We investigated how intranasal zinc (Zn) treatment affects symptoms of allergic rhinitis (AR), specifically focusing on individuals suffering from Japanese cedar pollinosis (JCP), a common seasonal allergy. In our study, we monitored 57 control subjects and 44 patients from preseason through the allergy season, observing the levels of Zn in both nasal fluid and serum.
Our findings showed that after exposure to pollen, the level of zinc in the nasal lining fluid of JCP patients significantly increased, while their serum zinc levels notably decreased compared to the control group during the JCP season. To delve deeper, we used model mice that could mimic these changes and the allergy symptoms of the patients.
The results from this mouse study were promising. We observed that treating these mice with a dose of zinc, similar to what humans might use, led to a notable improvement in their allergy symptoms. Additionally, the number of mucin-secreting goblet cells, which indicate a response to allergies, significantly decreased following the zinc treatment.
Our study points towards the potential of using intranasal zinc as a way to alleviate allergy symptoms, suggesting a new approach to managing allergic rhinitis.
Read More
9
Zinc effectively suppresses allergies
Zinc treatment prevents IgE-mediated Ca influx and allergic response in RBL-2H3 cells.
We explored the potential of zinc to manage allergic responses by examining its effects on a specific type of immune cell called RBL-2H3. This research highlighted how zinc sulfate (ZnSO) treatment can prevent cell degranulation, which is a process crucial for allergic reactions, triggered by antigens and IgE stimulation.
Our findings showed that ZnSO not only inhibited cell degranulation but also reduced the expression of certain immune signaling molecules such as IL-4, IL-13, and COX-2. We observed that the increased levels of calcium inside the cells, which usually accompany these allergic reactions, were significantly lowered with zinc treatment.
Interestingly, while zinc did not interfere with the activation of several key proteins in the signaling pathway, it was effective at reducing the overall calcium influx associated with allergic responses. This suggests that zinc might be acting on calcium release-activated channels, offering a preventative advantage in allergic conditions.
Overall, we conclude that treating with zinc sulfate could be a valuable strategy for suppressing allergic responses, making it a topic worth considering for further research and application in allergy management.
Read More
9
Zinc nanoparticles suppress allergic reactions
ZnO Nanoparticles as Potent Inducers of Dermal Immunosuppression in Contact Hypersensitivity in Mice.
We investigated how zinc oxide nanoparticles (nZnO), commonly found in skin products like sunscreens, influence allergic reactions in the skin. Using a specific mouse model that simulates contact allergies, we wanted to understand whether applying nZnO during the sensitization or challenge phases would alter the immune response.
Our research showed that these nanoparticles, when applied during the allergic reaction, were able to suppress the immune response significantly. We noted a reduction in skin inflammation, with the strongest effects observed within 24 hours of exposure, and these effects lasted up to 28 days. Interestingly, while nZnO didn't hinder the initial allergy sensitization process, it did prevent the allergic reaction from fully developing when the allergen was introduced.
We found that the immunosuppressive properties of nZnO are tied to its ability to disrupt certain inflammatory signaling pathways. These findings suggest that nZnO could provide relief for people dealing with contact allergies, especially those using products containing these nanoparticles. Overall, our study sheds light on the potential benefits and mechanisms of nZnO in managing skin allergies.
Read More
Most Useful Reviews
9
Boosts immunity
30 people found this helpful
Excellent zinc in an easily chelated form! Unlike pharmacy options, I experienced no side effects or allergies. I used to have issues with zinc-containing medications, but this chelate form suits me. I take one capsule daily, and it supports my immunity, hair, skin, thyroid, and reproductive system. No allergy issues this time! I recommend this to everyone. Remember to take copper too, as they can inhibit each other.
Read More
7.5
Improves focus
3 people found this helpful
Well! This zinc has notably helped my hyperactive child focus better and be less irritable. Coupled with fish oil, it has also reduced her allergies and skin irritation.
Read More
7.5
Less skin irritation
1 people found this helpful
Excellent! I take it nightly and have nearly finished the pack. It helps with my AD, and I’ve noticed a decrease in skin allergies. I really like this product and will continue taking zinc!
