Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.8
USERS' SCORE
Good
Based on 5 Reviews
8.3
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Oregano (leaf and flower) Oil containing 75% carvacrol (37.5 mg)
50 mg
**
Flaxseed Oil
25 mg
**
Top Medical Research Studies
9.5
We evaluated the protective effects of oregano (Origanum vulgare) on liver toxicity induced by cyclophosphamide, a commonly used chemotherapy drug known for its potential liver damage. In our study, we pre-treated mice with various doses of oregano extract for seven days before administering a chemotherapy dose.
After 24 hours, we collected blood samples and liver tissues from the animals to assess the liver's response. The results were promising: we found that serum markers indicating liver damage, such as ALT, AST, and ALP, were significantly elevated in the mice treated with cyclophosphamide alone. However, those receiving oregano extract showed a marked reduction in these markers, suggesting that oregano may help protect the liver from poisoning caused by chemotherapy.
The histological examinations aligned with these findings and confirmed that oregano extract has protective properties against liver damage. With its rich array of flavonoids and phenolic compounds, oregano seems capable of supporting liver health during challenging treatments. Thus, incorporating oregano may offer a supportive approach to mitigate the side effects of chemotherapy on the liver.
After 24 hours, we collected blood samples and liver tissues from the animals to assess the liver's response. The results were promising: we found that serum markers indicating liver damage, such as ALT, AST, and ALP, were significantly elevated in the mice treated with cyclophosphamide alone. However, those receiving oregano extract showed a marked reduction in these markers, suggesting that oregano may help protect the liver from poisoning caused by chemotherapy.
The histological examinations aligned with these findings and confirmed that oregano extract has protective properties against liver damage. With its rich array of flavonoids and phenolic compounds, oregano seems capable of supporting liver health during challenging treatments. Thus, incorporating oregano may offer a supportive approach to mitigate the side effects of chemotherapy on the liver.
Read More
9
We explored the effects of a natural flavone, didymin, derived from oregano (Origanum vulgare), on liver health. Our research aimed to understand how didymin can help prevent liver damage, specifically in cases induced by carbon tetrachloride (CCl), a commonly used chemical that can harm the liver.
In our study, we found that didymin significantly reduced indicators of liver injury in mice, including levels of important liver enzymes like ALT and AST. Furthermore, treatment with didymin led to lower levels of toxic substances and inflammatory markers in the liver, while boosting the activity of antioxidant enzymes that protect the liver from damage.
We also observed that didymin effectively inhibited key signaling pathways involved in inflammation, specifically the NF-κB and MAPK pathways. Impressively, didymin increased the expression of a protein known as RKIP, which plays a critical role in protecting liver cells. It was interesting to note that when we inhibited RKIP specifically, the protective effects of didymin were diminished.
Overall, our findings suggest that didymin from oregano holds promise in alleviating liver injury, primarily through its antioxidant properties and its ability to regulate inflammatory responses in the liver.
In our study, we found that didymin significantly reduced indicators of liver injury in mice, including levels of important liver enzymes like ALT and AST. Furthermore, treatment with didymin led to lower levels of toxic substances and inflammatory markers in the liver, while boosting the activity of antioxidant enzymes that protect the liver from damage.
We also observed that didymin effectively inhibited key signaling pathways involved in inflammation, specifically the NF-κB and MAPK pathways. Impressively, didymin increased the expression of a protein known as RKIP, which plays a critical role in protecting liver cells. It was interesting to note that when we inhibited RKIP specifically, the protective effects of didymin were diminished.
Overall, our findings suggest that didymin from oregano holds promise in alleviating liver injury, primarily through its antioxidant properties and its ability to regulate inflammatory responses in the liver.
Read More
9.5
In our exploration of oregano's beneficial effects on liver health, we conducted a study on Wistar rats to assess how an extract from Origanum vulgare could shield against liver damage caused by carbon tetrachloride (CCl4). The experiment was structured with various groups of rats: a control group, a group receiving only the oregano extract, and others treated with CCl4 alongside different doses of oregano over 15 days.
