Overview

SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.2
USERS' SCORE
Good
Based on 9 Reviews
8.4
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Zinc (as Zinc bisglycinate)
30 mg
273%

Top Medical Research Studies

We delved into an interesting case of a 76-year-old man who developed severe esophageal ulcers, likely due to zinc deficiency following a total gastrectomy. His symptoms included sore throat, heartburn, and difficulty swallowing.

After the diagnosis of zinc deficiency, he began oral zinc treatment. Remarkably, this led to significant symptom relief and visible healing of the ulcers during follow-up imaging. Impressively, he has maintained his zinc supplementation for five years without any recurrence of symptoms. This unique case shines a light on the potential role of zinc in ulcer healing.
Read More
We moved forward with a double-blind, placebo-controlled study to see how zinc affects ulcers in patients with Behçet's disease. Over 12 weeks, 50 participants received either zinc gluconate or a placebo.

The results revealed that zinc significantly reduced the occurrence of genital ulcers and inflammation markers like NLRP3 and caspase-1. In fact, zinc supplementation improved clinical conditions and decreased inflammatory markers, showing promise as an additional therapy for managing Behçet's disease.
Read More
8
Zinc treatment comparable for ulcers
We explored how polaprezinc combined with a proton pump inhibitor (PPI) stacks up against rebamipide with PPI treatment for ulcers resulting from endoscopic submucosal dissection (ESD). Involving 210 patients, the study randomly assigned them to either treatment group and evaluated their ulcer healing rates after four weeks.

We found that polaprezinc's healing effectiveness was comparable to that of rebamipide, with healing rates at 90.3% and 91.4% respectively. This means that while both treatments are effective, we didn’t observe a significant advantage of one over the other in promoting ulcer healing.
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Most Useful Reviews

9
Reduction in complications
18 people found this helpful
I find that zinc is critical for health. A deficiency can disrupt bodily functions, resulting in issues like skin diseases and ulcers. It's difficult to get adequate zinc from food alone, so I often rely on supplements. Additionally, recent studies indicate that zinc is more effective than vitamin C in combating colds by halting virus progression and softening disease severity. I'm pleased with its effectiveness in managing ulcers and would recommend it wholeheartedly.
Read More
9
Ulcer healing
2 people found this helpful
When I received my zinc, I was struggling with painful ulcers. After just a few days of ensuring sufficient zinc levels, I'm now healed and my appetite has returned.
Read More
10
Ulcer relief
1 people found this helpful
I bought Zinc Chelate for a colleague suffering from recurrent mouth ulcers. Since starting this combined with folic acid and B12, she hasn’t experienced them anymore. I've introduced it to others facing the same issue, and they've also found relief from painful mouth ulcers. This product is indeed impressive!
Read More

Medical Researches

SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.2
  • All Researches
9.5
Zinc's role in ulcer treatment
We explored the impact of zinc when incorporated into first-line treatments for Helicobacter pylori infections, particularly in patients suffering from ulcers. In a multicenter registry study involving 800 patients, we noted that the most common factors leading to treatment were dyspepsia and gastroduodenal ulcers.

The findings indicated that quadruple therapy—both with and without bismuth—improved eradication rates significantly, achieving about 94.9%. Meanwhile, zinc as a part of a sequential therapy showed an impressive effectiveness of 95.6%. However, since zinc was combined with other treatments, it’s challenging to pinpoint its isolated effects on ulcer healing or eradication efficacy.

We also observed that adverse events, though reported in nearly 29% of cases, were generally mild, suggesting that the treatments were well-tolerated. Overall, the report highlighted that while zinc may enhance treatment effectiveness when combined, its individual contribution remains undetermined.
Read More
We investigated the effects of zinc hyaluronate (ZnHA) on ulcerative colitis (UC) using a mouse model that simulates the condition. This study aimed to explore how ZnHA could potentially alleviate the symptoms of UC, focusing on factors like inflammation and gut health.

