Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.8
USERS' SCORE
Good
Based on 16 Reviews
8.6
Supplement Facts
Serving Size: 2 Gummies
Amount Per Serving
%DV
Calories
15
Total Carbohydrate
3 g
1%**
Total Sugars
2 g
***
Includes 2 g Added Sugars
4%**
Vitamin C (as Ascorbic Acid)
15 mg
17%
Vitamin E (as dl-Alpha Tocopheryl Acetate)
6.7 mg
45%
Biotin (as d-Biotin)
2,500 mcg
8,333%
Sodium
10 mg
<1%
Top Medical Research Studies
9.5
We explored the effects of biotin therapy on a neonate suffering from a rare metabolic disorder known as holocarboxylase synthetase deficiency. After initiating a biotin mega-dose regimen, we observed impressive results, with the baby showing notable clinical improvement just one day later.
Within six days, mechanical ventilation was no longer necessary, and the child maintained stable health through follow-ups. This case underscores the importance of early genetic testing and how effective biotin can be in treating specific metabolic issues.
Within six days, mechanical ventilation was no longer necessary, and the child maintained stable health through follow-ups. This case underscores the importance of early genetic testing and how effective biotin can be in treating specific metabolic issues.
9.5
Biotin treatment showed significant effect
We examined a patient diagnosed with holocarboxylase synthetase (HCS) deficiency, who presented with a notable rash and other severe symptoms. This condition disrupts biotin's incorporation into enzymes, leading to serious health challenges.
After starting biotin treatment, we observed remarkable improvement in the patient’s condition, including normal growth and development over three years. This case highlights the importance of prompt diagnosis and treatment to avoid serious complications associated with biotin deficiency.
After starting biotin treatment, we observed remarkable improvement in the patient’s condition, including normal growth and development over three years. This case highlights the importance of prompt diagnosis and treatment to avoid serious complications associated with biotin deficiency.
8
Biotin treatment mitigates rash symptoms
This study looked at children with partial biotinidase deficiency to understand its effects and inheritance. While many were healthy at diagnosis, we found that one child developed skin rash, hair loss, and muscle weakness—symptoms that improved following biotin treatment.
Notably, other family members also displayed partial deficiency without symptoms, but one adult had minor issues that were alleviated with biotin. Overall, while most individuals are symptom-free at birth, this research suggests that biotin therapy could be beneficial for preventing future complications.
Notably, other family members also displayed partial deficiency without symptoms, but one adult had minor issues that were alleviated with biotin. Overall, while most individuals are symptom-free at birth, this research suggests that biotin therapy could be beneficial for preventing future complications.
Most Useful Reviews
9
Rash improved
453 people found this helpful
I'm enthusiastic about these vitamins! Recently, I developed a rash on my forehead and brittle nails. As a mother with a hectic schedule, I recognised the need for vitamins. I ordered these based on reviews, hoping they would help. I’ve been taking them for a month now, and the results are impressive. The rash has disappeared, my nails feel stronger, and my skin has improved significantly. Notably, my hair has begun to grow again, with new strands sprouting. I would recommend these vitamins to anyone looking for a boost!
9
Rash gone
8 people found this helpful
I bought this for my sister since my hair started falling out. The gummies taste delightful and are effective against dandruff, hair loss, brittle nails, and facial skin issues. Firstly, the rash has gone, nails are stronger, skin condition has improved, and new hair is sprouting.
10
Rash resolved
4 people found this helpful
These vitamins restored my hair! After noticing significant bald patches, I was desperate for a solution. I took them without researching and didn’t expect much. However, after a month, new hair began to grow, nails improved and no rashes appeared. I feel inspired to keep taking these, as the results are remarkable.
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.8
- All Researches
9.5
We explored the effects of biotin therapy on a neonate suffering from a rare metabolic disorder known as holocarboxylase synthetase deficiency. After initiating a biotin mega-dose regimen, we observed impressive results, with the baby showing notable clinical improvement just one day later.
Within six days, mechanical ventilation was no longer necessary, and the child maintained stable health through follow-ups. This case underscores the importance of early genetic testing and how effective biotin can be in treating specific metabolic issues.
Within six days, mechanical ventilation was no longer necessary, and the child maintained stable health through follow-ups. This case underscores the importance of early genetic testing and how effective biotin can be in treating specific metabolic issues.
