Overview
Top Medical Research Studies
After 24 hours, we collected blood samples and liver tissues from the animals to assess the liver's response. The results were promising: we found that serum markers indicating liver damage, such as ALT, AST, and ALP, were significantly elevated in the mice treated with cyclophosphamide alone. However, those receiving oregano extract showed a marked reduction in these markers, suggesting that oregano may help protect the liver from poisoning caused by chemotherapy.
The histological examinations aligned with these findings and confirmed that oregano extract has protective properties against liver damage. With its rich array of flavonoids and phenolic compounds, oregano seems capable of supporting liver health during challenging treatments. Thus, incorporating oregano may offer a supportive approach to mitigate the side effects of chemotherapy on the liver.
In our study, we found that didymin significantly reduced indicators of liver injury in mice, including levels of important liver enzymes like ALT and AST. Furthermore, treatment with didymin led to lower levels of toxic substances and inflammatory markers in the liver, while boosting the activity of antioxidant enzymes that protect the liver from damage.
We also observed that didymin effectively inhibited key signaling pathways involved in inflammation, specifically the NF-κB and MAPK pathways. Impressively, didymin increased the expression of a protein known as RKIP, which plays a critical role in protecting liver cells. It was interesting to note that when we inhibited RKIP specifically, the protective effects of didymin were diminished.
Overall, our findings suggest that didymin from oregano holds promise in alleviating liver injury, primarily through its antioxidant properties and its ability to regulate inflammatory responses in the liver.
Throughout the study, we measured key indicators of liver function, including enzymes in the serum, the levels of lipid peroxides, and antioxidant markers in liver tissues. We found that CCl4 led to clear signs of liver injury, but the administration of oregano extract showed significant protective effects. This improvement was most pronounced at the highest dose of 150 mg/kg.
Our analyses revealed that oregano not only helped in reducing liver enzyme levels indicative of damage but also boosted antioxidant activity in the liver. Histopathological examinations aligned with these biochemical improvements, indicating healthier liver cells after treatment with oregano. This study suggests that oregano could be a valuable ally in protecting against liver toxicity.
Most Useful Reviews
Medical Researches
- All Researches
After 24 hours, we collected blood samples and liver tissues from the animals to assess the liver's response. The results were promising: we found that serum markers indicating liver damage, such as ALT, AST, and ALP, were significantly elevated in the mice treated with cyclophosphamide alone. However, those receiving oregano extract showed a marked reduction in these markers, suggesting that oregano may help protect the liver from poisoning caused by chemotherapy.
The histological examinations aligned with these findings and confirmed that oregano extract has protective properties against liver damage. With its rich array of flavonoids and phenolic compounds, oregano seems capable of supporting liver health during challenging treatments. Thus, incorporating oregano may offer a supportive approach to mitigate the side effects of chemotherapy on the liver.
Throughout the study, we measured key indicators of liver function, including enzymes in the serum, the levels of lipid peroxides, and antioxidant markers in liver tissues. We found that CCl4 led to clear signs of liver injury, but the administration of oregano extract showed significant protective effects. This improvement was most pronounced at the highest dose of 150 mg/kg.
Our analyses revealed that oregano not only helped in reducing liver enzyme levels indicative of damage but also boosted antioxidant activity in the liver. Histopathological examinations aligned with these biochemical improvements, indicating healthier liver cells after treatment with oregano. This study suggests that oregano could be a valuable ally in protecting against liver toxicity.
Remarkably, we observed a reduction in harmful substances like cholesterol and triglycerides, alongside an increase in beneficial high-density lipoprotein. This indicates a positive shift in the mice's overall liver health. Additionally, the fat accumulation in the liver decreased notably, which is a key factor in non-alcoholic fatty liver disease.
Furthermore, we examined the expression of certain genes related to fat metabolism and discovered that their activity went down significantly in the mice that received oregano treatment. This suggests that oregano may help regulate how the body processes fats, potentially leading to better management of obesity and fat-related liver issues.
The calves that received essential oils showed a positive trend in body weight compared to the control group. We observed notable improvements in their blood parameters, including higher leukocyte counts and lower levels of certain liver enzymes, suggesting that oregano may help reduce liver stress. This group also exhibited lower oxidative stress markers and reduced inflammation as indicated by lower serum levels of haptoglobin and C-reactive protein.
In contrast, the control group displayed signs of liver stress and inflammation upon analysis. Our findings indicate that oregano, alongside other essential oils, could mitigate the negative effects of trichothecenes on liver health in calves, serving as a potential aid in improving overall animal wellbeing and health resilience.
