A randomized, double-blind, placebo-controlled, multicenter study assessing the efficacy of magnesium oxide monohydrate in the treatment of nocturnal leg cramps.
We conducted a study to evaluate how effective magnesium oxide monohydrate (MOMH) is in treating nocturnal leg cramps (NLC). This was a randomized, double-blind, placebo-controlled trial involving multiple centers in Ukraine, where participants took either MOMH or a placebo nightly for 60 days.
Our focus was on measuring the frequency and duration of cramps, the pain they caused, and how they affected sleep quality and overall life satisfaction. We used thorough statistical methods to compare the results between the two groups.
The findings indicated that MOMH is both effective and safe for individuals dealing with NLC. Participants reported improvements in their symptoms, demonstrating that this magnesium supplement can play a helpful role in managing nocturnal leg cramps.
Read More
9
Magnesium reduces pregnancy leg cramps
Oral magnesium for relief in pregnancy-induced leg cramps: a randomised controlled trial.
We sought to understand the effectiveness of oral magnesium in treating leg cramps experienced by pregnant women. Our study was well-structured, involving a double-blind, randomized, placebo-controlled design. It included 86 healthy pregnant women between 14 to 34 weeks of gestation who encountered leg cramps at least twice a week, and we followed them over a four-week period.
At the end of the study, we discovered that the women taking magnesium bisglycinate chelate (300 mg per day) reported a significant reduction in cramp frequency—86% experienced at least a 50% drop compared to only 60.5% of those taking the placebo. Additionally, those on magnesium also noted a notable decrease in cramp intensity, with 69.8% achieving a similar improvement versus just 48.8% in the placebo group.
Encouragingly, we found no major side effects reported in either group, such as nausea or diarrhea. Our findings suggest that magnesium supplements can effectively reduce both the frequency and severity of leg cramps during pregnancy, offering a potential treatment option for women dealing with this common issue.
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7
Magnesium's potential against cramps
Randomised, cross-over, placebo controlled trial of magnesium citrate in the treatment of chronic persistent leg cramps.
We set out to investigate whether magnesium citrate could be an effective remedy for those who experience bothersome leg cramps, particularly at night. In our study, we used a randomised, double-blind, cross-over, placebo-controlled design to ensure reliable results. Participants suffering from regular leg cramps were recruited and given either magnesium citrate or a matching placebo over six weeks.
Our findings revealed that those who began the trial with the placebo experienced an average reduction in cramps when taking magnesium, with a median of 5 cramps compared to 9 on the placebo. Moreover, a notable percentage of participants felt that the magnesium treatment had indeed helped them, with 78% reporting benefits, as opposed to 54% who felt the placebo was effective.
While these results suggest that magnesium may have a positive impact, it’s essential to mention that the impact on cramp severity and duration wasn’t significantly different between the two groups. Additionally, some participants did report experiencing diarrhoea as a side effect of magnesium. Overall, we believe magnesium shows promise in alleviating nocturnal leg cramps and recommend further research to fully evaluate its effectiveness.
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Most Useful Reviews
9
Calmer legs
38 people found this helpful
I began to take magnesium on my doctor’s recommendation, as they often cause my legs to cramp. The doctor prescribed 500 mg daily. After several weeks of use, I feel calmer and, most importantly, the leg cramps have ceased.
Read More
7.5
Positive family effects
30 people found this helpful
☆☆☆☆☆ Despite the magnesium being a less absorbable form, both my mother and wife noted positive effects. My mother no longer suffers from night leg cramps, and my wife has become calmer. Both report improved sleep. The impact of this oxide form is remarkable, especially given the low price compared to pharmacies! I hope my feedback helps you in choosing the right supplement.
Read More
9
Restful sleep
22 people found this helpful
I really like this magnesium. After using it for more than a week without side effects, it has helped alleviate my restless legs syndrome. Previously, I would experience leg cramps that made it difficult to sleep, but now those terrible symptoms are gone. I can fall asleep calmly. Highly recommend this manufacturer! 😊👌🏻👍
We explored the effects of magnesium treatment in a unique case involving a 62-year-old woman with stage IV colon cancer undergoing oxaliplatin therapy. Shortly after her first infusion, we observed that she experienced significant neurological symptoms, including right hemibody paresthesia, muscle cramping in her right calf, and dysphonia.
To address these symptoms, she was administered intravenous magnesium sulfate along with calcium gluconate. Remarkably, within three hours, all her symptoms resolved. While this case suggests that magnesium can provide relief from cramps and other neurological side effects, it is important to note that magnesium was used in conjunction with other medications, making it challenging to assess its isolated effectiveness.
