Nature's Bounty Vitamin D3
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Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D (as D3 Cholecalciferol)
50 mcg (2,000 IU)
250% 

The product is found useful for the following medical conditions

Allergies details

SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.6
USERS' SCORE
Good
Based on 3 Reviews
8.8
8
Vitamin D deficiency linked to allergies
Does vitamin D deficiency predispose to allergic proctocolitis?
Most Relevant Research
We investigated the potential connection between vitamin D deficiency and allergic proctocolitis (AP) in infants. Our study involved a careful comparison of vitamin D levels in infants diagnosed with AP against those of healthy infants. This meticulous, prospective approach allows us to draw insightful conclusions about how vitamin D might be influencing allergic conditions.

We found that vitamin D levels were noticeably lower in infants suffering from AP compared to their healthy peers. Notably, a significant percentage of AP patients—34.7%—were found to be vitamin D deficient or insufficient. Furthermore, the study revealed that infants with vitamin D levels below 40.75 mcg/L were 3.5 times more likely to develop AP.

Our findings suggest an intriguing association between vitamin D deficiency and allergic proctocolitis, hinting that the rising rates of such allergies may be influenced by environmental factors. It appears crucial that we assess vitamin D levels in infants diagnosed with AP, as this could contribute to better understanding and management of the condition.
10
Highly recommended
Most Useful Review
I've been using Vitamin D3 from NB for a long time. I recommend it to all my friends because I can feel the benefits, and it doesn’t cause any allergies.

Blood Clot details

SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.6
USERS' SCORE
Good
Based on 3 Reviews
8.7
9
Vitamin D counteracts blood clotting
Vitamin D Inhibits IL-6 Pro-Atherothrombotic Effects in Human Endothelial Cells: A Potential Mechanism for Protection against COVID-19 Infection?
Most Relevant Research
Our research focused on understanding how Vitamin D (VitD) might influence blood clotting, especially in the context of COVID-19. We found that when human endothelial cells were exposed to IL-6—an inflammatory cytokine associated with severe COVID-19—it led to dysfunction in these cells. This dysfunction was marked by increased levels of Tissue Factor (TF) and cell adhesion molecules (CAMs), which promote blood clotting.

Remarkably, when we treated these endothelial cells with VitD, we observed a reversal of these harmful effects. VitD appeared to inhibit the expression of TF and CAMs and even modulated the levels of the ACE2 receptor, which is crucial for the entry of the virus into cells. Our findings suggest that VitD could play a protective role against the blood clotting complications associated with COVID-19 by counteracting IL-6's effects on endothelial cells.

Overall, this study paves the way for further research into VitD as a potential therapeutic option for mitigating thrombotic risks in COVID-19 patients.
9.5
Family health improved
Most Useful Review
A wonderful supplement! My entire family takes it, and we continue throughout the summer. Since we started consistently using vitamin D3, our health has significantly improved. Prior to starting, I had tests conducted for D25 OH to check for vitamin D deficiency in the blood, particularly for the children due to the high costs of testing. Six months later, we retested, and the results had greatly improved. We will continue taking it, as I’m pleased with this manufacturer’s dosages and the small capsule size.

Chronic Fatigue Syndrome details

SCIENTIFIC SCORE
Questionable
Based on 3 Researches
5.8
USERS' SCORE
Good
Based on 4 Reviews
8.7
0
Vitamin D3 ineffective for CFS relief
Effect of intermittent vitamin D3 on vascular function and symptoms in chronic fatigue syndrome--a randomised controlled trial.
Most Relevant Research
We conducted a study to see if high-dose vitamin D3 could improve vascular health and reduce fatigue in individuals suffering from chronic fatigue syndrome (CFS). This was a well-structured trial involving 50 participants, all of whom met specific diagnostic criteria for CFS. Participants were divided into two groups: one received 100,000 units of vitamin D3 every two months, while the other received a placebo over a period of six months.

