Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Magnesium (as Magnesium Oxide)
500 mg
119%
The product is found useful for the following medical conditions
Sleep Apnea details
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Good
Based on 60 Reviews
8.9
7
Magnesium's role in sleep apnea
Association between magnesium deficiency score and sleep quality in adults: A population-based cross-sectional study.
Most Relevant Research
We aimed to uncover the relationship between magnesium levels and sleep quality, particularly focusing on sleep apnea. Our study analyzed data from a large group of adults aged 20 and older, using a well-structured method to assess magnesium levels and the prevalence of sleep issues.
We found a notable connection between lower magnesium levels, measured as the magnesium depletion score (MDS), and the likelihood of experiencing sleep apnea. Specifically, individuals with higher MDS levels were significantly more likely to report sleep apnea, showing over three times the odds compared to those with adequate magnesium levels.
Interestingly, our research did not link magnesium deficiency to other sleep problems like insomnia or restless legs syndrome, suggesting a more complex relationship with sleep apnea alone. Additionally, we noticed that older adults with depressive symptoms showed a tendency toward excessive sleep rather than insufficient sleep.
While our findings highlight the association between magnesium deficiency and sleep apnea, they also point towards the potential of adequate magnesium intake in reducing this risk. This emphasizes the importance of maintaining proper magnesium levels for better sleep quality, especially in those at higher risk for sleep apnea.
We found a notable connection between lower magnesium levels, measured as the magnesium depletion score (MDS), and the likelihood of experiencing sleep apnea. Specifically, individuals with higher MDS levels were significantly more likely to report sleep apnea, showing over three times the odds compared to those with adequate magnesium levels.
Interestingly, our research did not link magnesium deficiency to other sleep problems like insomnia or restless legs syndrome, suggesting a more complex relationship with sleep apnea alone. Additionally, we noticed that older adults with depressive symptoms showed a tendency toward excessive sleep rather than insufficient sleep.
While our findings highlight the association between magnesium deficiency and sleep apnea, they also point towards the potential of adequate magnesium intake in reducing this risk. This emphasizes the importance of maintaining proper magnesium levels for better sleep quality, especially in those at higher risk for sleep apnea.
9.5
Husband's sleep improved
Most Useful Review
This magnesium works well. I chose this brand for my husband, and I noticed his sleep improved from the first capsule. I haven't felt the effects yet, but I'm calmer and no longer have persistent thoughts at night, which helps with my sleep. Highly recommend!
Leg Cramps details
SCIENTIFIC SCORE
Likely Ineffective
Based on 17 Researches
4.8
USERS' SCORE
Good
Based on 50 Reviews
8.8
9
Magnesium oxide treats leg cramps
A randomized, double-blind, placebo-controlled, multicenter study assessing the efficacy of magnesium oxide monohydrate in the treatment of nocturnal leg cramps.
Most Relevant Research
We conducted a study to evaluate how effective magnesium oxide monohydrate (MOMH) is in treating nocturnal leg cramps (NLC). This was a randomized, double-blind, placebo-controlled trial involving multiple centers in Ukraine, where participants took either MOMH or a placebo nightly for 60 days.
Our focus was on measuring the frequency and duration of cramps, the pain they caused, and how they affected sleep quality and overall life satisfaction. We used thorough statistical methods to compare the results between the two groups.
The findings indicated that MOMH is both effective and safe for individuals dealing with NLC. Participants reported improvements in their symptoms, demonstrating that this magnesium supplement can play a helpful role in managing nocturnal leg cramps.
Our focus was on measuring the frequency and duration of cramps, the pain they caused, and how they affected sleep quality and overall life satisfaction. We used thorough statistical methods to compare the results between the two groups.
The findings indicated that MOMH is both effective and safe for individuals dealing with NLC. Participants reported improvements in their symptoms, demonstrating that this magnesium supplement can play a helpful role in managing nocturnal leg cramps.
9.5
Calmer legs
Most Useful Review
I began to take magnesium on my doctor’s recommendation, as they often cause my legs to cramp. The doctor prescribed 500 mg daily. After several weeks of use, I feel calmer and, most importantly, the leg cramps have ceased.
Flu details
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Good
Based on 3 Reviews
8.7
7
Magnesium essential for immune response
Mg regulation of kinase signaling and immune function.
Most Relevant Research
We explored how magnesium affects our immune response, particularly in relation to fighting off influenza. By examining how magnesium levels influence T cell function, we noticed that lower levels of magnesium in the body could hinder the T cell receptor (TCR) activation process. This is significant because TCR activation is crucial for mounting an effective immune response against viruses like influenza.
Our findings revealed that insufficient magnesium decreases the activation of important immune cells, specifically CD8 T cells, which are vital for responding to infections. This was further demonstrated in mice where reduced serum magnesium concentrations led to weaker immune responses and more severe illness from influenza A virus.
Overall, we observed that magnesium not only serves as an essential cofactor in cellular processes but also plays a direct role in maintaining strong immune function. Ensuring an adequate intake of magnesium is therefore important for enhancing our ability to combat viral infections effectively.
Our findings revealed that insufficient magnesium decreases the activation of important immune cells, specifically CD8 T cells, which are vital for responding to infections. This was further demonstrated in mice where reduced serum magnesium concentrations led to weaker immune responses and more severe illness from influenza A virus.
Overall, we observed that magnesium not only serves as an essential cofactor in cellular processes but also plays a direct role in maintaining strong immune function. Ensuring an adequate intake of magnesium is therefore important for enhancing our ability to combat viral infections effectively.
9.5
Natural anti-stress effect
Most Useful Review
Magnesium aids in relaxing muscle fibres, including those in blood vessels and internal organs. Its primary benefit is its role as a natural anti-stress factor that inhibits excitement in the central nervous system and lessens sensitivity to external factors. Thanks to this medication, I have become calmer. Highly recommend!