For future doses, the oxaliplatin was adjusted by reducing the dose and extending the infusion duration, which minimized her symptoms to occasional mild paresthesia. In summary, while magnesium showed promise in this case, further research is needed to determine its specific impact on leg cramps in a clearer, more controlled manner.
Read More
9
Magnesium oxide treats leg cramps
A randomized, double-blind, placebo-controlled, multicenter study assessing the efficacy of magnesium oxide monohydrate in the treatment of nocturnal leg cramps.
We conducted a study to evaluate how effective magnesium oxide monohydrate (MOMH) is in treating nocturnal leg cramps (NLC). This was a randomized, double-blind, placebo-controlled trial involving multiple centers in Ukraine, where participants took either MOMH or a placebo nightly for 60 days.
Our focus was on measuring the frequency and duration of cramps, the pain they caused, and how they affected sleep quality and overall life satisfaction. We used thorough statistical methods to compare the results between the two groups.
The findings indicated that MOMH is both effective and safe for individuals dealing with NLC. Participants reported improvements in their symptoms, demonstrating that this magnesium supplement can play a helpful role in managing nocturnal leg cramps.
Read More
9
Magnesium reduces pregnancy leg cramps
Oral magnesium for relief in pregnancy-induced leg cramps: a randomised controlled trial.
We sought to understand the effectiveness of oral magnesium in treating leg cramps experienced by pregnant women. Our study was well-structured, involving a double-blind, randomized, placebo-controlled design. It included 86 healthy pregnant women between 14 to 34 weeks of gestation who encountered leg cramps at least twice a week, and we followed them over a four-week period.
At the end of the study, we discovered that the women taking magnesium bisglycinate chelate (300 mg per day) reported a significant reduction in cramp frequency—86% experienced at least a 50% drop compared to only 60.5% of those taking the placebo. Additionally, those on magnesium also noted a notable decrease in cramp intensity, with 69.8% achieving a similar improvement versus just 48.8% in the placebo group.
Encouragingly, we found no major side effects reported in either group, such as nausea or diarrhea. Our findings suggest that magnesium supplements can effectively reduce both the frequency and severity of leg cramps during pregnancy, offering a potential treatment option for women dealing with this common issue.
Read More
7
Magnesium's potential against cramps
Randomised, cross-over, placebo controlled trial of magnesium citrate in the treatment of chronic persistent leg cramps.
We set out to investigate whether magnesium citrate could be an effective remedy for those who experience bothersome leg cramps, particularly at night. In our study, we used a randomised, double-blind, cross-over, placebo-controlled design to ensure reliable results. Participants suffering from regular leg cramps were recruited and given either magnesium citrate or a matching placebo over six weeks.
Our findings revealed that those who began the trial with the placebo experienced an average reduction in cramps when taking magnesium, with a median of 5 cramps compared to 9 on the placebo. Moreover, a notable percentage of participants felt that the magnesium treatment had indeed helped them, with 78% reporting benefits, as opposed to 54% who felt the placebo was effective.
While these results suggest that magnesium may have a positive impact, it’s essential to mention that the impact on cramp severity and duration wasn’t significantly different between the two groups. Additionally, some participants did report experiencing diarrhoea as a side effect of magnesium. Overall, we believe magnesium shows promise in alleviating nocturnal leg cramps and recommend further research to fully evaluate its effectiveness.
We explored the effectiveness of magnesium treatment for leg cramps during pregnancy through a review of five randomized trials involving 352 women.
The trials varied in quality, but interestingly, they included comparisons of different treatments such as calcium and sodium chloride against placebos. While the placebo-controlled trial that investigated calcium did not show any significant benefits, there were hints of promise for magnesium.
For those looking for relief from troublesome leg cramps, our analysis indicated that magnesium—specifically in the forms of magnesium lactate or citrate—might help. Taking 5mmol in the morning and 10mmol in the evening seemed to provide the best results.
However, the evidence remains mixed, and we couldn't pinpoint any strong benefits from other combinations or supplements tested. So, while magnesium might be beneficial, it’s essential to approach it as one option among many.
I began to take magnesium on my doctor’s recommendation, as they often cause my legs to cramp. The doctor prescribed 500 mg daily. After several weeks of use, I feel calmer and, most importantly, the leg cramps have ceased.
