We delved into an interesting case of a 76-year-old man who developed severe esophageal ulcers, likely due to zinc deficiency following a total gastrectomy. His symptoms included sore throat, heartburn, and difficulty swallowing.
After the diagnosis of zinc deficiency, he began oral zinc treatment. Remarkably, this led to significant symptom relief and visible healing of the ulcers during follow-up imaging. Impressively, he has maintained his zinc supplementation for five years without any recurrence of symptoms. This unique case shines a light on the potential role of zinc in ulcer healing.
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8
Zinc aids in ulcer reduction
Regulation of NLRP3 inflammasome by zinc supplementation in Behçet's disease patients: A double-blind, randomized placebo-controlled clinical trial.
We moved forward with a double-blind, placebo-controlled study to see how zinc affects ulcers in patients with Behçet's disease. Over 12 weeks, 50 participants received either zinc gluconate or a placebo.
The results revealed that zinc significantly reduced the occurrence of genital ulcers and inflammation markers like NLRP3 and caspase-1. In fact, zinc supplementation improved clinical conditions and decreased inflammatory markers, showing promise as an additional therapy for managing Behçet's disease.
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8
Zinc treatment comparable for ulcers
Comparison of the Efficacy of Polaprezinc Plus Proton Pump Inhibitor and Rebamipide Plus Proton Pump Inhibitor Treatments for Endoscopic Submucosal Dissection-induced Ulcers.
We explored how polaprezinc combined with a proton pump inhibitor (PPI) stacks up against rebamipide with PPI treatment for ulcers resulting from endoscopic submucosal dissection (ESD). Involving 210 patients, the study randomly assigned them to either treatment group and evaluated their ulcer healing rates after four weeks.
We found that polaprezinc's healing effectiveness was comparable to that of rebamipide, with healing rates at 90.3% and 91.4% respectively. This means that while both treatments are effective, we didn’t observe a significant advantage of one over the other in promoting ulcer healing.
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Most Useful Reviews
9
Safe for ulcers
Very suitable for my family... safe for stomach ulcers and GERD.
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7.5
Supports ulcer healing
Zinc is a nutrient that must be consistently obtained from food and supplements, as the body does not produce or store it. It is essential for immune system protection and wound healing. A deficiency can increase susceptibility to diseases. Zinc aids immune function and wound recovery, making it vital for addressing chronic wounds and ulcers. It has been shown that seniors taking zinc may respond better to flu vaccinations and have a lower risk of infectious diseases. Overall, proper zinc intake is crucial for maintaining skin and mucous membrane health, especially in ulcer treatment.
Read More
6
Effective for ulcers
Cheap, so buy it! I've heard that zinc supplementation is beneficial for oral ulcers.
We explored the impact of zinc when incorporated into first-line treatments for Helicobacter pylori infections, particularly in patients suffering from ulcers. In a multicenter registry study involving 800 patients, we noted that the most common factors leading to treatment were dyspepsia and gastroduodenal ulcers.
The findings indicated that quadruple therapy—both with and without bismuth—improved eradication rates significantly, achieving about 94.9%. Meanwhile, zinc as a part of a sequential therapy showed an impressive effectiveness of 95.6%. However, since zinc was combined with other treatments, it’s challenging to pinpoint its isolated effects on ulcer healing or eradication efficacy.
We also observed that adverse events, though reported in nearly 29% of cases, were generally mild, suggesting that the treatments were well-tolerated. Overall, the report highlighted that while zinc may enhance treatment effectiveness when combined, its individual contribution remains undetermined.
Read More
9
Zinc treatment has therapeutic potential
Treatment of Acute Ulcerative Colitis with Zinc Hyaluronate in Mice.
We investigated the effects of zinc hyaluronate (ZnHA) on ulcerative colitis (UC) using a mouse model that simulates the condition. This study aimed to explore how ZnHA could potentially alleviate the symptoms of UC, focusing on factors like inflammation and gut health.
Our experiments showed that ZnHA significantly reduced key symptoms associated with UC, such as weight loss, loose stools, and the presence of blood in stools. We also noticed notable changes at a cellular level; ZnHA helped decrease levels of inflammatory markers like tumor necrosis factor-α and interleukin-6 while boosting interleukin-10, a factor known for anti-inflammatory effects.