Our experiments showed that ZnHA significantly reduced key symptoms associated with UC, such as weight loss, loose stools, and the presence of blood in stools. We also noticed notable changes at a cellular level; ZnHA helped decrease levels of inflammatory markers like tumor necrosis factor-α and interleukin-6 while boosting interleukin-10, a factor known for anti-inflammatory effects.

Additionally, our findings revealed that ZnHA positively impacted gut bacteria. It fostered the growth of beneficial bacteria that produce propionic acid, which is crucial for gut health. We also observed that ZnHA enhanced the function of proteins that maintain the intestinal barrier, such as ZO-1 and occludin.

Overall, our exploration highlights the potential of ZnHA as a supportive treatment for UC by targeting inflammation and promoting a healthy gut environment. This study provides new insights that could encourage further development of hyaluronic acid-based treatments for UC and similar conditions.
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9
Zinc enhances diabetic ulcer healing
We explored how a new treatment for diabetic foot ulcers (DFUs) works, focusing on the role of zinc. This innovative formulation combines zinc with other therapeutic agents in a chitosan-based hydrogel that responds to heat. Our aim was to see if this treatment could not only fight bacteria but also help the body heal more effectively.

The combination of zinc with chlorogenic acid and indocyanine green promotes a healing environment by reducing inflammation and oxidative stress at the ulcer site. This hydrogel is designed to release its active ingredients right where they’re needed, and we found that it significantly enhances the expression of proteins important for blood vessel formation, including VEGF and CD31.

In our experiments, both in the lab and in real-life conditions, this zinc-enriched hydrogel showed promising results. It effectively inhibited the growth of the common bacteria Staphylococcus aureus after applying laser treatment and helped wounds remodel within 14 days.

This study suggests that incorporating zinc into wound care strategies could significantly improve treatment outcomes for patients suffering from DFUs. Overall, our findings open up new avenues for managing this challenging health issue.
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9
New treatment reduces digital dermatitis
We embarked on an investigation to understand whether a new hoof care product featuring iron, zinc, and aluminum can effectively reduce and prevent digital dermatitis (DD) in dairy cows. In a controlled trial involving over 130 dairy cows, we treated one hind foot of each cow twice a week with this product while leaving the other foot untreated for comparison.

The results were revealing! Our analysis indicated that the use of the hoof care product significantly reduced the severity of DD compared to the untreated group. In fact, cows treated with the product had a much lower chance of developing lesions. The outcome showed that in the control group, the odds of having a lesion were four times higher than in the treated group, and the likelihood of experiencing an active lesion versus an inactive one was even more pronounced.

Interestingly, we also observed positive outcomes in heifers, with only one developing an active lesion in the treated group, showcasing the potential for this product to help manage and prevent DD even before these young cows enter the herd. The study indicates that the combination of ingredients in this hoof care product could be a promising alternative to traditional, harsher treatments.

While zinc is included as one of the components in the product, it's essential to note that we can't isolate its effect on ulcers from the other ingredients. Therefore, we can't definitively conclude zinc's sole effectiveness when it comes to DD treatment, but the overall findings are encouraging for improving hoof health in dairy cows.
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9
Zinc and Polaprezinc's synergistic effects
We explored the potential impact of Polaprezinc, a drug commonly used for gastric ulcers, on neuroinflammation, a key factor in neurodegenerative diseases. By using LPS-induced BV-2 microglia, we observed that Polaprezinc significantly reduced the production of harmful compounds like nitric oxide and reactive oxygen species. Additionally, it inhibited the expression of inflammatory markers, suggesting its anti-inflammatory properties may extend beyond ulcer treatment.

Interestingly, we also examined how the combination of Polaprezinc with Aspergillusidone G could enhance these effects. When we treated the microglia with both substances, the results were promising. The duo improved the inhibition of nitric oxide generation from about 30% to an impressive 80%. This indicates a possible synergistic anti-inflammatory effect that could offer new approaches in managing neuroinflammatory conditions.