We delved into the effectiveness of zinc treatment in managing allergic rhinitis, aided by a systematic review of clinical studies. Our exploration began with a thorough search of major databases, revealing insights from five clinical reports that met the necessary criteria for inclusion. These studies involved participants ranging from 40 to 180 individuals, providing a balanced mix of genders.
The results spotlighted the positive impact of combining quail egg-based supplements (QES) with zinc. Notably, this combination significantly improved several key measures, such as peak nasal inspiratory flow and mucociliary transport time. We observed that patients experienced relief from troublesome symptoms like nasal congestion, rhinorrhea, and sneezing. Moreover, this combination seemed to reduce the need for standard allergy medications, offering an appealing alternative for those seeking symptom relief.
Importantly, zinc and QES were generally well tolerated, with few reported side effects, which were usually mild and temporary. However, it’s crucial to highlight that individuals with egg allergies should avoid these supplements. As such, while our findings suggest that zinc, particularly in conjunction with QES, can play a role in alleviating allergic rhinitis symptoms, further research is encouraged to solidify these promising results.
Read More
9
Zinc may relieve allergy symptoms
Alleviating effect of intranasal zinc on symptoms of allergic rhinitis.
We investigated how intranasal zinc (Zn) treatment affects symptoms of allergic rhinitis (AR), specifically focusing on individuals suffering from Japanese cedar pollinosis (JCP), a common seasonal allergy. In our study, we monitored 57 control subjects and 44 patients from preseason through the allergy season, observing the levels of Zn in both nasal fluid and serum.
Our findings showed that after exposure to pollen, the level of zinc in the nasal lining fluid of JCP patients significantly increased, while their serum zinc levels notably decreased compared to the control group during the JCP season. To delve deeper, we used model mice that could mimic these changes and the allergy symptoms of the patients.
The results from this mouse study were promising. We observed that treating these mice with a dose of zinc, similar to what humans might use, led to a notable improvement in their allergy symptoms. Additionally, the number of mucin-secreting goblet cells, which indicate a response to allergies, significantly decreased following the zinc treatment.
Our study points towards the potential of using intranasal zinc as a way to alleviate allergy symptoms, suggesting a new approach to managing allergic rhinitis.
Read More
9
Zinc effectively suppresses allergies
Zinc treatment prevents IgE-mediated Ca influx and allergic response in RBL-2H3 cells.
We explored the potential of zinc to manage allergic responses by examining its effects on a specific type of immune cell called RBL-2H3. This research highlighted how zinc sulfate (ZnSO) treatment can prevent cell degranulation, which is a process crucial for allergic reactions, triggered by antigens and IgE stimulation.
Our findings showed that ZnSO not only inhibited cell degranulation but also reduced the expression of certain immune signaling molecules such as IL-4, IL-13, and COX-2. We observed that the increased levels of calcium inside the cells, which usually accompany these allergic reactions, were significantly lowered with zinc treatment.
Interestingly, while zinc did not interfere with the activation of several key proteins in the signaling pathway, it was effective at reducing the overall calcium influx associated with allergic responses. This suggests that zinc might be acting on calcium release-activated channels, offering a preventative advantage in allergic conditions.
Overall, we conclude that treating with zinc sulfate could be a valuable strategy for suppressing allergic responses, making it a topic worth considering for further research and application in allergy management.
Read More
9
Zinc nanoparticles suppress allergic reactions
ZnO Nanoparticles as Potent Inducers of Dermal Immunosuppression in Contact Hypersensitivity in Mice.
We investigated how zinc oxide nanoparticles (nZnO), commonly found in skin products like sunscreens, influence allergic reactions in the skin. Using a specific mouse model that simulates contact allergies, we wanted to understand whether applying nZnO during the sensitization or challenge phases would alter the immune response.
Our research showed that these nanoparticles, when applied during the allergic reaction, were able to suppress the immune response significantly. We noted a reduction in skin inflammation, with the strongest effects observed within 24 hours of exposure, and these effects lasted up to 28 days. Interestingly, while nZnO didn't hinder the initial allergy sensitization process, it did prevent the allergic reaction from fully developing when the allergen was introduced.