Additionally, our findings revealed that ZnHA positively impacted gut bacteria. It fostered the growth of beneficial bacteria that produce propionic acid, which is crucial for gut health. We also observed that ZnHA enhanced the function of proteins that maintain the intestinal barrier, such as ZO-1 and occludin.
Overall, our exploration highlights the potential of ZnHA as a supportive treatment for UC by targeting inflammation and promoting a healthy gut environment. This study provides new insights that could encourage further development of hyaluronic acid-based treatments for UC and similar conditions.
Read More
9
Zinc enhances diabetic ulcer healing
Enhanced diabetic foot ulcer treatment with a chitosan-based thermosensitive hydrogel loaded self-assembled multi-functional nanoparticles for antibacterial and angiogenic effects.
We explored how a new treatment for diabetic foot ulcers (DFUs) works, focusing on the role of zinc. This innovative formulation combines zinc with other therapeutic agents in a chitosan-based hydrogel that responds to heat. Our aim was to see if this treatment could not only fight bacteria but also help the body heal more effectively.
The combination of zinc with chlorogenic acid and indocyanine green promotes a healing environment by reducing inflammation and oxidative stress at the ulcer site. This hydrogel is designed to release its active ingredients right where they’re needed, and we found that it significantly enhances the expression of proteins important for blood vessel formation, including VEGF and CD31.
In our experiments, both in the lab and in real-life conditions, this zinc-enriched hydrogel showed promising results. It effectively inhibited the growth of the common bacteria Staphylococcus aureus after applying laser treatment and helped wounds remodel within 14 days.
This study suggests that incorporating zinc into wound care strategies could significantly improve treatment outcomes for patients suffering from DFUs. Overall, our findings open up new avenues for managing this challenging health issue.
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9
New treatment reduces digital dermatitis
Investigation on the effectiveness of a new hoof care product to sustainably reduce and prevent digital dermatitis in dairy cow herds.
We embarked on an investigation to understand whether a new hoof care product featuring iron, zinc, and aluminum can effectively reduce and prevent digital dermatitis (DD) in dairy cows. In a controlled trial involving over 130 dairy cows, we treated one hind foot of each cow twice a week with this product while leaving the other foot untreated for comparison.
The results were revealing! Our analysis indicated that the use of the hoof care product significantly reduced the severity of DD compared to the untreated group. In fact, cows treated with the product had a much lower chance of developing lesions. The outcome showed that in the control group, the odds of having a lesion were four times higher than in the treated group, and the likelihood of experiencing an active lesion versus an inactive one was even more pronounced.
Interestingly, we also observed positive outcomes in heifers, with only one developing an active lesion in the treated group, showcasing the potential for this product to help manage and prevent DD even before these young cows enter the herd. The study indicates that the combination of ingredients in this hoof care product could be a promising alternative to traditional, harsher treatments.
While zinc is included as one of the components in the product, it's essential to note that we can't isolate its effect on ulcers from the other ingredients. Therefore, we can't definitively conclude zinc's sole effectiveness when it comes to DD treatment, but the overall findings are encouraging for improving hoof health in dairy cows.
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9
Zinc and Polaprezinc's synergistic effects
Aspergillusidone G Potentiates the Anti-Inflammatory Effects of Polaprezinc in LPS-Induced BV2 Microglia: A Bioinformatics and Experimental Study.
We explored the potential impact of Polaprezinc, a drug commonly used for gastric ulcers, on neuroinflammation, a key factor in neurodegenerative diseases. By using LPS-induced BV-2 microglia, we observed that Polaprezinc significantly reduced the production of harmful compounds like nitric oxide and reactive oxygen species. Additionally, it inhibited the expression of inflammatory markers, suggesting its anti-inflammatory properties may extend beyond ulcer treatment.
Interestingly, we also examined how the combination of Polaprezinc with Aspergillusidone G could enhance these effects. When we treated the microglia with both substances, the results were promising. The duo improved the inhibition of nitric oxide generation from about 30% to an impressive 80%. This indicates a possible synergistic anti-inflammatory effect that could offer new approaches in managing neuroinflammatory conditions.
Overall, our findings shed light on the importance of zinc's role in the therapeutic effects of Polaprezinc, especially when paired with other compounds like Aspergillusidone G. This combination opens up exciting avenues for research into treatments for neurodegenerative diseases, highlighting the crucial connection between inflammation and zinc in the context of ulcer management.