Despite a noticeable increase of 22 nmol/L in vitamin D levels for those who received the treatment compared to the placebo group, we found no significant benefits. There was no change in arterial stiffness, a key vascular health indicator, nor improvements in overall fatigue as measured by the Piper Fatigue scale.

In essence, our findings indicate that high-dose oral vitamin D3 does not offer the hoped-for relief in vascular function or fatigue for patients with chronic fatigue syndrome. This suggests that other therapeutic options may need to be explored for individuals suffering from this condition.
9.5
No more fatigue
Most Useful Review
Quality product. I have been purchasing from this shop for some time, and it is always delivered on time and well-packaged. The dosage was recommended by my doctor, and absorption is quick. This product is excellent for managing vitamin deficiency, especially since I don’t receive much sunlight. With 150 capsules in the bottle, I appreciate that it has no taste. Since starting it, I no longer feel chronic fatigue syndrome; it has made a significant difference in my energy levels.

Cold details

SCIENTIFIC SCORE
Questionable
Based on 5 Researches
6.8
USERS' SCORE
Good
Based on 14 Reviews
8.7
8
Vitamin D reduces cold severity
Influence of Vitamin D Supplementation by Simulated Sunlight or Oral D3 on Respiratory Infection during Military Training.
Most Relevant Research
We explored the connection between vitamin D levels and upper respiratory tract infections (URTIs) among military recruits during their training. This observation spanned across different seasons and included over 1,600 recruits. Our aim was to understand how achieving sufficient vitamin D levels could potentially impact the frequency and severity of colds among physically active individuals.

In an additional phase of the research, we conducted a randomized controlled trial with 250 male recruits. They received either a placebo, simulated sunlight exposure, or oral vitamin D3 supplements during winter. This comparison allowed us to see if these methods effectively increased vitamin D levels to a sufficient status of 25(OH)D at 50 nmol/L or higher.

Notably, our findings showed that only 21% of recruits had adequate vitamin D during winter, yet those who did were 40% less likely to suffer from URTIs. Furthermore, both vitamin D supplementation strategies similarly helped nearly all participants achieve sufficient levels. Vitamin D supplementation notably reduced the severity of URTI symptoms by 15% and the number of days with URTIs by 36% compared to placebo.

While the supplementation strategies did not significantly alter other immune factors, such as salivary secretory immunoglobulin A, the overall reduction in respiratory infections indicates a beneficial effect of maintaining vitamin D sufficiency during military training.
9.5
Condition resolved
Most Useful Review
Regular consumption of D3 is prone to colds and allergies. The condition is completely gone.

Common Cold details

SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.9
USERS' SCORE
Good
Based on 6 Reviews
8.7
8
Vitamin D reduces cold severity
Influence of Vitamin D Supplementation by Simulated Sunlight or Oral D3 on Respiratory Infection during Military Training.
Most Relevant Research
We explored the connection between vitamin D levels and the frequency of upper respiratory tract infections (URTI) in physically active individuals throughout different seasons. In our research, we observed over 1,600 military recruits during their basic training, noting that only 21% were vitamin D sufficient during winter. Alarmingly, those who had sufficient vitamin D levels were found to be 40% less likely to experience URTIs compared to their deficient counterparts, suggesting that maintaining adequate vitamin D may be crucial for better respiratory health during demanding training periods.

Building on these findings, we conducted a follow-up study with 250 recruits, where we implemented various vitamin D supplementation strategies. Participants received either a placebo, simulated sunlight exposure, or oral vitamin D3 supplementation. The results were promising: vitamin D helped alleviate the severity of URTI symptoms and significantly reduced the number of days experiencing a cold. Notably, both sunlight and dietary supplementation were equally effective in boosting vitamin D levels and improving outcomes.

Overall, achieving vitamin D sufficiency can markedly reduce the burden of URTIs, particularly in physically demanding scenarios such as military training.
9.5
Condition improved
Most Useful Review
Regular consumption of D3 helps lessen colds and allergies. My condition has completely improved.