9.5
We reviewed the clinical and biochemical characteristics of 28 Chinese patients with holocarboxylase synthetase (HLCS) deficiency. Through this retrospective analysis, we observed that most patients exhibited symptoms like rash, seizures, and vomiting. However, after timely biotin supplementation, almost all showed remarkable improvement in their symptoms and overall health.
This suggests that biotin therapy plays a vital role in managing HLCS deficiency, leading to low mortality rates and encouraging long-term outcomes. Early diagnosis through newborn screening is highlighted as essential for effective treatment.
This suggests that biotin therapy plays a vital role in managing HLCS deficiency, leading to low mortality rates and encouraging long-term outcomes. Early diagnosis through newborn screening is highlighted as essential for effective treatment.
9.5
We explored a fascinating case involving a 6-year-old Vietnamese boy diagnosed with holocarboxylase synthetase deficiency, which is linked to biotin metabolism issues. The boy had a significant skin rash and metabolic acidosis, raising suspicion of multiple carboxylase deficiency. After confirming the diagnosis through urine and genetic tests, he began treatment with biotin.
Remarkably, he experienced a dramatic improvement in his condition within just days of starting the treatment. This strongly suggests that biotin can effectively address symptoms related to this deficiency, including skin rashes.
Remarkably, he experienced a dramatic improvement in his condition within just days of starting the treatment. This strongly suggests that biotin can effectively address symptoms related to this deficiency, including skin rashes.
9.5
We explored a case involving a 2-month-old boy who presented with severe symptoms, including seizures and rash, and was quickly suspected of having biotinidase deficiency. After starting him on biotin supplements, we observed remarkable improvement within just 48 hours. His skin conditions, including perioral and perianal rashes, as well as overall health, significantly improved after regular biotin intake. At 10 months, the child is thriving and seizure-free, showcasing how effective timely biotin treatment can be in alleviating symptoms and resolving rash in such cases.
9.5
Biotin treatment showed significant effect
We examined a patient diagnosed with holocarboxylase synthetase (HCS) deficiency, who presented with a notable rash and other severe symptoms. This condition disrupts biotin's incorporation into enzymes, leading to serious health challenges.
After starting biotin treatment, we observed remarkable improvement in the patient’s condition, including normal growth and development over three years. This case highlights the importance of prompt diagnosis and treatment to avoid serious complications associated with biotin deficiency.
After starting biotin treatment, we observed remarkable improvement in the patient’s condition, including normal growth and development over three years. This case highlights the importance of prompt diagnosis and treatment to avoid serious complications associated with biotin deficiency.
User Reviews
USERS' SCORE
Good
Based on 16 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Rash improved
453 people found this helpful
I'm enthusiastic about these vitamins! Recently, I developed a rash on my forehead and brittle nails. As a mother with a hectic schedule, I recognised the need for vitamins. I ordered these based on reviews, hoping they would help. I’ve been taking them for a month now, and the results are impressive. The rash has disappeared, my nails feel stronger, and my skin has improved significantly. Notably, my hair has begun to grow again, with new strands sprouting. I would recommend these vitamins to anyone looking for a boost!
9
Rash gone
8 people found this helpful
I bought this for my sister since my hair started falling out. The gummies taste delightful and are effective against dandruff, hair loss, brittle nails, and facial skin issues. Firstly, the rash has gone, nails are stronger, skin condition has improved, and new hair is sprouting.
10
Rash resolved
4 people found this helpful
These vitamins restored my hair! After noticing significant bald patches, I was desperate for a solution. I took them without researching and didn’t expect much. However, after a month, new hair began to grow, nails improved and no rashes appeared. I feel inspired to keep taking these, as the results are remarkable.
7.5
Hair loss stopped
1 people found this helpful
Very tasty and met my expectations. Since taking these, my nails have stopped breaking, rashes have reduced, and my hair no longer falls out.
9
Rashes decreased
These vitamins suited me well. They taste good, and the dosage is fine. I observe a positive effect; my skin has become softer, rashes clear up faster, and their occurrence has significantly decreased. My nails grow steadily but have gained strength.
Frequently Asked Questions
9
Skin clearer
2 people found this helpful
I bought this supplement to tackle skin rashes, and within three weeks, my face feels clearer and healthier. My nails are stronger and look much better under varnish after this supplement.