Very suitable for my family... safe for stomach ulcers and GERD.
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7.5
Supports ulcer healing
Zinc is a nutrient that must be consistently obtained from food and supplements, as the body does not produce or store it. It is essential for immune system protection and wound healing. A deficiency can increase susceptibility to diseases. Zinc aids immune function and wound recovery, making it vital for addressing chronic wounds and ulcers. It has been shown that seniors taking zinc may respond better to flu vaccinations and have a lower risk of infectious diseases. Overall, proper zinc intake is crucial for maintaining skin and mucous membrane health, especially in ulcer treatment.
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6
Effective for ulcers
Cheap, so buy it! I've heard that zinc supplementation is beneficial for oral ulcers.
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Frequently Asked Questions
An ulcer is a sore that develops on the lining of the stomach, small intestine, or colon. It occurs when the digestive tract is damaged or inflamed, often due to an imbalance between stomach acid and the protective factors in the digestive system. The most common types of ulcers include peptic ulcers, which can be further categorized into gastric ulcers (located in the stomach) and duodenal ulcers (found in the first part of the small intestine). Symptoms may include burning stomach pain, bloating, and nausea, which can vary in intensity based on the severity of the condition.
Zinc is a versatile metal known for its various applications in industry and health. It is a bluish-white metallic element represented by the symbol Zn and atomic number 30 on the periodic table. Zinc is primarily used for galvanizing steel to prevent rusting, in the manufacturing of alloys, and as a component in batteries. Additionally, zinc plays a crucial role in biological processes, making it an essential trace element in the human diet. It is involved in immune function, protein synthesis, wound healing, and DNA synthesis, highlighting its importance in maintaining overall health and well-being.
Zinc is known to play a role in immune function and wound healing, which can be beneficial for those suffering from ulcers. Research indicates that zinc may help reduce inflammation and promote cell repair, contributing to the healing process of gastric and peptic ulcers. It's important to note that while zinc can support overall gut health and immune function, it should not be viewed as a standalone treatment for ulcers. Instead, it may act as a complementary supplement to other conventional therapies.
Before adding zinc or any supplement to your regimen, it's best to consult with a healthcare provider. They can provide guidance on the appropriate dosage and ensure it won't interact with any medications you may be taking for your ulcer. Furthermore, maintaining a balanced diet rich in antioxidants, vitamins, and minerals is crucial for supporting ulcer healing. While zinc can certainly be a helpful addition to your overall health strategy, relying solely on it without proper medical advice may not yield the desired results.
Based on user reviews, the time it takes to see results from taking supplements for ulcers can vary. Some users noted that zinc, a key component for treating ulcers, can aid in the healing process; however, specific timelines were not mentioned. One user highlighted that zinc is essential for healing and immune function, suggesting that consistent intake may yield noticeable improvement over time Read Review.
While one reviewer mentioned the supplement being suitable for family members with stomach ulcers and GERD, the exact duration for seeing results was not specified Read Review. Therefore, individual responses may vary, and it’s advisable to monitor your progress and consult with a healthcare professional for tailored advice.
Current scientific research points to several promising roles for zinc in the treatment of different types of ulcers, particularly those related to ulcerative colitis and others stemming from bacterial infections. For instance, a study demonstrated that zinc hyaluronate significantly alleviated symptoms of ulcerative colitis in mice by reducing inflammation and promoting healthy gut bacteria [1]. Other studies have shown that forms of zinc, such as zinc oxide nanoparticles, also exhibit protective effects against ulcerative colitis by mitigating inflammation and oxidative stress in the colon [8]. However, while zinc-enhanced treatments have shown beneficial effects in experimental settings, translating these findings to human treatments remains complex.
In the context of ulcers caused by Helicobacter pylori, zinc has been incorporated into treatment regimens and has shown improved eradication rates when used in conjunction with other therapies [5]. Likewise, zinc supplementation has been associated with some improvement in reducing recurrent mouth ulcers, particularly in patients without other underlying conditions like Behçet's disease [2]. Nonetheless, individual effects of zinc on healing various types of ulcers may be influenced by multiple factors, including the presence of other ingredients in formulations [10]. Therefore, while there's scientific support for zinc's role in ulcer management, results can vary, and further research is necessary to fully understand its potential as a standalone treatment.