Heartburn details
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.5
USERS' SCORE
Good
Based on 3 Reviews
8.7
9
Magnesium alginate offers heartburn relief
Emerging from gastroesophageal reflux (EMERGE): An Italian survey - II the viewpoint of the patient.
Most Relevant Research
We explored the impact of a new treatment, Marial®, on patients suffering from gastroesophageal reflux disease (GERD). In a large survey involving 56 gastroenterological offices across Italy, patients were treated with either proton pump inhibitors (PPIs), a combination of PPIs and an additional remedy, or the Marial® formulation containing magnesium alginate. The results showed that both Marial® and the combination therapy significantly reduced heartburn symptoms, with Marial® proving to be more effective than the combination. Overall, patients reported a marked improvement in their GERD-related symptoms.
9.5
Calmness from heartburn
Most Useful Review
Great drug! Of all the magnesium preparations, this is my favourite! It is well absorbed; after 2-3 days of taking it, I felt calm and peaceful. The dosage of 500 mg is convenient, as I took one tablet an hour before bedtime. The tablets are small and easy to swallow, and there was no heartburn! I truly appreciated the effect; my nervousness and irritability subsided, and my sleep improved! I recommend it to anyone with nerve issues! :)
Nausea details
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.8
USERS' SCORE
Good
Based on 4 Reviews
8.7
8
Magnesium effectively reduces PONV
Effects of intra-operative magnesium sulfate infusion on orthognathic surgery: A prospective and randomized controlled trial.
Most Relevant Research
We conducted a study to discover how magnesium sulfate affects nausea during orthognathic surgery. In this research, we divided 75 adult patients into two groups: one group received magnesium sulfate, while the other received a placebo saline solution.
We discovered that those who received magnesium experienced significantly less postoperative nausea and vomiting (PONV) compared to the control group. Specifically, at two hours post-surgery, patients in the magnesium group reported less severe PONV.
Additionally, this group also had lower requirements for remifentanil, a pain reliever, indicating that magnesium not only helps with nausea but may also play a role in overall pain management during recovery. The magnesium levels in the blood after surgery were notably higher in the magnesium group, further supporting its effectiveness.
This research suggests that incorporating magnesium sulfate into treatment protocols during orthognathic surgeries can greatly enhance patient comfort by minimizing nausea and improving pain control.
We discovered that those who received magnesium experienced significantly less postoperative nausea and vomiting (PONV) compared to the control group. Specifically, at two hours post-surgery, patients in the magnesium group reported less severe PONV.
Additionally, this group also had lower requirements for remifentanil, a pain reliever, indicating that magnesium not only helps with nausea but may also play a role in overall pain management during recovery. The magnesium levels in the blood after surgery were notably higher in the magnesium group, further supporting its effectiveness.
This research suggests that incorporating magnesium sulfate into treatment protocols during orthognathic surgeries can greatly enhance patient comfort by minimizing nausea and improving pain control.
9.5
No discomfort noted
Most Useful Review
This magnesium works excellently and does not cause any discomfort, such as nausea or stomach issues. The price is great, and I find no reason to search for a better alternative.
Osteoporosis details
SCIENTIFIC SCORE
Moderately Effective
Based on 19 Researches
8.2
USERS' SCORE
Good
Based on 3 Reviews
8.7
9
Magnesium's role in osteoporosis therapy
Mg-ZIF nanozyme regulates the switch between osteogenic and lipogenic differentiation in BMSCs via lipid metabolism.
Most Relevant Research
We explored the effects of a special material called magnesium-based zeolitic imidazolate frameworks, or Mg-ZIF, on osteoporosis. This study aimed to find a way to tackle osteoporosis by reducing reactive oxygen species (ROS)—harmful molecules that affect our bone health.
Our findings revealed that Mg-ZIF is effective at scavenging ROS, which helps boost the bone-forming ability of bone mesenchymal stem cells (BMSCs). By promoting osteogenic differentiation, Mg-ZIF supports the formation of new bone while simultaneously discouraging the development of fat cells from BMSCs, a process known as lipogenic differentiation.
In our in vivo experiments, we confirmed that administering Mg-ZIF could successfully lower ROS levels and mitigate the effects of osteoporosis. On a deeper level, the mechanism behind this involves Mg-ZIF enhancing BMSC differentiation into bone-forming cells by upregulating specific lipid metabolic pathways.
Overall, we believe that Mg-ZIF holds promise as a therapeutic approach for osteoporosis. By addressing the oxidative stress in the bone marrow environment, it opens a new door for potential treatments targeting this common bone disease.
Our findings revealed that Mg-ZIF is effective at scavenging ROS, which helps boost the bone-forming ability of bone mesenchymal stem cells (BMSCs). By promoting osteogenic differentiation, Mg-ZIF supports the formation of new bone while simultaneously discouraging the development of fat cells from BMSCs, a process known as lipogenic differentiation.
In our in vivo experiments, we confirmed that administering Mg-ZIF could successfully lower ROS levels and mitigate the effects of osteoporosis. On a deeper level, the mechanism behind this involves Mg-ZIF enhancing BMSC differentiation into bone-forming cells by upregulating specific lipid metabolic pathways.
Overall, we believe that Mg-ZIF holds promise as a therapeutic approach for osteoporosis. By addressing the oxidative stress in the bone marrow environment, it opens a new door for potential treatments targeting this common bone disease.
9.5
Prevents osteoporosis
Most Useful Review
Magnesium is a crucial mineral within the human body, with around 60% stored in bone tissue, making it vital for osteoporosis prevention and maintaining good bone density. Additionally, magnesium regulates nervous system functions, aids in DNA synthesis, facilitates muscle relaxation and contraction, and supports energy extraction from food.
Reflux details
SCIENTIFIC SCORE
Moderately Effective
Based on 11 Researches
8.1
USERS' SCORE
Good
Based on 3 Reviews
8.7
9
Magnesium alginate effectively treats LPR
Magnesium alginate in patients with laryngopharyngeal reflux.