Throughout the study, we measured key indicators of liver function, including enzymes in the serum, the levels of lipid peroxides, and antioxidant markers in liver tissues. We found that CCl4 led to clear signs of liver injury, but the administration of oregano extract showed significant protective effects. This improvement was most pronounced at the highest dose of 150 mg/kg.
Our analyses revealed that oregano not only helped in reducing liver enzyme levels indicative of damage but also boosted antioxidant activity in the liver. Histopathological examinations aligned with these biochemical improvements, indicating healthier liver cells after treatment with oregano. This study suggests that oregano could be a valuable ally in protecting against liver toxicity.
Throughout the study, we measured key indicators of liver function, including enzymes in the serum, the levels of lipid peroxides, and antioxidant markers in liver tissues. We found that CCl4 led to clear signs of liver injury, but the administration of oregano extract showed significant protective effects. This improvement was most pronounced at the highest dose of 150 mg/kg.
Our analyses revealed that oregano not only helped in reducing liver enzyme levels indicative of damage but also boosted antioxidant activity in the liver. Histopathological examinations aligned with these biochemical improvements, indicating healthier liver cells after treatment with oregano. This study suggests that oregano could be a valuable ally in protecting against liver toxicity.
Read More
Most Useful Reviews
9
Supports liver health
19 people found this helpful
This is a powerful herbal antibiotic! My SIBO syndromes disappeared after I took three capsules three times daily for a month. It's crucial to use it alongside medications to support liver health, as the liver removes toxins. After two weeks, I began taking a delayed-release probiotic to help restore healthy flora in my intestines.
Read More
7.5
Liver cell regeneration
6 people found this helpful
Oregano oil offers numerous benefits! It combats bacteria, fungi, and yeast infections while helping to expel parasites. Recent studies suggest it's effective against colitis and aids liver cell regeneration without side effects. I consume it during my antiparasitic programme to enhance results and support my liver.
Read More
7.5
Improved liver function
1 people found this helpful
Very satisfied! The company's high-quality products gave me confidence when purchasing. My family took the capsules in a course of 20, and I feel better overall. I wake up easier, and no one fell ill during flu season. Our monthly cycles were also easier, needing only one pill initially. I will continue using them to support liver function during illness season.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.8
- All Researches
9.5
We evaluated the protective effects of oregano (Origanum vulgare) on liver toxicity induced by cyclophosphamide, a commonly used chemotherapy drug known for its potential liver damage. In our study, we pre-treated mice with various doses of oregano extract for seven days before administering a chemotherapy dose.
After 24 hours, we collected blood samples and liver tissues from the animals to assess the liver's response. The results were promising: we found that serum markers indicating liver damage, such as ALT, AST, and ALP, were significantly elevated in the mice treated with cyclophosphamide alone. However, those receiving oregano extract showed a marked reduction in these markers, suggesting that oregano may help protect the liver from poisoning caused by chemotherapy.
The histological examinations aligned with these findings and confirmed that oregano extract has protective properties against liver damage. With its rich array of flavonoids and phenolic compounds, oregano seems capable of supporting liver health during challenging treatments. Thus, incorporating oregano may offer a supportive approach to mitigate the side effects of chemotherapy on the liver.
After 24 hours, we collected blood samples and liver tissues from the animals to assess the liver's response. The results were promising: we found that serum markers indicating liver damage, such as ALT, AST, and ALP, were significantly elevated in the mice treated with cyclophosphamide alone. However, those receiving oregano extract showed a marked reduction in these markers, suggesting that oregano may help protect the liver from poisoning caused by chemotherapy.
