Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7
USERS' SCORE
Good
Based on 10 Reviews
8.2
Top Medical Research Studies
9
Our research explored the effects of a new calcium-loaded complex, made from Antarctic krill protein and enriched with pectin, on calcium absorption and bone health in mice with calcium deficiency. We created a model that simulated calcium deficiency, which is a significant concern as it can contribute to osteoporosis.
We observed that chronic calcium deprivation led to decreased calcium absorption and deterioration of bone structure. However, the P + Ca + HMP complex significantly improved calcium retention and increased the strength of the femur, indicating a positive impact on bone health.
Additionally, this complex improved the structure of the trabecular network, which is essential for maintaining strong bones. The presence of beneficial bacteria in the gut also rose after the intervention, and these were linked to better calcium absorption and bone synthesis. Overall, these findings point to the potential of the P + Ca + HMP complex as an effective calcium supplement that could help prevent calcium deficiency and thus support bone health.
We observed that chronic calcium deprivation led to decreased calcium absorption and deterioration of bone structure. However, the P + Ca + HMP complex significantly improved calcium retention and increased the strength of the femur, indicating a positive impact on bone health.
Additionally, this complex improved the structure of the trabecular network, which is essential for maintaining strong bones. The presence of beneficial bacteria in the gut also rose after the intervention, and these were linked to better calcium absorption and bone synthesis. Overall, these findings point to the potential of the P + Ca + HMP complex as an effective calcium supplement that could help prevent calcium deficiency and thus support bone health.
Read More
8
Calcium's role in osteoporosis explored
We sought to understand whether individuals with affective disorders (AD) receive different levels of osteoporosis treatment compared to those without these mental health conditions. To do this, we analyzed a large group of people over a ten-year period, looking at how often patients with AD received calcium prescriptions and referrals for osteoporosis screening.
Our findings show that people with AD were more likely to receive calcium treatments, including calcium alone and calcium combined with vitamin D, compared to healthy controls. Specifically, the study highlighted that individuals with AD had a 64% higher chance of receiving a calcium prescription and a 125% higher likelihood of being referred for screening within two years of their diagnosis.
Despite these increased rates of screening and treatment, there remains a question about whether such efforts are effectively reducing the risk of osteoporosis and fractures in this vulnerable group. Factors such as age, sex, ethnic background, and use of analgesics also played significant roles in the treatment pathways for these patients, indicating that while there are advancements in management, the overall effectiveness still requires further investigation.
Our findings show that people with AD were more likely to receive calcium treatments, including calcium alone and calcium combined with vitamin D, compared to healthy controls. Specifically, the study highlighted that individuals with AD had a 64% higher chance of receiving a calcium prescription and a 125% higher likelihood of being referred for screening within two years of their diagnosis.
Despite these increased rates of screening and treatment, there remains a question about whether such efforts are effectively reducing the risk of osteoporosis and fractures in this vulnerable group. Factors such as age, sex, ethnic background, and use of analgesics also played significant roles in the treatment pathways for these patients, indicating that while there are advancements in management, the overall effectiveness still requires further investigation.
Read More
9
We explored how salmon calcitonin (sCT) works in tandem with calcium antagonists—specifically verapamil, nifedipine, and diltiazem—to influence blood calcium and phosphorus levels in female rats with osteoporosis post-ovarian removal.
The study involved a systematic approach where we administered these combinations to different groups of osteoporotic rats and measured their blood levels. Our findings revealed that combining sCT with nifedipine had a particularly strong effect in lowering both calcium and phosphorus in the blood, outperforming the use of sCT alone.
Our analysis indicated that while sCT with nifedipine was most effective, the combinations with verapamil and diltiazem also showed beneficial effects, albeit to a lesser extent. These insights provide valuable information on how combination therapies might be targeted for treating postmenopausal osteoporosis, potentially paving the way for more effective treatment options in human patients.
The study involved a systematic approach where we administered these combinations to different groups of osteoporotic rats and measured their blood levels. Our findings revealed that combining sCT with nifedipine had a particularly strong effect in lowering both calcium and phosphorus in the blood, outperforming the use of sCT alone.