Most Relevant Research
We examined the role of magnesium alginate in treating laryngopharyngeal reflux (LPR), which causes symptoms like voice issues, swallowing difficulties, and coughing. In a study involving 100 outpatients, patients were treated with alginate for two months, visiting at the start and then at 15, 30, and 60 days.
The results were promising, showing a significant reduction in all symptoms assessed. This suggests that magnesium alginate could be a safe and effective alternative for managing LPR, especially for those who cannot fully rely on conventional treatments like proton pump inhibitors.
The results were promising, showing a significant reduction in all symptoms assessed. This suggests that magnesium alginate could be a safe and effective alternative for managing LPR, especially for those who cannot fully rely on conventional treatments like proton pump inhibitors.
9.5
Reduced reflux symptoms
Most Useful Review
Great! I love it. It significantly improves my acid reflux! It also works wonders for heartburn and constipation too!
Anxiety details
SCIENTIFIC SCORE
Questionable
Based on 12 Researches
6.9
USERS' SCORE
Good
Based on 9 Reviews
8.6
8
Magnesium treats anxiety in MS
Nanoparticulate MgH ameliorates anxiety/depression-like behaviors in a mouse model of multiple sclerosis by regulating microglial polarization and oxidative stress.
Most Relevant Research
We aimed to understand the impact of nanoparticulate magnesium hydride (MgH) on anxiety and depression associated with multiple sclerosis (MS). Our exploration involved studying how MgH affects mood disorders in a model we designed, specifically using experimental autoimmune encephalomyelitis (EAE) mice.
We discovered that MgH treatment significantly alleviated anxiety and depression-like behaviors in these mice. Not only did MgH help improve their mood, but it also reduced overall disease severity and inflammatory damage within the central nervous system.
Importantly, our findings suggest that MgH could be working by promoting healthier microglial activity. It appears to encourage the beneficial M2 polarization while inhibiting the harmful M1 polarization, alongside reducing oxidative stress. This mechanism offers a glimpse into how magnesium might truly enhance well-being for those dealing with MS-related psychiatric issues.
In summary, our research indicates that nanoparticulate MgH holds promise as a non-toxic and effective treatment option for anxiety and depression in people suffering from MS, showcasing a potential breakthrough in managing these debilitating conditions.
We discovered that MgH treatment significantly alleviated anxiety and depression-like behaviors in these mice. Not only did MgH help improve their mood, but it also reduced overall disease severity and inflammatory damage within the central nervous system.
Importantly, our findings suggest that MgH could be working by promoting healthier microglial activity. It appears to encourage the beneficial M2 polarization while inhibiting the harmful M1 polarization, alongside reducing oxidative stress. This mechanism offers a glimpse into how magnesium might truly enhance well-being for those dealing with MS-related psychiatric issues.
In summary, our research indicates that nanoparticulate MgH holds promise as a non-toxic and effective treatment option for anxiety and depression in people suffering from MS, showcasing a potential breakthrough in managing these debilitating conditions.
9.5
Infrequent anxiety now
Most Useful Review
This magnesium is excellent! After a month of taking it, I feel much calmer and will continue to use it. Previously, anxiety was a common issue for me, but now it occurs very rarely.
Athlete’s Foot details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 4 Reviews
8.6
9.5
Improved sleep quality
Most Useful Review
Magnesium plays a crucial role in maintaining nerve stability. I previously endured foot twitching during the night, but after consuming sufficient magnesium, the twitches ceased, aiding my sleep tremendously.
Autoimmune Disorder details
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.4
USERS' SCORE
Good
Based on 6 Reviews
8.6
9
Magnesium shows promise for RA treatment
Magnesium Supplementation Modifies Arthritis Synovial and Splenic Transcriptomic Signatures Including Ferroptosis and Cell Senescence Biological Pathways.
Most Relevant Research
We analyzed how magnesium supplementation affects the biology of rheumatoid arthritis (RA) in mice. By feeding one group a diet rich in magnesium and another a standard diet over 15 days, we examined changes in their tissue responses.
Our findings revealed that increased magnesium intake may alter gene expression linked to oxidative stress and cellular aging, processes that are significant in RA development. This suggests that magnesium could be beneficial for managing RA and potentially other autoimmune disorders by reducing disease severity and joint damage.
Our findings revealed that increased magnesium intake may alter gene expression linked to oxidative stress and cellular aging, processes that are significant in RA development. This suggests that magnesium could be beneficial for managing RA and potentially other autoimmune disorders by reducing disease severity and joint damage.
9.5
Improved sleep quality
Most Useful Review
This magnesium is fantastic, and I wouldn't choose anything else! It effectively calms my nervous system and enhances my sleep. I combine it with vitamin B6. The tablets are large yet easy to swallow. This magnesium is the best I have found, and I plan to reorder once I finish. Thank you to the manufacturer for affordable quality.
Blood Clot details
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.5
USERS' SCORE
Good
Based on 5 Reviews
8.6
8
Magnesium scaffold shows promising results
A new resorbable magnesium scaffold for de novo coronary lesions (DREAMS 3): one-year results of the BIOMAG-I first-in-human study.
Most Relevant Research
We investigated the clinical safety and performance of a new magnesium scaffold known as DREAMS 3G. This innovative treatment aims to match the effectiveness of drug-eluting stents in coronary interventions.
Over one year, a total of 116 patients were monitored, showing promising results with minimal lumen loss and no adverse events like cardiac death or major thrombosis. Despite a few revascularization interventions, the scaffold appears to be a viable alternative.
Overall, our findings support its potential use in heart treatments.
Over one year, a total of 116 patients were monitored, showing promising results with minimal lumen loss and no adverse events like cardiac death or major thrombosis. Despite a few revascularization interventions, the scaffold appears to be a viable alternative.
Overall, our findings support its potential use in heart treatments.
