Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 26 Researches
7.6
USERS' SCORE
Good
Based on 2 Reviews
8.5
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
15
Total Fat
1.5 g
2%**
Saturated Fat
0.5 g
3%**
Cholesterol
10 mg
3%
Fish Oilprovides 360 mg of Total Omega-3 Fatty Acids†comprising of:EPA (Eicosapentaenoic Acid)DHA (Docosahexaenoic Acid)Other Fatty Acids
1,200 mg (1.2 g)
***************
Top Medical Research Studies
8
We discovered that a diet enriched with omega-3 fatty acids can effectively reduce symptoms of allergic conjunctivitis (AC) in mice. This reduction occurred without influencing the typical immune responses usually associated with allergies. Instead, omega-3s worked by changing the lipid molecules linked to inflammation.
Notably, these fatty acids completely suppressed itching near the eyes and significantly decreased the presence of eosinophils, cells commonly involved in allergic reactions. However, total serum IgE levels and T2 cytokine expression remained unchanged, suggesting that omega-3s tackle AC symptoms in a unique way.
Notably, these fatty acids completely suppressed itching near the eyes and significantly decreased the presence of eosinophils, cells commonly involved in allergic reactions. However, total serum IgE levels and T2 cytokine expression remained unchanged, suggesting that omega-3s tackle AC symptoms in a unique way.
Read More
We uncovered intriguing insights into how eicosapentaenoic acid (EPA) and its metabolite, 12-hydroxyeicosapentaenoic acid (12-HEPE), play a role in managing allergic responses, particularly in the skin. Our study revealed that when mice consumed an omega-3 fatty acid-rich diet, 12-HEPE became a significant metabolite in their skin.
Interestingly, we observed that the enzymes responsible for producing 12-HEPE were more active in the skin compared to other organs. This effective metabolite appeared to reduce inflammation caused by contact hypersensitivity. Specifically, we found that applying 12-HEPE topically limited the influx of neutrophils, a type of white blood cell involved in inflammatory responses.
Taking our research a step further, we investigated the effects of 12-HEPE on human skin cells, or keratinocytes, in lab conditions. Our findings showed that 12-HEPE inhibited two specific genes that cause neutrophils to be attracted to the site of inflammation, showcasing its potential as a therapeutic agent for allergy management. Overall, we identified 12-HEPE as a potent metabolite in the skin, suggesting that dietary omega-3 fatty acids could be a beneficial strategy in controlling allergic reactions.
Interestingly, we observed that the enzymes responsible for producing 12-HEPE were more active in the skin compared to other organs. This effective metabolite appeared to reduce inflammation caused by contact hypersensitivity. Specifically, we found that applying 12-HEPE topically limited the influx of neutrophils, a type of white blood cell involved in inflammatory responses.
Taking our research a step further, we investigated the effects of 12-HEPE on human skin cells, or keratinocytes, in lab conditions. Our findings showed that 12-HEPE inhibited two specific genes that cause neutrophils to be attracted to the site of inflammation, showcasing its potential as a therapeutic agent for allergy management. Overall, we identified 12-HEPE as a potent metabolite in the skin, suggesting that dietary omega-3 fatty acids could be a beneficial strategy in controlling allergic reactions.
Read More
9.5
Maternal omega-3 reduces allergy risks
We conducted a comprehensive meta-analysis to explore how omega-3 supplementation affects food allergy risks in children, focusing on whether maternal intake during pregnancy or childhood supplementation is more effective.
Our findings revealed that mothers who took omega-3 during pregnancy and lactation significantly lowered the chances of their infants developing allergies to eggs and peanuts.
However, omega-3 consumption later in childhood did not show similar benefits in allergy prevention. This emphasizes the critical timing of supplementation in allergy risk management.
Our findings revealed that mothers who took omega-3 during pregnancy and lactation significantly lowered the chances of their infants developing allergies to eggs and peanuts.