We found that the immunosuppressive properties of nZnO are tied to its ability to disrupt certain inflammatory signaling pathways. These findings suggest that nZnO could provide relief for people dealing with contact allergies, especially those using products containing these nanoparticles. Overall, our study sheds light on the potential benefits and mechanisms of nZnO in managing skin allergies.
Read More
8
Zinc supplementation may reduce allergies
Zinc Deficiency and Zinc Supplementation in Allergic Diseases.
We explored how zinc interacts with allergic diseases, which have been rising in prevalence worldwide, affecting both Western and developing nations. The question we aimed to answer was whether zinc deficiency contributes to these allergies and if zinc supplementation can help alleviate symptoms.
Our findings highlight that zinc is an essential trace element crucial for modulating our immune response. This was first noted over 60 years ago, and since then, we have continued to observe the connection between zinc levels and allergic reactions. Allergic conditions like asthma, allergic rhinitis, and skin allergies occur when the immune system overreacts to normally harmless substances, leading to chronic inflammation.
Notably, zinc deficiency can mimic some of the immune responses seen in these allergies, showing how intertwined our nutrition is with our immune health. We noted that while different clinical trials on zinc supplementation yield varied results due to factors like dosage and study design, the overall literature suggests that increasing zinc intake can positively influence immune function and help reduce allergic symptoms.
In conclusion, while further investigation is needed to fully understand the nuances, it appears that maintaining adequate zinc levels could be beneficial for those suffering from allergic diseases.
Excellent zinc in an easily chelated form! Unlike pharmacy options, I experienced no side effects or allergies. I used to have issues with zinc-containing medications, but this chelate form suits me. I take one capsule daily, and it supports my immunity, hair, skin, thyroid, and reproductive system. No allergy issues this time! I recommend this to everyone. Remember to take copper too, as they can inhibit each other.
Read More
7.5
Improves focus
3 people found this helpful
Well! This zinc has notably helped my hyperactive child focus better and be less irritable. Coupled with fish oil, it has also reduced her allergies and skin irritation.
Read More
7.5
Less skin irritation
1 people found this helpful
Excellent! I take it nightly and have nearly finished the pack. It helps with my AD, and I’ve noticed a decrease in skin allergies. I really like this product and will continue taking zinc!
Read More
9
No allergy issues
Excellent! I ordered this for my family after experiencing allergies with pharmacy zinc. Since taking this one, I’ve had no allergy problems. Thank you!
Read More
9
Aids immune response
Zinc is essential for health, reducing infection susceptibility, allergy issues, and aiding skin conditions. Its properties significantly boost immune responses and help reduce the duration of viral illnesses.
Allergies are the body's immune system responses to substances known as allergens, which can be harmless in most individuals. When a person with allergies encounters these allergens, their immune system mistakenly identifies them as a threat and launches a response. This can lead to symptoms ranging from mild, such as sneezing, itching, and rashes, to severe reactions known as anaphylaxis, which can be life-threatening. Common allergens include pollen, pet dander, certain foods like nuts and shellfish, insect stings, and medications.
Managing allergies often involves avoiding known allergens and using medications such as antihistamines or corticosteroids to alleviate symptoms. In some cases, doctors might recommend allergy shots or immunotherapy to help patients build tolerance over time. If you suspect you have allergies, consulting with a healthcare professional for proper diagnosis and treatment options is crucial. Understanding your triggers and how to live with allergies can significantly improve your quality of life.
Zinc is a versatile metal known for its various applications in industry and health. It is a bluish-white metallic element represented by the symbol Zn and atomic number 30 on the periodic table. Zinc is primarily used for galvanizing steel to prevent rusting, in the manufacturing of alloys, and as a component in batteries. Additionally, zinc plays a crucial role in biological processes, making it an essential trace element in the human diet. It is involved in immune function, protein synthesis, wound healing, and DNA synthesis, highlighting its importance in maintaining overall health and well-being.
Zinc has been studied for its potential effects on the immune system, and some research suggests that it may play a role in managing allergic responses. While zinc is essential for maintaining overall immune function, a direct link between zinc supplementation and reduction in allergy symptoms has not been firmly established. Some studies indicate that zinc may help modulate inflammation and could potentially benefit those with allergic rhinitis or other allergic conditions, but results can vary widely among individuals.
