Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.4
USERS' SCORE
Good
Based on 11 Reviews
8.5
Supplement Facts
Serving Size: 2 Gummies
Amount Per Serving
%DV
Calories
15
Total Carbohydrate
3 g
1%**
Total Sugars
2 g
***
Includes 2 g Added Sugars
4%**
Vitamin C (as Ascorbic Acid)
15 mg
17%
Vitamin E (as dl-Alpha Tocopheryl Acetate)
6.7 mg
45%
Biotin (as d-Biotin)
2,500 mcg
8,333%
Sodium
10 mg
<1%
Top Medical Research Studies
7
We evaluated the effectiveness of high-dose biotin in treating multiple sclerosis through a systematic review of randomized controlled trials.
Our findings suggest that patients could see some benefit from using high-dose biotin over a period of 12 to 15 months.
However, it's important to note that this potential upside comes with a notable downside: an increased likelihood of affecting laboratory test results.
Overall, the evidence remains moderately certain, indicating a cautious approach is necessary for those considering biotin treatment for multiple sclerosis.
Our findings suggest that patients could see some benefit from using high-dose biotin over a period of 12 to 15 months.
However, it's important to note that this potential upside comes with a notable downside: an increased likelihood of affecting laboratory test results.
Overall, the evidence remains moderately certain, indicating a cautious approach is necessary for those considering biotin treatment for multiple sclerosis.
Read More
7
We evaluated the effectiveness of high-dose pharmaceutical-grade biotin (MD1003) in enhancing treatment responses for patients with progressive multiple sclerosis (PMS). Over one year, we monitored 48 newly treated patients, using clinical assessments and brain volume metrics.
Encouragingly, 27% of patients experienced a notable reduction in disability scores. Additionally, improvements in brain and cervical spinal cord volume were observed in several patients. Yet, those with higher levels of neurofilament light chains or older age at MS onset appeared to have less positive responses to treatment.
Encouragingly, 27% of patients experienced a notable reduction in disability scores. Additionally, improvements in brain and cervical spinal cord volume were observed in several patients. Yet, those with higher levels of neurofilament light chains or older age at MS onset appeared to have less positive responses to treatment.
Read More
8
Dexamethasone delivery variations studied
We explored how different linkers and lengths in biotin-dexamethasone conjugates affect drug delivery to the liver, particularly in autoimmune hepatitis. Through in vitro and in vivo studies, we noted that certain combinations enhance drug stability and uptake in liver cells.
Our findings suggest that tweaking the construction of these nanoparticles can meaningfully influence how effectively the drug works in the body. This could lead to better steroid formulations tailored for various medical needs.
Our findings suggest that tweaking the construction of these nanoparticles can meaningfully influence how effectively the drug works in the body. This could lead to better steroid formulations tailored for various medical needs.
Read More
Most Useful Reviews
9
Rash improvement
453 people found this helpful
I'm enthusiastic about these vitamins! I developed a rash on my forehead and brittle nails due to my autoimmune disorder. I ordered these vitamins based on reviews, and after a month, I've seen improvement. The rash has disappeared, my nails are stronger, my skin has improved, and I even have new hair growth. I would definitely order more, and I recommend them!
Read More
9
Stronger hair
I really like these vitamins. They're convenient, taste good, and have provided good results. My hair now falls less and my nails have become exceptionally strong. I wish I could order them in summer, though.
Read More
9
Stronger nails
1 people found this helpful
These vitamins are very good and super tasty. After completing my course, my nails improved, my hair stopped shedding, and my facial skin became smoother. I'm happy with the results and will order more. I highly recommend them!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.4
- All Researches
9
We explored the unusual manifestations of biotinidase deficiency (BTD), showcasing three cases initially diagnosed as neuromyelitis optica spectrum disorder (NMOSD).
These patients exhibited severe symptoms such as quadriplegia and vision loss. Although some responded to immune therapy initially, they relapsed, while one did not improve at all.