However, omega-3 consumption later in childhood did not show similar benefits in allergy prevention. This emphasizes the critical timing of supplementation in allergy risk management.
Read More
Most Useful Reviews
9
Reversed hair loss
3 people found this helpful
I give my dogs fish oil and find the price for this product fantastic. One of my dogs had severe allergies, causing hair loss, but that has reversed thanks to this. The company was very prompt with their responses to my inquiries.
Read More
7.5
Reduces allergy symptoms
Great value packaging. Fish oil can alleviate allergy symptoms and also benefits heart health. The taste is not too fishy, and a sufficient dose of omega makes it a great choice.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 26 Researches
7.6
- All Researches
9.5
Maternal omega-3 reduces allergy risks
We conducted a comprehensive meta-analysis to explore how omega-3 supplementation affects food allergy risks in children, focusing on whether maternal intake during pregnancy or childhood supplementation is more effective.
Our findings revealed that mothers who took omega-3 during pregnancy and lactation significantly lowered the chances of their infants developing allergies to eggs and peanuts.
However, omega-3 consumption later in childhood did not show similar benefits in allergy prevention. This emphasizes the critical timing of supplementation in allergy risk management.
Our findings revealed that mothers who took omega-3 during pregnancy and lactation significantly lowered the chances of their infants developing allergies to eggs and peanuts.
However, omega-3 consumption later in childhood did not show similar benefits in allergy prevention. This emphasizes the critical timing of supplementation in allergy risk management.
Read More
9
We explored the impact of dietary eicosapentaenoic acid (EPA) in children suffering from atopic dermatitis, a common allergic skin condition. In a well-structured study, forty-eight children were divided into two groups: one received 250 mg of EPA twice daily, while the other was given a placebo for four weeks.
The study aimed to measure the effectiveness of EPA by examining improvements in the SCORing Atopic Dermatitis (SCORAD) index and the need for topical corticosteroids. What we found was quite promising—after just two weeks, the EPA group showed significant improvement in their SCORAD scores compared to the placebo group.
Additionally, by the end of four weeks, fewer children in the EPA group required corticosteroids, indicating a potential reduction in the severity of their condition. Overall, the results suggest that EPA supplementation is both effective and well-tolerated among young patients with atopic dermatitis, offering a supportive strategy for managing this allergy-related issue.
The study aimed to measure the effectiveness of EPA by examining improvements in the SCORing Atopic Dermatitis (SCORAD) index and the need for topical corticosteroids. What we found was quite promising—after just two weeks, the EPA group showed significant improvement in their SCORAD scores compared to the placebo group.
Additionally, by the end of four weeks, fewer children in the EPA group required corticosteroids, indicating a potential reduction in the severity of their condition. Overall, the results suggest that EPA supplementation is both effective and well-tolerated among young patients with atopic dermatitis, offering a supportive strategy for managing this allergy-related issue.
Read More
9
We assessed how eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, influences airway inflammation related to allergies in university athletes. In our study, we had 23 male participants divided into three groups based on their levels of airway inflammation, measured by fractional exhaled nitric oxide (FeNO).
These athletes took daily supplements containing 600 mg of EPA for three weeks. During this time, we tracked changes in their FeNO levels and other respiratory factors. Our findings revealed a significant drop in FeNO levels among athletes with eosinophilic airway inflammation, indicating a reduction in airway inflammation.
Notably, while the athletes with high FeNO levels benefited from the supplementation, those without eosinophilic characteristics saw no significant changes in their respiratory status. This suggests that EPA may be particularly effective for certain allergy-related conditions, rather than universally beneficial for all types of respiratory issues.
These athletes took daily supplements containing 600 mg of EPA for three weeks. During this time, we tracked changes in their FeNO levels and other respiratory factors. Our findings revealed a significant drop in FeNO levels among athletes with eosinophilic airway inflammation, indicating a reduction in airway inflammation.