Users have reported a range of improvements in their symptoms related to ulcers and digestive issues after incorporating zinc supplements into their regimen. Some reviews indicate that individuals found the supplements beneficial for managing stomach ulcers and GERD, with one user saying they were "very suitable" for their family members dealing with these conditions Read Review. Additionally, zinc is highlighted as essential for immune system function and wound healing, suggesting that its consistent intake can lead to decreased susceptibility to infections and better overall health, which may positively impact ulcer recovery Read Review.
Moreover, anecdotal evidence suggests that zinc supplementation may also be beneficial for oral ulcers, with users noting that it could support healing in these instances Read Review. However, as with any supplement, individual experiences can vary widely, and results may depend on several factors, including dosage, duration of use, and overall health. For these reasons, it's advisable for users to consult with a healthcare professional for personalized recommendations and to monitor their progress.
Users have reported favorable outcomes when combining zinc supplements with their regimen for managing ulcers. One review highlighted that the supplement is "very suitable" for individuals dealing with stomach ulcers and GERD, indicating its perceived safety and effectiveness in combination with other treatments Read Review. This suggests that zinc can be a complementary option alongside standard ulcer management strategies, contributing to an overall enhancement in digestive health.
Additionally, zinc's role in immune function and wound healing is often emphasized in user feedback, which may imply that its integration with other supplements could bolster recovery. One reviewer pointed out the necessity of zinc for maintaining mucous membranes and skin health, particularly in ulcer treatment scenarios Read Review. This synergistic approach highlights the importance of combining zinc with other nutrients, as there are claims that it could also aid in the healing of oral ulcers, thus opening avenues for those managing different forms of ulceration Read Review. Overall, users seem to advocate for a thoughtful integration of zinc with other supplements for enhanced ulcer management.
Users report that zinc can be a beneficial supplement for treating ulcers, particularly due to its role in immune function and wound healing. One review mentions that zinc is essential for addressing chronic wounds and ulcers, highlighting its importance in maintaining skin and mucous membrane health, especially when dealing with conditions like stomach ulcers and GERD Read Review. Another user emphasizes that zinc supplementation is not only helpful for stomach ulcers but may also assist in the treatment of oral ulcers Read Review.
Additionally, proper zinc intake is noted as crucial, with users referencing the need for consistent supplementation since the body does not produce or store it, which makes it even more vital for those suffering from ulcers Read Review. However, the reviews do not specify an exact dosage, emphasizing the general benefits of zinc rather than detailing a precise recommendation. Overall, the consensus seems to advocate for zinc as a supportive nutrient in the management of ulcerative conditions.
7.5
Supports ulcer healing
Zinc is a nutrient that must be consistently obtained from food and supplements, as the body does not produce or store it. It is essential for immune system protection and wound healing. A deficiency can increase susceptibility to diseases. Zinc aids immune function and wound recovery, making it vital for addressing chronic wounds and ulcers. It has been shown that seniors taking zinc may respond better to flu vaccinations and have a lower risk of infectious diseases. Overall, proper zinc intake is crucial for maintaining skin and mucous membrane health, especially in ulcer treatment.
9
Safe for ulcers
Very suitable for my family... safe for stomach ulcers and GERD.
6
Effective for ulcers
Cheap, so buy it! I've heard that zinc supplementation is beneficial for oral ulcers.
9
Zinc treatment has therapeutic potential
Treatment of Acute Ulcerative Colitis with Zinc Hyaluronate in Mice.
We investigated the effects of zinc hyaluronate (ZnHA) on ulcerative colitis (UC) using a mouse model that simulates the condition. This study aimed to explore how ZnHA could potentially alleviate the symptoms of UC, focusing on factors like inflammation and gut health.
Our experiments showed that ZnHA significantly reduced key symptoms associated with UC, such as weight loss, loose stools, and the presence of blood in stools. We also noticed notable changes at a cellular level; ZnHA helped decrease levels of inflammatory markers like tumor necrosis factor-α and interleukin-6 while boosting interleukin-10, a factor known for anti-inflammatory effects.
Additionally, our findings revealed that ZnHA positively impacted gut bacteria. It fostered the growth of beneficial bacteria that produce propionic acid, which is crucial for gut health. We also observed that ZnHA enhanced the function of proteins that maintain the intestinal barrier, such as ZO-1 and occludin.
