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Our findings revealed that over half of the patients had low vitamin D levels, specifically 56.1% of the 513 individuals studied. We observed a clear association between these low levels of vitamin D and increased experiences of nausea and vomiting. This was particularly notable in patients with delayed gastric emptying, where those with low vitamin D levels reported significantly more nausea.
While the study showed a correlation, it did not address whether supplementing with vitamin D could directly alleviate these symptoms. Instead, we found that lower vitamin D levels also related to a greater retention of food in the stomach after meals, which hints at a connection to gastric neuromuscular dysfunction. Overall, our study emphasized a noteworthy link between vitamin D and nausea but stopped short of confirming any direct treatment benefits.
We discovered that those who received magnesium experienced significantly less postoperative nausea and vomiting (PONV) compared to the control group. Specifically, at two hours post-surgery, patients in the magnesium group reported less severe PONV.
Additionally, this group also had lower requirements for remifentanil, a pain reliever, indicating that magnesium not only helps with nausea but may also play a role in overall pain management during recovery. The magnesium levels in the blood after surgery were notably higher in the magnesium group, further supporting its effectiveness.
This research suggests that incorporating magnesium sulfate into treatment protocols during orthognathic surgeries can greatly enhance patient comfort by minimizing nausea and improving pain control.
For a period of up to 24 weeks, we aimed to maintain their zinc levels within a specific target range while closely monitoring for side effects. One of our main goals was to see if NPC-25 could maintain these target zinc levels similarly to NOBELZIN™.
Our findings revealed that NPC-25 was indeed non-inferior to NOBELZIN™, meaning it worked just as well. Importantly, we also observed that those taking NPC-25 reported fewer digestive issues, like nausea and vomiting. This suggests that while both treatments were effective, NPC-25 might be the gentler option.
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While our findings showed that the LOA protocol was more effective in reducing nausea and vomiting compared to traditional opioid analgesia, we didn’t isolate magnesium’s specific role in this improvement. This limitation makes it challenging to determine just how much magnesium alone contributes to reducing nausea.
Nevertheless, the study suggests that using a low-opioid method can enhance patient comfort in the postoperative period. Overall, we found that incorporating non-opioid analgesia and the LOA strategy should be considered more widely in surgical practices.
Our findings revealed that over half of the patients had low vitamin D levels, specifically 56.1% of the 513 individuals studied. We observed a clear association between these low levels of vitamin D and increased experiences of nausea and vomiting. This was particularly notable in patients with delayed gastric emptying, where those with low vitamin D levels reported significantly more nausea.
While the study showed a correlation, it did not address whether supplementing with vitamin D could directly alleviate these symptoms. Instead, we found that lower vitamin D levels also related to a greater retention of food in the stomach after meals, which hints at a connection to gastric neuromuscular dysfunction. Overall, our study emphasized a noteworthy link between vitamin D and nausea but stopped short of confirming any direct treatment benefits.
We discovered that those who received magnesium experienced significantly less postoperative nausea and vomiting (PONV) compared to the control group. Specifically, at two hours post-surgery, patients in the magnesium group reported less severe PONV.
Additionally, this group also had lower requirements for remifentanil, a pain reliever, indicating that magnesium not only helps with nausea but may also play a role in overall pain management during recovery. The magnesium levels in the blood after surgery were notably higher in the magnesium group, further supporting its effectiveness.
This research suggests that incorporating magnesium sulfate into treatment protocols during orthognathic surgeries can greatly enhance patient comfort by minimizing nausea and improving pain control.
Our primary focus was on how much morphine the patients needed on the first day after surgery, which gives us insight into their pain levels. While we noted the overall benefits of combining these two non-opioid treatments for pain relief, the study did mention postoperative nausea and vomiting as secondary outcomes. However, it's important to clarify that the findings did not specifically highlight any significant advantages of magnesium in reducing nausea when compared to the other treatments or placebos.
In essence, while we observed that the combination of magnesium sulfate and pregabalin effectively reduced opioid consumption and improved pain management post-surgery, it did not yield clear evidence pointing to magnesium's effectiveness specifically for alleviating nausea. This nuanced insight is valuable as we continue exploring the best strategies for managing multiple aspects of patient comfort during the recovery process.
