5/13/2025
Last update
5/13/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.4
USERS' SCORE
Good
Based on 1 Review
8.4
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
15
Total Fat
1.5 g
2%**
Saturated Fat
0.5 g
3%**
Cholesterol
10 mg
3%
Fish Oilprovides 360 mg of Total Omega-3 Fatty Acids†comprising of:EPA (Eicosapentaenoic Acid)DHA (Docosahexaenoic Acid)Other Fatty Acids
1,200 mg (1.2 g)
***************
Top Medical Research Studies
9
Eicosapentaenoic acid improves asthma
We compared how different types of forage affected asthma in Thoroughbred racehorses. Our focus was on assessing dust exposure, airway health, and the presence of eicosapentaenoic acid (EPA), an omega-3 fatty acid known for its anti-inflammatory properties. The horses were randomly assigned to three diets: dry hay, steamed hay, or haylage for a period of six weeks.
Throughout the study, we observed that horses fed steamed hay and haylage had significantly lower dust exposure compared to those that consumed dry hay. Interestingly, those on the haylage diet not only showed reduced levels of neutrophils in their bronchoalveolar lavage fluid, indicating better airway health, but they also had an increase in the ratio of anti-inflammatory to pro-inflammatory lipids, particularly EPA.
In fact, the horses on haylage had higher ratios of eicosapentaenoic acid compared to both their baseline measurements and horses on the other diets. This suggests that incorporating haylage could be beneficial for managing asthma symptoms in racehorses. Overall, it appears that haylage may help improve respiratory health by reducing inflammation linked to asthma through its higher anti-inflammatory lipid profile.
Throughout the study, we observed that horses fed steamed hay and haylage had significantly lower dust exposure compared to those that consumed dry hay. Interestingly, those on the haylage diet not only showed reduced levels of neutrophils in their bronchoalveolar lavage fluid, indicating better airway health, but they also had an increase in the ratio of anti-inflammatory to pro-inflammatory lipids, particularly EPA.
In fact, the horses on haylage had higher ratios of eicosapentaenoic acid compared to both their baseline measurements and horses on the other diets. This suggests that incorporating haylage could be beneficial for managing asthma symptoms in racehorses. Overall, it appears that haylage may help improve respiratory health by reducing inflammation linked to asthma through its higher anti-inflammatory lipid profile.
Read More
8
We aimed to understand the relationship between eicosapentaenoic acid, a type of n-3 polyunsaturated fatty acid, and its potential effects on asthma and other allergic conditions. Through analysis of blood samples taken from 940 children at age 8, we looked at how the proportions of eicosapentaenoic acid and other fatty acids might influence the development of asthma and allergic diseases by age 16.
Our findings were compelling. We observed that higher levels of eicosapentaenoic acid in the blood corresponded with a lower risk of asthma, nasal allergies, and general allergic sensitization when the children turned 16. Specifically, the data showed that for every increase in eicosapentaenoic acid, there was a notable decrease in the chances of developing asthma over the years. This suggests that maintaining higher levels of this fatty acid could potentially help in managing or even reducing the incidence of asthma in children.
Additionally, our study revealed that arachidonic acid, another fatty acid, also played a beneficial role, showing an association with remission from asthma and rhinitis between the ages of 8 and 16. These insights underscore the importance of certain fatty acids in the diet and their potential in shaping long-term health outcomes regarding allergic diseases.
Our findings were compelling. We observed that higher levels of eicosapentaenoic acid in the blood corresponded with a lower risk of asthma, nasal allergies, and general allergic sensitization when the children turned 16. Specifically, the data showed that for every increase in eicosapentaenoic acid, there was a notable decrease in the chances of developing asthma over the years. This suggests that maintaining higher levels of this fatty acid could potentially help in managing or even reducing the incidence of asthma in children.
Additionally, our study revealed that arachidonic acid, another fatty acid, also played a beneficial role, showing an association with remission from asthma and rhinitis between the ages of 8 and 16. These insights underscore the importance of certain fatty acids in the diet and their potential in shaping long-term health outcomes regarding allergic diseases.
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8
We explored the effects of eicosapentaenoic acid (EPA) on asthma, focusing particularly on its ability to alleviate eosinophilic airway inflammation. Through a well-structured experiment, male C57BL6 mice were sensitized and challenged with ovalbumin, simulating allergic airway responses. After treating these mice with EPA, we measured various outcomes, including cell counts in bronchoalveolar lavage fluid and mRNA expressions in the lungs.
Our findings were encouraging! We observed that EPA not only reduced eosinophil accumulation in the airway but also lowered the expression of certain inflammatory mediators in the lungs. Moreover, when analyzing the metabolites of EPA, we identified 12-hydroxy-17,18-epoxyeicosatetraenoic acid (12-OH-17,18-EpETE) as a significant player in these processes. This metabolite's production increased with EPA treatment and allergic inflammation.