Overall, our findings shed light on the importance of zinc's role in the therapeutic effects of Polaprezinc, especially when paired with other compounds like Aspergillusidone G. This combination opens up exciting avenues for research into treatments for neurodegenerative diseases, highlighting the crucial connection between inflammation and zinc in the context of ulcer management.
Read More

User Reviews

USERS' SCORE
Good
Based on 9 Reviews
8.4
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Reduction in complications
18 people found this helpful
I find that zinc is critical for health. A deficiency can disrupt bodily functions, resulting in issues like skin diseases and ulcers. It's difficult to get adequate zinc from food alone, so I often rely on supplements. Additionally, recent studies indicate that zinc is more effective than vitamin C in combating colds by halting virus progression and softening disease severity. I'm pleased with its effectiveness in managing ulcers and would recommend it wholeheartedly.
Read More
9
Ulcer healing
2 people found this helpful
When I received my zinc, I was struggling with painful ulcers. After just a few days of ensuring sufficient zinc levels, I'm now healed and my appetite has returned.
Read More
10
Ulcer relief
1 people found this helpful
I bought Zinc Chelate for a colleague suffering from recurrent mouth ulcers. Since starting this combined with folic acid and B12, she hasn’t experienced them anymore. I've introduced it to others facing the same issue, and they've also found relief from painful mouth ulcers. This product is indeed impressive!
Read More
7.5
Boosted immunity
47 people found this helpful
I must emphasise the importance of zinc. It's essential for numerous bodily functions, including maintaining a balanced immune system. Zinc is vital for cell growth, and its absence can lead to issues like poor wound healing and increased susceptibility to infections. I recommend that everyone ensure their multivitamin includes zinc, as it can significantly enhance immunity, particularly in older adults. My experiences with it have been immensely positive, especially concerning ulcer healing and overall health.
Read More
9
Ulcer prevention
Initially, I hadn’t taken zinc, but once I did, my mouth ulcers disappeared. It's an effective solution for anyone struggling with these painful issues.
Read More

Frequently Asked Questions

9
Ulcer healing
2 people found this helpful
When I received my zinc, I was struggling with painful ulcers. After just a few days of ensuring sufficient zinc levels, I'm now healed and my appetite has returned.
10
Ulcer relief
1 people found this helpful
I bought Zinc Chelate for a colleague suffering from recurrent mouth ulcers. Since starting this combined with folic acid and B12, she hasn’t experienced them anymore. I've introduced it to others facing the same issue, and they've also found relief from painful mouth ulcers. This product is indeed impressive!
7.5
Boosted immunity
47 people found this helpful
I must emphasise the importance of zinc. It's essential for numerous bodily functions, including maintaining a balanced immune system. Zinc is vital for cell growth, and its absence can lead to issues like poor wound healing and increased susceptibility to infections. I recommend that everyone ensure their multivitamin includes zinc, as it can significantly enhance immunity, particularly in older adults. My experiences with it have been immensely positive, especially concerning ulcer healing and overall health.
9
Ulcer prevention
Initially, I hadn’t taken zinc, but once I did, my mouth ulcers disappeared. It's an effective solution for anyone struggling with these painful issues.
9
Reduction in complications
18 people found this helpful
I find that zinc is critical for health. A deficiency can disrupt bodily functions, resulting in issues like skin diseases and ulcers. It's difficult to get adequate zinc from food alone, so I often rely on supplements. Additionally, recent studies indicate that zinc is more effective than vitamin C in combating colds by halting virus progression and softening disease severity. I'm pleased with its effectiveness in managing ulcers and would recommend it wholeheartedly.
7.5
Supports recovery
The 30 mg dosage is perfect for adults looking to boost their immunity. I've found that chelated zinc can assist with ulcers as well, which is a great benefit.
7.5
Enhanced immunity
2 people found this helpful
This zinc is chelated, making it easier to absorb without burdening the body. The dosage suits adults well, and I've noticed improvements in my immunity. Zinc supports growth and mental development, while a deficiency can lead to issues with appetite and ulcers. I recommend it for maintaining overall health and improving immunity, particularly if one experiences symptoms associated with ulcers.
9.5
Zinc's role in ulcer treatment
We explored the impact of zinc when incorporated into first-line treatments for Helicobacter pylori infections, particularly in patients suffering from ulcers. In a multicenter registry study involving 800 patients, we noted that the most common factors leading to treatment were dyspepsia and gastroduodenal ulcers.