We analyzed the chemical makeup of oregano's hexane extract, identifying 25 different compounds, with prominent elements like cholesten-3-one and gamma-tocopherol. To test its effectiveness, we divided the rats into seven groups: a control group, groups receiving different doses of oregano, and groups treated with thioacetamide (TAA), which induces HE.
Throughout the study, we measured various outcomes, including behavior changes, body weight, and blood markers. TAA caused anxiety and cognitive impairments in the rats, alongside significant weight changes and liver stress. Remarkably, treatment with oregano significantly improved these symptoms, showcasing its potential as a hepato- and neuroprotective agent.
We found that oregano’s protective effects were comparable to those of silymarin, a standard liver treatment. Both treatments helped mitigate the damaging effects of TAA on the liver and brain, suggesting that oregano could be an excellent alternative in supporting liver health and function.
User Reviews
- All Reviews
- Positive Reviews
- Negative Reviews
Frequently Asked Questions
Liver disease encompasses a variety of conditions that affect the liver's ability to function effectively. The liver is a vital organ responsible for many important tasks, including metabolizing nutrients, detoxifying harmful substances, and producing bile for digestion. Common forms of liver disease include hepatitis, fatty liver disease, cirrhosis, and liver cancer. Each of these conditions can significantly impact liver function and overall health, leading to symptoms that range from fatigue and jaundice to more serious complications requiring urgent medical attention.
The causes of liver disease are diverse and can include chronic alcohol abuse, viral infections, autoimmune disorders, and metabolic conditions like obesity and diabetes. Early detection is key to managing liver disease effectively, often involving lifestyle changes, medications, and sometimes surgical interventions. Regular check-ups and liver function tests are recommended for individuals at higher risk, such as those with a family history of liver disease or those who lead certain lifestyle habits. Adopting a balanced diet and reducing alcohol intake can greatly aid in liver health and help prevent the onset of these conditions.
Oregano oil supplements are nutritional products derived from the leaves and flowers of the oregano plant, primarily Origanum vulgare. Known for their potent antioxidant and antimicrobial properties, these supplements are often used to support immune health, aid digestion, and combat infections. Oregano oil is rich in compounds like carvacrol and thymol, which are believed to contribute to its therapeutic effects. They come in various forms, including softgels, capsules, and liquid extracts, making it easy for anyone to incorporate them into their daily routine.
When considering oregano oil supplements, it's important to choose high-quality products that provide standardized amounts of active ingredients. The recommended dosage can vary based on individual health needs, so it’s always wise to consult a healthcare professional before starting any new supplement regimen. Overall, oregano oil supplements can be a convenient way to harness the health benefits associated with this aromatic herb, but users should remain informed about potential interactions and side effects, particularly regarding dosage and individual health conditions.
Based on user reviews, the time it typically takes to see results when using supplements for liver health can vary. Some users reported noticeable improvements as quickly as two weeks, indicating that consistent use of the supplement can yield rapid benefits. For instance, one user noted, "After two weeks, I began taking a delayed-release probiotic to help restore healthy flora in my intestines" (Read Review). Others mentioned longer usage periods, suggesting a course of several days or weeks for maximum effectiveness; one user felt a general uplift in their well-being after a month of consistent use (Read Review).
Overall, while some individuals may begin to feel benefits within two weeks, fully optimizing liver support may take longer, often around a month or more of regular intake. The effectiveness is often reported in conjunction with other health practices, such as dietary adjustments and the use of additional supplements (Read Review), emphasizing the importance of a holistic approach to health.
The scientific research strongly supports the potential benefits of oregano for liver disease. Numerous studies have shown that different forms of oregano, including extracts and oil, may provide protective effects against liver damage caused by various toxins, like carbon tetrachloride and cadmium. For instance, one study demonstrated that oregano oil improved liver function markers and reduced cellular damage in rats exposed to carbon tetrachloride, indicating its protective capabilities [2]. Furthermore, the beneficial effects of oregano were supported by findings where it significantly reduced liver enzyme levels and oxidative stress, suggesting its role in managing liver health [15].
Additionally, oregano's potential extends to athletic and metabolic contexts, as research has revealed that it can positively influence liver health by regulating fat metabolism and mitigating issues like non-alcoholic fatty liver disease [1]. With compounds like didymin showing promise in reducing liver damage and inflammation, oregano represents a natural and multifaceted approach to supporting liver health. Overall, the existing body of research presents a compelling case for incorporating oregano into strategies aimed at protecting and enhancing liver function
Users have reported a range of improvements in symptoms after using oregano oil, especially concerning digestive and liver health. For instance, one user shared that after a month of taking three capsules three times daily, their SIBO symptoms completely vanished, highlighting the oil's effectiveness when used alongside medications that support liver function (Read Review). Additionally, another user noted they felt much better overall after a course of using the product, experiencing benefits that included easier wake-ups and healthier monthly cycles (Read Review).