Our analysis indicated that while sCT with nifedipine was most effective, the combinations with verapamil and diltiazem also showed beneficial effects, albeit to a lesser extent. These insights provide valuable information on how combination therapies might be targeted for treating postmenopausal osteoporosis, potentially paving the way for more effective treatment options in human patients.
Read More
Most Useful Reviews
9
Significant improvement
26 people found this helpful
The BEST calcium/bone formula on the market! I have been taking "Alive! Calcium Bone Formula" since March 2017. My bone density improved by 18% in my back between September 2016 and October 2018. This increase was far more significant than what I experienced with Actonel or Fosamax. I was diagnosed with osteoporosis in 2008, and after taking Actonel for two years, I developed a slight stress fracture, prompting me to stop. There have been no side effects with "Alive". Being a Pharmacist, I highly recommend this effective product instead of those "nasty" bisphosphonates. It not only contains calcium but also magnesium, vitamin D, vitamin K2, Strontium, and Boron for better absorption. I proved that taking "Alive" and engaging in proper weight-bearing exercise CAN increase bone density!
Read More
8
Price increase concern
5 people found this helpful
Amazon has nearly doubled the price! I love this supplement, and my doctor approves too, as I have severe osteoporosis. However, the price on Amazon has significantly increased over the last few months. Fortunately, I found other suppliers selling it for around $20, the price I originally paid.
Read More
7.5
Beneficial for both
4 people found this helpful
This calcium is the best we have found. When my husband was diagnosed with osteoporosis, it was recommended to us, and we have both benefited from it.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7
- All Researches
9
Our research explored the effects of a new calcium-loaded complex, made from Antarctic krill protein and enriched with pectin, on calcium absorption and bone health in mice with calcium deficiency. We created a model that simulated calcium deficiency, which is a significant concern as it can contribute to osteoporosis.
We observed that chronic calcium deprivation led to decreased calcium absorption and deterioration of bone structure. However, the P + Ca + HMP complex significantly improved calcium retention and increased the strength of the femur, indicating a positive impact on bone health.
Additionally, this complex improved the structure of the trabecular network, which is essential for maintaining strong bones. The presence of beneficial bacteria in the gut also rose after the intervention, and these were linked to better calcium absorption and bone synthesis. Overall, these findings point to the potential of the P + Ca + HMP complex as an effective calcium supplement that could help prevent calcium deficiency and thus support bone health.
We observed that chronic calcium deprivation led to decreased calcium absorption and deterioration of bone structure. However, the P + Ca + HMP complex significantly improved calcium retention and increased the strength of the femur, indicating a positive impact on bone health.
Additionally, this complex improved the structure of the trabecular network, which is essential for maintaining strong bones. The presence of beneficial bacteria in the gut also rose after the intervention, and these were linked to better calcium absorption and bone synthesis. Overall, these findings point to the potential of the P + Ca + HMP complex as an effective calcium supplement that could help prevent calcium deficiency and thus support bone health.
Read More
9
We explored how salmon calcitonin (sCT) works in tandem with calcium antagonists—specifically verapamil, nifedipine, and diltiazem—to influence blood calcium and phosphorus levels in female rats with osteoporosis post-ovarian removal.
The study involved a systematic approach where we administered these combinations to different groups of osteoporotic rats and measured their blood levels. Our findings revealed that combining sCT with nifedipine had a particularly strong effect in lowering both calcium and phosphorus in the blood, outperforming the use of sCT alone.
Our analysis indicated that while sCT with nifedipine was most effective, the combinations with verapamil and diltiazem also showed beneficial effects, albeit to a lesser extent. These insights provide valuable information on how combination therapies might be targeted for treating postmenopausal osteoporosis, potentially paving the way for more effective treatment options in human patients.
The study involved a systematic approach where we administered these combinations to different groups of osteoporotic rats and measured their blood levels. Our findings revealed that combining sCT with nifedipine had a particularly strong effect in lowering both calcium and phosphorus in the blood, outperforming the use of sCT alone.