9.5
Needed magnesium
Most Useful Review
Excellent product! I have a medical requirement for magnesium, which Nature's Bounty has successfully met. My blood work has improved significantly, moving from 'red' to 'green'. Although I take 2500 mg daily, I trust this product more than others claiming to provide higher dosages.
Chronic Cough details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.6
8.8
Supports chronic conditions
Most Useful Review
Excellent! Magnesium is primarily found in bones, influencing their growth and maintenance. It also exists in muscles, soft tissues, and extracellular fluid. This element acts as a reservoir that ensures a normal concentration in the blood. It plays a critical role in synthesising genetic materials (DNA and RNA) and proteins. Moreover, magnesium is essential for cell division, growth, productivity, and energy conservation. I always take magnesium, especially during spring's off-season when chronic diseases tend to worsen. I favour this manufacturer!
Diabetes details
SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.5
USERS' SCORE
Good
Based on 5 Reviews
8.6
8
Magnesium intake benefits diabetes patients
Associations of dietary magnesium intake with the risk of atherosclerotic cardiovascular disease and mortality in individuals with and without type 2 diabetes: A prospective study in the UK Biobank.
Most Relevant Research
We investigated the link between dietary magnesium intake and the risk of heart disease and death in over 149,000 individuals, including those with type 2 diabetes. Through careful analysis over a median of 12 years, we found that higher magnesium intake was associated with significantly lower risks of heart disease and mortality in individuals with diabetes.
However, this benefit wasn't seen in those without diabetes. Our findings highlight the potential for magnesium to play a crucial role in health management for people living with type 2 diabetes, signaling the need for tailored dietary guidance.
However, this benefit wasn't seen in those without diabetes. Our findings highlight the potential for magnesium to play a crucial role in health management for people living with type 2 diabetes, signaling the need for tailored dietary guidance.
9.5
Beneficial for diabetes
Most Useful Review
I liked it! Magnesium has been a real salvation for my family and me. We began incorporating magnesium into our daily routine, and the results are remarkable. As a diabetic, I find it incredibly beneficial as it improves insulin sensitivity, lowering my sugar and stress levels. Beyond helping with diabetes, our family experiences increased energy and overall well-being. Magnesium supports heart health, strong bones and muscles, and even promotes better sleep. This product is truly essential for all of us. Thank you for such an amazing item!
Hypertension details
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.6
USERS' SCORE
Good
Based on 3 Reviews
8.6
9
Magnesium intake linked to reduced hypertension
Associations between dietary magnesium intake and hypertension, diabetes, and hyperlipidemia.
Most Relevant Research
We explored the connection between dietary magnesium intake and hypertension along with other health issues in US adults. In our study, we analyzed data from over 24,000 people, taking into account various lifestyle factors.
We found that those with higher magnesium intake had significantly lower rates of hypertension, diabetes, and hyperlipidemia compared to those with the least intake. Notably, participants in the highest quintile of magnesium consumption were less likely to suffer from these conditions.
These results suggest that increasing magnesium-rich foods in our diets could help prevent these prevalent health concerns.
We found that those with higher magnesium intake had significantly lower rates of hypertension, diabetes, and hyperlipidemia compared to those with the least intake. Notably, participants in the highest quintile of magnesium consumption were less likely to suffer from these conditions.
These results suggest that increasing magnesium-rich foods in our diets could help prevent these prevalent health concerns.
9.5
Heart and vessel support
Most Useful Review
I am 45 years old and take magnesium for hypertension as prescribed by my doctor. He recommended this product from iHerb. Magnesium positively influences heart and blood vessel function.
Insomnia details
SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.4
USERS' SCORE
Good
Based on 6 Reviews
8.6
9
Magnesium improves elderly insomnia
The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial.
Most Relevant Research
We conducted a double-blind, placebo-controlled clinical trial to investigate the effects of magnesium supplementation on insomnia in elderly individuals. Our study involved 46 participants who were assigned either to receive 500 mg of magnesium daily or a placebo for a duration of 8 weeks.
Throughout the study, we employed various questionnaires, including the Insomnia Severity Index (ISI), to evaluate the participants' sleep quality both before and after the treatment period. We also monitored the intake of other nutrients and performed blood tests to assess hormone levels related to sleep.
The results showed that magnesium supplementation led to significant improvements in areas such as sleep efficiency, sleep onset timing, and overall insomnia severity. We observed increases in serum levels of melatonin and changes in cortisol and renin levels, indicating a physiological response that could enhance sleep quality.
Overall, it seems that supplementing with magnesium has the potential to improve sleep for older adults struggling with insomnia. This finding could pave the way for new, accessible treatment options for those affected by sleep disorders.
Throughout the study, we employed various questionnaires, including the Insomnia Severity Index (ISI), to evaluate the participants' sleep quality both before and after the treatment period. We also monitored the intake of other nutrients and performed blood tests to assess hormone levels related to sleep.
The results showed that magnesium supplementation led to significant improvements in areas such as sleep efficiency, sleep onset timing, and overall insomnia severity. We observed increases in serum levels of melatonin and changes in cortisol and renin levels, indicating a physiological response that could enhance sleep quality.
Overall, it seems that supplementing with magnesium has the potential to improve sleep for older adults struggling with insomnia. This finding could pave the way for new, accessible treatment options for those affected by sleep disorders.
10
Sleep improvement
Most Useful Review
I use it as a remedy for insomnia, and with just two tablets, I sleep like a baby. I highly recommend it.
Migraine details
SCIENTIFIC SCORE
Possibly Effective
Based on 17 Researches
7.4
USERS' SCORE
Good
Based on 5 Reviews
8.6
9
We explored how magnesium supplementation can help alleviate migraines, a condition that affects countless individuals and can be incredibly disabling. Research has shown a strong link between magnesium deficiency and various factors that contribute to migraines, such as neurological changes and inflammation.
Studies, including randomized controlled trials, indicate that magnesium can reduce the frequency and severity of migraine attacks, both in the short term and as a preventative measure. This effectiveness is thought to stem from magnesium's ability to influence nerve function and reduce stress responses in the body.