The findings indicated that quadruple therapy—both with and without bismuth—improved eradication rates significantly, achieving about 94.9%. Meanwhile, zinc as a part of a sequential therapy showed an impressive effectiveness of 95.6%. However, since zinc was combined with other treatments, it’s challenging to pinpoint its isolated effects on ulcer healing or eradication efficacy.

We also observed that adverse events, though reported in nearly 29% of cases, were generally mild, suggesting that the treatments were well-tolerated. Overall, the report highlighted that while zinc may enhance treatment effectiveness when combined, its individual contribution remains undetermined.
9
Zinc nanoparticles may protect intestinal health
We explored the impact of zinc oxide nanoparticles (ZnO NPs) derived from the Cassia alata plant on ulcerative colitis (UC) in a mouse model. Ulcerative colitis is a common inflammatory bowel disease that results in chronic inflammation of the colorectal area, leading to various symptoms and complications. The study aimed to determine whether these zinc nanoparticles could provide protective benefits against UC, particularly following induction with dextran sodium sulfate (DSS).

Our findings revealed that the ZnO NPs showed promise in mitigating several negative effects associated with UC. We observed improvements in weight loss, disease activity index, colon shortening, and overall colon health in the treated mice. The green synthesized ZnO NPs demonstrated anti-inflammatory properties, helping to reduce hypersensitivity and oxidative stress, effectively protecting the mucosal layer of the colon.

However, it is important to note that the study focused on ZnO NPs as part of a natural herbal treatment, rather than isolating zinc as a singular therapeutic agent. Although our results indicate a potential protective effect, further research would be beneficial to fully understand the role of zinc itself in treating ulcerative colitis.
We set out to explore how zinc, when included in oral nutritional formulas, impacts the healing of chronic ulcers. Our investigation looked at various research involving a total of 741 patients with different types of wounds, which primarily included pressure injuries and diabetic foot ulcers.

Among the studies we examined, some suggested that a hypercaloric and hyperproteic formula enriched with zinc, along with important vitamins A, C, and E, could promote wound healing effectively. Specifically, four studies indicated that these enriched formulas led to a noticeable reduction in wound area, showcasing an increase in healing rates.

However, it's worth noting that two studies reported no significant differences in healing rates when zinc was incorporated into the treatment. Additionally, other approaches featuring combinations like arginine and glutamine did not show significant improvements over the control groups, further complicating the picture.

This indicates that while zinc might play a beneficial role, the evidence isn't uniformly strong regarding its isolated effect on ulcer healing. Overall, we found that a desirable formula for promoting healing seems to focus on high calories, protein content, and antioxidants, which may include zinc as part of a larger cocktail of nutrients.