Our analysis indicated that while sCT with nifedipine was most effective, the combinations with verapamil and diltiazem also showed beneficial effects, albeit to a lesser extent. These insights provide valuable information on how combination therapies might be targeted for treating postmenopausal osteoporosis, potentially paving the way for more effective treatment options in human patients.
Read More
8
Calcium's role in osteoporosis explored
We sought to understand whether individuals with affective disorders (AD) receive different levels of osteoporosis treatment compared to those without these mental health conditions. To do this, we analyzed a large group of people over a ten-year period, looking at how often patients with AD received calcium prescriptions and referrals for osteoporosis screening.
Our findings show that people with AD were more likely to receive calcium treatments, including calcium alone and calcium combined with vitamin D, compared to healthy controls. Specifically, the study highlighted that individuals with AD had a 64% higher chance of receiving a calcium prescription and a 125% higher likelihood of being referred for screening within two years of their diagnosis.
Despite these increased rates of screening and treatment, there remains a question about whether such efforts are effectively reducing the risk of osteoporosis and fractures in this vulnerable group. Factors such as age, sex, ethnic background, and use of analgesics also played significant roles in the treatment pathways for these patients, indicating that while there are advancements in management, the overall effectiveness still requires further investigation.
Our findings show that people with AD were more likely to receive calcium treatments, including calcium alone and calcium combined with vitamin D, compared to healthy controls. Specifically, the study highlighted that individuals with AD had a 64% higher chance of receiving a calcium prescription and a 125% higher likelihood of being referred for screening within two years of their diagnosis.
Despite these increased rates of screening and treatment, there remains a question about whether such efforts are effectively reducing the risk of osteoporosis and fractures in this vulnerable group. Factors such as age, sex, ethnic background, and use of analgesics also played significant roles in the treatment pathways for these patients, indicating that while there are advancements in management, the overall effectiveness still requires further investigation.
Read More
7
We explored how calcium treatment influences bone mineralization, particularly in the context of osteoporosis. Our study involved human mesenchymal stem cells (hMSCs) that were cultured in two different environments: one with calcium and another with dexamethasone, a medication often used to treat inflammation and other conditions.
Interestingly, while both treatments increased mineralization of hMSCs, we noted that levels of a specific microRNA, miR-125b, decreased with exposure to either calcium or dexamethasone. When we introduced a miR-125b mimic in the dexamethasone-treated cells, mineralization increased; however, it did the opposite in the calcium-treated cells. This suggests that calcium's effect can vary significantly depending on the context in which it is applied.
We also identified key targets of miR-125b that play roles in bone development, highlighting the complexity behind how calcium treatments might work in conjunction with other factors like dexamethasone. Overall, our findings contribute to a deeper understanding of bone metabolism and suggest that while calcium is important, its effectiveness might not be straightforward and may require further exploration.
Interestingly, while both treatments increased mineralization of hMSCs, we noted that levels of a specific microRNA, miR-125b, decreased with exposure to either calcium or dexamethasone. When we introduced a miR-125b mimic in the dexamethasone-treated cells, mineralization increased; however, it did the opposite in the calcium-treated cells. This suggests that calcium's effect can vary significantly depending on the context in which it is applied.
We also identified key targets of miR-125b that play roles in bone development, highlighting the complexity behind how calcium treatments might work in conjunction with other factors like dexamethasone. Overall, our findings contribute to a deeper understanding of bone metabolism and suggest that while calcium is important, its effectiveness might not be straightforward and may require further exploration.
Read More
5
Calcium's risks for kidney stones
We explored the effects of calcium and vitamin D supplementation on osteoporosis, particularly focusing on the risk of kidney stones. In our study, 204 older adults in southwest China took daily doses of calcium and vitamin D for at least a year. We used various statistical analyses to understand the relationship between these supplements and kidney stone formation.
Our findings reveal that there is a potential link between the use of calcium supplements for osteoporosis and an increased risk of developing kidney stones. It seems that a history of kidney stones can elevate the likelihood of experiencing them again while undergoing such supplementation, likely due to higher urinary calcium levels.