We've examined the accumulating evidence from case studies and clinical trials, and it clearly points to magnesium being a valuable option for those suffering from migraines. By addressing magnesium deficiency, we may offer a new avenue for relief and improved management of this challenging condition.
Studies, including randomized controlled trials, indicate that magnesium can reduce the frequency and severity of migraine attacks, both in the short term and as a preventative measure. This effectiveness is thought to stem from magnesium's ability to influence nerve function and reduce stress responses in the body.
We've examined the accumulating evidence from case studies and clinical trials, and it clearly points to magnesium being a valuable option for those suffering from migraines. By addressing magnesium deficiency, we may offer a new avenue for relief and improved management of this challenging condition.
8.8
Significant reduction
Most Useful Review
Migraine relief. I take very high doses of magnesium to help combat my chronic migraines. I appreciate that it comes in 500mg tablets, so I only have to swallow a couple instead of many. It's definitely potent; I've gone from experiencing a migraine daily to having only a couple each month.
Pelvic Pain details
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.3
USERS' SCORE
Good
Based on 16 Reviews
8.6
8
Magnesium alleviates primary dysmenorrhea
Effectiveness of magnesium pidolate in the prophylactic treatment of primary dysmenorrhea.
Most Relevant Research
We evaluated how magnesium pidolate impacts primary dysmenorrhea in 30 young women. Over six menstrual cycles, we tracked their pain levels using a visual scale. Initially, no treatment was given, and subsequently, magnesium was administered just before menstruation.
The first day of menstrual pain showed a notable decrease with magnesium treatment, especially from the first to the sixth cycle. While there were some improvements on days two and three, those weren't statistically significant. Importantly, no side effects were reported, suggesting magnesium can be a reliable option for managing menstrual pain.
The first day of menstrual pain showed a notable decrease with magnesium treatment, especially from the first to the sixth cycle. While there were some improvements on days two and three, those weren't statistically significant. Importantly, no side effects were reported, suggesting magnesium can be a reliable option for managing menstrual pain.
9.5
Reduces pelvic pain
Most Useful Review
The daily dosage of one tablet lasts more than three months. I learned about magnesium at my gynaecologist's visit due to severe pelvic pain. They recommended a dosage of 500-800 mg daily, and I felt wonderful—the pain decreased significantly. I previously relied heavily on painkillers but feel great now after two months. Additionally, I am less anxious and wake easily in the mornings.
Swollen Lymph Nodes details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.6
9.5
Leg swelling relief
Most Useful Review
Magnesium has significantly helped with the swelling in my legs and alleviated the night pains I experienced from cramping. I recommend an appropriate dosage for best results.
Bone Pain details
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7
USERS' SCORE
Good
Based on 7 Reviews
8.5
7
CMT shows potential for pain relief
The efficacy of choline magnesium trisalicylate (CMT) in the management of metastatic bone pain: a pilot study.
Most Relevant Research
We investigated how choline magnesium trisalicylate (CMT) helps alleviate bone pain in patients with metastatic cancer. In a carefully designed study involving 26 participants, we compared CMT against a placebo in a crossover format, measuring pain relief at multiple intervals after dosing.
While we observed a significant reduction in pain just one hour post-treatment with CMT, other comparisons showed improvements that didn't reach statistical significance. This suggested that CMT might assist in managing bone pain, potentially complementing traditional opioids, but overall effectiveness is still under exploration.
While we observed a significant reduction in pain just one hour post-treatment with CMT, other comparisons showed improvements that didn't reach statistical significance. This suggested that CMT might assist in managing bone pain, potentially complementing traditional opioids, but overall effectiveness is still under exploration.
9.5
Healthy bones
Most Useful Review
Excellent! This is my favourite supplement! It promotes healthy bones and muscles, and the tablets are coated for easy swallowing. The quantity lasts a long time, and magnesium offers numerous benefits for the body. It suits vegetarians and has guaranteed quality. There is no unpleasant taste, and I consistently buy it as I follow the keto diet. It enhances my sleep quality and helps prevent pain in my joints and muscles.
Cardiovascular Disease details
SCIENTIFIC SCORE
Questionable
Based on 12 Researches
6.8
USERS' SCORE
Good
Based on 3 Reviews
8.5
8
Magnesium's impact on heart health
The Role of Dietary Magnesium in Cardiovascular Disease.
Most Relevant Research
We examined the connection between dietary magnesium and cardiovascular disease, focusing on how magnesium intake or serum levels relate to heart health. Over the last couple of decades, numerous studies have shown that low magnesium levels are associated with several heart-related issues, including high blood pressure, heart attacks, and even heart failure.
Our insights reveal that even mild or moderate magnesium deficiencies can trigger physiological and metabolic changes that may heighten cardiovascular risks. When magnesium levels are insufficient, we see a rise in inflammation, oxidative stress, and issues with how fats are processed in the body, which can lead to serious heart problems.
Furthermore, we noted that many individuals often consume less magnesium than what is recommended, particularly those who do not regularly eat whole grains, legumes, or green vegetables. This widespread lack of magnesium is concerning, as it could be a significant factor influencing heart disease in the general population.
Our insights reveal that even mild or moderate magnesium deficiencies can trigger physiological and metabolic changes that may heighten cardiovascular risks. When magnesium levels are insufficient, we see a rise in inflammation, oxidative stress, and issues with how fats are processed in the body, which can lead to serious heart problems.
Furthermore, we noted that many individuals often consume less magnesium than what is recommended, particularly those who do not regularly eat whole grains, legumes, or green vegetables. This widespread lack of magnesium is concerning, as it could be a significant factor influencing heart disease in the general population.
8.8
Boosts digestion
Most Useful Review
This product has positively impacted my digestive system and supports cardiovascular function. I highly recommend it for anyone looking to improve their health.