The histological examinations aligned with these findings and confirmed that oregano extract has protective properties against liver damage. With its rich array of flavonoids and phenolic compounds, oregano seems capable of supporting liver health during challenging treatments. Thus, incorporating oregano may offer a supportive approach to mitigate the side effects of chemotherapy on the liver.
Read More
9.5
In our exploration of oregano's beneficial effects on liver health, we conducted a study on Wistar rats to assess how an extract from Origanum vulgare could shield against liver damage caused by carbon tetrachloride (CCl4). The experiment was structured with various groups of rats: a control group, a group receiving only the oregano extract, and others treated with CCl4 alongside different doses of oregano over 15 days.
Throughout the study, we measured key indicators of liver function, including enzymes in the serum, the levels of lipid peroxides, and antioxidant markers in liver tissues. We found that CCl4 led to clear signs of liver injury, but the administration of oregano extract showed significant protective effects. This improvement was most pronounced at the highest dose of 150 mg/kg.
Our analyses revealed that oregano not only helped in reducing liver enzyme levels indicative of damage but also boosted antioxidant activity in the liver. Histopathological examinations aligned with these biochemical improvements, indicating healthier liver cells after treatment with oregano. This study suggests that oregano could be a valuable ally in protecting against liver toxicity.
Throughout the study, we measured key indicators of liver function, including enzymes in the serum, the levels of lipid peroxides, and antioxidant markers in liver tissues. We found that CCl4 led to clear signs of liver injury, but the administration of oregano extract showed significant protective effects. This improvement was most pronounced at the highest dose of 150 mg/kg.
Our analyses revealed that oregano not only helped in reducing liver enzyme levels indicative of damage but also boosted antioxidant activity in the liver. Histopathological examinations aligned with these biochemical improvements, indicating healthier liver cells after treatment with oregano. This study suggests that oregano could be a valuable ally in protecting against liver toxicity.
Read More
9
We evaluated how oregano seed extract, specifically its ethyl acetate fraction, affects liver health in mice that were fed a high-fat diet. Over a period of 10 weeks, we found that when these mice were given 100 mg/kg of oregano seed extract alongside their high-fat diet, their weight and various liver enzyme levels significantly improved.
Remarkably, we observed a reduction in harmful substances like cholesterol and triglycerides, alongside an increase in beneficial high-density lipoprotein. This indicates a positive shift in the mice's overall liver health. Additionally, the fat accumulation in the liver decreased notably, which is a key factor in non-alcoholic fatty liver disease.
Furthermore, we examined the expression of certain genes related to fat metabolism and discovered that their activity went down significantly in the mice that received oregano treatment. This suggests that oregano may help regulate how the body processes fats, potentially leading to better management of obesity and fat-related liver issues.
Remarkably, we observed a reduction in harmful substances like cholesterol and triglycerides, alongside an increase in beneficial high-density lipoprotein. This indicates a positive shift in the mice's overall liver health. Additionally, the fat accumulation in the liver decreased notably, which is a key factor in non-alcoholic fatty liver disease.
Furthermore, we examined the expression of certain genes related to fat metabolism and discovered that their activity went down significantly in the mice that received oregano treatment. This suggests that oregano may help regulate how the body processes fats, potentially leading to better management of obesity and fat-related liver issues.
Read More
9
Oregano may protect liver health
We explored the impact of essential oils, specifically oregano, on liver health in dairy calves affected by trichothecenes from Fusarium sporotrichioides. In this study, we divided twelve calves into two groups: one receiving a blend of essential oils (including oregano) and the other as a control. Over 40 days, we monitored their growth, blood health, and overall wellness while ensuring both groups consumed feed contaminated with trichothecenes.
The calves that received essential oils showed a positive trend in body weight compared to the control group. We observed notable improvements in their blood parameters, including higher leukocyte counts and lower levels of certain liver enzymes, suggesting that oregano may help reduce liver stress. This group also exhibited lower oxidative stress markers and reduced inflammation as indicated by lower serum levels of haptoglobin and C-reactive protein.