References

  1. Zhang L, Fu X, Li J, Xiao W, Xiong X, et al. Treatment of Acute Ulcerative Colitis with Zinc Hyaluronate in Mice. J Microbiol Biotechnol. 2025;35:e2408050. doi:10.4014/jmb.2408.08050
  2. Seo HR, Chung KB, Kim DY. The Possible Impact of Zinc-Enriched Multivitamins on Treatment-Naïve Recurrent Aphthous Stomatitis Patients. J Clin Med. 2025;14. doi:10.3390/jcm14010260
  3. Wu Z, Wu W, Zhang C, Zhang W, Li Y, et al. Enhanced diabetic foot ulcer treatment with a chitosan-based thermosensitive hydrogel loaded self-assembled multi-functional nanoparticles for antibacterial and angiogenic effects. Carbohydr Polym. 2025;347:122740. doi:10.1016/j.carbpol.2024.122740
  4. Grimm K, Fiedler A, Kröger C. Investigation on the effectiveness of a new hoof care product to sustainably reduce and prevent digital dermatitis in dairy cow herds. J Dairy Sci. 2025;108:1869. doi:10.3168/jds.2024-25134
  5. Laudanno O, Ahumaran G, Thome M, Adami P, Ustares F, et al. [Argentinean registry on the management of Helicobacter pylori infection: effectiveness and safety of first line treatment]. Medicina (B Aires). 2024;84:884.
  6. Huang Y, Shang S, Du H. Causal association of micronutrients and supplements with pressure ulcer: A Mendelian randomization study. Skin Res Technol. 2024;30:e13904. doi:10.1111/srt.13904
  7. Ban F, Zhou L, Yang Z, Liu Y, Zhang Y. Aspergillusidone G Potentiates the Anti-Inflammatory Effects of Polaprezinc in LPS-Induced BV2 Microglia: A Bioinformatics and Experimental Study. Mar Drugs. 2024;22. doi:10.3390/md22070324
  8. Govindarasu M, Vaiyapuri M, Kim JC. Protective effect of zinc oxide nanoparticles synthesized using Cassia alata for DSS-induced ulcerative colitis in mice model. Bioprocess Biosyst Eng. 2024;47:1393. doi:10.1007/s00449-024-03047-8
  9. Zheng M, Xie C, Ye D, Chen Y, Wang Z, et al. Qingzhuan dark tea polysaccharides-zinc alleviates dextran sodium sulfate-induced ulcerative colitis. J Sci Food Agric. 2024;104:7617. doi:10.1002/jsfa.13597
  10. Santo ACSDE, Sugizaki CSA, de Morais Junior AC, Costa NA, Bachion MM, et al. Impact of oral nutritional supplement composition on healing of different chronic wounds: A systematic review. Nutrition. 2024;124:112449. doi:10.1016/j.nut.2024.112449
  11. Hayashi A, Taki Y, Arai K, Sato S, Higashizono K, et al. Esophageal ulcer related to zinc deficiency following a total gastrectomy. Nutrition. 2023;110:111999. doi:10.1016/j.nut.2023.111999
  12. Faghfouri AH, Baradaran B, Khabbazi A, Abdoli Shadbad M, Papi S, et al. Regulation of NLRP3 inflammasome by zinc supplementation in Behçet's disease patients: A double-blind, randomized placebo-controlled clinical trial. Int Immunopharmacol. 2022;109:108825. doi:10.1016/j.intimp.2022.108825
  13. Jung DH, Park JC, Lee YC, Lee SK, Shin SK, et al. Comparison of the Efficacy of Polaprezinc Plus Proton Pump Inhibitor and Rebamipide Plus Proton Pump Inhibitor Treatments for Endoscopic Submucosal Dissection-induced Ulcers. J Clin Gastroenterol. 2021;55:233. doi:10.1097/MCG.0000000000001357
  14. Scheid PL, Lâm TT, Sinsch U, Balczun C. Vermamoeba vermiformis as etiological agent of a painful ulcer close to the eye. Parasitol Res. 2019;118:1999. doi:10.1007/s00436-019-06312-y
  15. Ficarra G, Cicchi P, Amorosi A, Piluso S. Oral Crohn's disease and pyostomatitis vegetans. An unusual association. Oral Surg Oral Med Oral Pathol. 1993;75:220.
  16. Cho CH, Ogle CW, Dai S. Effects of zinc chloride on gastric secretion and ulcer formation in pylorus-occluded rats. Eur J Pharmacol. 1976;38:337.
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