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SCIENTIFIC SCORE
Moderately Effective
Based on 8 Researches
8.3
USERS' SCORE
Good
Based on 5 Reviews
8.6
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Zinc (as Zinc bisglycinate)
30 mg
273%
Top Medical Research Studies
8
Zinc protects against gastritis damage
Zinc supplementation alleviates oxidative stress to inhibit chronic gastritis the ROS/NF-κB pathway in a mouse model.
Study highlights zinc's effectiveness
We investigated how zinc supplementation impacts chronic gastritis, particularly in the context of oxidative stress and inflammation. By establishing models of inflammatory injury in C57BL/6 mice, we were able to analyze the effects of zinc on the gastric mucosa, which is crucial for maintaining digestive health.
Our findings revealed that when the mice were exposed to a compound known to induce inflammation, there was a noticeable rise in reactive oxygen species (ROS), signaling an increase in oxidative stress. This stress resulted in an uptick in certain harmful factors related to inflammation and cell death. However, when we introduced zinc as a supplement, it effectively reduced these damaging factors, alleviating inflammation and the resulting cell death in both the mouse stomach and cultured cells.
Overall, our study indicates that zinc supplementation can play a significant role in controlling inflammation and protecting against cellular damage caused by oxidative stress in chronic gastritis. By modulating the ROS/NF-κB signaling pathway, zinc demonstrates potential as a protective agent for gastric health.
Our findings revealed that when the mice were exposed to a compound known to induce inflammation, there was a noticeable rise in reactive oxygen species (ROS), signaling an increase in oxidative stress. This stress resulted in an uptick in certain harmful factors related to inflammation and cell death. However, when we introduced zinc as a supplement, it effectively reduced these damaging factors, alleviating inflammation and the resulting cell death in both the mouse stomach and cultured cells.
Overall, our study indicates that zinc supplementation can play a significant role in controlling inflammation and protecting against cellular damage caused by oxidative stress in chronic gastritis. By modulating the ROS/NF-κB signaling pathway, zinc demonstrates potential as a protective agent for gastric health.
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8
Zinc shows effectiveness against H. pylori
Comparison of antimicrobial activity of zinc chloride and bismuth subsalicylate against clinical isolates of Helicobacter pylori.
Significant but not isolated findings
We explored the effectiveness of zinc chloride (ZnCl) in treating Helicobacter pylori (H. pylori) infections, particularly concerning various gastritis conditions. Our study involved testing 116 clinical isolates of H. pylori to see how they responded to ZnCl, bismuth subsalicylate (BSS), and clarithromycin (CLR).
Using a method called agar gel dilution, we found that 95% of the H. pylori strains tested were susceptible to ZnCl at a concentration of 40 μg/ml. This is a promising figure, especially when compared to 98% susceptibility for BSS and 79% for CLR. Interestingly, H. pylori isolates from patients with nonulcer dyspepsia and peptic ulcers showed similar levels of susceptibility to ZnCl.
It's important to note that while ZnCl demonstrated a significant antimicrobial effect against H. pylori, making it a potential candidate for treatment, the study also indicated that its effectiveness was comparable to CLR, but slightly less than BSS. This suggests that while ZnCl may be beneficial in treating H. pylori infections, it should not be viewed as a standalone solution, particularly in gastritis management.
Ultimately, our findings indicate that zinc chloride holds promise in tackling H. pylori, potentially contributing to improved treatment strategies for those suffering from gastritis and related disorders.
Using a method called agar gel dilution, we found that 95% of the H. pylori strains tested were susceptible to ZnCl at a concentration of 40 μg/ml. This is a promising figure, especially when compared to 98% susceptibility for BSS and 79% for CLR. Interestingly, H. pylori isolates from patients with nonulcer dyspepsia and peptic ulcers showed similar levels of susceptibility to ZnCl.
It's important to note that while ZnCl demonstrated a significant antimicrobial effect against H. pylori, making it a potential candidate for treatment, the study also indicated that its effectiveness was comparable to CLR, but slightly less than BSS. This suggests that while ZnCl may be beneficial in treating H. pylori infections, it should not be viewed as a standalone solution, particularly in gastritis management.
Ultimately, our findings indicate that zinc chloride holds promise in tackling H. pylori, potentially contributing to improved treatment strategies for those suffering from gastritis and related disorders.