Overall, our exploration highlights the potential of ZnHA as a supportive treatment for UC by targeting inflammation and promoting a healthy gut environment. This study provides new insights that could encourage further development of hyaluronic acid-based treatments for UC and similar conditions.
9
Zinc nanoparticles may protect intestinal health
Protective effect of zinc oxide nanoparticles synthesized using Cassia alata for DSS-induced ulcerative colitis in mice model.
We explored the impact of zinc oxide nanoparticles (ZnO NPs) derived from the Cassia alata plant on ulcerative colitis (UC) in a mouse model. Ulcerative colitis is a common inflammatory bowel disease that results in chronic inflammation of the colorectal area, leading to various symptoms and complications. The study aimed to determine whether these zinc nanoparticles could provide protective benefits against UC, particularly following induction with dextran sodium sulfate (DSS).
Our findings revealed that the ZnO NPs showed promise in mitigating several negative effects associated with UC. We observed improvements in weight loss, disease activity index, colon shortening, and overall colon health in the treated mice. The green synthesized ZnO NPs demonstrated anti-inflammatory properties, helping to reduce hypersensitivity and oxidative stress, effectively protecting the mucosal layer of the colon.
However, it is important to note that the study focused on ZnO NPs as part of a natural herbal treatment, rather than isolating zinc as a singular therapeutic agent. Although our results indicate a potential protective effect, further research would be beneficial to fully understand the role of zinc itself in treating ulcerative colitis.
9.5
Zinc's role in ulcer treatment
[Argentinean registry on the management of Helicobacter pylori infection: effectiveness and safety of first line treatment].
We explored the impact of zinc when incorporated into first-line treatments for Helicobacter pylori infections, particularly in patients suffering from ulcers. In a multicenter registry study involving 800 patients, we noted that the most common factors leading to treatment were dyspepsia and gastroduodenal ulcers.
The findings indicated that quadruple therapy—both with and without bismuth—improved eradication rates significantly, achieving about 94.9%. Meanwhile, zinc as a part of a sequential therapy showed an impressive effectiveness of 95.6%. However, since zinc was combined with other treatments, it’s challenging to pinpoint its isolated effects on ulcer healing or eradication efficacy.
We also observed that adverse events, though reported in nearly 29% of cases, were generally mild, suggesting that the treatments were well-tolerated. Overall, the report highlighted that while zinc may enhance treatment effectiveness when combined, its individual contribution remains undetermined.
7
Zinc shows promise for ulcers
The Possible Impact of Zinc-Enriched Multivitamins on Treatment-Naïve Recurrent Aphthous Stomatitis Patients.
We explored how zinc-enriched multivitamins could help patients suffering from recurrent aphthous stomatitis, a condition marked by painful mouth ulcers. Our study focused on those who had not yet tried any treatments and aimed to find a safer alternative to traditional medications. Over a decade, we gathered data from 201 patients who took a daily zinc supplement called ZnVita for at least a month.
After analyzing the results, we found that 58.7% of patients experienced some level of relief from their symptoms. Notably, those who had symptoms related to Behçet's disease were less likely to benefit from the zinc treatment. We were pleased to see that the treatment was generally well-tolerated, with only a small percentage reporting mild digestive issues.
Overall, our findings suggest that zinc supplementation could provide valuable relief for a significant number of patients dealing with these painful ulcers, particularly for those without concurrent Behçet's disease symptoms. This could lead to a reduced reliance on more invasive treatments in the future.
8
Zinc's Impact on Chronic Ulcers
Impact of oral nutritional supplement composition on healing of different chronic wounds: A systematic review.
We set out to explore how zinc, when included in oral nutritional formulas, impacts the healing of chronic ulcers. Our investigation looked at various research involving a total of 741 patients with different types of wounds, which primarily included pressure injuries and diabetic foot ulcers.
Among the studies we examined, some suggested that a hypercaloric and hyperproteic formula enriched with zinc, along with important vitamins A, C, and E, could promote wound healing effectively. Specifically, four studies indicated that these enriched formulas led to a noticeable reduction in wound area, showcasing an increase in healing rates.
However, it's worth noting that two studies reported no significant differences in healing rates when zinc was incorporated into the treatment. Additionally, other approaches featuring combinations like arginine and glutamine did not show significant improvements over the control groups, further complicating the picture.
