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SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.3
USERS' SCORE
Good
Based on 1 Review
8.6
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B-6 (as Pyridoxine Hydrochloride)
100 mg
5,882%
Top Medical Research Studies
8
Vitamin B6 may lower kidney stones
Intake of vitamins B6 and C and the risk of kidney stones in women.
Focus on vitamin B6 effects
We examined the relationship between vitamin B6 intake and kidney stone formation in women. This research involved over 85,000 women with no prior history of kidney stones, monitored over 14 years. The study utilized food-frequency questionnaires to track participants' dietary vitamin consumption from both food and supplements.
Our findings revealed that higher vitamin B6 intake appeared to lower the risk of developing kidney stones. Specifically, women consuming 40 mg or more of vitamin B6 per day had a risk reduction, with a relative risk of 0.66 compared to those taking less than 3 mg per day. This suggests that large doses of vitamin B6 might help in preventing the formation of these painful stones.
On the other hand, vitamin C intake did not show a significant link to kidney stone risk. Women who consumed high amounts of vitamin C didn't experience an increased or decreased risk of kidney stones relative to those with lower intake levels. Therefore, we conclude that while vitamin B6 may provide protective benefits against kidney stones, restricting vitamin C isn't necessary for prevention.
Our findings revealed that higher vitamin B6 intake appeared to lower the risk of developing kidney stones. Specifically, women consuming 40 mg or more of vitamin B6 per day had a risk reduction, with a relative risk of 0.66 compared to those taking less than 3 mg per day. This suggests that large doses of vitamin B6 might help in preventing the formation of these painful stones.
On the other hand, vitamin C intake did not show a significant link to kidney stone risk. Women who consumed high amounts of vitamin C didn't experience an increased or decreased risk of kidney stones relative to those with lower intake levels. Therefore, we conclude that while vitamin B6 may provide protective benefits against kidney stones, restricting vitamin C isn't necessary for prevention.
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9
Vitamin B6 aids in kidney stone prevention
[Morphometrical study on inhibitory effect of vitamin B6 and banana-stem extract on calcium crystallization].
Study relevant for kidney stone treatment
We conducted a study to investigate the potential of vitamin B6 and banana stem extract in preventing kidney stones, specifically focusing on their effects on calcium oxalate crystallization. Our research involved thirty-six male China-1 mice, which were placed into four groups: a normal group, a crystallization group, and two treatment groups receiving vitamin B6 and banana stem extract, respectively. The mice in the latter three groups were induced with calcium oxalate crystallization through specific solutions for a duration of three weeks.
After the experimental period, we carefully observed the results. We found that both vitamin B6 and banana stem extract significantly reduced the areas of crystallization compared to the crystallization-only group. Interestingly, the banana stem extract group showed even more promising results, indicating the lowest crystallization density. Additionally, the levels of oxalate in the renal tissue were notably decreased in both treatment groups. However, it's worth mentioning that neither treatment appeared to impact the calcium content in the kidney tissues.
Our findings suggest that vitamin B6 may offer beneficial effects alongside banana stem extract in managing conditions related to kidney stones, particularly in cases of hypercalciuric urolithiasis. This opens up avenues for further exploration in dietary interventions for individuals prone to kidney stone formation.
After the experimental period, we carefully observed the results. We found that both vitamin B6 and banana stem extract significantly reduced the areas of crystallization compared to the crystallization-only group. Interestingly, the banana stem extract group showed even more promising results, indicating the lowest crystallization density. Additionally, the levels of oxalate in the renal tissue were notably decreased in both treatment groups. However, it's worth mentioning that neither treatment appeared to impact the calcium content in the kidney tissues.
Our findings suggest that vitamin B6 may offer beneficial effects alongside banana stem extract in managing conditions related to kidney stones, particularly in cases of hypercalciuric urolithiasis. This opens up avenues for further exploration in dietary interventions for individuals prone to kidney stone formation.
Read More
8
Vitamin B6 may prevent stones
Multivitamins co-intake can reduce the prevalence of kidney stones: a large-scale cross-sectional study.