Read More
9.5
Zinc Carnosine Enhances Eradication
Zinc carnosine-based modified bismuth quadruple therapy standard triple therapy for eradication: A randomized controlled study.
Relevant to gastritis treatment
We conducted a study to explore the effectiveness of a modified bismuth quadruple therapy that included zinc carnosine in treating gastritis, compared to the standard triple therapy. Our participant group consisted of 92 patients who showed symptoms of dyspepsia and tested positive on a urea breath test for the infection.
The study was structured with one group receiving the traditional 14-day standard treatment, which included esomeprazole, amoxicillin, and clarithromycin. The other group was treated with a 10-day regimen that added bismuth subcitrate and zinc carnosine to the same foundational therapies. After completing their courses, we retested the patients to assess the success of the eradication therapy.
Our findings revealed that the modified therapy group achieved a significantly higher eradication rate of 93.5% compared to just 69.6% in the standard treatment group. Besides dizziness, the side effects were similar between the two therapies, indicating that the addition of zinc carnosine did not introduce significant new risks.
This research suggests that zinc carnosine can be beneficial in enhancing the effectiveness of treatments for gastritis while maintaining a favorable safety profile. Therefore, those dealing with difficult-to-treat gastritis might find hope in this innovative approach.
The study was structured with one group receiving the traditional 14-day standard treatment, which included esomeprazole, amoxicillin, and clarithromycin. The other group was treated with a 10-day regimen that added bismuth subcitrate and zinc carnosine to the same foundational therapies. After completing their courses, we retested the patients to assess the success of the eradication therapy.
Our findings revealed that the modified therapy group achieved a significantly higher eradication rate of 93.5% compared to just 69.6% in the standard treatment group. Besides dizziness, the side effects were similar between the two therapies, indicating that the addition of zinc carnosine did not introduce significant new risks.
This research suggests that zinc carnosine can be beneficial in enhancing the effectiveness of treatments for gastritis while maintaining a favorable safety profile. Therefore, those dealing with difficult-to-treat gastritis might find hope in this innovative approach.
Read More
Most Useful Reviews
8.3
Comfortable zinc intake
I suffer from atrophic gastritis and functional dyspepsia. I struggled with stomachaches from zinc, but this bisglycinate chelated zinc was recommended for those with sensitive stomachs. Now, I can take it comfortably, and I haven’t experienced the white spots on my nails since starting. If you have stomach discomfort with zinc, try zinc bisglycinate.
Read More
8.8
Effective for gastritis
Excellent! I found this Zinc very effective, as it does not irritate my stomach. I recommend it for gastritis.
Read More
9.5
Suitable for absorption
I take one at a time, combined with other medications. I opted for the chelated form, which is ideal due to my autoimmune atrophic gastritis, as only chelated forms are absorbed more effectively.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 8 Researches
8.3
9.5
Zinc Carnosine Enhances Eradication
Zinc carnosine-based modified bismuth quadruple therapy standard triple therapy for eradication: A randomized controlled study.
Relevant to gastritis treatment
We conducted a study to explore the effectiveness of a modified bismuth quadruple therapy that included zinc carnosine in treating gastritis, compared to the standard triple therapy. Our participant group consisted of 92 patients who showed symptoms of dyspepsia and tested positive on a urea breath test for the infection.
The study was structured with one group receiving the traditional 14-day standard treatment, which included esomeprazole, amoxicillin, and clarithromycin. The other group was treated with a 10-day regimen that added bismuth subcitrate and zinc carnosine to the same foundational therapies. After completing their courses, we retested the patients to assess the success of the eradication therapy.
Our findings revealed that the modified therapy group achieved a significantly higher eradication rate of 93.5% compared to just 69.6% in the standard treatment group. Besides dizziness, the side effects were similar between the two therapies, indicating that the addition of zinc carnosine did not introduce significant new risks.
This research suggests that zinc carnosine can be beneficial in enhancing the effectiveness of treatments for gastritis while maintaining a favorable safety profile. Therefore, those dealing with difficult-to-treat gastritis might find hope in this innovative approach.
The study was structured with one group receiving the traditional 14-day standard treatment, which included esomeprazole, amoxicillin, and clarithromycin. The other group was treated with a 10-day regimen that added bismuth subcitrate and zinc carnosine to the same foundational therapies. After completing their courses, we retested the patients to assess the success of the eradication therapy.