Furthermore, reviewers indicated that oregano oil may aid in promoting liver cell regeneration while effectively addressing various infections, including colitis, without side effects (Read Review). Some users have incorporated the oil into their routines during antiparasitic treatment programs and noted significant support for their liver's functionality during illness seasons, reinforcing its multifaceted benefits for health (Read Review). While these anecdotal experiences are promising, it's essential to remember that individual results may vary.
Based on user reviews, many individuals have shared their positive experiences of combining oregano oil with other supplements to effectively manage liver disease. One user noted that using oregano oil alongside medications that support liver health was crucial for addressing SIBO symptoms, emphasizing the importance of the liver's role in removing toxins (Read Review). This sentiment is echoed by other users who reported enhanced liver support when integrating oregano oil into antiparasitic treatment programs, highlighting its multifaceted benefits alongside other health practices (Read Review).
Furthermore, users have also taken a holistic approach by combining oregano oil with additional supplements like vitamin C and zinc, particularly when dealing with initial signs of illness (Read Review). Overall, the feedback indicates a trend among users toward leveraging oregano oil as part of a broader regimen that includes dietary changes and other supplements, reinforcing the idea that a comprehensive strategy may yield the best results for liver health and overall wellness.
Based on user reviews, the dosage of oregano oil supplements for treating liver disease appears to vary, but a common regimen reported includes taking three capsules three times daily. Users have noted that this dosage has effectively supported their liver health, particularly when combined with medications and other supplements like probiotics to restore gut flora (Read Review). Additionally, some users mention taking a more moderate approach, with courses of 20 capsules showing beneficial effects on overall wellness and liver function (Read Review).
Moreover, users highlight the importance of integrating oregano oil into broader health routines, including antiparasitic programs to enhance liver support (Read Review). The feedback suggests that while higher doses may be effective, many individuals also find significant benefits from consistent, lower dosages. Overall, the overarching theme emphasizes the need for complementary dietary practices alongside the supplementation of oregano oil for optimal liver health.
CCl is known for causing severe liver injury, leading to problems like reduced protein synthesis and hematological disorders, such as changes in red and white blood cell counts. Our findings revealed that both doses of oregano oil provided protective effects on the liver. We observed improvements in protein synthesis and liver function markers, while also noting a reduction in the cytogenetic changes that typically occur in liver cells following CCl exposure.
Interestingly, the high dose of oregano oil was particularly effective in protecting red blood cells, though its impact on hemoglobin production was less pronounced. We also noticed that while the higher dose helped reduce white blood cell and lymphocyte counts, this could potentially weaken the immune response. However, it showed improved efficacy against thrombocytosis, or increased platelet aggregation.
Overall, our study suggests that oregano oil may serve as a beneficial treatment option for liver injury, balancing its protective benefits against some potential downsides associated with higher doses.
Throughout the study, we measured key indicators of liver function, including enzymes in the serum, the levels of lipid peroxides, and antioxidant markers in liver tissues. We found that CCl4 led to clear signs of liver injury, but the administration of oregano extract showed significant protective effects. This improvement was most pronounced at the highest dose of 150 mg/kg.
Our analyses revealed that oregano not only helped in reducing liver enzyme levels indicative of damage but also boosted antioxidant activity in the liver. Histopathological examinations aligned with these biochemical improvements, indicating healthier liver cells after treatment with oregano. This study suggests that oregano could be a valuable ally in protecting against liver toxicity.
Remarkably, we observed a reduction in harmful substances like cholesterol and triglycerides, alongside an increase in beneficial high-density lipoprotein. This indicates a positive shift in the mice's overall liver health. Additionally, the fat accumulation in the liver decreased notably, which is a key factor in non-alcoholic fatty liver disease.
Furthermore, we examined the expression of certain genes related to fat metabolism and discovered that their activity went down significantly in the mice that received oregano treatment. This suggests that oregano may help regulate how the body processes fats, potentially leading to better management of obesity and fat-related liver issues.