If you're considering zinc as a supplement for allergies, it’s vital to consult with a healthcare professional first. They can provide personalized advice based on your health status and any medications you might be taking. Additionally, focusing on a balanced diet rich in zinc-containing foods like nuts, seeds, legumes, and whole grains can offer support to your overall health and immune function, which may indirectly influence how your body handles allergens.
Based on user reviews, the time it typically takes to see results from taking zinc supplements for allergies can vary, but many users report experiencing benefits relatively quickly. For example, one reviewer mentioned that since switching to a non-pharmacy zinc supplement, they have seen no allergy problems at all, indicating immediate positive effects (Read Review). Another user noted a significant reduction in allergy symptoms during the season, suggesting prompt results after starting their regimen (Read Review).
Other reviewers highlighted ongoing improvements after continued use, with reports of reduced skin allergies and overall health benefits after consistently taking zinc supplements. One user noted significant health improvements regarding allergies after multiple purchases of the supplement, indicating that while some may see results right away, others might experience enhanced effects over time (Read Review). Overall, while immediate benefits may be observed, continued use appears to contribute to sustained improvements in allergy symptoms.
The research surrounding zinc supplementation for allergies suggests promising benefits, particularly for conditions like allergic rhinitis. A systematic review of clinical studies demonstrated that the combination of quail egg-based supplements and zinc significantly improved key symptoms such as nasal congestion and sneezing, while also reducing the need for standard medications [1]. Additionally, another investigation showed that intranasal zinc treatment led to improvements in allergy symptoms in patients with Japanese cedar pollinosis, indicating that zinc may enhance immune function and alleviate allergic responses [2].
Furthermore, numerous studies have explored the role of zinc in managing allergic diseases, revealing that higher levels of zinc can help reduce the risk of conditions such as allergic rhinitis and asthma [5]. Research has indicated that zinc's interaction with immune cells can effectively suppress allergic responses and inflammation [3]. While a variety of zinc supplements exist, it is crucial for individuals to consult their healthcare professionals before starting any new supplementation, especially if allergies to specific ingredients, like eggs, are a concern [1]. Overall, while more studies are warranted, current evidence supports the potential benefits of zinc for managing allergy symptoms.
Users have reported a range of improvements in allergy symptoms and overall health after using zinc supplements. Many have experienced significant reductions in allergy issues, with one user noting that they had no allergy problems at all after switching to a zinc chelate form that suited them better than pharmacy options (Read Review). Another reviewer mentioned that their child became less irritable and more focused, with a notable reduction in skin irritation and allergies when combining zinc with fish oil (Read Review).
Furthermore, several individuals indicated ongoing improvements. One user described a decrease in skin allergies and felt that the product significantly aided their attention deficit symptoms (Read Review). Additional reviewers highlighted enhanced immunity and fewer respiratory issues during allergy season, suggesting that while some users may gain immediate benefits, others notice improvements over time with consistent use (Read Review; Read Review). Overall, while individual outcomes can vary, many users have found zinc supplements effective in alleviating various allergy-related symptoms.
Users have reported positive outcomes from combining this zinc supplement with other products for managing allergies. For instance, one parent shared that their child saw improved focus and reduced irritability when zinc was taken alongside fish oil, leading to a notable decrease in allergies and skin irritation (Read Review). Another user mentioned that integrating this zinc supplement with other immune-boosting supplements contributed to alleviating their seasonal allergies, indicating that a multi-supplement approach can enhance overall effectiveness (Read Review).
Moreover, multiple reviewers echoed the sentiment that zinc plays a crucial role in reducing allergy symptoms and enhancing immune responses. One user noted significant health improvements for both themselves and their child, particularly regarding allergies, after using zinc alongside their regular supplements (Read Review). This feedback suggests that users value the combined approach to allergy management, allowing for a more comprehensive method in tackling allergy-related issues.
Users report varying experiences with the dosage of zinc for treating allergies. Many recommend taking one capsule daily, emphasizing that this dosage has significantly helped to alleviate their allergy symptoms. For instance, one user noted that since starting to take a chelated form of zinc, they experienced no allergy problems and appreciated the immune-boosting benefits it provided Read Review. Another user highlighted a similar experience, stating that taking zinc helped reduce their skin allergies and respiratory issues during allergy season Read Review.