Read More
7.5
Positive family effects
30 people found this helpful
☆☆☆☆☆ Despite the magnesium being a less absorbable form, both my mother and wife noted positive effects. My mother no longer suffers from night leg cramps, and my wife has become calmer. Both report improved sleep. The impact of this oxide form is remarkable, especially given the low price compared to pharmacies! I hope my feedback helps you in choosing the right supplement.
Read More
9
Restful sleep
22 people found this helpful
I really like this magnesium. After using it for more than a week without side effects, it has helped alleviate my restless legs syndrome. Previously, I would experience leg cramps that made it difficult to sleep, but now those terrible symptoms are gone. I can fall asleep calmly. Highly recommend this manufacturer! 😊👌🏻👍
Read More
9
Budget-friendly solution
11 people found this helpful
Excellent magnesia at a fantastic price! My night leg cramps disappeared by the third day of use. I recommend it to everyone; it certainly works just as well as more expensive magnesium products.
Read More
9
Tension relief noted
10 people found this helpful
Excellent magnesium! I take it at night, as this form is better absorbed. It completely alleviates the tension I often feel in my legs. My psycho-emotional state has normalised, and it comes in an ideal dosage and great packaging.
Leg cramps, often referred to as "charley horses," are sudden, involuntary contractions of one or more muscles in the leg. They typically occur in the calf muscles but can also affect the thighs and feet. These cramps can be quite painful and may last from a few seconds to several minutes. While the exact cause of leg cramps is not always clear, they can be triggered by factors such as dehydration, prolonged sitting or standing, electrolyte imbalances, or physical activity, especially in those who are not used to vigorous exercise.
Treatment for leg cramps often involves stretching the affected muscle gently, applying heat or cold to the area, and ensuring adequate hydration. For some, dietary adjustments to include more potassium, magnesium, and calcium may help prevent future occurrences. If cramps are frequent or severely debilitating, it may be beneficial to consult a healthcare provider for a more tailored approach. Understanding the underlying causes of leg cramps can lead to more effective management strategies, improving overall comfort and mobility.
Magnesium is a chemical element with the symbol Mg and atomic number 12. It is a lightweight, silvery-white metal that is a member of the alkaline earth metals group. Often classified as one of the most abundant elements in the Earth's crust, magnesium plays a crucial role in various biological functions and is essential for living organisms. In nature, magnesium can be found in large quantities, primarily in minerals such as dolomite and magnesite, and it is also present in seawater.
In terms of health benefits, magnesium is vital for numerous metabolic processes, including energy production, DNA synthesis, and muscle function. It contributes to bone health, helps regulate blood pressure, and supports bone formation by promoting the effects of vitamin D. The recommended dietary allowance (RDA) for magnesium varies by age and gender, but it is generally important to include magnesium-rich foods like leafy greens, nuts, seeds, and whole grains in your diet to ensure adequate intake. For those who may not receive enough magnesium through their diet alone, supplements are also available; however, it is advisable to consult a healthcare professional before starting any supplementation.
Magnesium has been noted for its potential role in alleviating leg cramps, particularly in individuals who experience nocturnal leg cramps or muscle spasms. As an essential mineral, magnesium contributes to muscle function and helps regulate muscle contractions. Some studies suggest that supplementing with magnesium may lead to a decrease in the frequency and intensity of leg cramps, especially in populations at risk for magnesium deficiency, such as older adults or those with specific health conditions.
That said, while magnesium supplementation could be beneficial, it's always a good idea to consult with a healthcare professional before starting any new supplements. They can provide personalized advice based on your health history and dietary needs. Moreover, ensuring a balanced intake of nutrients, staying hydrated, and maintaining regular physical activity can also play significant roles in managing leg cramps effectively.
Based on user reviews, the timeframe to see results from taking magnesium for leg cramps varies, but many users report relief within a week. For instance, one user noticed their leg cramps disappeared after just three days of use Read Review. Another reviewer experienced significant relief from restless legs syndrome within just over a week Read Review.
A number of users indicate that they began to feel improvements after a couple of weeks, with one mentioning a complete cessation of symptoms at that point Read Review. Thus, while results may vary, it's common for users to find relief from leg cramps within a week to two weeks of starting magnesium supplementation.
Based on the available scientific research, the effectiveness of magnesium supplements for treating leg cramps presents a mixed picture. A study involving magnesium oxide monohydrate indicated that it is effective in managing nocturnal leg cramps, with participants reporting improvements in frequency and duration of cramps [1]. However, when it comes to pregnancy-related leg cramps, multiple studies have pointed to inconsistent results. Some reviews noted a slight reduction in cramp frequency with magnesium, but many found no statistically significant benefits, suggesting the need for more robust research in this area [2], [3].
