SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.4
USERS' SCORE
Good
Based on 11 Reviews
8.8
Supplement Facts
Serving Size: 2 Gummies
Amount Per Serving
%DV
Calories
15
Total Carbohydrate
3 g
1%**
Total Sugars
2 g
***
Includes 2 g Added Sugars
4%**
Vitamin C (as Ascorbic Acid)
15 mg
17%
Vitamin E (as dl-Alpha Tocopheryl Acetate)
6.7 mg
45%
Biotin (as d-Biotin)
2,500 mcg
8,333%
Sodium
10 mg
<1%
Top Medical Research Studies
7
Moderate benefits, high testing interference
High-dose biotin for multiple sclerosis: A systematic review and meta-analyses of randomized controlled trials.
Scores suggest moderate relevance
We evaluated the effectiveness of high-dose biotin in treating multiple sclerosis through a systematic review of randomized controlled trials.
Our findings suggest that patients could see some benefit from using high-dose biotin over a period of 12 to 15 months.
However, it's important to note that this potential upside comes with a notable downside: an increased likelihood of affecting laboratory test results.
Overall, the evidence remains moderately certain, indicating a cautious approach is necessary for those considering biotin treatment for multiple sclerosis.
Our findings suggest that patients could see some benefit from using high-dose biotin over a period of 12 to 15 months.
However, it's important to note that this potential upside comes with a notable downside: an increased likelihood of affecting laboratory test results.
Overall, the evidence remains moderately certain, indicating a cautious approach is necessary for those considering biotin treatment for multiple sclerosis.
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7
Biotin improves disability in PMS
Biomarkers of treatment response in patients with progressive multiple sclerosis treated with high-dose pharmaceutical-grade biotin (MD1003).
Moderate effectiveness in treatment response
We evaluated the effectiveness of high-dose pharmaceutical-grade biotin (MD1003) in enhancing treatment responses for patients with progressive multiple sclerosis (PMS). Over one year, we monitored 48 newly treated patients, using clinical assessments and brain volume metrics.
Encouragingly, 27% of patients experienced a notable reduction in disability scores. Additionally, improvements in brain and cervical spinal cord volume were observed in several patients. Yet, those with higher levels of neurofilament light chains or older age at MS onset appeared to have less positive responses to treatment.
Encouragingly, 27% of patients experienced a notable reduction in disability scores. Additionally, improvements in brain and cervical spinal cord volume were observed in several patients. Yet, those with higher levels of neurofilament light chains or older age at MS onset appeared to have less positive responses to treatment.
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8
Dexamethasone delivery variations studied
The mode of dexamethasone decoration influences avidin-nucleic-acid-nano-assembly organ biodistribution and in vivo drug persistence.
High relevance in drug delivery
We explored how different linkers and lengths in biotin-dexamethasone conjugates affect drug delivery to the liver, particularly in autoimmune hepatitis. Through in vitro and in vivo studies, we noted that certain combinations enhance drug stability and uptake in liver cells.
Our findings suggest that tweaking the construction of these nanoparticles can meaningfully influence how effectively the drug works in the body. This could lead to better steroid formulations tailored for various medical needs.
Our findings suggest that tweaking the construction of these nanoparticles can meaningfully influence how effectively the drug works in the body. This could lead to better steroid formulations tailored for various medical needs.
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Most Useful Reviews
9.5
Rash improvement
I'm enthusiastic about these vitamins! I developed a rash on my forehead and brittle nails due to my autoimmune disorder. I ordered these vitamins based on reviews, and after a month, I've seen improvement. The rash has disappeared, my nails are stronger, my skin has improved, and I even have new hair growth. I would definitely order more, and I recommend them!
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8.3
Stronger hair
I really like these vitamins. They're convenient, taste good, and have provided good results. My hair now falls less and my nails have become exceptionally strong. I wish I could order them in summer, though.
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9.5
Stronger nails
These vitamins are very good and super tasty. After completing my course, my nails improved, my hair stopped shedding, and my facial skin became smoother. I'm happy with the results and will order more. I highly recommend them!
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Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.4
- All Researches
9
Biotin shows promise in BTD
Atypical presentation of biotinidase deficiency: masquerading neuromyelitis optica spectrum disorder.
Highly relevant clinical findings
We explored the unusual manifestations of biotinidase deficiency (BTD), showcasing three cases initially diagnosed as neuromyelitis optica spectrum disorder (NMOSD).
These patients exhibited severe symptoms such as quadriplegia and vision loss. Although some responded to immune therapy initially, they relapsed, while one did not improve at all.
Following further testing, it became clear that BTD was the true culprit. Remarkably, two patients experienced significant recovery after starting biotin supplementation, highlighting the potential of biotin in treating this deficiency.
These patients exhibited severe symptoms such as quadriplegia and vision loss. Although some responded to immune therapy initially, they relapsed, while one did not improve at all.