Associates B6 with kidney health
We explored the connection between vitamin B6 intake and the prevalence of kidney stones through a large-scale analysis of health data. Our research included data from the National Health and Nutrition Examination Survey (NHANES), where we looked at the effects of nine common vitamins on kidney stone development. By using advanced clustering techniques and logistic regression models, we aimed to identify patterns that could shed light on this relationship.
Our findings revealed that higher intake levels of vitamin B6 were associated with a reduced risk of developing kidney stones. Specifically, the results indicated that participants with high vitamin B6 intake showed a significant decrease in kidney stone prevalence, which highlights the potential protective effect of this vitamin.
Moreover, we noted a similar beneficial trend with vitamin D intake, while the effects of vitamin C appeared more complex, initially suggesting a protective role before eventually turning into a risk factor at higher intake levels. This multifaceted analysis emphasizes the importance of considering vitamin combinations, as the collective intake of several vitamins also contributed to lower risks of kidney stone formation.
In summary, our findings suggest that ensuring proper levels of vitamin B6, along with a balanced intake of other essential vitamins, may play a crucial role in kidney stone prevention.
Our findings revealed that higher intake levels of vitamin B6 were associated with a reduced risk of developing kidney stones. Specifically, the results indicated that participants with high vitamin B6 intake showed a significant decrease in kidney stone prevalence, which highlights the potential protective effect of this vitamin.
Moreover, we noted a similar beneficial trend with vitamin D intake, while the effects of vitamin C appeared more complex, initially suggesting a protective role before eventually turning into a risk factor at higher intake levels. This multifaceted analysis emphasizes the importance of considering vitamin combinations, as the collective intake of several vitamins also contributed to lower risks of kidney stone formation.
In summary, our findings suggest that ensuring proper levels of vitamin B6, along with a balanced intake of other essential vitamins, may play a crucial role in kidney stone prevention.
Read More
Most Useful Reviews
9.5
Removes kidney stones
Pills dissolve kidney stones effectively.
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Most Recommended Products for Kidney Stones
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.3
9
Vitamin B6 may reduce stones
Pyridoxamine lowers oxalate excretion and kidney crystals in experimental hyperoxaluria: a potential therapy for primary hyperoxaluria.
Moderate relevance to vitamin B6
The study examined the potential of pyridoxamine, a derivative of vitamin B6, in reducing kidney stones and oxalate excretion in conditions known as hyperoxaluria. The researchers aimed to find an effective treatment that would lower urine oxalate levels, which contribute significantly to kidney stone formation.
They tested this using an experimental model with rats, comparing those treated with pyridoxamine to a control group. We observed marked reductions in both urine glycolate and oxalate excretion in the rats given pyridoxamine. These reductions were notable, approximately 50%, when compared to the untreated hyperoxaluric animals.
Additionally, the treatment led to a significant drop in the formation of calcium oxalate crystals, which are a primary component of kidney stones. This finding, combined with the safety profile of pyridoxamine in humans, suggests that it could be a promising option for managing primary hyperoxaluria and related kidney stone issues.
Overall, the potential of pyridoxamine as a therapeutic treatment appears significant and worthy of further exploration for those suffering from kidney stone diseases.
They tested this using an experimental model with rats, comparing those treated with pyridoxamine to a control group. We observed marked reductions in both urine glycolate and oxalate excretion in the rats given pyridoxamine. These reductions were notable, approximately 50%, when compared to the untreated hyperoxaluric animals.
Additionally, the treatment led to a significant drop in the formation of calcium oxalate crystals, which are a primary component of kidney stones. This finding, combined with the safety profile of pyridoxamine in humans, suggests that it could be a promising option for managing primary hyperoxaluria and related kidney stone issues.
Overall, the potential of pyridoxamine as a therapeutic treatment appears significant and worthy of further exploration for those suffering from kidney stone diseases.
Read More
9
Vitamin B6 aids in kidney stone prevention
[Morphometrical study on inhibitory effect of vitamin B6 and banana-stem extract on calcium crystallization].
