Last update
8/13/2025
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.9
USERS' SCORE
Good
Based on 2 Reviews
8.6
Supplement Facts
Serving Size: 1 Tablet
Serving Per Container: 275
Amount Per Serving
%DV
Total Carbohydrates
1 g
<1%**
Calcium (as Calcium Carbonate)
98 mg
8%
Proprietary BlendCascara Sagrada powder (bark), Fennel powder (seed), Psyllium powder (seed husk), Ginger powder (rhizome), Acacia Gum, Barley Grass powder (aerial), Beet powder (root), Glucomannan, Karaya Gum, Lemon Peel powder (peel), Oat Bran powder, Peppermint powder (leaf), Red Raspberry (Rubus idaeus) powder (leaf), Slippery Elm powder (bark), Chlorella powder, Guar Gum, Lactobacillus acidophilus (1 million/g *** )
542 mg
†
Top Medical Research Studies
9
Lactobacillus acidophilus shows promise in autoimmune management
We explored how specific Lactobacillus acidophilus strains can impact autoimmune disorders by reducing leptin production in mice. In our study, we compared the effects of CBA4P and other lactobacilli on adipocytes from mice sensitive to Th1 immune diseases.
Results showed that CBA4P significantly lowered leptin levels and inhibited the activation of immune lymphocytes in the SJL mouse strain. This suggests that CBA4P might help manage Th1-related inflammatory conditions, representing a potentially valuable probiotic option for autoimmune control.
Results showed that CBA4P significantly lowered leptin levels and inhibited the activation of immune lymphocytes in the SJL mouse strain. This suggests that CBA4P might help manage Th1-related inflammatory conditions, representing a potentially valuable probiotic option for autoimmune control.
Read More
8
Probiotics benefit rheumatoid arthritis patients
This study looked at how probiotic supplements, particularly Lactobacillus acidophilus, impacted patients with rheumatoid arthritis (RA). We conducted a randomized, double-blind, placebo-controlled trial, involving sixty patients who took either the probiotics or a placebo for eight weeks.
We observed improvements in several health markers, such as the Disease Activity Score of 28 joints (DAS-28) and lower insulin and hs-CRP levels. While the results were promising, some improvements were only borderline significant. Ultimately, this suggests probiotics may be beneficial for RA patients.
We observed improvements in several health markers, such as the Disease Activity Score of 28 joints (DAS-28) and lower insulin and hs-CRP levels. While the results were promising, some improvements were only borderline significant. Ultimately, this suggests probiotics may be beneficial for RA patients.
Read More
8
We explored the effects of Lactobacillus acidophilus and propionate on Sjögren's syndrome in a mouse model. Our study involved comparing the gut microbiomes of young and older mice while treating them for up to 24 weeks.
Notably, we observed that Lactobacillus acidophilus improved symptoms of Sjögren's syndrome and led to an increase in beneficial propionate-producing bacteria. This treatment appears to work by modulating key signaling pathways involved in the condition.
Overall, our findings suggest that Lactobacillus acidophilus and propionate might offer promising therapeutic options for managing Sjögren's syndrome.
Notably, we observed that Lactobacillus acidophilus improved symptoms of Sjögren's syndrome and led to an increase in beneficial propionate-producing bacteria. This treatment appears to work by modulating key signaling pathways involved in the condition.
Overall, our findings suggest that Lactobacillus acidophilus and propionate might offer promising therapeutic options for managing Sjögren's syndrome.
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Most Useful Reviews
9
Effective for constipation
1 people found this helpful
I have suffered from constipation all my life and have been taking this drug for over two years. There is no addiction, and it works gently. I take 2 tablets in the evening, and in the morning, everything functions well. One tablet suffices for my daughter; it varies by individual. I've updated my review as I've now used it for 3 years with no addiction. I recommend it.
Read More
9
Great for digestion
Excellent! This is a must-have for me; I order it constantly and use it periodically to avoid addiction. It’s great for lazy bowels. I take one tablet in the morning and one in the evening!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.9
- All Researches
9
We examined how a special probiotic mix, known as IRT5, affects autoimmune diabetes in non-obese diabetic (NOD) mice. Administered frequently over 36 weeks, this combination not only reduced diabetes incidence but also lowered insulitis scores and increased insulin-producing β-cell mass.