Cancer details

SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.3
USERS' SCORE
Good
Based on 4 Reviews
8.6
5
Vitamin D's role in breast disease
Levels of Serum 25-Hydroxy Vitamin D in Benign and Malignant Breast Disease Patients: An Observational Study.
Most Relevant Research
We conducted an observational study to examine the levels of vitamin D in female patients with benign and malignant breast diseases. The research aimed to determine if there is a significant difference in vitamin D levels between those with non-cancerous conditions and those diagnosed with breast cancer.

During the study, we analyzed adult female patients admitted to a surgical department. Importantly, we excluded those who had taken vitamin D supplements recently or who had prior vitamin D deficiencies. By measuring serum vitamin D levels through a specific testing method, we were able to gather meaningful data about their relationship to breast health.

Our findings indicated a notable difference in average vitamin D levels when comparing the two groups. This suggests that inadequate vitamin D could be linked to an increased risk of developing breast cancer. Therefore, we explored the potential benefits of vitamin D supplementation as a preventive measure against breast cancer—though we acknowledge that larger and more controlled studies are essential to draw firm conclusions.

At the same time, we recognize that vitamin D has effects beyond bone health, and it is crucial to consider these broader impacts when discussing its role in cancer risk.
9.5
Resists cancer growth
Most Useful Review
I have repeatedly ordered this manufacturer's D3! This vitamin aids in muscle tone, enhances immunity, and is essential for thyroid function and blood clotting. It helps restore nerve protective membranes and plays a role in regulating blood pressure and heart rate, while resisting cancer cell growth. The quality is excellent, and I highly recommend this product!

Depression details

SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7
USERS' SCORE
Good
Based on 3 Reviews
8.6
9
Vitamin D supports depression management
Effects of cholecalciferol supplementation on depressive symptoms, C-peptide, serotonin, and neurotrophin-3 in type 2 diabetes mellitus: A double-blind, randomized, placebo-controlled trial.
Most Relevant Research
We conducted a double-blind, randomized, placebo-controlled trial to explore how cholecalciferol, a form of vitamin D, influences depressive symptoms in individuals suffering from type 2 diabetes mellitus (T2DM). This clinical study lasted for 12 weeks and involved participants who were either given a daily dose of 4000 IU of cholecalciferol or a placebo.

Throughout the study, we measured various factors, including the participants’ depression levels using the Beck Depression Inventory-II, as well as important biological markers like C-peptide, serotonin, and neurotrophin-3.

Our findings showed a significant reduction in depression scores among those taking cholecalciferol compared to the placebo group. Additionally, we observed a notable increase in C-peptide levels, which may indicate some metabolic benefits, although no significant changes were found in serotonin and neurotrophin-3 levels.

Ultimately, while cholecalciferol appears to alleviate mild to moderate depressive symptoms in T2DM patients through improved C-peptide levels, its impact on serotonin and neurotrophin-3 remains unclear. This highlights vitamin D as a potentially helpful option for managing depression alongside diabetes.
9.5
Mood improvement noted
Most Useful Review
Currently, many doctors regard vitamin D3 as akin to hormones, as its deficiency can lead to severe consequences, including stress and persistent depression. It aids calcium, phosphorus, and magnesium absorption, crucial for bone health. Additionally, it enhances metabolic processes, uplifts mood, alleviates anxiety and neuropsychiatric disorders, and helps with insomnia. Due to limited sunlight throughout the year, my family and I take this vitamin, promoting a tranquil atmosphere at home.

Heart Attack details

SCIENTIFIC SCORE
Questionable
Based on 11 Researches
5.7
USERS' SCORE
Good
Based on 3 Reviews
8.6
4
Vitamin D and heart attack risk
Effects of Vitamin D Levels on Long-Term Coronary Events in Patients with Proven Coronary Artery Disease: Six-Year Follow-Up.
Most Relevant Research
We explored the relationship between vitamin D levels and long-term heart-related events in patients already diagnosed with coronary artery disease (CAD). This study involved 408 patients, grouped by their vitamin D levels: group 1 with levels below 10 ng/mL, group 2 with levels between 10 and 20 ng/mL, and group 3 with levels above 20 ng/mL.