Notably, while the athletes with high FeNO levels benefited from the supplementation, those without eosinophilic characteristics saw no significant changes in their respiratory status. This suggests that EPA may be particularly effective for certain allergy-related conditions, rather than universally beneficial for all types of respiratory issues.
Read More
9
We focused on understanding how the levels of eicosapentaenoic acid (EPA) at birth relate to allergies in children. Through a systematic review, we analyzed multiple studies, narrowing it down to 14 key articles that matched our criteria. The findings suggested that lower levels of EPA in cord blood were linked to a higher likelihood of allergic conditions later in childhood.
When we looked deeper, we discovered that not only high levels of EPA, but also docosahexaenoic acid (DHA) and total n-3 long-chain polyunsaturated fatty acids were associated with a significant drop—at least 38%—in the risk of developing allergies in various studies. Additionally, we noted that the higher the levels of EPA, DHA, and docosapentaenoic acid in cord blood, the lower the laboratory measurements indicating allergic traits.
This paints a promising picture for the potential of these fatty acids in managing allergy risks. Overall, our findings can guide recommendations for the fatty acid intake that pregnant women should consider for better health outcomes for their children.
When we looked deeper, we discovered that not only high levels of EPA, but also docosahexaenoic acid (DHA) and total n-3 long-chain polyunsaturated fatty acids were associated with a significant drop—at least 38%—in the risk of developing allergies in various studies. Additionally, we noted that the higher the levels of EPA, DHA, and docosapentaenoic acid in cord blood, the lower the laboratory measurements indicating allergic traits.
This paints a promising picture for the potential of these fatty acids in managing allergy risks. Overall, our findings can guide recommendations for the fatty acid intake that pregnant women should consider for better health outcomes for their children.
Read More
9
Eicosapentaenoic acid aids allergy treatment
We examined how eicosapentaenoic acid (EPA) could influence allergic reactions, particularly through its metabolite known as 17,18-epoxyeicosatetraenoic acid (17,18-EpETE). This metabolite is recognized for its strong anti-allergic and anti-inflammatory properties.
Our findings highlighted that 17,18-EpETE can alleviate skin contact hypersensitivity, a common allergic response. Notably, this effect was not shared by its enantiomer, 17(),18()-EpETE, indicating that the specific form of the metabolite makes a significant difference in efficacy.
We discovered that a specific enzyme, cytochrome P450 BM-3, was effective in converting EPA into the beneficial 17,18-EpETE. This conversion served to inhibit neutrophil migration, a key component of allergic reactions, through a mechanism involving G protein-coupled receptor 40.
These results suggest that utilizing this bacterial enzyme may pave the way for producing this important lipid mediator in larger quantities, which could be advantageous for developing new allergy treatments. Overall, our research underscores the potential of EPA in addressing allergic conditions and contributes to the growing understanding of how dietary components can affect health.
Our findings highlighted that 17,18-EpETE can alleviate skin contact hypersensitivity, a common allergic response. Notably, this effect was not shared by its enantiomer, 17(),18()-EpETE, indicating that the specific form of the metabolite makes a significant difference in efficacy.
We discovered that a specific enzyme, cytochrome P450 BM-3, was effective in converting EPA into the beneficial 17,18-EpETE. This conversion served to inhibit neutrophil migration, a key component of allergic reactions, through a mechanism involving G protein-coupled receptor 40.
These results suggest that utilizing this bacterial enzyme may pave the way for producing this important lipid mediator in larger quantities, which could be advantageous for developing new allergy treatments. Overall, our research underscores the potential of EPA in addressing allergic conditions and contributes to the growing understanding of how dietary components can affect health.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Reversed hair loss
3 people found this helpful
I give my dogs fish oil and find the price for this product fantastic. One of my dogs had severe allergies, causing hair loss, but that has reversed thanks to this. The company was very prompt with their responses to my inquiries.