Additionally, IRT5 improved gut health and changed the makeup of immune cells in the pancreas and intestines. While some immune responses stayed the same, the shift towards more gut-focused regulatory T cells suggests it could be a promising treatment for type 1 diabetes.
Additionally, IRT5 improved gut health and changed the makeup of immune cells in the pancreas and intestines. While some immune responses stayed the same, the shift towards more gut-focused regulatory T cells suggests it could be a promising treatment for type 1 diabetes.
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9
Synbiotics improve rheumatoid arthritis symptoms
We investigated how synbiotic supplementation affects patients with rheumatoid arthritis (RA). In an 8-week, randomized, double-blind trial involving 54 participants, we compared the outcomes of those taking synbiotic capsules with a placebo group.
After the trial, those who received synbiotics showed a significant drop in inflammation markers and pain levels. Additionally, improvements were observed in insulin resistance and overall metabolic responses.
These findings suggest that synbiotics might benefit individuals managing RA by reducing inflammation and enhancing metabolic health.
After the trial, those who received synbiotics showed a significant drop in inflammation markers and pain levels. Additionally, improvements were observed in insulin resistance and overall metabolic responses.
These findings suggest that synbiotics might benefit individuals managing RA by reducing inflammation and enhancing metabolic health.
Read More
9
Lactobacillus acidophilus shows promise in autoimmune management
We explored how specific Lactobacillus acidophilus strains can impact autoimmune disorders by reducing leptin production in mice. In our study, we compared the effects of CBA4P and other lactobacilli on adipocytes from mice sensitive to Th1 immune diseases.
Results showed that CBA4P significantly lowered leptin levels and inhibited the activation of immune lymphocytes in the SJL mouse strain. This suggests that CBA4P might help manage Th1-related inflammatory conditions, representing a potentially valuable probiotic option for autoimmune control.
Results showed that CBA4P significantly lowered leptin levels and inhibited the activation of immune lymphocytes in the SJL mouse strain. This suggests that CBA4P might help manage Th1-related inflammatory conditions, representing a potentially valuable probiotic option for autoimmune control.
Read More
8
Lactic acid bacteria combat autoimmune symptoms
We investigated the potential of Lactobacillus and Bifidobacterium in alleviating symptoms of multiple sclerosis using a rat model. The study involved 48 male rats, which were divided into groups to evaluate the effects of these bacteria on demyelination caused by cuprizone.
The results showed that treatment with lactic acid bacteria notably improved behavioral impairments, decreased demyelination, reduced oxidative stress, and elevated serum levels of vitamins D and B.
Overall, these findings indicate that Lactobacillus and Bifidobacterium may be beneficial in managing autoimmune conditions like multiple sclerosis.
The results showed that treatment with lactic acid bacteria notably improved behavioral impairments, decreased demyelination, reduced oxidative stress, and elevated serum levels of vitamins D and B.
Overall, these findings indicate that Lactobacillus and Bifidobacterium may be beneficial in managing autoimmune conditions like multiple sclerosis.
Read More
8
This randomized, double-blind trial sought to see how synbiotics, including Lactobacillus acidophilus, could help patients with systemic lupus erythematosus (SLE). Fifty patients were divided into two groups: one received synbiotics alongside their standard therapy, while the other got standard therapy alone over two months.
We observed that those who took the synbiotics showed a meaningful drop in inflammatory markers like interleukin-17A and overall disease activity. Meanwhile, the placebo group didn’t see these improvements. While these findings are promising, we recognize that more research is necessary to fully understand how synbiotics work in SLE management.
We observed that those who took the synbiotics showed a meaningful drop in inflammatory markers like interleukin-17A and overall disease activity. Meanwhile, the placebo group didn’t see these improvements. While these findings are promising, we recognize that more research is necessary to fully understand how synbiotics work in SLE management.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Effective for constipation
1 people found this helpful
I have suffered from constipation all my life and have been taking this drug for over two years. There is no addiction, and it works gently. I take 2 tablets in the evening, and in the morning, everything functions well. One tablet suffices for my daughter; it varies by individual. I've updated my review as I've now used it for 3 years with no addiction. I recommend it.