Over six years, we monitored the patients for various cardiac incidents, including heart attacks and mortality. Interestingly, we found no significant differences in mortality rates among the groups. However, there were notable differences in cardiac events.

Almost half of the patients in group 3 experienced no cardiac events at all, while this was true for only about 28% in group 1 and 29% in group 2. The findings showed that patients with higher vitamin D levels had significantly lower rates of non-ST-elevated myocardial infarction and unstable angina, suggesting that while vitamin D deficiency does not seem to increase the risk of dying, it strongly correlates with a higher risk of specific heart issues.
8.8
Health benefits noted
Most Useful Review
The quality is excellent. The capsule size is standard, and the dosage is high; take only under a doctor's advice. Vitamin D3 offers numerous health benefits, strengthening bones and muscles, boosting immunity, enhancing mood, providing an anti-inflammatory effect, and improving heart function.

Knee Pain details

SCIENTIFIC SCORE
Questionable
Based on 16 Researches
6.8
USERS' SCORE
Good
Based on 2 Reviews
8.6
8
Vitamin D3 shows promise for knee OA
The influence of vitamin D supplementation on the expression of mediators of inflammation in knee osteoarthritis.
Most Relevant Research
We explored the potential benefits of vitamin D3 supplementation in alleviating knee pain associated with osteoarthritis (OA). In this open-label clinical trial, we assessed the effects of daily doses of 4000 IU vitamin D3 over three months in 80 patients suffering from knee OA.

Our findings revealed notable improvements in pain levels and overall physical function. The patients showed significant reductions in pain scores measured by the Visual Analog Scale (VAS) and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) subscores after the treatment period. Remarkably, 86.7% of those treated responded positively to the therapy.

Interestingly, we observed changes in systemic cytokine levels: while some pro-inflammatory markers increased, others, including TNF-α and IL-17, showed significant reductions. This suggests that vitamin D3 not only helps with pain relief but also may influence inflammatory processes in the body.

Overall, our results indicate that vitamin D3 supplementation could be a promising therapeutic option for managing symptoms of knee OA. Nonetheless, future research should further investigate the role of specific inflammatory mediators, like IL-33, in the progression of knee osteoarthritis.
9.5
Immense help
Most Useful Review
I’m very pleased with the quality and effectiveness of this D3, as it has greatly aided me concerning bone and joint strength, reduced knee pain, and appears to be easily absorbed. I will continue to purchase.

Osteoporosis details

SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.4
USERS' SCORE
Good
Based on 3 Reviews
8.6
8
Vitamin D's impact on osteoporosis
The Vitamin D-Sirt1/PGC1α Axis Regulates Bone Metabolism and Counteracts Osteoporosis.
Most Relevant Research
We aimed to understand how vitamin D influences bone health and helps combat osteoporosis, a condition that weakens bones. In our study, we used various mouse models, including those that mimic a deficiency in active vitamin D. Through a range of advanced methods, we assessed how changes in vitamin D levels affected bone structure and metabolism.

The research revealed that insufficient vitamin D led to a drop in Sirt1, a gene that plays a crucial role in maintaining bone density. This lack of Sirt1 resulted in increased bone loss. However, when we boosted Sirt1 levels in bone stem cells, we observed a reversal in bone loss. This improvement happened because higher Sirt1 levels reduced oxidative stress, slowed down aging processes in bone cells, and enhanced new bone formation while curbing bone resorption.

Additionally, our findings indicated that vitamin D directly stimulates Sirt1 expression in these stem cells, which is vital for bone health. We also explored the effects of resveratrol, a natural compound known for activating Sirt1, and found it helped alleviate osteoporosis symptoms linked to vitamin D deficiency by enhancing the relationship between Sirt1 and another protein called PGC1α, which supports bone formation and energy metabolism.