We observed that while both medications were used, magnesium sulfate appeared to offer benefits over lidocaine. Notably, the group receiving magnesium experienced a significantly lower rate of nausea and vomiting compared to those treated with lidocaine. This points to magnesium's potential effectiveness in managing post-operative nausea.
However, it’s essential to note that our study did not find any significant difference in terms of laryngospasm incidence between the two groups. Overall, magnesium sulfate showcased an advantage with fewer instances of nausea and other distressing symptoms, suggesting its role as a valuable option for patient care in similar surgical scenarios.
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Frequently Asked Questions
Nausea is a sensation that often precedes vomiting and is characterized by an uneasy feeling in the stomach. It can be caused by a variety of factors, including motion sickness, certain medications, food poisoning, or underlying health conditions. The experience of nausea can range from mildly uncomfortable to intensely distressing and is often accompanied by other symptoms such as sweating, increased salivation, or a feeling of lightheadedness.
Many people experience nausea at some point in their lives, making it a common issue. Fortunately, there are several remedies and treatments available that can help alleviate this unpleasant sensation. Over-the-counter medications, home remedies like ginger tea, and lifestyle changes, such as eating smaller meals or avoiding certain triggers, can be effective in reducing nausea. However, if nausea is persistent or accompanied by severe symptoms like severe abdominal pain or fever, it’s essential to consult with a healthcare professional for an accurate diagnosis and appropriate treatment.
Calcium is a chemical element represented by the symbol Ca and atomic number 20. It is an essential mineral in the body, playing a critical role in various physiological processes. As one of the most abundant elements in nature, calcium is particularly vital for maintaining strong bones and teeth, where about 99% of the body's calcium is stored. Beyond its structural function, calcium is crucial in muscle contraction, blood clotting, and nerve transmission, making it a key player in overall health.
Dietary sources of calcium include dairy products such as milk, yogurt, and cheese, as well as leafy green vegetables, nuts, seeds, and fortified foods. The recommended daily intake of calcium varies by age and sex, but generally, adults should aim for approximately 1,000 mg per day. For those who may struggle to meet their needs through diet alone, calcium supplements are available but should be taken with caution. It's essential to consult with a healthcare provider before starting any supplement regimen to avoid potential side effects or interactions with medications.
Based on user reviews, the timeframe for seeing results from this supplement varies significantly. Some users, for instance, reported improvements in energy and mood within just ten days of consistent use, indicating a relatively quick onset of benefits for some individuals (Read Review). However, it's important to note that experiences can differ widely; while a few users find relief quickly, others have encountered ongoing issues with nausea that may arise after starting the supplement or upon resuming after a break (Read Review).
Moreover, some reviews highlight that certain formulations led to nausea rather than alleviating it, suggesting that individual reactions can vary markedly based on the specific ingredients and personal tolerance (Read Review). Consequently, if you are considering using this supplement for nausea relief, it might be beneficial to monitor your body's response, as some users found no nausea after consistent use of particular zinc products (Read Review). Ultimately, the timing of noticeable results can be highly individual.
Scientific research does suggest that certain supplements, particularly vitamin D and magnesium, may play a role in managing nausea in various contexts, although more conclusive evidence is needed. For instance, a study examining patients with gastroparesis found a significant association between low vitamin D levels and increased nausea, indicating that those suffering from this condition might benefit from monitoring their vitamin D status [1]. Another study in premenstrual women highlighted a genetic linkage that affects how vitamin D influences nausea, emphasizing the complexity of individual responses to supplementation [2]. However, it remains unclear whether supplementing with vitamin D directly alleviates nausea, as no direct treatment benefits were confirmed in the research.
On the front of magnesium, multiple studies have pointed to its efficacy in reducing postoperative nausea, particularly in surgical scenarios. For example, research found that magnesium sulfate resulted in significantly less postoperative nausea in patients undergoing orthognathic surgery [3]. Similarly, magnesium showed promise in managing nausea among pediatric patients after tonsillectomy [6]. Nevertheless, while these findings hint at magnesium's potential benefits for nausea, the research does not comprehensively isolate its effectiveness for this specific symptom across all conditions. Overall, while vitamin D and magnesium are supported by some scientific evidence for nausea management, the results indicate a need for further research to determine their definitive roles.