Following further testing, it became clear that BTD was the true culprit. Remarkably, two patients experienced significant recovery after starting biotin supplementation, highlighting the potential of biotin in treating this deficiency.
These patients exhibited severe symptoms such as quadriplegia and vision loss. Although some responded to immune therapy initially, they relapsed, while one did not improve at all.
Following further testing, it became clear that BTD was the true culprit. Remarkably, two patients experienced significant recovery after starting biotin supplementation, highlighting the potential of biotin in treating this deficiency.
Read More
9
We observed a fascinating case of a four-year-old girl diagnosed with Thiamine Metabolism Dysfunction Syndrome 5 and acute disseminated encephalomyelitis, who exhibited marked improvement after treatment with biotin and thiamine. Initially presenting with fever and agitation post-vaccination, genetic tests later revealed a pathogenic variant in the TPK1 gene. The girl's clinical status improved significantly, with resolution of autism spectrum disorder symptoms, supporting the role of early intervention. This case strengthens the evidence for biotin and thiamine in treating metabolic deficiencies related to TPK1.
Read More
8
Dexamethasone delivery variations studied
We explored how different linkers and lengths in biotin-dexamethasone conjugates affect drug delivery to the liver, particularly in autoimmune hepatitis. Through in vitro and in vivo studies, we noted that certain combinations enhance drug stability and uptake in liver cells.
Our findings suggest that tweaking the construction of these nanoparticles can meaningfully influence how effectively the drug works in the body. This could lead to better steroid formulations tailored for various medical needs.
Our findings suggest that tweaking the construction of these nanoparticles can meaningfully influence how effectively the drug works in the body. This could lead to better steroid formulations tailored for various medical needs.
Read More
8
We explored two intriguing cases of biotinidase deficiency, a rare genetic disorder that can mimic conditions like Neuromyelitis Optica Spectrum Disorder. Initially, both patients received treatments for immune-mediated disorders, but when their symptoms worsened, further testing revealed biotinidase deficiency.
Remarkably, after starting biotin supplementation, both children showed significant improvement. This highlights the importance of recognizing atypical neurological signs, as early diagnosis and treatment of biotinidase deficiency can lead to effective intervention.
Remarkably, after starting biotin supplementation, both children showed significant improvement. This highlights the importance of recognizing atypical neurological signs, as early diagnosis and treatment of biotinidase deficiency can lead to effective intervention.
Read More
7
We set out to examine the effects of high-dose pharmaceutical-grade biotin on patients with different types of demyelinating neuropathies.
In a pilot study involving 15 participants, we aimed to see if this treatment could improve various nerve function measures.
While the main goal of achieving a 10% improvement in specific nerve conduction measurements wasn’t reached, many participants showed better sensory and motor abilities.
Overall, these findings suggest that high-dose biotin might help in some ways, and the treatment was well-tolerated by participants.
In a pilot study involving 15 participants, we aimed to see if this treatment could improve various nerve function measures.
While the main goal of achieving a 10% improvement in specific nerve conduction measurements wasn’t reached, many participants showed better sensory and motor abilities.
Overall, these findings suggest that high-dose biotin might help in some ways, and the treatment was well-tolerated by participants.
Read More
User Reviews
USERS' SCORE
Good
Based on 11 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Rash improvement
453 people found this helpful
I'm enthusiastic about these vitamins! I developed a rash on my forehead and brittle nails due to my autoimmune disorder. I ordered these vitamins based on reviews, and after a month, I've seen improvement. The rash has disappeared, my nails are stronger, my skin has improved, and I even have new hair growth. I would definitely order more, and I recommend them!
Read More
9
Stronger hair
I really like these vitamins. They're convenient, taste good, and have provided good results. My hair now falls less and my nails have become exceptionally strong. I wish I could order them in summer, though.