While calcium is essential for bone health, our results suggest that patients need to be cautious. This research highlights the importance of monitoring kidney health while receiving calcium and vitamin D treatment to prevent complications like kidney stones.
Our findings reveal that there is a potential link between the use of calcium supplements for osteoporosis and an increased risk of developing kidney stones. It seems that a history of kidney stones can elevate the likelihood of experiencing them again while undergoing such supplementation, likely due to higher urinary calcium levels.
While calcium is essential for bone health, our results suggest that patients need to be cautious. This research highlights the importance of monitoring kidney health while receiving calcium and vitamin D treatment to prevent complications like kidney stones.
Read More
User Reviews
USERS' SCORE
Good
Based on 10 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Significant improvement
26 people found this helpful
The BEST calcium/bone formula on the market! I have been taking "Alive! Calcium Bone Formula" since March 2017. My bone density improved by 18% in my back between September 2016 and October 2018. This increase was far more significant than what I experienced with Actonel or Fosamax. I was diagnosed with osteoporosis in 2008, and after taking Actonel for two years, I developed a slight stress fracture, prompting me to stop. There have been no side effects with "Alive". Being a Pharmacist, I highly recommend this effective product instead of those "nasty" bisphosphonates. It not only contains calcium but also magnesium, vitamin D, vitamin K2, Strontium, and Boron for better absorption. I proved that taking "Alive" and engaging in proper weight-bearing exercise CAN increase bone density!
Read More
8
Price increase concern
5 people found this helpful
Amazon has nearly doubled the price! I love this supplement, and my doctor approves too, as I have severe osteoporosis. However, the price on Amazon has significantly increased over the last few months. Fortunately, I found other suppliers selling it for around $20, the price I originally paid.
Read More
7.5
Beneficial for both
4 people found this helpful
This calcium is the best we have found. When my husband was diagnosed with osteoporosis, it was recommended to us, and we have both benefited from it.
Read More
9
Promising results
2 people found this helpful
These have everything I have wanted to help osteoporosis. I have been taking them for about six months now and am looking forward to my next bone scan.
Read More
7.5
Major role improvement
17 people found this helpful
Osteoporosis to osteopenia! After my osteoporosis diagnosis and researching Big Pharma, I was terrified of their drugs. I devised a natural programme with this product as the cornerstone. I took additional supplements and made dietary and exercise changes, but I feel this product played a major role in my improvement.
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Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Wang JC, Chung SM, Wu PT, Tu YK, Lai PC, et al. Optimizing bone health in people living with HIV: insights from a network meta-analysis of randomized controlled trials. EClinicalMedicine. 2025;81:103103. 10.1016/j.eclinm.2025.103103
- Chen L, Lin S, He X, Ye J, Huang Y, et al. A calcium-loaded complex based on Antarctic krill protein and supplemented with pectin promotes calcium absorption and bone health. Int J Biol Macromol. 2025. 10.1016/j.ijbiomac.2025.141634
- Ma R, Romano E, Ashworth M, Vancampfort D, Solmi M, et al. Is there a disparity in osteoporosis referral and treatment among people with affective disorders? A ten-year data linkage study. Gen Hosp Psychiatry. 2025;94:56. 10.1016/j.genhosppsych.2025.02.009
- Chen J, Wang J, Jia W, Zhang Y, Li H, et al. Effect of salmon calcitonin combined with calcium antagonist on blood calcium and phosphorus ion concentration in osteoporosis rats. Eur J Med Res. 2025;30:115. 10.1186/s40001-025-02384-y
- Shi L, Bao Y, Deng X, Xu X, Hu J. Association between calcium and vitamin D supplementation and increased risk of kidney stone formation in patients with osteoporosis in Southwest China: a cross-sectional study. BMJ Open. 2025;15:e092901. 10.1136/bmjopen-2024-092901
- Joris V, Balmayor ER, van Griensven M. miR-125b differentially impacts mineralization in dexamethasone and calcium-treated human mesenchymal stem cells. Mol Ther Nucleic Acids. 2025;36:102446. 10.1016/j.omtn.2024.102446