Based on user reviews, many individuals have reported noticeable improvements in their symptoms after using various zinc supplements. For instance, some users experienced increased energy levels and relief from headaches within just ten days of starting the supplement, along with enhanced mood and overall well-being ((Read Review)). Additionally, those who were previously sensitive to zinc due to nausea noted that certain formulations eliminated that issue completely, allowing them to benefit from the supplement without discomfort ((Read Review)).
However, it's important to highlight that experiences vary widely. Users have shared that while some formulations helped with hair growth and improved nail strength, others faced adverse reactions such as gastrointestinal issues, nausea, or dizziness when stopping and resuming the supplement ((Read Review)). Therefore, those considering using these supplements should keep in mind that individual tolerance can significantly impact the outcome, as some found the product to be beneficial while others reported discomfort ((Read Review)).
Based on user reviews, combining this supplement with other ingredients can yield mixed results, particularly when it comes to handling nausea. Some users have reported that specific formulations, especially those containing zinc, did not cause nausea and even alleviated their symptoms completely. For instance, one user noted that they previously struggled with pure zinc supplements due to nausea but found a particular manufacturer’s product resolved that issue entirely (Read Review). Additionally, several users have mentioned their positive experiences with the supplement, stating that they did not experience nausea at all while taking it daily (Read Review).
However, not all experiences were positive. Some reported adverse effects, including nausea and gastrointestinal upset, especially after stopping or resuming the supplement (Read Review)(Read Review). Furthermore, one user suggested that zinc is better taken alone to avoid unpleasant sensations resulting from a combination with other minerals (Read Review). Ultimately, the compatibility of supplements can vary widely, and users are encouraged to consider their individual tolerance levels when combining different products.
Based on user reviews, the appropriate dose of calcium for treating nausea varies widely among individuals. Many users noted that while some supplements containing calcium, zinc, and magnesium worked well without causing nausea (see reviews (Read Review), (Read Review)), others experienced unpleasant side effects such as nausea or gastrointestinal discomfort when taking similar products (see reviews (Read Review), (Read Review)).
Users suggest that individual tolerance can greatly affect the experience, with some reporting positive results and no nausea after consistent use of one capsule daily (as mentioned in review (Read Review)), while others found that specific formulations led to stomach upset (review (Read Review)). Therefore, it may be beneficial to experiment with different formulations or doses under the guidance of a healthcare professional to find the right balance and avoid the discomfort of nausea.
Our findings revealed that over half of the patients had low vitamin D levels, specifically 56.1% of the 513 individuals studied. We observed a clear association between these low levels of vitamin D and increased experiences of nausea and vomiting. This was particularly notable in patients with delayed gastric emptying, where those with low vitamin D levels reported significantly more nausea.
While the study showed a correlation, it did not address whether supplementing with vitamin D could directly alleviate these symptoms. Instead, we found that lower vitamin D levels also related to a greater retention of food in the stomach after meals, which hints at a connection to gastric neuromuscular dysfunction. Overall, our study emphasized a noteworthy link between vitamin D and nausea but stopped short of confirming any direct treatment benefits.
By classifying participants as either vitamin D sufficient or insufficient based on their plasma levels, we examined how these levels correlated with nausea, alongside a specific genetic variation in the vitamin D receptor gene. Interestingly, we found that women with the CC genotype who had low vitamin D levels were more likely to experience nausea, whereas those with the TT genotype exhibited a low likelihood of suffering from nausea under similar conditions.
Overall, we can say that vitamin D's impact on nausea does not occur in isolation; it is modified by genetic factors. This highlights the importance of considering both vitamin D status and genetic background when trying to understand the factors contributing to PMS symptoms like nausea.
We discovered that those who received magnesium experienced significantly less postoperative nausea and vomiting (PONV) compared to the control group. Specifically, at two hours post-surgery, patients in the magnesium group reported less severe PONV.
Additionally, this group also had lower requirements for remifentanil, a pain reliever, indicating that magnesium not only helps with nausea but may also play a role in overall pain management during recovery. The magnesium levels in the blood after surgery were notably higher in the magnesium group, further supporting its effectiveness.