This indicates that while zinc might play a beneficial role, the evidence isn't uniformly strong regarding its isolated effect on ulcer healing. Overall, we found that a desirable formula for promoting healing seems to focus on high calories, protein content, and antioxidants, which may include zinc as part of a larger cocktail of nutrients.
References
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Seo HR, Chung KB, Kim DY. The Possible Impact of Zinc-Enriched Multivitamins on Treatment-Naïve Recurrent Aphthous Stomatitis Patients. J Clin Med. 2025;14. doi:10.3390/jcm14010260
Wu Z, Wu W, Zhang C, Zhang W, Li Y, et al. Enhanced diabetic foot ulcer treatment with a chitosan-based thermosensitive hydrogel loaded self-assembled multi-functional nanoparticles for antibacterial and angiogenic effects. Carbohydr Polym. 2025;347:122740. doi:10.1016/j.carbpol.2024.122740
Grimm K, Fiedler A, Kröger C. Investigation on the effectiveness of a new hoof care product to sustainably reduce and prevent digital dermatitis in dairy cow herds. J Dairy Sci. 2025;108:1869. doi:10.3168/jds.2024-25134
Laudanno O, Ahumaran G, Thome M, Adami P, Ustares F, et al. [Argentinean registry on the management of Helicobacter pylori infection: effectiveness and safety of first line treatment]. Medicina (B Aires). 2024;84:884.
Huang Y, Shang S, Du H. Causal association of micronutrients and supplements with pressure ulcer: A Mendelian randomization study. Skin Res Technol. 2024;30:e13904. doi:10.1111/srt.13904
Ban F, Zhou L, Yang Z, Liu Y, Zhang Y. Aspergillusidone G Potentiates the Anti-Inflammatory Effects of Polaprezinc in LPS-Induced BV2 Microglia: A Bioinformatics and Experimental Study. Mar Drugs. 2024;22. doi:10.3390/md22070324
Govindarasu M, Vaiyapuri M, Kim JC. Protective effect of zinc oxide nanoparticles synthesized using Cassia alata for DSS-induced ulcerative colitis in mice model. Bioprocess Biosyst Eng. 2024;47:1393. doi:10.1007/s00449-024-03047-8
Zheng M, Xie C, Ye D, Chen Y, Wang Z, et al. Qingzhuan dark tea polysaccharides-zinc alleviates dextran sodium sulfate-induced ulcerative colitis. J Sci Food Agric. 2024;104:7617. doi:10.1002/jsfa.13597
Santo ACSDE, Sugizaki CSA, de Morais Junior AC, Costa NA, Bachion MM, et al. Impact of oral nutritional supplement composition on healing of different chronic wounds: A systematic review. Nutrition. 2024;124:112449. doi:10.1016/j.nut.2024.112449
Hayashi A, Taki Y, Arai K, Sato S, Higashizono K, et al. Esophageal ulcer related to zinc deficiency following a total gastrectomy. Nutrition. 2023;110:111999. doi:10.1016/j.nut.2023.111999
Faghfouri AH, Baradaran B, Khabbazi A, Abdoli Shadbad M, Papi S, et al. Regulation of NLRP3 inflammasome by zinc supplementation in Behçet's disease patients: A double-blind, randomized placebo-controlled clinical trial. Int Immunopharmacol. 2022;109:108825. doi:10.1016/j.intimp.2022.108825
Jung DH, Park JC, Lee YC, Lee SK, Shin SK, et al. Comparison of the Efficacy of Polaprezinc Plus Proton Pump Inhibitor and Rebamipide Plus Proton Pump Inhibitor Treatments for Endoscopic Submucosal Dissection-induced Ulcers. J Clin Gastroenterol. 2021;55:233. doi:10.1097/MCG.0000000000001357
Scheid PL, Lâm TT, Sinsch U, Balczun C. Vermamoeba vermiformis as etiological agent of a painful ulcer close to the eye. Parasitol Res. 2019;118:1999. doi:10.1007/s00436-019-06312-y
Ficarra G, Cicchi P, Amorosi A, Piluso S. Oral Crohn's disease and pyostomatitis vegetans. An unusual association. Oral Surg Oral Med Oral Pathol. 1993;75:220.
Cho CH, Ogle CW, Dai S. Effects of zinc chloride on gastric secretion and ulcer formation in pylorus-occluded rats. Eur J Pharmacol. 1976;38:337.