Our findings revealed that the modified therapy group achieved a significantly higher eradication rate of 93.5% compared to just 69.6% in the standard treatment group. Besides dizziness, the side effects were similar between the two therapies, indicating that the addition of zinc carnosine did not introduce significant new risks.
This research suggests that zinc carnosine can be beneficial in enhancing the effectiveness of treatments for gastritis while maintaining a favorable safety profile. Therefore, those dealing with difficult-to-treat gastritis might find hope in this innovative approach.
Read More
9.5
Zinc supports recovery in CCS
Case of Cronkhite Canada syndrome shows improvement with enteral supplements.
Multi-component treatment assessed
Our examination focuses on the intriguing case of a 33-year-old man diagnosed with Cronkhite-Canada syndrome (CCS), a rare condition affecting the gastrointestinal tract and skin. During his hospital stay, he presented with severe gastrointestinal symptoms alongside notable skin changes.
To address his condition, the treatment regime included high protein supplements, proton pump inhibitors, and zinc-vitamin supplements. Over the course of five months, we observed a complete improvement in his symptoms. While this particular case emphasizes the role of zinc within a comprehensive treatment plan, it’s important to note that zinc was part of a multi-component strategy that makes it difficult to isolate its individual effects on gastritis directly.
Nonetheless, this case illustrates how early diagnosis and a well-structured treatment approach—integrating nutritional support—can lead to significant recovery in rare syndromes like CCS.
To address his condition, the treatment regime included high protein supplements, proton pump inhibitors, and zinc-vitamin supplements. Over the course of five months, we observed a complete improvement in his symptoms. While this particular case emphasizes the role of zinc within a comprehensive treatment plan, it’s important to note that zinc was part of a multi-component strategy that makes it difficult to isolate its individual effects on gastritis directly.
Nonetheless, this case illustrates how early diagnosis and a well-structured treatment approach—integrating nutritional support—can lead to significant recovery in rare syndromes like CCS.
Read More
8
Zinc protects against gastritis damage
Zinc supplementation alleviates oxidative stress to inhibit chronic gastritis the ROS/NF-κB pathway in a mouse model.
Study highlights zinc's effectiveness
We investigated how zinc supplementation impacts chronic gastritis, particularly in the context of oxidative stress and inflammation. By establishing models of inflammatory injury in C57BL/6 mice, we were able to analyze the effects of zinc on the gastric mucosa, which is crucial for maintaining digestive health.
Our findings revealed that when the mice were exposed to a compound known to induce inflammation, there was a noticeable rise in reactive oxygen species (ROS), signaling an increase in oxidative stress. This stress resulted in an uptick in certain harmful factors related to inflammation and cell death. However, when we introduced zinc as a supplement, it effectively reduced these damaging factors, alleviating inflammation and the resulting cell death in both the mouse stomach and cultured cells.
Overall, our study indicates that zinc supplementation can play a significant role in controlling inflammation and protecting against cellular damage caused by oxidative stress in chronic gastritis. By modulating the ROS/NF-κB signaling pathway, zinc demonstrates potential as a protective agent for gastric health.
Our findings revealed that when the mice were exposed to a compound known to induce inflammation, there was a noticeable rise in reactive oxygen species (ROS), signaling an increase in oxidative stress. This stress resulted in an uptick in certain harmful factors related to inflammation and cell death. However, when we introduced zinc as a supplement, it effectively reduced these damaging factors, alleviating inflammation and the resulting cell death in both the mouse stomach and cultured cells.
Overall, our study indicates that zinc supplementation can play a significant role in controlling inflammation and protecting against cellular damage caused by oxidative stress in chronic gastritis. By modulating the ROS/NF-κB signaling pathway, zinc demonstrates potential as a protective agent for gastric health.
Read More
8
Polaprezinc shows promise in gastritis
Efficacy and Safety of Polaprezinc-Based Therapy versus the Standard Triple Therapy for Eradication: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Study relevance is somewhat limited
We conducted a systematic review to assess how Polaprezinc, a zinc-l-carnosine complex, might influence the treatment of gastritis. Focusing on its effectiveness when combined with standard triple therapy, which includes antibiotics, we analyzed data from three randomized controlled trials involving 396 participants.