This research underscores the importance of the vitamin D-Sirt1/PGC1α axis in bone metabolism, providing insight into how vitamin D can serve as a target for osteoporosis prevention and treatment.
9.5
Recommended for osteoporosis
Most Useful Review
I have severe osteoporosis (-2.9) and recommend this to everyone. My orthopaedic specialist tested my vitamin D concentration and found it low, advising me to supplement with Vitamin D3. After taking Nature's Treasure Vitamin D3, 2000IU daily along with 1200 seaweed calcium, I've made lifestyle changes and will test my bone density again in a year. I'm now at (-2.3). Even though I'm not keen on swallowing pills, these are easy to take. The dosage varies based on personal needs, but I truly recommend it.

Sleep Apnea details

SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.1
USERS' SCORE
Good
Based on 2 Reviews
8.5
7
Vitamin D's role in sleep apnea
Sleepiness and Vitamin D Levels in Patients with Obstructive Sleep Apnea.
Most Relevant Research
We aimed to explore the connection between Vitamin D levels and excessive daytime sleepiness in patients diagnosed with obstructive sleep apnea (OSA). In this study, we analyzed serum Vitamin D levels in a group of newly diagnosed OSA patients, dividing them into two categories: those who experienced excessive daytime sleepiness (EDS) and those who did not.

Our findings indicated that patients with EDS had significantly lower levels of Vitamin D compared to their non-somnolent counterparts. The study showed that lower Vitamin D levels correlated with higher apnea-hypopnea indices (AHI) and lower oxyhemoglobin saturation during sleep. This suggests that sleep-related hypoxia may impact Vitamin D status and contribute to sleepiness.

Moreover, our analysis indicated that lower Vitamin D levels were independent predictors of EDS. This further emphasizes the potential role of Vitamin D in managing sleep quality for these patients. In summary, our study highlights an important association between Vitamin D levels and daytime sleepiness in people with sleep apnea, suggesting that improving Vitamin D status could be beneficial for managing EDS in these individuals.
8.8
Improved sleep quality
Most Useful Review
Vitamin D3 has become an essential part of my daily health routine. Daily supplementation not only boosts my energy but also enhances my mood. The benefits of this sunshine vitamin extend beyond immunity to strengthening my bone health and reducing calcium loss. Since I started taking vitamin D3, my sleep quality has noticeably improved, making me feel more resilient against seasonal colds. Overall, this supplement is vital for my healthy lifestyle and has led me towards greater overall health.

Pelvic Pain details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.4
9
Decreased pain
Most Useful Review
I’m very satisfied with this D3. It has significantly improved my bone and joint strength, reduced my pelvic pain, and is quickly absorbed. I will continue to purchase it.

Bone Pain details

SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.7
USERS' SCORE
Moderately Good
Based on 7 Reviews
7.9
9
Vitamin D3 correction improves pain
Role of Pre-operative Correction of Vitamin D3 Deficiency in Controlling Post-operative Bone Pain after Unicompartmental Knee Arthroplasty.
Most Relevant Research
We explored the impact of vitamin D3 levels on bone pain that patients experience after undergoing unicompartmental knee arthroplasty (UKA). The study involved 240 participants who were divided into three groups based on their vitamin D status—some received treatment before surgery, some after, and others had normal levels to begin with.

By administering vitamin D3 in three doses, we aimed to see if correcting deficiencies could alleviate post-operative bone pain. Throughout the recovery period, we measured pain levels using the visual analog scale at various intervals after the surgery.

Our findings clearly demonstrated that patients who corrected their vitamin D3 deficiency before surgery reported significantly better pain control after the operation compared to those who were treated afterwards or those who started with adequate levels. This highlights the importance of testing and addressing vitamin D status prior to orthopedic procedures, showing that it is a modifiable risk factor affecting recovery.
8.8
Supports immunity effectively
Most Useful Review
My Favourite Sunshine Vitamin! We drink it regularly as a family. I give it to everyone, especially for parents with bone pain. It's excellent for early signs of a cold. Our doctor suggested one capsule daily, and the results are very favourable. The quality is superb; we consistently take it, following our doctor's advice.
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