In contrast, the control group displayed signs of liver stress and inflammation upon analysis. Our findings indicate that oregano, alongside other essential oils, could mitigate the negative effects of trichothecenes on liver health in calves, serving as a potential aid in improving overall animal wellbeing and health resilience.
The calves that received essential oils showed a positive trend in body weight compared to the control group. We observed notable improvements in their blood parameters, including higher leukocyte counts and lower levels of certain liver enzymes, suggesting that oregano may help reduce liver stress. This group also exhibited lower oxidative stress markers and reduced inflammation as indicated by lower serum levels of haptoglobin and C-reactive protein.
In contrast, the control group displayed signs of liver stress and inflammation upon analysis. Our findings indicate that oregano, alongside other essential oils, could mitigate the negative effects of trichothecenes on liver health in calves, serving as a potential aid in improving overall animal wellbeing and health resilience.
Read More
9
In our exploration of the effects of oregano (Origanum vulgare) on liver health, we conducted a thorough study using rats to assess its potential as a treatment for hepatic encephalopathy (HE). This condition is often linked with chronic liver disease and can lead to a decline in brain function due to elevated ammonia levels.
We analyzed the chemical makeup of oregano's hexane extract, identifying 25 different compounds, with prominent elements like cholesten-3-one and gamma-tocopherol. To test its effectiveness, we divided the rats into seven groups: a control group, groups receiving different doses of oregano, and groups treated with thioacetamide (TAA), which induces HE.
Throughout the study, we measured various outcomes, including behavior changes, body weight, and blood markers. TAA caused anxiety and cognitive impairments in the rats, alongside significant weight changes and liver stress. Remarkably, treatment with oregano significantly improved these symptoms, showcasing its potential as a hepato- and neuroprotective agent.
We found that oregano’s protective effects were comparable to those of silymarin, a standard liver treatment. Both treatments helped mitigate the damaging effects of TAA on the liver and brain, suggesting that oregano could be an excellent alternative in supporting liver health and function.
We analyzed the chemical makeup of oregano's hexane extract, identifying 25 different compounds, with prominent elements like cholesten-3-one and gamma-tocopherol. To test its effectiveness, we divided the rats into seven groups: a control group, groups receiving different doses of oregano, and groups treated with thioacetamide (TAA), which induces HE.
Throughout the study, we measured various outcomes, including behavior changes, body weight, and blood markers. TAA caused anxiety and cognitive impairments in the rats, alongside significant weight changes and liver stress. Remarkably, treatment with oregano significantly improved these symptoms, showcasing its potential as a hepato- and neuroprotective agent.
We found that oregano’s protective effects were comparable to those of silymarin, a standard liver treatment. Both treatments helped mitigate the damaging effects of TAA on the liver and brain, suggesting that oregano could be an excellent alternative in supporting liver health and function.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Supports liver health
19 people found this helpful
This is a powerful herbal antibiotic! My SIBO syndromes disappeared after I took three capsules three times daily for a month. It's crucial to use it alongside medications to support liver health, as the liver removes toxins. After two weeks, I began taking a delayed-release probiotic to help restore healthy flora in my intestines.
Read More
7.5
Liver cell regeneration
6 people found this helpful
Oregano oil offers numerous benefits! It combats bacteria, fungi, and yeast infections while helping to expel parasites. Recent studies suggest it's effective against colitis and aids liver cell regeneration without side effects. I consume it during my antiparasitic programme to enhance results and support my liver.
Read More
7.5
Improved liver function
1 people found this helpful
Very satisfied! The company's high-quality products gave me confidence when purchasing. My family took the capsules in a course of 20, and I feel better overall. I wake up easier, and no one fell ill during flu season. Our monthly cycles were also easier, needing only one pill initially. I will continue using them to support liver function during illness season.