Read More
7.5
Reduces allergy symptoms
Great value packaging. Fish oil can alleviate allergy symptoms and also benefits heart health. The taste is not too fishy, and a sufficient dose of omega makes it a great choice.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Saika A, Nagatake T, Kishino S, Kitamura N, Honda T, et al. The omega-3 postbiotic -10--15-octadecadienoic acid attenuates contact hypersensitivity in mice through downregulation of vascular endothelial growth factor A. Front Cell Infect Microbiol. 2024;14:1355679. doi:10.3389/fcimb.2024.1355679
- Tsuji S, Adachi Y, Tsuchida A, Hamazaki K, Matsumura K, et al. Association of allergies in children younger than 3 years with levels of maternal intake of n-3 polyunsaturated fatty acids or fish during pregnancy: A nationwide birth cohort study, the Japan Environment and Children's Study. Allergol Int. 2024;73:282. doi:10.1016/j.alit.2023.12.004
- Huynh LBP, Nguyen NN, Fan HY, Huang SY, Huang CH, et al. Maternal Omega-3 Supplementation During Pregnancy, but Not Childhood Supplementation, Reduces the Risk of Food Allergy Diseases in Offspring. J Allergy Clin Immunol Pract. 2023;11:2862. doi:10.1016/j.jaip.2023.06.005
- Peng S, Du Z, He Y, Zhao F, Chen Y, et al. Association of Maternal Erythrocyte PUFA during Pregnancy with Offspring Allergy in the Chinese Population. Nutrients. 2022;14. doi:10.3390/nu14112312
- Adjibade M, Davisse-Paturet C, Bernard JY, Adel-Patient K, Divaret-Chauveau A, et al. Enrichment of infant formula with long-chain polyunsaturated fatty acids and risk of infection and allergy in the nationwide ELFE birth cohort. Allergy. 2022;77:1522. doi:10.1111/all.15137
- Miles EA, Childs CE, Calder PC. Long-Chain Polyunsaturated Fatty Acids (LCPUFAs) and the Developing Immune System: A Narrative Review. Nutrients. 2021;13. doi:10.3390/nu13010247
- Hirata SI, Nagatake T, Sawane K, Hosomi K, Honda T, et al. Maternal ω3 docosapentaenoic acid inhibits infant allergic dermatitis through TRAIL-expressing plasmacytoid dendritic cells in mice. Allergy. 2020;75:1939. doi:10.1111/all.14217
- Huhmann R, Mueller RS. A cream containing omega-3-fatty acids, humectants and emollients as an aid in the treatment of equine Culicoides hypersensitivity. Vet Dermatol. 2019;30:155. doi:10.1111/vde.12728
- Vahdaninia M, Mackenzie H, Dean T, Helps S. ω-3 LCPUFA supplementation during pregnancy and risk of allergic outcomes or sensitization in offspring: A systematic review and meta-analysis. Ann Allergy Asthma Immunol. 2019;122:302. doi:10.1016/j.anai.2018.12.008
- Hirakata T, Lee HC, Ohba M, Saeki K, Okuno T, et al. Dietary ω-3 fatty acids alter the lipid mediator profile and alleviate allergic conjunctivitis without modulating T2 immune responses. FASEB J. 2019;33:3392. doi:10.1096/fj.201801805R
- Clausen M, Jonasson K, Keil T, Beyer K, Sigurdardottir ST. Fish oil in infancy protects against food allergy in Iceland-Results from a birth cohort study. Allergy. 2018;73:1305. doi:10.1111/all.13385
- Hansen S, Strøm M, Maslova E, Dahl R, Hoffmann HJ, et al. Fish oil supplementation during pregnancy and allergic respiratory disease in the adult offspring. J Allergy Clin Immunol. 2017;139:104. doi:10.1016/j.jaci.2016.02.042