Notably, administering 12-OH-17,18-EpETE directly into the bloodstream helped in decreasing airway eosinophilic inflammation by downregulating a specific inflammatory signal in the lungs. In our in vitro studies, this compound also inhibited the release of an inflammatory substance known as CCL11 from human airway cells that were stimulated by interleukin-4.
Overall, these results suggest that EPA has a favorable impact against asthma by converting into beneficial metabolites. Specifically, 12-OH-17,18-EpETE appears to be a promising therapeutic agent for asthma sufferers.
Our findings were encouraging! We observed that EPA not only reduced eosinophil accumulation in the airway but also lowered the expression of certain inflammatory mediators in the lungs. Moreover, when analyzing the metabolites of EPA, we identified 12-hydroxy-17,18-epoxyeicosatetraenoic acid (12-OH-17,18-EpETE) as a significant player in these processes. This metabolite's production increased with EPA treatment and allergic inflammation.
Notably, administering 12-OH-17,18-EpETE directly into the bloodstream helped in decreasing airway eosinophilic inflammation by downregulating a specific inflammatory signal in the lungs. In our in vitro studies, this compound also inhibited the release of an inflammatory substance known as CCL11 from human airway cells that were stimulated by interleukin-4.
Overall, these results suggest that EPA has a favorable impact against asthma by converting into beneficial metabolites. Specifically, 12-OH-17,18-EpETE appears to be a promising therapeutic agent for asthma sufferers.
Read More
Most Useful Reviews
7.5
Helps with inflammation
2 people found this helpful
Good for Asthma. I endorse this product for those with asthma, as it effectively aids in reducing inflammation.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.4
- All Researches
9
Eicosapentaenoic acid improves asthma
We compared how different types of forage affected asthma in Thoroughbred racehorses. Our focus was on assessing dust exposure, airway health, and the presence of eicosapentaenoic acid (EPA), an omega-3 fatty acid known for its anti-inflammatory properties. The horses were randomly assigned to three diets: dry hay, steamed hay, or haylage for a period of six weeks.
Throughout the study, we observed that horses fed steamed hay and haylage had significantly lower dust exposure compared to those that consumed dry hay. Interestingly, those on the haylage diet not only showed reduced levels of neutrophils in their bronchoalveolar lavage fluid, indicating better airway health, but they also had an increase in the ratio of anti-inflammatory to pro-inflammatory lipids, particularly EPA.
In fact, the horses on haylage had higher ratios of eicosapentaenoic acid compared to both their baseline measurements and horses on the other diets. This suggests that incorporating haylage could be beneficial for managing asthma symptoms in racehorses. Overall, it appears that haylage may help improve respiratory health by reducing inflammation linked to asthma through its higher anti-inflammatory lipid profile.
Throughout the study, we observed that horses fed steamed hay and haylage had significantly lower dust exposure compared to those that consumed dry hay. Interestingly, those on the haylage diet not only showed reduced levels of neutrophils in their bronchoalveolar lavage fluid, indicating better airway health, but they also had an increase in the ratio of anti-inflammatory to pro-inflammatory lipids, particularly EPA.
In fact, the horses on haylage had higher ratios of eicosapentaenoic acid compared to both their baseline measurements and horses on the other diets. This suggests that incorporating haylage could be beneficial for managing asthma symptoms in racehorses. Overall, it appears that haylage may help improve respiratory health by reducing inflammation linked to asthma through its higher anti-inflammatory lipid profile.
Read More
9
We set out to understand how eicosapentaenoic acid (EPA) might enhance the effects of mesenchymal stromal cell (MSC) therapy for allergic asthma. In our study, we used mice to create a model of severe allergic asthma by exposing them to house dust mite extracts. After the final exposure, we administered either unstimulated or EPA-stimulated MSCs to see how they impacted the mice's lung health and inflammation.
Our findings were quite promising. The mice that received EPA-stimulated MSCs showed notable improvements in their lung function and overall respiratory health compared to those treated with unstimulated MSCs. Specifically, we noticed a reduction in bronchoconstriction, less alveolar collapse, and decreased overall cell counts in the lungs, which is a sign of lower inflammation. Additionally, we saw an increase in beneficial markers such as IL-10 and changes in macrophage types, indicating a shift toward a more anti-inflammatory state.
This research underscores the potential of combining EPA with MSC therapy as a new approach for tackling allergic asthma. By enhancing the anti-inflammatory effects of MSCs, EPA might not only improve lung mechanics but also protect against further airway damage. Our work suggests that this strategy could be an exciting avenue for developing better treatments for asthma and potentially other inflammatory conditions.