9
Rash improved
453 people found this helpful
I'm enthusiastic about these vitamins! Recently, I developed a rash on my forehead and brittle nails. As a mother with a hectic schedule, I recognised the need for vitamins. I ordered these based on reviews, hoping they would help. I’ve been taking them for a month now, and the results are impressive. The rash has disappeared, my nails feel stronger, and my skin has improved significantly. Notably, my hair has begun to grow again, with new strands sprouting. I would recommend these vitamins to anyone looking for a boost!
7.5
Single rashes reduced
Good vitamins for beauty! After a couple of weeks, the results on my hair were evident as it stopped falling out, and I noticed new growth near my forehead. My skin also improved; single rashes ceased to appear, and it became more elastic. They are quite tasty to consume.
0
Rash persistent
1 people found this helpful
Unfortunately, there was no positive effect on my hair or nails. After a week of taking these, a rash and itching appeared. I stopped them, which alleviated the symptoms, but they returned when I tried again at a lower dose.
6
Minor rash noted
Delicious jelly! After the first week, I developed a rash on my face, but it's not as concerning as it may sound. The effect on my hair was good, and eventually, everything subsided.
9
Rash gone
8 people found this helpful
I bought this for my sister since my hair started falling out. The gummies taste delightful and are effective against dandruff, hair loss, brittle nails, and facial skin issues. Firstly, the rash has gone, nails are stronger, skin condition has improved, and new hair is sprouting.
10
Rash resolved
4 people found this helpful
These vitamins restored my hair! After noticing significant bald patches, I was desperate for a solution. I took them without researching and didn’t expect much. However, after a month, new hair began to grow, nails improved and no rashes appeared. I feel inspired to keep taking these, as the results are remarkable.
6
Skin improved
3 people found this helpful
You won’t forget to take these vitamins! They are the tastiest I’ve tried, providing a beneficial dose of biotin for skin, nails, and hair. Each serving contains 2500 mcg, which is sufficient for strengthening hair and nails. It’s crucial to follow the recommended dose as excessive use can lead to skin rashes and other adverse effects. I take two gummies each morning, which taste like sweet treats. Although I've noticed only small improvements so far, my skin's condition and hair quality are gradually enhancing.
2
Rash disappeared quickly
I experienced an allergic reaction on my skin from this product. Once I stopped taking it, the red rashes vanished. It may be effective, but it just didn't work for me.
We evaluated two premature twin infants who experienced serious health issues due to riboflavin and biotin deficiencies. They presented with skin rash and other severe complications while receiving prolonged parenteral nutrition.
After starting biotin and riboflavin supplementation, the surviving twin showed significant improvement within a few days. Remarkably, the rash and other clinical signs improved, allowing him to be discharged in stable condition.
This case highlights the positive impact of biotin on rash resolution in the context of vitamin deficiencies.
After starting biotin and riboflavin supplementation, the surviving twin showed significant improvement within a few days. Remarkably, the rash and other clinical signs improved, allowing him to be discharged in stable condition.
This case highlights the positive impact of biotin on rash resolution in the context of vitamin deficiencies.
9.5
We reviewed the clinical and biochemical characteristics of 28 Chinese patients with holocarboxylase synthetase (HLCS) deficiency. Through this retrospective analysis, we observed that most patients exhibited symptoms like rash, seizures, and vomiting. However, after timely biotin supplementation, almost all showed remarkable improvement in their symptoms and overall health.
This suggests that biotin therapy plays a vital role in managing HLCS deficiency, leading to low mortality rates and encouraging long-term outcomes. Early diagnosis through newborn screening is highlighted as essential for effective treatment.
This suggests that biotin therapy plays a vital role in managing HLCS deficiency, leading to low mortality rates and encouraging long-term outcomes. Early diagnosis through newborn screening is highlighted as essential for effective treatment.
9
We examined a rare case of a 3-year-old boy who faced severe respiratory distress and a persistent rash due to biotinidase deficiency. Initially, the symptoms were typical but progressed to include restlessness and mental decline over two years. After a detailed examination, we diagnosed him with this uncommon condition and began treatment with supplemental biotin. Remarkably, he responded well to the treatment, highlighting biotin's role in addressing the rash and other symptoms associated with this metabolic disorder.
7
Biotin supplementation improves rash symptoms
We explored how valproic acid (VPA), a common treatment for seizures, influences biotin levels and skin rashes in children. In our study with 75 young patients, we discovered that VPA can lower biotinidase activity, leading to dermatological issues like rashes and hair loss.