Read More
7.5
Eases liver issues
Oregano oil effectively destroys bacteria, various fungal infections, and helps expel parasites while combating respiratory viruses and skin issues. Studies affirm it’s better than prescription drugs for colitis and has no side effects. It also promotes liver cell regeneration.
Read More
6
Aids intestinal balance
1 people found this helpful
Oregano oil serves as a natural antibiotic. If someone suffers from intestinal dysbiosis or candidiasis, it may help along with a low-carb diet. It's effective at the first signs of illness, especially when combined with vitamin C and zinc.
Read More
Frequently Asked Questions
9
Supports liver health
19 people found this helpful
This is a powerful herbal antibiotic! My SIBO syndromes disappeared after I took three capsules three times daily for a month. It's crucial to use it alongside medications to support liver health, as the liver removes toxins. After two weeks, I began taking a delayed-release probiotic to help restore healthy flora in my intestines.
7.5
Improved liver function
1 people found this helpful
Very satisfied! The company's high-quality products gave me confidence when purchasing. My family took the capsules in a course of 20, and I feel better overall. I wake up easier, and no one fell ill during flu season. Our monthly cycles were also easier, needing only one pill initially. I will continue using them to support liver function during illness season.
7.5
Eases liver issues
Oregano oil effectively destroys bacteria, various fungal infections, and helps expel parasites while combating respiratory viruses and skin issues. Studies affirm it’s better than prescription drugs for colitis and has no side effects. It also promotes liver cell regeneration.
7.5
Liver cell regeneration
6 people found this helpful
Oregano oil offers numerous benefits! It combats bacteria, fungi, and yeast infections while helping to expel parasites. Recent studies suggest it's effective against colitis and aids liver cell regeneration without side effects. I consume it during my antiparasitic programme to enhance results and support my liver.
6
Aids intestinal balance
1 people found this helpful
Oregano oil serves as a natural antibiotic. If someone suffers from intestinal dysbiosis or candidiasis, it may help along with a low-carb diet. It's effective at the first signs of illness, especially when combined with vitamin C and zinc.
8
Oregano oil's protective liver effects
We explored how oregano oil, specifically Origanum minutiflorum, could protect the liver from damage caused by carbon tetrachloride (CCl). In our study, we used two doses of oregano oil: a lower dose of 20 mg/kg and a higher dose of 60 mg/kg, over a period of two weeks.
CCl is known for causing severe liver injury, leading to problems like reduced protein synthesis and hematological disorders, such as changes in red and white blood cell counts. Our findings revealed that both doses of oregano oil provided protective effects on the liver. We observed improvements in protein synthesis and liver function markers, while also noting a reduction in the cytogenetic changes that typically occur in liver cells following CCl exposure.
Interestingly, the high dose of oregano oil was particularly effective in protecting red blood cells, though its impact on hemoglobin production was less pronounced. We also noticed that while the higher dose helped reduce white blood cell and lymphocyte counts, this could potentially weaken the immune response. However, it showed improved efficacy against thrombocytosis, or increased platelet aggregation.
Overall, our study suggests that oregano oil may serve as a beneficial treatment option for liver injury, balancing its protective benefits against some potential downsides associated with higher doses.
CCl is known for causing severe liver injury, leading to problems like reduced protein synthesis and hematological disorders, such as changes in red and white blood cell counts. Our findings revealed that both doses of oregano oil provided protective effects on the liver. We observed improvements in protein synthesis and liver function markers, while also noting a reduction in the cytogenetic changes that typically occur in liver cells following CCl exposure.
Interestingly, the high dose of oregano oil was particularly effective in protecting red blood cells, though its impact on hemoglobin production was less pronounced. We also noticed that while the higher dose helped reduce white blood cell and lymphocyte counts, this could potentially weaken the immune response. However, it showed improved efficacy against thrombocytosis, or increased platelet aggregation.
Overall, our study suggests that oregano oil may serve as a beneficial treatment option for liver injury, balancing its protective benefits against some potential downsides associated with higher doses.