Read More
9
Stronger nails
1 people found this helpful
These vitamins are very good and super tasty. After completing my course, my nails improved, my hair stopped shedding, and my facial skin became smoother. I'm happy with the results and will order more. I highly recommend them!
Read More
9
Hair condition improvement
1 people found this helpful
The taste is delightful, and I've noticed significant progress in my hair's condition. This is my repeat order, and I appreciate the excellent packaging. I'm pleased with the results!
Read More
9
Effective treatment
1 people found this helpful
This vitamin is excellent! It has quality ingredients, only requires one dose per day, and has immeasurable benefits. The flavour is pleasant, and it's effective for brittle nails and hair loss, as well as improving skin quality. I've purchased it multiple times and would recommend it, especially for those with these issues.
Read More
Frequently Asked Questions
9
Rash improvement
453 people found this helpful
I'm enthusiastic about these vitamins! I developed a rash on my forehead and brittle nails due to my autoimmune disorder. I ordered these vitamins based on reviews, and after a month, I've seen improvement. The rash has disappeared, my nails are stronger, my skin has improved, and I even have new hair growth. I would definitely order more, and I recommend them!
7.5
Nail and hair growth
73 people found this helpful
This supplement contains biotin with vitamins C and E. Biotin is essential for various bodily functions and helps improve skin condition while also accelerating hair and nail growth. I started taking it despite initial doubts and have been pleasantly surprised. My nails now grow faster, and my hair growth is remarkable but requires more frequent dyeing. I am very satisfied with the results.
2
No results observed
I have been taking this for a month, but I have yet to see any results. It might be wiser to order a complete bioactive complex of B vitamins instead.
9
Stronger nails
1 people found this helpful
These vitamins are very good and super tasty. After completing my course, my nails improved, my hair stopped shedding, and my facial skin became smoother. I'm happy with the results and will order more. I highly recommend them!
0
Facial inflammation
1 people found this helpful
Despite studying the reviews, I decided to order these vitamins but only took half the dose. They tasted nice, but I soon developed unexpected facial inflammations, which I never encountered before. While my hair grew quickly, the condition of my nails did not improve, and I won't continue with them.
0
Acne outbreak
I can only give two stars for the taste, which is very nice, but I've experienced severe acne from this product. I'm disappointed, as I've had to stop using it due to the breakout.
9
We explored the unusual manifestations of biotinidase deficiency (BTD), showcasing three cases initially diagnosed as neuromyelitis optica spectrum disorder (NMOSD).
These patients exhibited severe symptoms such as quadriplegia and vision loss. Although some responded to immune therapy initially, they relapsed, while one did not improve at all.
Following further testing, it became clear that BTD was the true culprit. Remarkably, two patients experienced significant recovery after starting biotin supplementation, highlighting the potential of biotin in treating this deficiency.
These patients exhibited severe symptoms such as quadriplegia and vision loss. Although some responded to immune therapy initially, they relapsed, while one did not improve at all.
Following further testing, it became clear that BTD was the true culprit. Remarkably, two patients experienced significant recovery after starting biotin supplementation, highlighting the potential of biotin in treating this deficiency.
7
We set out to examine the effects of high-dose pharmaceutical-grade biotin on patients with different types of demyelinating neuropathies.
In a pilot study involving 15 participants, we aimed to see if this treatment could improve various nerve function measures.
While the main goal of achieving a 10% improvement in specific nerve conduction measurements wasn’t reached, many participants showed better sensory and motor abilities.
Overall, these findings suggest that high-dose biotin might help in some ways, and the treatment was well-tolerated by participants.
In a pilot study involving 15 participants, we aimed to see if this treatment could improve various nerve function measures.
While the main goal of achieving a 10% improvement in specific nerve conduction measurements wasn’t reached, many participants showed better sensory and motor abilities.
Overall, these findings suggest that high-dose biotin might help in some ways, and the treatment was well-tolerated by participants.