Overall, users agree that incorporating zinc into their daily routine has led to improved health outcomes related to allergies. They also mention that this mineral can enhance immune responses and decrease the duration of allergy symptoms Read Review. However, experiences can vary, as one user found this particular zinc product ineffective for facial rashes, despite not having allergy issues Read Review. Overall, starting with a daily intake of zinc seems to be a commonly reported approach among users seeking relief from allergies.
9
No allergy issues
Excellent! I ordered this for my family after experiencing allergies with pharmacy zinc. Since taking this one, I’ve had no allergy problems. Thank you!
7.5
Eases allergies
A great budget option for chelated zinc! I take it during allergy season, and it significantly helps ease my respiratory issues. I’ve noticed reduced allergy symptoms and strengthened immunity during low times.
7.5
Improves allergies
After multiple purchases, both my child and I have experienced significant health improvements, particularly regarding allergies.
7.5
Improves focus
3 people found this helpful
Well! This zinc has notably helped my hyperactive child focus better and be less irritable. Coupled with fish oil, it has also reduced her allergies and skin irritation.
7.5
Less skin irritation
1 people found this helpful
Excellent! I take it nightly and have nearly finished the pack. It helps with my AD, and I’ve noticed a decrease in skin allergies. I really like this product and will continue taking zinc!
7.5
Supports allergies
I’ve been taking this and other immune-boosting supplements, and it has helped with my seasonal allergies.
9
Boosts immunity
30 people found this helpful
Excellent zinc in an easily chelated form! Unlike pharmacy options, I experienced no side effects or allergies. I used to have issues with zinc-containing medications, but this chelate form suits me. I take one capsule daily, and it supports my immunity, hair, skin, thyroid, and reproductive system. No allergy issues this time! I recommend this to everyone. Remember to take copper too, as they can inhibit each other.
9
Aids immune response
Zinc is essential for health, reducing infection susceptibility, allergy issues, and aiding skin conditions. Its properties significantly boost immune responses and help reduce the duration of viral illnesses.
2
Unsatisfactory results
7 people found this helpful
I tried this brand of zinc, but compared to others, it was ineffective. While I had no allergy issues, it didn’t help with facial rashes. I won’t reorder this product.
9
Zinc and QES alleviate allergies
Quail Egg-Based Supplements in Allergic Rhinitis: A Systematic Review of Clinical Studies.
We delved into the effectiveness of zinc treatment in managing allergic rhinitis, aided by a systematic review of clinical studies. Our exploration began with a thorough search of major databases, revealing insights from five clinical reports that met the necessary criteria for inclusion. These studies involved participants ranging from 40 to 180 individuals, providing a balanced mix of genders.
The results spotlighted the positive impact of combining quail egg-based supplements (QES) with zinc. Notably, this combination significantly improved several key measures, such as peak nasal inspiratory flow and mucociliary transport time. We observed that patients experienced relief from troublesome symptoms like nasal congestion, rhinorrhea, and sneezing. Moreover, this combination seemed to reduce the need for standard allergy medications, offering an appealing alternative for those seeking symptom relief.
Importantly, zinc and QES were generally well tolerated, with few reported side effects, which were usually mild and temporary. However, it’s crucial to highlight that individuals with egg allergies should avoid these supplements. As such, while our findings suggest that zinc, particularly in conjunction with QES, can play a role in alleviating allergic rhinitis symptoms, further research is encouraged to solidify these promising results.
9
Zinc may relieve allergy symptoms
Alleviating effect of intranasal zinc on symptoms of allergic rhinitis.
We investigated how intranasal zinc (Zn) treatment affects symptoms of allergic rhinitis (AR), specifically focusing on individuals suffering from Japanese cedar pollinosis (JCP), a common seasonal allergy. In our study, we monitored 57 control subjects and 44 patients from preseason through the allergy season, observing the levels of Zn in both nasal fluid and serum.
Our findings showed that after exposure to pollen, the level of zinc in the nasal lining fluid of JCP patients significantly increased, while their serum zinc levels notably decreased compared to the control group during the JCP season. To delve deeper, we used model mice that could mimic these changes and the allergy symptoms of the patients.
