Medical Researches
Moderately Effective
Based on 10 Researches
Zinc's role in ulcer treatment[Argentinean registry on the management of Helicobacter pylori infection: effectiveness and safety of first line treatment].
Effectiveness of combined therapies
We explored the impact of zinc when incorporated into first-line treatments for Helicobacter pylori infections, particularly in patients suffering from ulcers. In a multicenter registry study involving 800 patients, we noted that the most common factors leading to treatment were dyspepsia and gastroduodenal ulcers.
The findings indicated that quadruple therapy—both with and without bismuth—improved eradication rates significantly, achieving about 94.9%. Meanwhile, zinc as a part of a sequential therapy showed an impressive effectiveness of 95.6%. However, since zinc was combined with other treatments, it’s challenging to pinpoint its isolated effects on ulcer healing or eradication efficacy.
We also observed that adverse events, though reported in nearly 29% of cases, were generally mild, suggesting that the treatments were well-tolerated. Overall, the report highlighted that while zinc may enhance treatment effectiveness when combined, its individual contribution remains undetermined.
Read More
We investigated the effects of zinc hyaluronate (ZnHA) on ulcerative colitis (UC) using a mouse model that simulates the condition. This study aimed to explore how ZnHA could potentially alleviate the symptoms of UC, focusing on factors like inflammation and gut health.
Our experiments showed that ZnHA significantly reduced key symptoms associated with UC, such as weight loss, loose stools, and the presence of blood in stools. We also noticed notable changes at a cellular level; ZnHA helped decrease levels of inflammatory markers like tumor necrosis factor-α and interleukin-6 while boosting interleukin-10, a factor known for anti-inflammatory effects.
Additionally, our findings revealed that ZnHA positively impacted gut bacteria. It fostered the growth of beneficial bacteria that produce propionic acid, which is crucial for gut health. We also observed that ZnHA enhanced the function of proteins that maintain the intestinal barrier, such as ZO-1 and occludin.
Overall, our exploration highlights the potential of ZnHA as a supportive treatment for UC by targeting inflammation and promoting a healthy gut environment. This study provides new insights that could encourage further development of hyaluronic acid-based treatments for UC and similar conditions.
Read More
Zinc enhances diabetic ulcer healingEnhanced diabetic foot ulcer treatment with a chitosan-based thermosensitive hydrogel loaded self-assembled multi-functional nanoparticles for antibacterial and angiogenic effects.
Significant contribution of zinc noted
We explored how a new treatment for diabetic foot ulcers (DFUs) works, focusing on the role of zinc. This innovative formulation combines zinc with other therapeutic agents in a chitosan-based hydrogel that responds to heat. Our aim was to see if this treatment could not only fight bacteria but also help the body heal more effectively.
The combination of zinc with chlorogenic acid and indocyanine green promotes a healing environment by reducing inflammation and oxidative stress at the ulcer site. This hydrogel is designed to release its active ingredients right where they’re needed, and we found that it significantly enhances the expression of proteins important for blood vessel formation, including VEGF and CD31.
In our experiments, both in the lab and in real-life conditions, this zinc-enriched hydrogel showed promising results. It effectively inhibited the growth of the common bacteria Staphylococcus aureus after applying laser treatment and helped wounds remodel within 14 days.
This study suggests that incorporating zinc into wound care strategies could significantly improve treatment outcomes for patients suffering from DFUs. Overall, our findings open up new avenues for managing this challenging health issue.
Read More
New treatment reduces digital dermatitisInvestigation on the effectiveness of a new hoof care product to sustainably reduce and prevent digital dermatitis in dairy cow herds.
Mix limits zinc's isolated impact
We embarked on an investigation to understand whether a new hoof care product featuring iron, zinc, and aluminum can effectively reduce and prevent digital dermatitis (DD) in dairy cows. In a controlled trial involving over 130 dairy cows, we treated one hind foot of each cow twice a week with this product while leaving the other foot untreated for comparison.
The results were revealing! Our analysis indicated that the use of the hoof care product significantly reduced the severity of DD compared to the untreated group. In fact, cows treated with the product had a much lower chance of developing lesions. The outcome showed that in the control group, the odds of having a lesion were four times higher than in the treated group, and the likelihood of experiencing an active lesion versus an inactive one was even more pronounced.
Interestingly, we also observed positive outcomes in heifers, with only one developing an active lesion in the treated group, showcasing the potential for this product to help manage and prevent DD even before these young cows enter the herd. The study indicates that the combination of ingredients in this hoof care product could be a promising alternative to traditional, harsher treatments.
While zinc is included as one of the components in the product, it's essential to note that we can't isolate its effect on ulcers from the other ingredients. Therefore, we can't definitively conclude zinc's sole effectiveness when it comes to DD treatment, but the overall findings are encouraging for improving hoof health in dairy cows.
Read More
Zinc and Polaprezinc's synergistic effectsAspergillusidone G Potentiates the Anti-Inflammatory Effects of Polaprezinc in LPS-Induced BV2 Microglia: A Bioinformatics and Experimental Study.
Explored zinc’s ulcer connection
We explored the potential impact of Polaprezinc, a drug commonly used for gastric ulcers, on neuroinflammation, a key factor in neurodegenerative diseases. By using LPS-induced BV-2 microglia, we observed that Polaprezinc significantly reduced the production of harmful compounds like nitric oxide and reactive oxygen species. Additionally, it inhibited the expression of inflammatory markers, suggesting its anti-inflammatory properties may extend beyond ulcer treatment.
Interestingly, we also examined how the combination of Polaprezinc with Aspergillusidone G could enhance these effects. When we treated the microglia with both substances, the results were promising. The duo improved the inhibition of nitric oxide generation from about 30% to an impressive 80%. This indicates a possible synergistic anti-inflammatory effect that could offer new approaches in managing neuroinflammatory conditions.
Overall, our findings shed light on the importance of zinc's role in the therapeutic effects of Polaprezinc, especially when paired with other compounds like Aspergillusidone G. This combination opens up exciting avenues for research into treatments for neurodegenerative diseases, highlighting the crucial connection between inflammation and zinc in the context of ulcer management.
Read More
User Reviews
I bought Zinc Chelate for a colleague suffering from recurrent mouth ulcers. Since starting this combined with folic acid and B12, she hasn’t experienced them anymore. I've introduced it to others facing the same issue, and they've also found relief from painful mouth ulcers. This product is indeed impressive!
Read More
Reduction in complications
I find that zinc is critical for health. A deficiency can disrupt bodily functions, resulting in issues like skin diseases and ulcers. It's difficult to get adequate zinc from food alone, so I often rely on supplements. Additionally, recent studies indicate that zinc is more effective than vitamin C in combating colds by halting virus progression and softening disease severity. I'm pleased with its effectiveness in managing ulcers and would recommend it wholeheartedly.
Read More
Initially, I hadn’t taken zinc, but once I did, my mouth ulcers disappeared. It's an effective solution for anyone struggling with these painful issues.
I find this zinc very effective for treating my broken lips. After a tiring day and indulging in fried foods, I developed mouth ulcers. However, after continuous zinc intake, I felt a swift relief and regained my spirits. The tablets are small and easy to swallow, making them convenient for daily use.
Read More
I must emphasise the importance of zinc. It's essential for numerous bodily functions, including maintaining a balanced immune system. Zinc is vital for cell growth, and its absence can lead to issues like poor wound healing and increased susceptibility to infections. I recommend that everyone ensure their multivitamin includes zinc, as it can significantly enhance immunity, particularly in older adults. My experiences with it have been immensely positive, especially concerning ulcer healing and overall health.
Read More