Our findings suggest that adding Polaprezinc to the triple therapy improved the eradication rates of the bacteria responsible for gastritis. Specifically, we observed a significant increase in successful treatment outcomes, indicating a potential advantage of Polaprezinc as a complementary approach.
However, it's important to note that while the combination therapy showed better results, both treatment groups reported similar instances of adverse events. This means that Polaprezinc appears to offer a beneficial effect on treatment outcomes without increasing side effects.
Despite these positive results, we recognize that the evidence is still limited. More extensive trials are needed to confirm these findings and establish Polaprezinc's role in gastritis management firmly. Overall, this treatment could be a promising addition but needs further exploration before becoming a standard approach.
Our findings suggest that adding Polaprezinc to the triple therapy improved the eradication rates of the bacteria responsible for gastritis. Specifically, we observed a significant increase in successful treatment outcomes, indicating a potential advantage of Polaprezinc as a complementary approach.
However, it's important to note that while the combination therapy showed better results, both treatment groups reported similar instances of adverse events. This means that Polaprezinc appears to offer a beneficial effect on treatment outcomes without increasing side effects.
Despite these positive results, we recognize that the evidence is still limited. More extensive trials are needed to confirm these findings and establish Polaprezinc's role in gastritis management firmly. Overall, this treatment could be a promising addition but needs further exploration before becoming a standard approach.
Read More
8
Zinc's role in gastritis improvement
Study of Serum Ferritin, Zinc, and Copper Levels in Children With Helicobacter pylori Gastritis and the Effect of the Treatment.
Insights on zinc's importance
We conducted a study to understand how zinc influences children suffering from gastritis due to Helicobacter pylori infection. Our investigation included 70 young patients exhibiting symptoms of upper gastrointestinal distress. By dividing the group into H. pylori-positive and H. pylori-negative children, we could directly observe the differences in serum levels of hemoglobin, ferritin, zinc, and copper.
Notably, we found that children with H. pylori had lower levels of serum ferritin and zinc compared to those without the infection. However, the copper levels remained unaffected. Interestingly, after treating the infected children, we observed significant improvements in their hemoglobin, ferritin, and zinc levels. This suggests that while zinc deficiency is often present in these patients, simply providing zinc treatment alone cannot solely isolate its specific impact on gastritis.
Furthermore, we noted that more severe gastritis correlated with lower hemoglobin and zinc levels, and higher transferrin receptor levels. Although zinc appears to play a crucial role in the overall health of these children, our findings indicate that its treatment effect should be viewed alongside other potential factors influencing gastritis recovery.
Notably, we found that children with H. pylori had lower levels of serum ferritin and zinc compared to those without the infection. However, the copper levels remained unaffected. Interestingly, after treating the infected children, we observed significant improvements in their hemoglobin, ferritin, and zinc levels. This suggests that while zinc deficiency is often present in these patients, simply providing zinc treatment alone cannot solely isolate its specific impact on gastritis.
Furthermore, we noted that more severe gastritis correlated with lower hemoglobin and zinc levels, and higher transferrin receptor levels. Although zinc appears to play a crucial role in the overall health of these children, our findings indicate that its treatment effect should be viewed alongside other potential factors influencing gastritis recovery.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.6
9.5
Suitable for absorption
I take one at a time, combined with other medications. I opted for the chelated form, which is ideal due to my autoimmune atrophic gastritis, as only chelated forms are absorbed more effectively.
8.8
Effective for gastritis
Excellent! I found this Zinc very effective, as it does not irritate my stomach. I recommend it for gastritis.
8.8
Well tolerated
The Zinc from this company is well tolerated by my husband and me, despite our gastritis. I highly recommend it, and the price is reasonable too!
8.8
No nausea experienced
This supplement usually makes my stomach feel heavy. I have chronic gastritis, but I can take this product daily without feeling nauseous, especially when taking it with more water.
8.3
Comfortable zinc intake
I suffer from atrophic gastritis and functional dyspepsia. I struggled with stomachaches from zinc, but this bisglycinate chelated zinc was recommended for those with sensitive stomachs. Now, I can take it comfortably, and I haven’t experienced the white spots on my nails since starting. If you have stomach discomfort with zinc, try zinc bisglycinate.
Read More