9.5
In our exploration of oregano's beneficial effects on liver health, we conducted a study on Wistar rats to assess how an extract from Origanum vulgare could shield against liver damage caused by carbon tetrachloride (CCl4). The experiment was structured with various groups of rats: a control group, a group receiving only the oregano extract, and others treated with CCl4 alongside different doses of oregano over 15 days.
Throughout the study, we measured key indicators of liver function, including enzymes in the serum, the levels of lipid peroxides, and antioxidant markers in liver tissues. We found that CCl4 led to clear signs of liver injury, but the administration of oregano extract showed significant protective effects. This improvement was most pronounced at the highest dose of 150 mg/kg.
Our analyses revealed that oregano not only helped in reducing liver enzyme levels indicative of damage but also boosted antioxidant activity in the liver. Histopathological examinations aligned with these biochemical improvements, indicating healthier liver cells after treatment with oregano. This study suggests that oregano could be a valuable ally in protecting against liver toxicity.
Throughout the study, we measured key indicators of liver function, including enzymes in the serum, the levels of lipid peroxides, and antioxidant markers in liver tissues. We found that CCl4 led to clear signs of liver injury, but the administration of oregano extract showed significant protective effects. This improvement was most pronounced at the highest dose of 150 mg/kg.
Our analyses revealed that oregano not only helped in reducing liver enzyme levels indicative of damage but also boosted antioxidant activity in the liver. Histopathological examinations aligned with these biochemical improvements, indicating healthier liver cells after treatment with oregano. This study suggests that oregano could be a valuable ally in protecting against liver toxicity.
9
We evaluated how oregano seed extract, specifically its ethyl acetate fraction, affects liver health in mice that were fed a high-fat diet. Over a period of 10 weeks, we found that when these mice were given 100 mg/kg of oregano seed extract alongside their high-fat diet, their weight and various liver enzyme levels significantly improved.
Remarkably, we observed a reduction in harmful substances like cholesterol and triglycerides, alongside an increase in beneficial high-density lipoprotein. This indicates a positive shift in the mice's overall liver health. Additionally, the fat accumulation in the liver decreased notably, which is a key factor in non-alcoholic fatty liver disease.
Furthermore, we examined the expression of certain genes related to fat metabolism and discovered that their activity went down significantly in the mice that received oregano treatment. This suggests that oregano may help regulate how the body processes fats, potentially leading to better management of obesity and fat-related liver issues.
Remarkably, we observed a reduction in harmful substances like cholesterol and triglycerides, alongside an increase in beneficial high-density lipoprotein. This indicates a positive shift in the mice's overall liver health. Additionally, the fat accumulation in the liver decreased notably, which is a key factor in non-alcoholic fatty liver disease.
Furthermore, we examined the expression of certain genes related to fat metabolism and discovered that their activity went down significantly in the mice that received oregano treatment. This suggests that oregano may help regulate how the body processes fats, potentially leading to better management of obesity and fat-related liver issues.