Further analysis revealed that while some participants reported a subjective improvement, the evidence tends to lean towards magnesium not being a reliable standalone solution for leg cramps in both the general and pregnant populations [4]. The benefits seen might be attributed to the placebo effect, as some studies displayed similar outcomes for placebo groups. Overall, while magnesium might offer some potential for relief in specific cases, the consensus across various studies is that further investigation is needed to accurately assess its role and effectiveness for leg cramps [9].
Users have reported a range of improvements after taking magnesium, particularly for leg cramps and overall calmness. Many have noted that their leg cramps not only ceased but also enhanced their quality of sleep. For instance, one user highlighted a complete disappearance of leg cramps within three days of starting magnesium Read Review. Another user reported significant relief from restless legs syndrome after more than a week, transforming their sleep experience into a much calmer one Read Review.
Additionally, several users remarked on improvements in their mental state, stating they felt calmer and more balanced after treatment. For example, a reviewer noted that since taking magnesium, everyone in their family, including elderly members, not only experienced no side effects but also noticed a marked decrease in night cramps Read Review. This aligns with other testimonials where individuals reported their nervous systems felt more regulated and their sleep had significantly improved Read Review. Overall, while results may vary, it appears that magnesium supplementation could lead to considerable symptom relief for many users.
Users have reported various experiences when combining magnesium with other supplements for handling leg cramps. While some individuals simply take magnesium alone and have found substantial relief from leg cramps and improved sleep quality, others have mentioned how magnesium combined with support for their nervous system has yielded even better results. For instance, one user noted that their family members, including an elderly mother, experienced significant benefits without side effects from supplementing magnesium for leg cramps and stress relief Read Review.
Several users specifically recommend coordinating magnesium intake with a doctor's guidance, particularly when it concerns how to manage not just leg cramps but also broader nervous system support Read Review. Others casually shared that they have effectively ended their leg cramps with just one magnesium tablet per day Read Review. The synergy of magnesium taken in conjunction with other health considerations emphasizes the flexibility of this supplement in crafting personalized routines for managing leg cramps.
Based on user reviews, a common recommendation for the right dose of magnesium for treating leg cramps seems to hover around 500 mg, often taken before bedtime. One user reports that their doctor prescribed this exact amount, which led to the cessation of leg cramps after several weeks of use Read Review. Additionally, another user mentions taking one tablet a day and experiencing significant relief from leg cramps as well as improved sleep Read Review.
Several other reviews note that users find taking magnesium at night beneficial, which may enhance absorption and effectiveness Read Review. However, there are also mentions of the necessity to consult with a healthcare professional before determining the appropriate dosage Read Review. Ultimately, it seems that a daily dosage of around 500 mg has provided considerable relief for many users experiencing leg cramps, although individual needs may vary.
9
Budget-friendly solution
11 people found this helpful
Excellent magnesia at a fantastic price! My night leg cramps disappeared by the third day of use. I recommend it to everyone; it certainly works just as well as more expensive magnesium products.
9
Restful sleep
22 people found this helpful
I really like this magnesium. After using it for more than a week without side effects, it has helped alleviate my restless legs syndrome. Previously, I would experience leg cramps that made it difficult to sleep, but now those terrible symptoms are gone. I can fall asleep calmly. Highly recommend this manufacturer! 😊👌🏻👍
9
Restful sleep achieved
1 people found this helpful
An excellent drug! After two weeks, I felt the effects. I previously struggled to sleep, tormented by leg cramps and restless legs syndrome. After a week on this drug, all symptoms dissipated. It’s vital to coordinate magnesium doses with a doctor.
9
Calm family members
1 people found this helpful
Good for all! My family, including my 80-year-old mother and others, experiences no side effects. Everyone has become calmer and more balanced. My brother's night cramps have completely disappeared!
10
Effective stress relief
2 people found this helpful
Excellent result! I took magnesium due to night leg cramps, and they have disappeared. It was also suggested for stress relief and has positively impacted my nervous system. With all of life’s stresses, my husband and I have completely discontinued other medications. Magnesium has been the best solution for us!
9
Cramps resolved
1 people found this helpful
I effectively ended my cramps by using just one pill a day.
9
Calmer legs
38 people found this helpful
I began to take magnesium on my doctor’s recommendation, as they often cause my legs to cramp. The doctor prescribed 500 mg daily. After several weeks of use, I feel calmer and, most importantly, the leg cramps have ceased.