References
- Lee HJ, Bae JY, Park KW, Kim MJ. Ethyl acetate fraction of oregano seed protects non-alcoholic fatty liver in high-fat diet-induced obese mice through modulation of . Food Sci Nutr. 2024;12:2578. doi:10.1002/fsn3.3939
- Suljević D, Fočak M, Škrijelj R, Mitrašinović-Brulić M. Therapeutic benefit of oregano oil in the acute idiosyncratic hepatotoxicity induced by carbon tetrachloride in rats: Adverse effects of high dose of oreganum. Cell Biochem Funct. 2024;42:e4015. doi:10.1002/cbf.4015
- Machado M, Nora L, Zanin TBN, Bissacotti BF, Morsch VM, et al. Impacts of intake of trichothecenes (Fusarium sporotrichioides) for dairy calves: Effects on animal growth, oxidative and inflammatory response. Microb Pathog. 2024;190:106605. doi:10.1016/j.micpath.2024.106605
- Abdelghffar EAR, El-Nashar HAS, Fayez S, Obaid WA, Eldahshan OA. Ameliorative effect of oregano (Origanum vulgare) versus silymarin in experimentally induced hepatic encephalopathy. Sci Rep. 2022;12:17854. doi:10.1038/s41598-022-20412-3
- Bajagai YS, Radovanovic A, Steel JC, Stanley D. The Effects of Continual Consumption of on Liver Transcriptomics. Animals (Basel). 2021;11. doi:10.3390/ani11020398
- Khafaga AF, Naiel MAE, Dawood MAO, Abdel-Latif HMR. Dietary Origanum vulgare essential oil attenuates cypermethrin-induced biochemical changes, oxidative stress, histopathological alterations, apoptosis, and reduces DNA damage in Common carp (Cyprinus carpio). Aquat Toxicol. 2020;228:105624. doi:10.1016/j.aquatox.2020.105624
- Pasavei AG, Mohebbati R, Boroumand N, Ghorbani A, Hosseini A, et al. Anti-Hypolipidemic and Anti-Oxidative Effects of Hydroalcoholic Extract of on the Hepatosteatosis Induced with High-Fat Diet in Rats. Malays J Med Sci. 2020;27:57. doi:10.21315/mjms2020.27.1.6
- Oniga I, Pușcaș C, Silaghi-Dumitrescu R, Olah NK, Sevastre B, et al. ssp. : Chemical Composition and Biological Studies. Molecules. 2018;23. doi:10.3390/molecules23082077
- Aralbaeva AN, Mamataeva AT, Zhaparkulova NI, Utegalieva RS, Khanin M, et al. A composition of medicinal plants with an enhanced ability to suppress microsomal lipid peroxidation and a protective activity against carbon tetrachloride-induced hepatotoxicity. Biomed Pharmacother. 2017;96:1283. doi:10.1016/j.biopha.2017.11.085
- Huang Q, Bai F, Nie J, Lu S, Lu C, et al. Didymin ameliorates hepatic injury through inhibition of MAPK and NF-κB pathways by up-regulating RKIP expression. Int Immunopharmacol. 2017;42:130. doi:10.1016/j.intimp.2016.11.028
- Wei J, Huang Q, Bai F, Lin J, Nie J, et al. Didymin induces apoptosis through mitochondrial dysfunction and up-regulation of RKIP in human hepatoma cells. Chem Biol Interact. 2017;261:118. doi:10.1016/j.cbi.2016.11.026
- Fathy SA, Emam MA, Abo Agwa SH, Abu Zahra FA, Youssef FS, et al. The antiproliferative effect of Origanum majorana on human hepatocarcinoma cell line: suppression of NF-κB. Cell Mol Biol (Noisy-le-grand). 2016;62:80.
- Aristatile B, Al-Assaf AH, Pugalendi KV. Carvacrol ameliorates the PPAR-A and cytochrome P450 expression on D-galactosamine induced hepatotoxicity rats. Afr J Tradit Complement Altern Med. 2014;11:118.
- Habibi E, Shokrzadeh M, Chabra A, Naghshvar F, Keshavarz-Maleki R, et al. Protective effects of Origanum vulgare ethanol extract against cyclophosphamide-induced liver toxicity in mice. Pharm Biol. 2015;53:10. doi:10.3109/13880209.2014.908399
- Sikander M, Malik S, Parveen K, Ahmad M, Yadav D, et al. Hepatoprotective effect of Origanum vulgare in Wistar rats against carbon tetrachloride-induced hepatotoxicity. Protoplasma. 2013;250:483. doi:10.1007/s00709-012-0431-5
- Shati AA. Effects of Origanum majorana L. on cadmium induced hepatotoxicity and nephrotoxicity in albino rats. Saudi Med J. 2011;32:797.