Interestingly, when we supplemented these patients with biotin, we observed improvements in their skin lesions. This indicates that while VPA may cause side effects related to biotin deficiency, biotin treatment can help manage these reactions effectively.
Interestingly, when we supplemented these patients with biotin, we observed improvements in their skin lesions. This indicates that while VPA may cause side effects related to biotin deficiency, biotin treatment can help manage these reactions effectively.
References
- Zou H, Yang L, Zhang R, Qin Y. Case report: A case of holocarboxylase synthetase deficiency with respiratory tract as the initial symptom. Front Genet. 2024;15:1439343. 10.3389/fgene.2024.1439343
- Kim SW, Lee HJ, Choi N, Kim EK, Ko JM. Dramatic Clinical Improvement With Biotin Mega-Dose Therapy in a Neonate With Holocarboxylase Synthetase Deficiency. Mol Genet Genomic Med. 2024;12:e70002. 10.1002/mgg3.70002
- Adie MA, Martes Gomez M, Yom J, Durand M, Wertheimer F, et al. Twin Premature Infants With Riboflavin and Biotin Deficiency Presenting With Refractory Lactic Acidosis, Rash, and Multiorgan Failure During Prolonged Parenteral Nutrition. J Investig Med High Impact Case Rep. 2023;11:23247096231168111. 10.1177/23247096231168111
- Ling S, Qiu W, Zhang H, Liang L, Lu D, et al. Clinical, biochemical, and genetic analysis of 28 Chinese patients with holocarboxylase synthetase deficiency. Orphanet J Rare Dis. 2023;18:48. 10.1186/s13023-023-02656-y
- Shoaib M, Faraz A, Ahmed SA, Jamil M, Aijaz Z. Diagnostic Dilemma Of Biotinidase Deficiency: Case Of A Child From Pakistan. J Ayub Med Coll Abbottabad. 2016;28:821.
- Ogawa Y, Kiba T, Nakano K, Fujiwara K, Taniguchi H, et al. [Prospective study of biotin treatment in patients with erythema due to gefitinib or erlotinib]. Gan To Kagaku Ryoho. 2014;41:517.
- Hui J, Law E, Chung C, Fung S, Yuen P, et al. The first reported HLCS gene mutation causing holocarboxylase synthetase deficiency in a Vietnamese patient. World J Pediatr. 2012;8:278. 10.1007/s12519-011-0301-9
- Rajendiran A, Sampath S. Biotinidase deficiency--clinching the diagnosis rapidly can make all the difference!. BMJ Case Rep. 2011;2011. 10.1136/bcr.07.2011.4494
- Chou IC, Wang CS, Lin WD, Lin HC, Tsai CH, et al. Holocarboxylase synthetase deficiency: report of one case. Acta Paediatr Taiwan. 2006;47:309.
- Kimura M, Fukui T, Tagami Y, Fujiwaki T, Yokoyama M, et al. Normalization of low biotinidase activity in a child with biotin deficiency after biotin supplementation. J Inherit Metab Dis. 2003;26:715.
- Schulpis KH, Karikas GA, Tjamouranis J, Regoutas S, Tsakiris S. Low serum biotinidase activity in children with valproic acid monotherapy. Epilepsia. 2001;42:1359.
- Gulati S, Passi GR, Kumar A, Kabra M, Kalra V, et al. Biotinidase deficiency--a treatable entity. Indian J Pediatr. 2000;67:464.
- Suormala T, Fowler B, Duran M, Burtscher A, Fuchshuber A, et al. Five patients with a biotin-responsive defect in holocarboxylase formation: evaluation of responsiveness to biotin therapy in vivo and comparative biochemical studies in vitro. Pediatr Res. 1997;41:666.
- Livne M, Gibson KM, Amir N, Eshel G, Elpeleg ON. Holocarboxylase synthetase deficiency: a treatable metabolic disorder masquerading as cerebral palsy. J Child Neurol. 1994;9:170.
- Héron B, Gautier A, Dulac O, Ponsot G. [Biotinidase deficiency. Progressive encephalopathy curable with biotin]. Arch Fr Pediatr. 1993;50:875.
- McVoy JR, Levy HL, Lawler M, Schmidt MA, Ebers DD, et al. Partial biotinidase deficiency: clinical and biochemical features. J Pediatr. 1990;116:78.