Our findings were quite promising. The mice that received EPA-stimulated MSCs showed notable improvements in their lung function and overall respiratory health compared to those treated with unstimulated MSCs. Specifically, we noticed a reduction in bronchoconstriction, less alveolar collapse, and decreased overall cell counts in the lungs, which is a sign of lower inflammation. Additionally, we saw an increase in beneficial markers such as IL-10 and changes in macrophage types, indicating a shift toward a more anti-inflammatory state.
This research underscores the potential of combining EPA with MSC therapy as a new approach for tackling allergic asthma. By enhancing the anti-inflammatory effects of MSCs, EPA might not only improve lung mechanics but also protect against further airway damage. Our work suggests that this strategy could be an exciting avenue for developing better treatments for asthma and potentially other inflammatory conditions.
Read More
9
In our exploration of asthma treatment, we focused on sea cucumber extracts and their effects on allergic airway inflammation. Using a method that separated the extract into three distinct phases, we specifically looked at how the n-hexane phase—rich in fatty acids like eicosapentaenoic acid—could influence asthma symptoms in mice.
We observed that when mice with asthma were treated with this n-hexane phase, their symptoms improved. This phase not only elevated the expression of Il10, an important anti-inflammatory cytokine, but also reduced the presence of eosinophils and goblet cell hyperplasia around the airways. Remarkably, we found decreases in several Th2 and Th17-related cytokines, which are usually elevated during asthma attacks.
The increase in other markers, like TGF-β and IL-10, is particularly interesting, as these are associated with regulatory T cells, which help control inflammation. Our findings suggest that eicosapentaenoic acid, along with other components in the sea cucumber extract, plays a positive role in addressing asthma symptoms by modulating immune responses effectively.
We observed that when mice with asthma were treated with this n-hexane phase, their symptoms improved. This phase not only elevated the expression of Il10, an important anti-inflammatory cytokine, but also reduced the presence of eosinophils and goblet cell hyperplasia around the airways. Remarkably, we found decreases in several Th2 and Th17-related cytokines, which are usually elevated during asthma attacks.
The increase in other markers, like TGF-β and IL-10, is particularly interesting, as these are associated with regulatory T cells, which help control inflammation. Our findings suggest that eicosapentaenoic acid, along with other components in the sea cucumber extract, plays a positive role in addressing asthma symptoms by modulating immune responses effectively.
Read More
8
We investigated how eicosapentaenoic acid (EPA), a type of long-chain polyunsaturated fatty acid, could influence asthma symptoms, particularly in children. This research delved into various studies that highlighted EPA's potential to impact immune responses, especially when combined with other fatty acids like arachidonic acid and docosahexaenoic acid (DHA).
While some findings suggested that supplementation with n-3 LCPUFAs, including EPA, could enhance immune maturation and reduce the risks of allergic diseases, the isolated effect of EPA specifically on asthma remains challenging to pinpoint. The studies indicated mixed results, noting certain benefits like reduced sensitization to allergens, but we found that the overall evidence regarding EPA's direct impact on asthma outcomes specifically is limited.
Therefore, although there are positive indications linking LCPUFAs to improved immune responses and potential reductions in asthma severity, the specific contribution of EPA alone could benefit from further examination. In essence, while EPA shows promise as part of a broader approach to managing asthma, the direct evidence of its effectiveness is not conclusively established.
While some findings suggested that supplementation with n-3 LCPUFAs, including EPA, could enhance immune maturation and reduce the risks of allergic diseases, the isolated effect of EPA specifically on asthma remains challenging to pinpoint. The studies indicated mixed results, noting certain benefits like reduced sensitization to allergens, but we found that the overall evidence regarding EPA's direct impact on asthma outcomes specifically is limited.
Therefore, although there are positive indications linking LCPUFAs to improved immune responses and potential reductions in asthma severity, the specific contribution of EPA alone could benefit from further examination. In essence, while EPA shows promise as part of a broader approach to managing asthma, the direct evidence of its effectiveness is not conclusively established.
Read More
8
In this study, we examined how eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, might influence the development of asthma and allergic diseases in adolescents. We looked at data from 996 mother-child pairs to see how the mothers' nutrient intake and exposure to oxidative stressors during pregnancy affected their children's health.
Our findings highlighted that higher intake of eicosapentaenoic acid, alongside vitamin D, was associated with a reduced risk of asthma. Specifically, we noticed that among those with better EPA intake, there was about a 19% lower likelihood of developing current asthma symptoms.
While we identified potential protective factors, we also found that exposure to pollutants such as black carbon and particulate matter could significantly increase the risk of allergen sensitization. Interestingly, despite the associations we noted, there were no interactions between nutrient intake and oxidative stress sources.
Our findings highlighted that higher intake of eicosapentaenoic acid, alongside vitamin D, was associated with a reduced risk of asthma. Specifically, we noticed that among those with better EPA intake, there was about a 19% lower likelihood of developing current asthma symptoms.