Stroke details
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.5
USERS' SCORE
Good
Based on 2 Reviews
8.5
9
Magnesium shows neuroprotective promise
Neuroprotection on ischemic brain injury by Mg/H released from endovascular Mg implant.
Most Relevant Research
We embarked on an intriguing exploration of how magnesium might help during cerebral ischemia, particularly after an acute stroke. The study set out to determine the potential benefits of a biodegradable neuroprotective stent that releases magnesium into the bloodstream, targeting areas impacted by reperfusion injury.
To do this, we first looked at how pure magnesium affected neuron cells that had undergone oxygen-glucose deprivation and reoxygenation. Encouragingly, we found that the magnesium could indeed protect these cells from injury.
Building on this, we then tested out a magnesium wire in the carotid artery of rats, mimicking the human experience of stroke. The results indicated that this method successfully helped reduce behavioral issues, neural damage, and even blood-brain barrier disruption in the rats following a known stroke model.
In conclusion, magnesium-based implants may represent a promising local treatment option for alleviating the damage caused by strokes, bolstering support for using magnesium in neuroprotection.
To do this, we first looked at how pure magnesium affected neuron cells that had undergone oxygen-glucose deprivation and reoxygenation. Encouragingly, we found that the magnesium could indeed protect these cells from injury.
Building on this, we then tested out a magnesium wire in the carotid artery of rats, mimicking the human experience of stroke. The results indicated that this method successfully helped reduce behavioral issues, neural damage, and even blood-brain barrier disruption in the rats following a known stroke model.
In conclusion, magnesium-based implants may represent a promising local treatment option for alleviating the damage caused by strokes, bolstering support for using magnesium in neuroprotection.
8.3
Reduced cramps
Most Useful Review
Without magnesium, I feel hysterical. To maintain calm and respond appropriately to my children's antics, I take it each day. After my father had a stroke, he developed cramps in his limbs, which disappeared upon taking magnesium.
Brain Tumor details
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.2
USERS' SCORE
Good
Based on 2 Reviews
8.4
7
Magnesium reduces brain injury markers
Effect of magnesium on functional outcome and paraclinical parameters of patients undergoing supratentorial craniotomy for brain tumors: a randomized controlled trial.
Most Relevant Research
We examined how intravenous magnesium sulfate (MgSO4) affects patients undergoing surgery for brain tumors. Sixty patients were divided into two groups: one received magnesium treatment, while the other received a placebo.
The results showed that magnesium lowered significant protein levels linked to brain injury after surgery. However, it didn’t substantially change the overall functional outcomes for the patients. While MgSO4 appears safe and beneficial in reducing specific markers, more research is necessary to fully grasp magnesium's role in brain injury recovery.
The results showed that magnesium lowered significant protein levels linked to brain injury after surgery. However, it didn’t substantially change the overall functional outcomes for the patients. While MgSO4 appears safe and beneficial in reducing specific markers, more research is necessary to fully grasp magnesium's role in brain injury recovery.
7.5
Improved energy levels
Most Useful Review
I was recently diagnosed with the metabolic condition HPU. Since then, I have been taking this supplement on the advice of a holistic practitioner. While I am unsure which supplement is having the effect, I definitely feel less mood swings, significantly increased overall energy, and no more brain fog. I’m deducting one star because the pills are large and difficult to swallow.
Headache details
SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.4
USERS' SCORE
Good
Based on 6 Reviews
8.4
9
We explored the impact of magnesium on migraine headaches, focusing on its potential benefits based on various studies. Magnesium deficiency is quite common and can arise from different factors, such as not consuming enough through diet or losing more through bodily systems.
A wealth of research, including case reports and controlled trials, suggests that magnesium supplementation can effectively alleviate migraines, both in the short term and long term. The proposed reasons for this effectiveness range from magnesium's role in preventing spreading cortical depression to its ability to manage oxidative stress and inflammation.
This evidence leads us to consider magnesium not just as a dietary supplement but as an important player in migraine management. Understanding these links helps us contemplate magnesium’s role in prevention and treatment, promising a potential path for those who suffer from this debilitating condition.
A wealth of research, including case reports and controlled trials, suggests that magnesium supplementation can effectively alleviate migraines, both in the short term and long term. The proposed reasons for this effectiveness range from magnesium's role in preventing spreading cortical depression to its ability to manage oxidative stress and inflammation.
This evidence leads us to consider magnesium not just as a dietary supplement but as an important player in migraine management. Understanding these links helps us contemplate magnesium’s role in prevention and treatment, promising a potential path for those who suffer from this debilitating condition.
9.5
Helps headaches
Most Useful Review
Good, they work and help with headaches.
Heart Attack details
SCIENTIFIC SCORE
Questionable
Based on 23 Researches
6.6
USERS' SCORE
Good
Based on 3 Reviews
8.4
9
Magnesium implantation improves heart recovery
Magnesium implantation as a continuous hydrogen production generator for the treatment of myocardial infarction in rats.
Most Relevant Research
We explored the potential of magnesium implantation as a new approach to combat heart attacks, specifically myocardial infarction (MI). Our research centered on using magnesium slices implanted under the skin of rats to generate hydrogen gas continuously. This method could ensure a greater and longer-lasting concentration of hydrogen directly reaching the heart, which is crucial for its therapeutic effects.
Through our study, we measured how effectively the magnesium produced hydrogen and evaluated its safety. The results were promising; we observed that magnesium implantation not only improved cardiac function in rats suffering from MI, but also played a role in eliminating harmful free radicals from mitochondrial dysfunction. Furthermore, it helped reduce cell death in heart muscle cells, which is a common consequence of heart attacks.
Compared to traditional hydrogen inhalation, which has limitations in delivering sufficient doses over time, magnesium implantation proved to be a superior method. Overall, our findings pave the way for innovative treatments that could enhance recovery after heart attacks by harnessing the unique properties of magnesium for hydrogen production.