7
We evaluated the effectiveness of high-dose biotin in treating multiple sclerosis through a systematic review of randomized controlled trials.
Our findings suggest that patients could see some benefit from using high-dose biotin over a period of 12 to 15 months.
However, it's important to note that this potential upside comes with a notable downside: an increased likelihood of affecting laboratory test results.
Overall, the evidence remains moderately certain, indicating a cautious approach is necessary for those considering biotin treatment for multiple sclerosis.
Our findings suggest that patients could see some benefit from using high-dose biotin over a period of 12 to 15 months.
However, it's important to note that this potential upside comes with a notable downside: an increased likelihood of affecting laboratory test results.
Overall, the evidence remains moderately certain, indicating a cautious approach is necessary for those considering biotin treatment for multiple sclerosis.
4
We set out to investigate whether high-dose biotin (HDB) therapy might heighten the risk of relapses in patients with progressive multiple sclerosis (PMS). Our study, involving 2,628 patients receiving HDB and a matched control group, showed no significant increase in relapse rates.
Analyses indicated similar annualized relapse rates for both groups, meaning HDB doesn't appear to elevate relapse risks in PMS. Notably, previous relapses seemed to predict future ones, regardless of HDB treatment. Overall, our findings suggest that HDB may not contribute to an increased risk of relapse for PMS patients.
Analyses indicated similar annualized relapse rates for both groups, meaning HDB doesn't appear to elevate relapse risks in PMS. Notably, previous relapses seemed to predict future ones, regardless of HDB treatment. Overall, our findings suggest that HDB may not contribute to an increased risk of relapse for PMS patients.
References
- Ali F, Mukhtiar K, Raza M, Ibrahim S. Atypical presentation of biotinidase deficiency: masquerading neuromyelitis optica spectrum disorder. BMJ Case Rep. 2024;17. doi:10.1136/bcr-2023-258703
- Créange A, Hutin E, Sedel F, Le Vigouroux L, Lefaucheur JP. High-dose pharmaceutical-grade biotin in patients with demyelinating neuropathies: a phase 2b open label, uncontrolled, pilot study. BMC Neurol. 2023;23:389. doi:10.1186/s12883-023-03440-y
- Thompson ZE, Boyd NK, Khoshnood MM, Santoro JD. Thiamine metabolism dysfunction syndrome 5 (THMD5) mimicking acute disseminated encephalomyelitis. Am J Med Genet A. 2023;191:2868. doi:10.1002/ajmg.a.63376
- Ongaro A, Violatto MB, Casarin E, Pellerani I, Marchini G, et al. The mode of dexamethasone decoration influences avidin-nucleic-acid-nano-assembly organ biodistribution and in vivo drug persistence. Nanomedicine. 2022;40:102497. doi:10.1016/j.nano.2021.102497
- Espiritu AI, Remalante-Rayco PPM. High-dose biotin for multiple sclerosis: A systematic review and meta-analyses of randomized controlled trials. Mult Scler Relat Disord. 2021;55:103159. doi:10.1016/j.msard.2021.103159
- Collongues N, Kuhle J, Tsagkas C, Lamy J, Meyer N, et al. Biomarkers of treatment response in patients with progressive multiple sclerosis treated with high-dose pharmaceutical-grade biotin (MD1003). Brain Behav. 2021;11:e01998. doi:10.1002/brb3.1998
- Mathais S, Moisset X, Pereira B, Taithe F, Ciron J, et al. Relapses in Patients Treated with High-Dose Biotin for Progressive Multiple Sclerosis. Neurotherapeutics. 2021;18:378. doi:10.1007/s13311-020-00926-2
- Shah S, Khan N, Lakshmanan R, Lewis B, Nagarajan L. Biotinidase deficiency presenting as Neuromyelitis Optica Spectrum Disorder. Brain Dev. 2020;42:762. doi:10.1016/j.braindev.2020.07.007