References
- Lee HJ, Bae JY, Park KW, Kim MJ. Ethyl acetate fraction of oregano seed protects non-alcoholic fatty liver in high-fat diet-induced obese mice through modulation of . Food Sci Nutr. 2024;12:2578. doi:10.1002/fsn3.3939
- Suljević D, Fočak M, Škrijelj R, Mitrašinović-Brulić M. Therapeutic benefit of oregano oil in the acute idiosyncratic hepatotoxicity induced by carbon tetrachloride in rats: Adverse effects of high dose of oreganum. Cell Biochem Funct. 2024;42:e4015. doi:10.1002/cbf.4015
- Machado M, Nora L, Zanin TBN, Bissacotti BF, Morsch VM, et al. Impacts of intake of trichothecenes (Fusarium sporotrichioides) for dairy calves: Effects on animal growth, oxidative and inflammatory response. Microb Pathog. 2024;190:106605. doi:10.1016/j.micpath.2024.106605
- Abdelghffar EAR, El-Nashar HAS, Fayez S, Obaid WA, Eldahshan OA. Ameliorative effect of oregano (Origanum vulgare) versus silymarin in experimentally induced hepatic encephalopathy. Sci Rep. 2022;12:17854. doi:10.1038/s41598-022-20412-3
- Bajagai YS, Radovanovic A, Steel JC, Stanley D. The Effects of Continual Consumption of on Liver Transcriptomics. Animals (Basel). 2021;11. doi:10.3390/ani11020398
- Khafaga AF, Naiel MAE, Dawood MAO, Abdel-Latif HMR. Dietary Origanum vulgare essential oil attenuates cypermethrin-induced biochemical changes, oxidative stress, histopathological alterations, apoptosis, and reduces DNA damage in Common carp (Cyprinus carpio). Aquat Toxicol. 2020;228:105624. doi:10.1016/j.aquatox.2020.105624
- Pasavei AG, Mohebbati R, Boroumand N, Ghorbani A, Hosseini A, et al. Anti-Hypolipidemic and Anti-Oxidative Effects of Hydroalcoholic Extract of on the Hepatosteatosis Induced with High-Fat Diet in Rats. Malays J Med Sci. 2020;27:57. doi:10.21315/mjms2020.27.1.6
- Oniga I, Pușcaș C, Silaghi-Dumitrescu R, Olah NK, Sevastre B, et al. ssp. : Chemical Composition and Biological Studies. Molecules. 2018;23. doi:10.3390/molecules23082077
- Aralbaeva AN, Mamataeva AT, Zhaparkulova NI, Utegalieva RS, Khanin M, et al. A composition of medicinal plants with an enhanced ability to suppress microsomal lipid peroxidation and a protective activity against carbon tetrachloride-induced hepatotoxicity. Biomed Pharmacother. 2017;96:1283. doi:10.1016/j.biopha.2017.11.085
- Huang Q, Bai F, Nie J, Lu S, Lu C, et al. Didymin ameliorates hepatic injury through inhibition of MAPK and NF-κB pathways by up-regulating RKIP expression. Int Immunopharmacol. 2017;42:130. doi:10.1016/j.intimp.2016.11.028
- Wei J, Huang Q, Bai F, Lin J, Nie J, et al. Didymin induces apoptosis through mitochondrial dysfunction and up-regulation of RKIP in human hepatoma cells. Chem Biol Interact. 2017;261:118. doi:10.1016/j.cbi.2016.11.026
- Fathy SA, Emam MA, Abo Agwa SH, Abu Zahra FA, Youssef FS, et al. The antiproliferative effect of Origanum majorana on human hepatocarcinoma cell line: suppression of NF-κB. Cell Mol Biol (Noisy-le-grand). 2016;62:80.
- Aristatile B, Al-Assaf AH, Pugalendi KV. Carvacrol ameliorates the PPAR-A and cytochrome P450 expression on D-galactosamine induced hepatotoxicity rats. Afr J Tradit Complement Altern Med. 2014;11:118.
- Habibi E, Shokrzadeh M, Chabra A, Naghshvar F, Keshavarz-Maleki R, et al. Protective effects of Origanum vulgare ethanol extract against cyclophosphamide-induced liver toxicity in mice. Pharm Biol. 2015;53:10. doi:10.3109/13880209.2014.908399
- Sikander M, Malik S, Parveen K, Ahmad M, Yadav D, et al. Hepatoprotective effect of Origanum vulgare in Wistar rats against carbon tetrachloride-induced hepatotoxicity. Protoplasma. 2013;250:483. doi:10.1007/s00709-012-0431-5
- Shati AA. Effects of Origanum majorana L. on cadmium induced hepatotoxicity and nephrotoxicity in albino rats. Saudi Med J. 2011;32:797.