Through our study, we measured how effectively the magnesium produced hydrogen and evaluated its safety. The results were promising; we observed that magnesium implantation not only improved cardiac function in rats suffering from MI, but also played a role in eliminating harmful free radicals from mitochondrial dysfunction. Furthermore, it helped reduce cell death in heart muscle cells, which is a common consequence of heart attacks.
Compared to traditional hydrogen inhalation, which has limitations in delivering sufficient doses over time, magnesium implantation proved to be a superior method. Overall, our findings pave the way for innovative treatments that could enhance recovery after heart attacks by harnessing the unique properties of magnesium for hydrogen production.
8.3
Supports heart health
Most Useful Review
Wonderful! Excellent dosage. We take it every evening as a family to support our hearts and nervous systems. Great product. Thank you!
Irritable Bowel Syndrome details
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 9 Reviews
8.4
8
Magnesium boosts colonic activity
Effects of oral magnesium sulphate on colonic motility in patients with the irritable bowel syndrome.
Most Relevant Research
We set out to understand how magnesium sulphate influences the symptoms of irritable bowel syndrome (IBS). In a study involving 20 IBS patients, magnesium sulphate was administered orally, resulting in a quick boost in colonic motor activity. Most participants experienced this increase within just two to six minutes.
Specifically, the percentage of colonic activity rose from 16.2% to 23.7%, signaling a notable change. Those who often felt abdominal pain after eating showed even more pronounced reactions, with their activity jumping from 16.1% to 29.8%. However, it’s important to note that three of these patients still experienced their usual pain after taking magnesium, suggesting that while magnesium can enhance motility, it doesn’t eliminate the pain for everyone.
Ultimately, these findings lend support to the idea that some cases of abdominal pain related to food may stem from heightened intestinal responses to cholecystokinin, a hormone released by the intestine. So while magnesium shows promise for intriguing changes in colonic movement in IBS patients, its effectiveness in alleviating pain remains mixed.
Specifically, the percentage of colonic activity rose from 16.2% to 23.7%, signaling a notable change. Those who often felt abdominal pain after eating showed even more pronounced reactions, with their activity jumping from 16.1% to 29.8%. However, it’s important to note that three of these patients still experienced their usual pain after taking magnesium, suggesting that while magnesium can enhance motility, it doesn’t eliminate the pain for everyone.
Ultimately, these findings lend support to the idea that some cases of abdominal pain related to food may stem from heightened intestinal responses to cholecystokinin, a hormone released by the intestine. So while magnesium shows promise for intriguing changes in colonic movement in IBS patients, its effectiveness in alleviating pain remains mixed.
9.5
Improved bowel function
Most Useful Review
Excellent! I'm taking this magnesium and feel more able to manage everyday tasks. My bowels are functioning much better. I can't do without it. I highly recommend it.
Knee Pain details
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8
USERS' SCORE
Good
Based on 3 Reviews
8.3
9
Magnesium sulfate alleviates postoperative pain
Effects of magnesium sulfate on periarticular infiltration analgesia in total knee arthroplasty: a prospective, double-blind, randomized controlled trial.
Most Relevant Research
We explored the impact of magnesium sulfate on managing pain following total knee arthroplasty. In a randomized, double-blind trial with 90 patients, half received a blend of analgesics that included magnesium sulfate, while the other half did not.
Following surgery, the results showed that magnesium sulfate helped prolong pain relief and reduced the need for opioids. Patients receiving it experienced less postoperative pain and moved towards recovery more effectively.
Overall, adding magnesium sulfate appears beneficial for postoperative knee pain management.
Following surgery, the results showed that magnesium sulfate helped prolong pain relief and reduced the need for opioids. Patients receiving it experienced less postoperative pain and moved towards recovery more effectively.
Overall, adding magnesium sulfate appears beneficial for postoperative knee pain management.
8
Knee support
Most Useful Review
It helps the body relax at night and alleviates knee pain.
Food Poisoning details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.2
8
Calms nerves effectively
Most Useful Review
It's challenging to take "too much" magnesium... While it's indeed possible, these 500mg tablets of Magnesium Oxide are a wise purchase for me. I prefer them over smaller 250mg or 400mg options. I always take them with food and alongside my other morning supplements. I'm unsure whether it's the magnesium or a placebo effect, but generally, I feel less anxious when taking larger doses daily. I would definitely buy again, particularly when on sale.
Chronic Fatigue Syndrome details
SCIENTIFIC SCORE
Questionable
Based on 5 Researches
6.6
USERS' SCORE
Good
Based on 4 Reviews
8.1
8
Magnesium potentially benefits CFS patients
Red blood cell magnesium and chronic fatigue syndrome.
Most Relevant Research
We investigated the relationship between magnesium levels in red blood cells and chronic fatigue syndrome (CFS). A case-control study revealed that CFS patients had lower magnesium levels than healthy individuals.
In a randomized, double-blind trial, 32 CFS patients received either magnesium sulphate or a placebo for six weeks. Those treated with magnesium reported significant improvements in energy, emotional wellbeing, and pain relief, with twelve out of fifteen feeling better.
In contrast, only three out of seventeen patients on placebo reported any improvement. Overall, these findings suggest that magnesium treatment may positively impact the wellbeing of those suffering from CFS.
In a randomized, double-blind trial, 32 CFS patients received either magnesium sulphate or a placebo for six weeks. Those treated with magnesium reported significant improvements in energy, emotional wellbeing, and pain relief, with twelve out of fifteen feeling better.
In contrast, only three out of seventeen patients on placebo reported any improvement. Overall, these findings suggest that magnesium treatment may positively impact the wellbeing of those suffering from CFS.
8.3
Active lifestyle regained
Most Useful Review
I took these vitamins due to my rapid fatigue, and after a month, the results became apparent. My fatigue began to fade, and I felt more energetic and active.