While we identified potential protective factors, we also found that exposure to pollutants such as black carbon and particulate matter could significantly increase the risk of allergen sensitization. Interestingly, despite the associations we noted, there were no interactions between nutrient intake and oxidative stress sources.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Helps with inflammation
2 people found this helpful
Good for Asthma. I endorse this product for those with asthma, as it effectively aids in reducing inflammation.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Höglund N, Nieminen P, Mustonen AM, Käkelä R, Tollis S, et al. Fatty acid fingerprints in bronchoalveolar lavage fluid and its extracellular vesicles reflect equine asthma severity. Sci Rep. 2023;13:9821. 10.1038/s41598-023-36697-x
- Olave CJ, Ivester KM, Couetil LL, Burgess J, Park JH, et al. Effects of low-dust forages on dust exposure, airway cytology, and plasma omega-3 concentrations in Thoroughbred racehorses: A randomized clinical trial. J Vet Intern Med. 2023;37:338. 10.1111/jvim.16598
- Adjibade M, Davisse-Paturet C, Bernard JY, Adel-Patient K, Divaret-Chauveau A, et al. Enrichment of infant formula with long-chain polyunsaturated fatty acids and risk of infection and allergy in the nationwide ELFE birth cohort. Allergy. 2022;77:1522. 10.1111/all.15137
- Talaei M, Sdona E, Calder PC, Jones LR, Emmett PM, et al. Intake of -3 polyunsaturated fatty acids in childhood, genotype and incident asthma. Eur Respir J. 2021;58. 10.1183/13993003.03633-2020
- Miles EA, Childs CE, Calder PC. Long-Chain Polyunsaturated Fatty Acids (LCPUFAs) and the Developing Immune System: A Narrative Review. Nutrients. 2021;13. 10.3390/nu13010247
- Fussbroich D, Colas RA, Eickmeier O, Trischler J, Jerkic SP, et al. A combination of LCPUFA ameliorates airway inflammation in asthmatic mice by promoting pro-resolving effects and reducing adverse effects of EPA. Mucosal Immunol. 2020;13:481. 10.1038/s41385-019-0245-2
- Stoodley I, Garg M, Scott H, Macdonald-Wicks L, Berthon B, et al. Higher Omega-3 Index Is Associated with Better Asthma Control and Lower Medication Dose: A Cross-Sectional Study. Nutrients. 2019;12. 10.3390/nu12010074
- Sordillo JE, Rifas-Shiman SL, Switkowski K, Coull B, Gibson H, et al. Prenatal oxidative balance and risk of asthma and allergic disease in adolescence. J Allergy Clin Immunol. 2019;144:1534. 10.1016/j.jaci.2019.07.044
- Fussbroich D, Zimmermann K, Göpel A, Eickmeier O, Trischler J, et al. A specific combined long-chain polyunsaturated fatty acid supplementation reverses fatty acid profile alterations in a mouse model of chronic asthma. Lipids Health Dis. 2019;18:16. 10.1186/s12944-018-0947-6
- Abreu SC, Lopes-Pacheco M, da Silva AL, Xisto DG, de Oliveira TB, et al. Eicosapentaenoic Acid Enhances the Effects of Mesenchymal Stromal Cell Therapy in Experimental Allergic Asthma. Front Immunol. 2018;9:1147. 10.3389/fimmu.2018.01147
- Magnusson J, Ekström S, Kull I, Håkansson N, Nilsson S, et al. Polyunsaturated fatty acids in plasma at 8 years and subsequent allergic disease. J Allergy Clin Immunol. 2018;142:510. 10.1016/j.jaci.2017.09.023
- Lee DI, Kang SA, Md A, Jeong UC, Jin F, et al. Sea Cucumber Lipid-Soluble Extra Fraction Prevents Ovalbumin-Induced Allergic Airway Inflammation. J Med Food. 2018;21:21. 10.1089/jmf.2017.3994
- Bian X, Sun B, Zheng P, Li N, Wu JL. Derivatization enhanced separation and sensitivity of long chain-free fatty acids: Application to asthma using targeted and non-targeted liquid chromatography-mass spectrometry approach. Anal Chim Acta. 2017;989:59. 10.1016/j.aca.2017.08.009
- Mochimaru T, Fukunaga K, Miyata J, Matsusaka M, Masaki K, et al. 12-OH-17,18-Epoxyeicosatetraenoic acid alleviates eosinophilic airway inflammation in murine lungs. Allergy. 2018;73:369. 10.1111/all.13297
- Bisgaard H, Stokholm J, Chawes BL, Vissing NH, Bjarnadóttir E, et al. Fish Oil-Derived Fatty Acids in Pregnancy and Wheeze and Asthma in Offspring. N Engl J Med. 2016;375:2530. 10.1056/NEJMoa1503734