This research suggests that incorporating magnesium sulfate into treatment protocols during orthognathic surgeries can greatly enhance patient comfort by minimizing nausea and improving pain control.
We observed that while both medications were used, magnesium sulfate appeared to offer benefits over lidocaine. Notably, the group receiving magnesium experienced a significantly lower rate of nausea and vomiting compared to those treated with lidocaine. This points to magnesium's potential effectiveness in managing post-operative nausea.
However, it’s essential to note that our study did not find any significant difference in terms of laryngospasm incidence between the two groups. Overall, magnesium sulfate showcased an advantage with fewer instances of nausea and other distressing symptoms, suggesting its role as a valuable option for patient care in similar surgical scenarios.
References
- Koch KL, Parkman HP, Yates KP, Van Natta ML, Grover M, et al. Low Vitamin D Levels in Patients with Symptoms of Gastroparesis: Relationships with Nausea and Vomiting, Gastric Emptying and Gastric Myoelectrical Activity. Dig Dis Sci. 2024;69:2904. doi:10.1007/s10620-024-08520-8
- Jarosz AC, Noori D, Zeitoun T, Garcia-Bailo B, El-Sohemy A. Variation in the vitamin D receptor gene, plasma 25-hydroxyvitamin D, and risk of premenstrual symptoms. Genes Nutr. 2021;16:15. doi:10.1186/s12263-021-00696-2
- Hua X, Chen Y, Wu Z, Zheng G, Yang D, et al. Effects of intra-operative magnesium sulfate infusion on orthognathic surgery: A prospective and randomized controlled trial. Heliyon. 2024;10:e30342. doi:10.1016/j.heliyon.2024.e30342
- Kościuczuk U, Tarnowska K, Rynkiewicz-Szczepanska E. Are There Any Advantages of the Low Opioid Anaesthesia and Non-Opioid Postoperative Analgesia Protocol: A Clinical Observational Study. J Pain Res. 2024;17:941. doi:10.2147/JPR.S449563
- Tavanaei R, Rezaee-Naserabad SS, Alizadeh S, Yazdani KO, Zali A, et al. Analgesic Effects of Preoperative Combination of Oral Pregabalin and Intravenous Magnesium Sulfate on Postoperative Pain in Patients Undergoing Posterolateral Spinal Fusion Surgery: A 4-arm, Randomized, Double-blind, Placebo-controlled Trial. J Neurosurg Anesthesiol. 2024;36:134. doi:10.1097/ANA.0000000000000893
- Manouchehrian N, Abbasi R, Jiryaee N, Beigi RM. Comparison of intravenous injection of magnesium sulfate and lidocaine effectiveness on the prevention of laryngospasm and analgesic requirement in tonsillectomy. Eur J Transl Myol. 2022;32. doi:10.4081/ejtm.2022.10732
- Asaoka D, Ishihara T, Ezoe S, Hamada I, Kitamura M, et al. Randomized, multicenter, active-controlled open-label study of NPC-25, zinc histidine hydrate, (non-inferiority to NOBELZIN™, zinc acetate dihydrate) for patients with hypozincemia. J Trace Elem Med Biol. 2025;87:127558. doi:10.1016/j.jtemb.2024.127558
- Ezoe S, Ishihara T, Hosogai T, Kokubo T. Post-marketing surveillance of zinc acetate dihydrate for hypozincemia in Japan. Pharmazie. 2024;79:29. doi:10.1691/ph.2024.3630
- Parvizi A, Haddadi S, Akbari M, Akbarpour M, Taghipour Rudsari F, et al. Comparing the Effect of Zinc-impregnated Pharyngeal Packs with Conventional Methods on the Level of Sore Throat Among Patients Undergoing Septorhinoplasty. Anesth Pain Med. 2022;12:e127262. doi:10.5812/aapm-127262
- Nuzhat S, Ahmed T, Alam J, Billal SM, Khan AI, et al. New formulation zinc sulphate acceptability and adherence in children with acute diarrhoea: A prospective, open-label, interventional study in Bangladesh. J Paediatr Child Health. 2022;58:1215. doi:10.1111/jpc.15953
