhou K, Zhang J, Xu L, Yin W. Interventions for leg cramps in pregnancy. Cochrane Database Syst Rev. 2020;12:CD010655. 10.1002/14651858.CD010655.pub3
- Mansouri A, Mirghafourvand M, Charandabi SMA, Najafi M. The effect of Vitamin D and calcium plus Vitamin D on leg cramps in pregnant women: A randomized controlled trial. J Res Med Sci. 2017;22:24. 10.4103/1735-1995.200271
- Zhou K, West HM, Zhang J, Xu L, Li W. Interventions for leg cramps in pregnancy. Cochrane Database Syst Rev. 2015. 10.1002/14651858.CD010655.pub2
- Uña E. Atypical presentation of acute neurotoxicity secondary to oxaliplatin. J Oncol Pharm Pract. 2010;16:280. 10.1177/1078155209355849
- Ciapponi A, Laffaire E, Roqué M. Calcium dobesilate for chronic venous insufficiency: a systematic review. Angiology. 2004;55:147.
- Young GL, Jewell D. Interventions for leg cramps in pregnancy. Cochrane Database Syst Rev. 2002.
- Young GL, Jewell D. Interventions for leg cramps in pregnancy. Cochrane Database Syst Rev. 2000;2002:CD000121.
- Barna O, Lohoida P, Holovchenko Y, Bazylevych A, Velychko V, et al. A randomized, double-blind, placebo-controlled, multicenter study assessing the efficacy of magnesium oxide monohydrate in the treatment of nocturnal leg cramps. Nutr J. 2021;20:90. 10.1186/s12937-021-00747-9
- Liu J, Song G, Zhao G, Meng T. Effect of oral magnesium supplementation for relieving leg cramps during pregnancy: A meta-analysis of randomized controlled trials. Taiwan J Obstet Gynecol. 2021;60:609. 10.1016/j.tjog.2021.05.006
- Garrison SR, Korownyk CS, Kolber MR, Allan GM, Musini VM, et al. Magnesium for skeletal muscle cramps. Cochrane Database Syst Rev. 2020;9:CD009402. 10.1002/14651858.CD009402.pub3
- Araújo CAL, Lorena SB, Cavalcanti GCS, Leão GLS, Tenório GP, et al. Oral magnesium supplementation for leg cramps in pregnancy-An observational controlled trial. PLoS One. 2020;15:e0227497. 10.1371/journal.pone.0227497
- Sebo P, Haller D, Cerutti B, Maisonneuve H. A prospective observational study of the main features of nocturnal leg cramps in primary care. Swiss Med Wkly. 2019;149:w20048. 10.4414/smw.2019.20048
- Roguin Maor N, Alperin M, Shturman E, Khairaldeen H, Friedman M, et al. Effect of Magnesium Oxide Supplementation on Nocturnal Leg Cramps: A Randomized Clinical Trial. JAMA Intern Med. 2017;177:617. 10.1001/jamainternmed.2016.9261
- Sebo P, Cerutti B, Haller DM. Effect of magnesium therapy on nocturnal leg cramps: a systematic review of randomized controlled trials with meta-analysis using simulations. Fam Pract. 2014;31:7. 10.1093/fampra/cmt065
- Garrison SR, Allan GM, Sekhon RK, Musini VM, Khan KM. Magnesium for skeletal muscle cramps. Cochrane Database Syst Rev. 2012;2012:CD009402. 10.1002/14651858.CD009402.pub2
- Supakatisant C, Phupong V. Oral magnesium for relief in pregnancy-induced leg cramps: a randomised controlled trial. Matern Child Nutr. 2015;11:139. 10.1111/j.1740-8709.2012.00440.x
- Garrison SR, Birmingham CL, Koehler BE, McCollom RA, Khan KM. The effect of magnesium infusion on rest cramps: randomized controlled trial. J Gerontol A Biol Sci Med Sci. 2011;66:661. 10.1093/gerona/glq232
- Roffe C, Sills S, Crome P, Jones P. Randomised, cross-over, placebo controlled trial of magnesium citrate in the treatment of chronic persistent leg cramps. Med Sci Monit. 2002;8:CR326.
- Frusso R, Zárate M, Augustovski F, Rubinstein A. Magnesium for the treatment of nocturnal leg cramps: a crossover randomized trial. J Fam Pract. 1999;48:868.
- Dahle LO, Berg G, Hammar M, Hurtig M, Larsson L. The effect of oral magnesium substitution on pregnancy-induced leg cramps. Am J Obstet Gynecol. 1995;173:175.