Following further testing, it became clear that BTD was the true culprit. Remarkably, two patients experienced significant recovery after starting biotin supplementation, highlighting the potential of biotin in treating this deficiency.
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9
Biotin and thiamine improve symptoms
Thiamine metabolism dysfunction syndrome 5 (THMD5) mimicking acute disseminated encephalomyelitis.
Relevant case study findings
We observed a fascinating case of a four-year-old girl diagnosed with Thiamine Metabolism Dysfunction Syndrome 5 and acute disseminated encephalomyelitis, who exhibited marked improvement after treatment with biotin and thiamine. Initially presenting with fever and agitation post-vaccination, genetic tests later revealed a pathogenic variant in the TPK1 gene. The girl's clinical status improved significantly, with resolution of autism spectrum disorder symptoms, supporting the role of early intervention. This case strengthens the evidence for biotin and thiamine in treating metabolic deficiencies related to TPK1.
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8
Dexamethasone delivery variations studied
The mode of dexamethasone decoration influences avidin-nucleic-acid-nano-assembly organ biodistribution and in vivo drug persistence.
High relevance in drug delivery
We explored how different linkers and lengths in biotin-dexamethasone conjugates affect drug delivery to the liver, particularly in autoimmune hepatitis. Through in vitro and in vivo studies, we noted that certain combinations enhance drug stability and uptake in liver cells.
Our findings suggest that tweaking the construction of these nanoparticles can meaningfully influence how effectively the drug works in the body. This could lead to better steroid formulations tailored for various medical needs.
Our findings suggest that tweaking the construction of these nanoparticles can meaningfully influence how effectively the drug works in the body. This could lead to better steroid formulations tailored for various medical needs.
Read More
8
Biotin therapy improved symptoms
Biotinidase deficiency presenting as Neuromyelitis Optica Spectrum Disorder.
Biotinidase deficiency treatment insights
We explored two intriguing cases of biotinidase deficiency, a rare genetic disorder that can mimic conditions like Neuromyelitis Optica Spectrum Disorder. Initially, both patients received treatments for immune-mediated disorders, but when their symptoms worsened, further testing revealed biotinidase deficiency.
Remarkably, after starting biotin supplementation, both children showed significant improvement. This highlights the importance of recognizing atypical neurological signs, as early diagnosis and treatment of biotinidase deficiency can lead to effective intervention.
Remarkably, after starting biotin supplementation, both children showed significant improvement. This highlights the importance of recognizing atypical neurological signs, as early diagnosis and treatment of biotinidase deficiency can lead to effective intervention.
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7
Biotin shows potential in neuropathies
High-dose pharmaceutical-grade biotin in patients with demyelinating neuropathies: a phase 2b open label, uncontrolled, pilot study.
Moderate relevance to treatment efficacy
We set out to examine the effects of high-dose pharmaceutical-grade biotin on patients with different types of demyelinating neuropathies.
In a pilot study involving 15 participants, we aimed to see if this treatment could improve various nerve function measures.
While the main goal of achieving a 10% improvement in specific nerve conduction measurements wasn’t reached, many participants showed better sensory and motor abilities.
Overall, these findings suggest that high-dose biotin might help in some ways, and the treatment was well-tolerated by participants.
In a pilot study involving 15 participants, we aimed to see if this treatment could improve various nerve function measures.
While the main goal of achieving a 10% improvement in specific nerve conduction measurements wasn’t reached, many participants showed better sensory and motor abilities.
Overall, these findings suggest that high-dose biotin might help in some ways, and the treatment was well-tolerated by participants.
Read More
User Reviews
USERS' SCORE
Good
Based on 11 Reviews
8.8
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Rash improvement
I'm enthusiastic about these vitamins! I developed a rash on my forehead and brittle nails due to my autoimmune disorder. I ordered these vitamins based on reviews, and after a month, I've seen improvement. The rash has disappeared, my nails are stronger, my skin has improved, and I even have new hair growth. I would definitely order more, and I recommend them!
Read More
8.3
Stronger hair
I really like these vitamins. They're convenient, taste good, and have provided good results. My hair now falls less and my nails have become exceptionally strong. I wish I could order them in summer, though.
9.5
Stronger nails
These vitamins are very good and super tasty. After completing my course, my nails improved, my hair stopped shedding, and my facial skin became smoother. I'm happy with the results and will order more. I highly recommend them!
9.5
Hair condition improvement
The taste is delightful, and I've noticed significant progress in my hair's condition. This is my repeat order, and I appreciate the excellent packaging. I'm pleased with the results!
9.5
Effective treatment
This vitamin is excellent! It has quality ingredients, only requires one dose per day, and has immeasurable benefits. The flavour is pleasant, and it's effective for brittle nails and hair loss, as well as improving skin quality. I've purchased it multiple times and would recommend it, especially for those with these issues.
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Frequently Asked Questions
No FAQs are available for this product and symptom.