Read More
9
Great for digestion
Excellent! This is a must-have for me; I order it constantly and use it periodically to avoid addiction. It’s great for lazy bowels. I take one tablet in the morning and one in the evening!
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Kazemimiraki M, Moazamian E, Mokhtari MJ, Gholamzad M. The Role of Lactic Acid Bacteria in Improving Behavioral Deficits, Serum Levels of Vitamin D3, B12 and Reducing Oxidative Stress and Demyelination in a Cuprizone-induced Demyelination Model of Rat. Neuromolecular Med. 2025;27:14. 10.1007/s12017-025-08837-1
- Mirfeizi Z, Mahmoudi M, Jokar MH, Sahebari M, Noori E, et al. Impact of synbiotics on disease activity in systemic lupus erythematosus: Results from a randomized clinical trial. J Food Sci. 2024;89:9835. 10.1111/1750-3841.17460
- Woo JS, Hwang SH, Yang S, Lee KH, Lee YS, et al. Lactobacillus acidophilus and propionate attenuate Sjögren's syndrome by modulating the STIM1-STING signaling pathway. Cell Commun Signal. 2023;21:135. 10.1186/s12964-023-01141-0
- Kim DS, Park Y, Choi JW, Park SH, Cho ML, et al. Supplementation Exerts a Synergistic Effect on Tacrolimus Efficacy by Modulating Th17/Treg Balance in Lupus-Prone Mice the SIGNR3 Pathway. Front Immunol. 2021;12:696074. 10.3389/fimmu.2021.696074
- Cannarella LAT, Mari NL, Alcântara CC, Iryioda TMV, Costa NT, et al. Mixture of probiotics reduces inflammatory biomarkers and improves the oxidative/nitrosative profile in people with rheumatoid arthritis. Nutrition. 2021;89:111282. 10.1016/j.nut.2021.111282
- Kim TK, Lee JC, Im SH, Lee MS. Amelioration of Autoimmune Diabetes of NOD Mice by Immunomodulating Probiotics. Front Immunol. 2020;11:1832. 10.3389/fimmu.2020.01832
- Kamal Y, Kandil M, Eissa M, Yousef R, Elsaadany B. Probiotics as a prophylaxis to prevent oral candidiasis in patients with Sjogren's syndrome: a double-blinded, placebo-controlled, randomized trial. Rheumatol Int. 2020;40:873. 10.1007/s00296-020-04558-9
- Kim J, Choi SH, Kim YJ, Jeong HJ, Ryu JS, et al. Clinical Effect of IRT-5 Probiotics on Immune Modulation of Autoimmunity or Alloimmunity in the Eye. Nutrients. 2017;9. 10.3390/nu9111166
- Tamtaji OR, Kouchaki E, Salami M, Aghadavod E, Akbari E, et al. The Effects of Probiotic Supplementation on Gene Expression Related to Inflammation, Insulin, and Lipids in Patients With Multiple Sclerosis: A Randomized, Double-Blind, Placebo-Controlled Trial. J Am Coll Nutr. 2017;36:660. 10.1080/07315724.2017.1347074
- Zamani B, Farshbaf S, Golkar HR, Bahmani F, Asemi Z. Synbiotic supplementation and the effects on clinical and metabolic responses in patients with rheumatoid arthritis: a randomised, double-blind, placebo-controlled trial. Br J Nutr. 2017;117:1095. 10.1017/S000711451700085X
- Zamani B, Golkar HR, Farshbaf S, Emadi-Baygi M, Tajabadi-Ebrahimi M, et al. Clinical and metabolic response to probiotic supplementation in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled trial. Int J Rheum Dis. 2016;19:869. 10.1111/1756-185X.12888
- Bleau C, Lamontagne L, Savard R. New Lactobacillus acidophilus isolates reduce the release of leptin by murine adipocytes leading to lower interferon-gamma production. Clin Exp Immunol. 2005;140:427.