Constipation details
SCIENTIFIC SCORE
Questionable
Based on 22 Researches
6.8
USERS' SCORE
Good
Based on 23 Reviews
8
9
Effective treatment for chronic constipation
Senna Versus Magnesium Oxide for the Treatment of Chronic Constipation: A Randomized, Placebo-Controlled Trial.
Most Relevant Research
We explored the effectiveness of magnesium oxide (MgO) as a treatment for chronic constipation using a robust randomized, placebo-controlled trial. Over 28 days, participants received MgO, senna, or a placebo.
Both MgO and senna significantly improved bowel movement frequency and quality of life compared to placebo. About 68.3% of those using MgO reported symptom improvement, showcasing its potential as an effective osmotic agent alongside a stimulant laxative.
Importantly, there were no severe treatment-related side effects reported during the trial.
Both MgO and senna significantly improved bowel movement frequency and quality of life compared to placebo. About 68.3% of those using MgO reported symptom improvement, showcasing its potential as an effective osmotic agent alongside a stimulant laxative.
Importantly, there were no severe treatment-related side effects reported during the trial.
9.5
Effective treatment
Most Useful Review
Works well. I have three severe imbalances: sodium, magnesium, and potassium. Although I take prescription medication for one of them, the magnesium in these tablets is very good. I need to take three, but it’s worthwhile for my chronic constipation.
Bloating details
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.5
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.3
8
Magnesium alleviates menstrual bloating
Magnesium supplementation alleviates premenstrual symptoms of fluid retention.
Most Relevant Research
We explored the impact of magnesium supplementation on bloating as part of a larger study examining premenstrual symptoms. In our randomized, double-blind, placebo-controlled design, we administered a daily dose of 200 mg of magnesium (as MgO) to participants over the course of two menstrual cycles. Each volunteer kept track of their symptoms using a detailed diary with twenty-two items.
Initially, we found no difference in premenstrual symptoms between the magnesium and placebo groups during the first month. However, during the second month, participants taking magnesium experienced a notable decrease in bloating and hydration-related symptoms such as weight gain and breast tenderness. This reduction in symptoms was statistically significant, indicating that magnesium can indeed alleviate certain premenstrual symptoms like bloating.
Our findings suggest that magnesium supplementation, particularly in the context of fluid retention and bloating, could be beneficial for women experiencing these discomforts during their menstrual cycle. Overall, this study opens the door to considering magnesium as an effective remedy for mild premenstrual bloating.
Initially, we found no difference in premenstrual symptoms between the magnesium and placebo groups during the first month. However, during the second month, participants taking magnesium experienced a notable decrease in bloating and hydration-related symptoms such as weight gain and breast tenderness. This reduction in symptoms was statistically significant, indicating that magnesium can indeed alleviate certain premenstrual symptoms like bloating.
Our findings suggest that magnesium supplementation, particularly in the context of fluid retention and bloating, could be beneficial for women experiencing these discomforts during their menstrual cycle. Overall, this study opens the door to considering magnesium as an effective remedy for mild premenstrual bloating.
2.3
Laxative side effects
Most Useful Review
I took magnesium in oxide form at a hefty dosage of 2,000 mg for a couple of weeks. Almost immediately, I felt quite calm, but unfortunately, I experienced very strong laxative side effects and bloating, which made it impossible to leave the house. When I ceased taking it, my irritability returned within days, confirming that magnesium does not accumulate in the body, as my gastrointestinal tract returned to normal after about 1.5 weeks. I switched to other forms and brands of magnesium; this particular form is better suited as a laxative rather than for calming nerves. Unlike other brands, it is convenient having the daily dose in a single tablet.
Diarrhea details
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.6
USERS' SCORE
Medium or Average
Based on 6 Reviews
6.1
9.5
Magnesium shows potential for diarrhea
Mg2+ supplementation treats secretory diarrhea in mice by activating calcium-sensing receptor in intestinal epithelial cells.
Most Relevant Research
We explored the impact of magnesium on secretory diarrhea, particularly in the context of cholera, a significant global health issue. The focus was on understanding how magnesium, often overlooked, could serve as an effective treatment option. In our study, we found that increasing levels of magnesium can significantly inhibit chloride secretion in intestinal cells, which is crucial during episodes of diarrhea.
We observed that magnesium, at concentrations typically seen in stool, reduced this secretory process by a remarkable 65%. This effect primarily occurs through a specific receptor in the intestinal cells known as the calcium-sensing receptor (CaSR). Interestingly, we noted that magnesium also counteracted Cl- secretion triggered by cholera toxin and other enterotoxins by about 50%.
Using mouse models, we saw that administering magnesium effectively decreased fluid loss associated with cholera by 40%. In a model mimicking the intestinal environment during cholera, adding magnesium not only curbed fluid secretion but also reversed it, promoting absorption instead. Given that patients suffering from cholera often have negligible magnesium levels in their stool, our findings suggest that oral magnesium supplementation could be a simple but effective therapeutic strategy for managing cholera and potentially other forms of secretory diarrhea.
We observed that magnesium, at concentrations typically seen in stool, reduced this secretory process by a remarkable 65%. This effect primarily occurs through a specific receptor in the intestinal cells known as the calcium-sensing receptor (CaSR). Interestingly, we noted that magnesium also counteracted Cl- secretion triggered by cholera toxin and other enterotoxins by about 50%.
Using mouse models, we saw that administering magnesium effectively decreased fluid loss associated with cholera by 40%. In a model mimicking the intestinal environment during cholera, adding magnesium not only curbed fluid secretion but also reversed it, promoting absorption instead. Given that patients suffering from cholera often have negligible magnesium levels in their stool, our findings suggest that oral magnesium supplementation could be a simple but effective therapeutic strategy for managing cholera and potentially other forms of secretory diarrhea.
0
Immediate side effects
Most Useful Review
I do not recommend this product. I didn't check the form before purchasing and chose it merely due to the price. Diarrhea started immediately after taking it. I later read the details and realised my mistake. I strongly advise against it!