- Best KP, Sullivan T, Palmer D, Gold M, Kennedy DJ, et al. Prenatal Fish Oil Supplementation and Allergy: 6-Year Follow-up of a Randomized Controlled Trial. Pediatrics. 2016;137. doi:10.1542/peds.2015-4443
- Willemsen LEM. Dietary n-3 long chain polyunsaturated fatty acids in allergy prevention and asthma treatment. Eur J Pharmacol. 2016;785:174. doi:10.1016/j.ejphar.2016.03.062
- Warstedt K, Furuhjelm C, Fälth-Magnusson K, Fagerås M, Duchén K. High levels of omega-3 fatty acids in milk from omega-3 fatty acid-supplemented mothers are related to less immunoglobulin E-associated disease in infancy. Acta Paediatr. 2016;105:1337. doi:10.1111/apa.13395
- Ahmed N, Barrow CJ, Suphioglu C. Exploring the Effects of Omega-3 and Omega-6 Fatty Acids on Allergy Using a HEK-Blue Cell Line. Int J Mol Sci. 2016;17:220. doi:10.3390/ijms17020220
- Li SY, Zheng PY, Zhai YY, Zhang YD, Gan H, et al. [Analysis of the effect of early subcutaneous specific immunotherapy on the levels of dust mite allergen-specific antibodies and polyunsaturated fatty acid metabolism]. Zhonghua Yu Fang Yi Xue Za Zhi. 2024;58:778. doi:10.3760/cma.j.cn112150-20240124-00083
- Komulainen M, Saros L, Vahlberg T, Nermes M, Jartti T, et al. Maternal fish oil and/or probiotics intervention: Allergic diseases in children up to two years old. Pediatr Allergy Immunol. 2023;34:e14004. doi:10.1111/pai.14004
- Mirrahimi B, Moazemi M, Eslami N, Jamshidi E, Mir M, et al. Evaluating the Effect of Eicosapentaenoic Acid in Children With Atopic Dermatitis: A Randomized Triple-Blind Clinical Trial. J Pediatr Pharmacol Ther. 2023;28:29. doi:10.5863/1551-6776-28.1.29
- Imai T, Takada Y, Watanabe K. Effect of Omega-3 Polyunsaturated Fatty Acids Intake on Eosinophil Airway Inflammation in University Athletes. J Clin Med Res. 2022;14:466. doi:10.14740/jocmr4825
- Decsi T, Marosvölgyi T, Muszil E, Bódy B, Szabó É. Long-Chain Polyunsaturated Fatty Acid Status at Birth and Development of Childhood Allergy: A Systematic Review. Life (Basel). 2022;12. doi:10.3390/life12040526
- Saika A, Nagatake T, Hirata SI, Sawane K, Adachi J, et al. ω3 fatty acid metabolite, 12-hydroxyeicosapentaenoic acid, alleviates contact hypersensitivity by downregulation of CXCL1 and CXCL2 gene expression in keratinocytes via retinoid X receptor α. FASEB J. 2021;35:e21354. doi:10.1096/fj.202001687R
- Kanda N, Hoashi T, Saeki H. Nutrition and Atopic Dermatitis. J Nippon Med Sch. 2021;88:171. doi:10.1272/jnms.JNMS.2021_88-317
- Barman M, Rabe H, Hesselmar B, Johansen S, Sandberg AS, et al. Cord Blood Levels of EPA, a Marker of Fish Intake, Correlate with Infants' T- and B-Lymphocyte Phenotypes and Risk for Allergic Disease. Nutrients. 2020;12. doi:10.3390/nu12103000
- Hoppenbrouwers T, Fogliano V, Garssen J, Pellegrini N, Willemsen LEM, et al. Specific Polyunsaturated Fatty Acids Can Modulate Human moDC2s and Subsequent Th2 Cytokine Release. Front Immunol. 2020;11:748. doi:10.3389/fimmu.2020.00748
- Saika A, Nagatake T, Kishino S, Park SB, Honda T, et al. 17(),18()-epoxyeicosatetraenoic acid generated by cytochrome P450 BM-3 from inhibits the development of contact hypersensitivity via G-protein-coupled receptor 40-mediated neutrophil suppression. FASEB Bioadv. 2020;2:59. doi:10.1096/fba.2019-00061