The results from this mouse study were promising. We observed that treating these mice with a dose of zinc, similar to what humans might use, led to a notable improvement in their allergy symptoms. Additionally, the number of mucin-secreting goblet cells, which indicate a response to allergies, significantly decreased following the zinc treatment.
Our study points towards the potential of using intranasal zinc as a way to alleviate allergy symptoms, suggesting a new approach to managing allergic rhinitis.
7
Zinc's mixed effects on allergies
Micronutrients and Allergic Diseases: A Mendelian Randomization Study.
We examined the relationship between zinc levels and common allergic diseases like allergic asthma, atopic dermatitis, and allergic rhinitis. By leveraging Mendelian randomization analysis, we looked into how varying concentrations of zinc could influence the risk of these allergies.
Our findings suggest that higher zinc levels in the bloodstream may help lower the chances of developing allergic asthma and atopic dermatitis. However, we also observed that an increase in vitamin C could potentially raise the risk of atopic dermatitis, indicating a complex interaction among nutrients.
Additionally, it seems that zinc, alongside phosphorus, could play a role in reducing the risk of allergic rhinitis. While these results are promising, it's important to note that they don't fully isolate zinc’s effects from other micronutrients, which means more focused research could clarify its role in managing allergies.
9
Zinc effectively suppresses allergies
Zinc treatment prevents IgE-mediated Ca influx and allergic response in RBL-2H3 cells.
We explored the potential of zinc to manage allergic responses by examining its effects on a specific type of immune cell called RBL-2H3. This research highlighted how zinc sulfate (ZnSO) treatment can prevent cell degranulation, which is a process crucial for allergic reactions, triggered by antigens and IgE stimulation.
Our findings showed that ZnSO not only inhibited cell degranulation but also reduced the expression of certain immune signaling molecules such as IL-4, IL-13, and COX-2. We observed that the increased levels of calcium inside the cells, which usually accompany these allergic reactions, were significantly lowered with zinc treatment.
Interestingly, while zinc did not interfere with the activation of several key proteins in the signaling pathway, it was effective at reducing the overall calcium influx associated with allergic responses. This suggests that zinc might be acting on calcium release-activated channels, offering a preventative advantage in allergic conditions.
Overall, we conclude that treating with zinc sulfate could be a valuable strategy for suppressing allergic responses, making it a topic worth considering for further research and application in allergy management.
References
Antonelli M, Mazzoleni E, Donelli D. Quail Egg-Based Supplements in Allergic Rhinitis: A Systematic Review of Clinical Studies. Nutrients. 2025;17. doi:10.3390/nu17040712
Xu H, Tong K, Iwasaki N, Ohgami N, Tazaki A, et al. Alleviating effect of intranasal zinc on symptoms of allergic rhinitis. J Allergy Clin Immunol Glob. 2025;4:100408. doi:10.1016/j.jacig.2025.100408
Otsuka T, Sato K, Kamiya T, Tanaka H, Hara H. Zinc treatment prevents IgE-mediated Ca influx and allergic response in RBL-2H3 cells. Eur J Pharmacol. 2025;994:177391. doi:10.1016/j.ejphar.2025.177391
Wang S, Ilves M, Mäenpää K, Zhao L, El-Nezami H, et al. ZnO Nanoparticles as Potent Inducers of Dermal Immunosuppression in Contact Hypersensitivity in Mice. ACS Nano. 2024;18:29479. doi:10.1021/acsnano.4c04270
Changhai L, Zaichun W, Bo Y, Dan L, Shaohua W. Micronutrients and Allergic Diseases: A Mendelian Randomization Study. Int Arch Allergy Immunol. 2025;186:41. doi:10.1159/000540376
Maywald M, Rink L. Zinc Deficiency and Zinc Supplementation in Allergic Diseases. Biomolecules. 2024;14. doi:10.3390/biom14070863
Wei Y, Zhu X, Lin S, Yang W, Wang T, et al. Zinc gluconate improves atopic dermatitis by modulating CXCL10 release of keratinocytes via PPARα activation. Biomed Pharmacother. 2024;177:117129. doi:10.1016/j.biopha.2024.117129