Study relevant for kidney stone treatment
We conducted a study to investigate the potential of vitamin B6 and banana stem extract in preventing kidney stones, specifically focusing on their effects on calcium oxalate crystallization. Our research involved thirty-six male China-1 mice, which were placed into four groups: a normal group, a crystallization group, and two treatment groups receiving vitamin B6 and banana stem extract, respectively. The mice in the latter three groups were induced with calcium oxalate crystallization through specific solutions for a duration of three weeks.
After the experimental period, we carefully observed the results. We found that both vitamin B6 and banana stem extract significantly reduced the areas of crystallization compared to the crystallization-only group. Interestingly, the banana stem extract group showed even more promising results, indicating the lowest crystallization density. Additionally, the levels of oxalate in the renal tissue were notably decreased in both treatment groups. However, it's worth mentioning that neither treatment appeared to impact the calcium content in the kidney tissues.
Our findings suggest that vitamin B6 may offer beneficial effects alongside banana stem extract in managing conditions related to kidney stones, particularly in cases of hypercalciuric urolithiasis. This opens up avenues for further exploration in dietary interventions for individuals prone to kidney stone formation.
After the experimental period, we carefully observed the results. We found that both vitamin B6 and banana stem extract significantly reduced the areas of crystallization compared to the crystallization-only group. Interestingly, the banana stem extract group showed even more promising results, indicating the lowest crystallization density. Additionally, the levels of oxalate in the renal tissue were notably decreased in both treatment groups. However, it's worth mentioning that neither treatment appeared to impact the calcium content in the kidney tissues.
Our findings suggest that vitamin B6 may offer beneficial effects alongside banana stem extract in managing conditions related to kidney stones, particularly in cases of hypercalciuric urolithiasis. This opens up avenues for further exploration in dietary interventions for individuals prone to kidney stone formation.
Read More
8
Vitamin B6 may prevent stones
Multivitamins co-intake can reduce the prevalence of kidney stones: a large-scale cross-sectional study.
Associates B6 with kidney health
We explored the connection between vitamin B6 intake and the prevalence of kidney stones through a large-scale analysis of health data. Our research included data from the National Health and Nutrition Examination Survey (NHANES), where we looked at the effects of nine common vitamins on kidney stone development. By using advanced clustering techniques and logistic regression models, we aimed to identify patterns that could shed light on this relationship.
Our findings revealed that higher intake levels of vitamin B6 were associated with a reduced risk of developing kidney stones. Specifically, the results indicated that participants with high vitamin B6 intake showed a significant decrease in kidney stone prevalence, which highlights the potential protective effect of this vitamin.
Moreover, we noted a similar beneficial trend with vitamin D intake, while the effects of vitamin C appeared more complex, initially suggesting a protective role before eventually turning into a risk factor at higher intake levels. This multifaceted analysis emphasizes the importance of considering vitamin combinations, as the collective intake of several vitamins also contributed to lower risks of kidney stone formation.
In summary, our findings suggest that ensuring proper levels of vitamin B6, along with a balanced intake of other essential vitamins, may play a crucial role in kidney stone prevention.
Our findings revealed that higher intake levels of vitamin B6 were associated with a reduced risk of developing kidney stones. Specifically, the results indicated that participants with high vitamin B6 intake showed a significant decrease in kidney stone prevalence, which highlights the potential protective effect of this vitamin.
Moreover, we noted a similar beneficial trend with vitamin D intake, while the effects of vitamin C appeared more complex, initially suggesting a protective role before eventually turning into a risk factor at higher intake levels. This multifaceted analysis emphasizes the importance of considering vitamin combinations, as the collective intake of several vitamins also contributed to lower risks of kidney stone formation.
In summary, our findings suggest that ensuring proper levels of vitamin B6, along with a balanced intake of other essential vitamins, may play a crucial role in kidney stone prevention.
Read More
8
Vitamin B6 improves AGT function
Effects of alanine:glyoxylate aminotransferase variants and pyridoxine sensitivity on oxalate metabolism in a cell-based cytotoxicity assay.