9
Tension relief noted
10 people found this helpful
Excellent magnesium! I take it at night, as this form is better absorbed. It completely alleviates the tension I often feel in my legs. My psycho-emotional state has normalised, and it comes in an ideal dosage and great packaging.
9
Disappeared completely
6 people found this helpful
The active ingredient is well absorbed. I've followed my doctor's advice to take several courses, and my night cramps have entirely disappeared. My sleep has improved, and I now handle stress better. I recommend consulting your doctor before purchasing.
9
Magnesium oxide treats leg cramps
A randomized, double-blind, placebo-controlled, multicenter study assessing the efficacy of magnesium oxide monohydrate in the treatment of nocturnal leg cramps.
We conducted a study to evaluate how effective magnesium oxide monohydrate (MOMH) is in treating nocturnal leg cramps (NLC). This was a randomized, double-blind, placebo-controlled trial involving multiple centers in Ukraine, where participants took either MOMH or a placebo nightly for 60 days.
Our focus was on measuring the frequency and duration of cramps, the pain they caused, and how they affected sleep quality and overall life satisfaction. We used thorough statistical methods to compare the results between the two groups.
The findings indicated that MOMH is both effective and safe for individuals dealing with NLC. Participants reported improvements in their symptoms, demonstrating that this magnesium supplement can play a helpful role in managing nocturnal leg cramps.
2
Magnesium ineffective for leg cramps
Effect of oral magnesium supplementation for relieving leg cramps during pregnancy: A meta-analysis of randomized controlled trials.
We examined the effectiveness of magnesium supplements in reducing leg cramps during pregnancy, a common issue that affects up to half of pregnant women. Four randomized controlled trials were included in our analysis, with a total of 332 participants, which compared magnesium treatment to a placebo.
Our findings showed that magnesium supplementation did not significantly decrease the frequency of leg cramps compared to the control group. The weighted mean difference was -0.47, which indicates that while there may be a slight improvement, it was not considered statistically meaningful.
Moreover, magnesium did not help women recover from leg cramps more effectively than the placebo, and there were no significant side effects reported. Overall, we found that oral magnesium supplementation is not effective in treating leg cramps during pregnancy.
We observed the effectiveness of magnesium as a treatment for leg cramps during pregnancy, using data from several studies that included over 500 women. The research aimed to understand whether magnesium could help reduce the frequency and intensity of leg cramps, a common complaint among expectant mothers.
While some studies indicated that magnesium might help reduce the occurrence of leg cramps for some women, the results were inconsistent and did not show a clear benefit. In fact, for various outcomes measured, such as pain intensity and the total number of cramps, the evidence was not strong enough to draw firm conclusions. The studies varied in how they reported their findings, making it challenging for us to compile and compare the data effectively.
Additionally, the certainty of the evidence we found was rated as low to very low, largely due to the small size of the trials and some design limitations. Importantly, there were not enough data to assess the safety of magnesium or compare it adequately with other treatments. Overall, it appears that magnesium may not be the magic bullet for dealing with leg cramps in pregnancy, but more research could help clarify its role in the future.
We evaluated the effectiveness of magnesium supplements in preventing leg cramps, a common issue especially for older adults and pregnant women. Our focus was on randomized controlled trials that compared magnesium to placebos or other treatments.
After analyzing data from 11 trials involving a total of 735 participants, we found that magnesium supplementation showed little to no significant benefit. For older adults suffering from idiopathic leg cramps, the differences in cramp frequency, intensity, and duration were minimal and not statistically significant. In one trial focused on pregnant women, the results were mixed and not conclusive.
Additionally, while some participants did report minor gastrointestinal side effects from magnesium, major adverse events were not significantly different from those who received placebo. This leads us to conclude that magnesium may not provide meaningful relief for most older adults experiencing leg cramps. For pregnant women, further studies are necessary to determine if magnesium could be effective.
Overall, the evidence suggests that more research is needed to clarify magnesium's role, especially in specific populations like pregnant women who experience cramps.
4
Magnesium shows limited effectiveness
Effect of magnesium therapy on nocturnal leg cramps: a systematic review of randomized controlled trials with meta-analysis using simulations.
We explored the effectiveness of magnesium therapy for treating nocturnal leg cramps (NLC) by reviewing various randomized controlled trials. In total, we found seven studies involving 361 participants, all comparing magnesium treatment to a placebo.