Significant findings on AGT variants
We explored the relationship between vitamin B6, also known as pyridoxine, and kidney stone formation, specifically in patients with primary hyperoxaluria type 1 (PH1). This condition arises from a deficiency in the enzyme alanine:glyoxylate aminotransferase (AGT), crucial for breaking down certain compounds in the liver. Among PH1 patients, about one-third have shown a clinical response to pharmacological doses of pyridoxine, especially those carrying specific AGT mutations.
To investigate this further, we utilized a cell-based cytotoxicity assay involving CHO cells expressing glycolate oxidase (GO) and various AGT variants. This setup allowed us to measure how well these AGT variants could counteract the toxic effects of glycolate, a compound that contributes to kidney stone formation. We observed that normal AGTs helped reduce the levels of harmful oxalate and glyoxylate, which are byproducts of glycolate, effectively improving cell survival.
Moreover, we found that increasing extracellular pyridoxine concentrations—up to 0.3μM—enhanced the metabolic effectiveness of normal AGTs and the variant AGT-Gly170Arg. This enhancement was associated with a significant reduction in oxalate and glyoxylate levels, directly linking vitamin B6's role to improved management of the metabolic processes involved in kidney stone formation.
Overall, our findings support the idea that vitamin B6 can improve the functionality of AGT, thus potentially offering a therapeutic route for managing PH1 and its associated kidney stone risks. This research not only enhances our understanding of PH1 but also opens avenues for developing better treatments for kidney stone diseases in general.
To investigate this further, we utilized a cell-based cytotoxicity assay involving CHO cells expressing glycolate oxidase (GO) and various AGT variants. This setup allowed us to measure how well these AGT variants could counteract the toxic effects of glycolate, a compound that contributes to kidney stone formation. We observed that normal AGTs helped reduce the levels of harmful oxalate and glyoxylate, which are byproducts of glycolate, effectively improving cell survival.
Moreover, we found that increasing extracellular pyridoxine concentrations—up to 0.3μM—enhanced the metabolic effectiveness of normal AGTs and the variant AGT-Gly170Arg. This enhancement was associated with a significant reduction in oxalate and glyoxylate levels, directly linking vitamin B6's role to improved management of the metabolic processes involved in kidney stone formation.
Overall, our findings support the idea that vitamin B6 can improve the functionality of AGT, thus potentially offering a therapeutic route for managing PH1 and its associated kidney stone risks. This research not only enhances our understanding of PH1 but also opens avenues for developing better treatments for kidney stone diseases in general.
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8
Magnesium and Vitamin B6 prevent stones
[Experimental evidence of magnesium salts for treatment of calcium oxalate nephrolithiasis in an animal model based on sodium oxalate and a cyclooxygenase 2 selective inhibitor].
Influence of vitamin B6 assessed
We investigated the impact of magnesium salts, particularly magnesium L-aspartate and magnesium chloride, and their combination with vitamin B6 in preventing the formation of calcium oxalate kidney stones. In a controlled animal study, a specific diet high in sodium oxalate was used to induce kidney stone development.
Over the course of the study, we observed that rats treated with various magnesium salts showed a significant reduction in urinary oxalate levels—by about 45%. Furthermore, these treatments were linked to an increase in creatinine clearance, indicating improved kidney function. The ratio of calcium to magnesium also decreased, which is a positive outcome regarding stone formation.
Notably, when magnesium L-aspartate and MagneB6 were compared with other magnesium salts, they emerged as the most effective in preventing kidney stone formation. Our findings highlight the potential of combining vitamin B6 with magnesium as a promising strategy to mitigate calcium oxalate nephrolithiasis.
Over the course of the study, we observed that rats treated with various magnesium salts showed a significant reduction in urinary oxalate levels—by about 45%. Furthermore, these treatments were linked to an increase in creatinine clearance, indicating improved kidney function. The ratio of calcium to magnesium also decreased, which is a positive outcome regarding stone formation.
Notably, when magnesium L-aspartate and MagneB6 were compared with other magnesium salts, they emerged as the most effective in preventing kidney stone formation. Our findings highlight the potential of combining vitamin B6 with magnesium as a promising strategy to mitigate calcium oxalate nephrolithiasis.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.6
9.5
Removes kidney stones
Pills dissolve kidney stones effectively.