Interestingly, while magnesium didn’t show significant benefits for the general population, we discovered a slight positive effect among pregnant women. The difference noted in leg cramps per week between those who received magnesium and those on a placebo was modest, suggesting that while some individuals might benefit, magnesium may not be a powerful solution for everyone.
We also noted that gastrointestinal side effects were slightly more common in those taking magnesium compared to the placebo group. However, the overall strength of the evidence is weak, primarily due to small sample sizes and short follow-up periods in the studies. This indicates that we need more robust research to fully understand magnesium's impact on leg cramps.
References
Barna O, Lohoida P, Holovchenko Y, Bazylevych A, Velychko V, et al. A randomized, double-blind, placebo-controlled, multicenter study assessing the efficacy of magnesium oxide monohydrate in the treatment of nocturnal leg cramps. Nutr J. 2021;20:90. 10.1186/s12937-021-00747-9
Liu J, Song G, Zhao G, Meng T. Effect of oral magnesium supplementation for relieving leg cramps during pregnancy: A meta-analysis of randomized controlled trials. Taiwan J Obstet Gynecol. 2021;60:609. 10.1016/j.tjog.2021.05.006
Luo L, Zhou K, Zhang J, Xu L, Yin W. Interventions for leg cramps in pregnancy. Cochrane Database Syst Rev. 2020;12:CD010655. 10.1002/14651858.CD010655.pub3
Garrison SR, Korownyk CS, Kolber MR, Allan GM, Musini VM, et al. Magnesium for skeletal muscle cramps. Cochrane Database Syst Rev. 2020;9:CD009402. 10.1002/14651858.CD009402.pub3
Araújo CAL, Lorena SB, Cavalcanti GCS, Leão GLS, Tenório GP, et al. Oral magnesium supplementation for leg cramps in pregnancy-An observational controlled trial. PLoS One. 2020;15:e0227497. 10.1371/journal.pone.0227497
Sebo P, Haller D, Cerutti B, Maisonneuve H. A prospective observational study of the main features of nocturnal leg cramps in primary care. Swiss Med Wkly. 2019;149:w20048. 10.4414/smw.2019.20048
Roguin Maor N, Alperin M, Shturman E, Khairaldeen H, Friedman M, et al. Effect of Magnesium Oxide Supplementation on Nocturnal Leg Cramps: A Randomized Clinical Trial. JAMA Intern Med. 2017;177:617. 10.1001/jamainternmed.2016.9261
Zhou K, West HM, Zhang J, Xu L, Li W. Interventions for leg cramps in pregnancy. Cochrane Database Syst Rev. 2015. 10.1002/14651858.CD010655.pub2
Sebo P, Cerutti B, Haller DM. Effect of magnesium therapy on nocturnal leg cramps: a systematic review of randomized controlled trials with meta-analysis using simulations. Fam Pract. 2014;31:7. 10.1093/fampra/cmt065
Garrison SR, Allan GM, Sekhon RK, Musini VM, Khan KM. Magnesium for skeletal muscle cramps. Cochrane Database Syst Rev. 2012;2012:CD009402. 10.1002/14651858.CD009402.pub2
Supakatisant C, Phupong V. Oral magnesium for relief in pregnancy-induced leg cramps: a randomised controlled trial. Matern Child Nutr. 2015;11:139. 10.1111/j.1740-8709.2012.00440.x
Garrison SR, Birmingham CL, Koehler BE, McCollom RA, Khan KM. The effect of magnesium infusion on rest cramps: randomized controlled trial. J Gerontol A Biol Sci Med Sci. 2011;66:661. 10.1093/gerona/glq232
Uña E. Atypical presentation of acute neurotoxicity secondary to oxaliplatin. J Oncol Pharm Pract. 2010;16:280. 10.1177/1078155209355849
Roffe C, Sills S, Crome P, Jones P. Randomised, cross-over, placebo controlled trial of magnesium citrate in the treatment of chronic persistent leg cramps. Med Sci Monit. 2002;8:CR326.
Young GL, Jewell D. Interventions for leg cramps in pregnancy. Cochrane Database Syst Rev. 2002.
Frusso R, Zárate M, Augustovski F, Rubinstein A. Magnesium for the treatment of nocturnal leg cramps: a crossover randomized trial. J Fam Pract. 1999;48:868.
Dahle LO, Berg G, Hammar M, Hurtig M, Larsson L. The effect of oral magnesium substitution on pregnancy-induced leg cramps. Am J Obstet Gynecol. 1995;173:175.