We explored the impact of inositol on cold stress in rapeseed, an essential oilseed crop affected by low temperatures. Notably, we found that inositol plays a significant role in enhancing cold tolerance in these plants by boosting calcium ion (Ca) influx.
Our study involved identifying various genes associated with inositol and analyzing their expression under cold conditions. Interestingly, inositol appeared to inhibit the expression of calcineurin B-like genes, which are involved in regulating calcium flow, suggesting a unique pathway through which inositol aids in cold resilience.
Additionally, when we overexpressed certain genes linked to calcium flux, we noted a stronger response to cold stress, further emphasizing the importance of the inositol-Ca pathway in facilitating cold tolerance in rapeseed. These findings not only deepen our understanding of how rapeseed copes with cold conditions but also present a potential strategy for enhancing crop resilience in the face of climate challenges.
Read More
9
MIOX gene enhances cold tolerance
Genome-wide identification of the myo-inositol oxygenase gene family in alfalfa (Medicago sativa L.) and expression analysis under abiotic stress.
We explored how myo-inositol oxygenase (MIOX), an important enzyme, might help alfalfa, a type of forage crop, adapt to challenging cold conditions. The study identified ten MsMIOX genes in the alfalfa genome, which were found distributed across three chromosomes.
Through analysis, we noted that these genes exhibited similarities in structure and conserved features, hinting at a functional role important for the plant's survival under stress.
Our qRT-PCR tests showed that different MsMIOX genes could be triggered by cold and other abiotic stress factors like drought and salinity. Notably, the activity of MIOX in alfalfa significantly increased under these harsh conditions.
By overexpressing the MsMIOX2 gene in yeast, we found that it notably enhanced resistance to cold stresses. Additionally, when MsMIOX2 was overexpressed in alfalfa’s hairy roots, it reduced reactive oxygen species and improved the plant's resilience against cold.
This study provides valuable insights into how inositol plays a part in helping alfalfa thrive even in cold weather, presenting a candidate for future efforts to enhance the plant’s stress tolerance.
Read More
9
Myo-inositol boosts cold tolerance
SlFHY3 and SlHY5 act compliantly to enhance cold tolerance through the integration of myo-inositol and light signaling in tomato.
We explored how low red to far-red light ratios influence cold tolerance in tomato plants. The focus was on two key proteins, SlFHY3 and SlHY5, which play a role in increasing the accumulation of myo-inositol, a compound linked with cold resistance.
Our findings revealed that when tomato plants experienced low light ratios, it encouraged the production of SlFHY3 under cold stress. Knocking out this gene led to lower myo-inositol levels and made the plants more vulnerable to cold, while overexpressing it had the opposite effect.
Moreover, we found that SlFHY3 works closely with SlHY5 to boost writing activity for a particular gene involved in myo-inositol synthesis. This interaction is crucial, as it significantly enhances both myo-inositol levels and the plants' ability to withstand cold conditions. Without these proteins or the inositol synthesis gene, the cold resistance we observed was diminished.
Ultimately, our study shines a light on the important relationship between light signals, inositol accumulation, and cold tolerance in tomatoes, unveiling how plants manage environmental stress.
Read More
Most Useful Reviews
9
Boosts immunity remarkably
20 people found this helpful
Excellent Product. I typically fall ill with flu or cold easily. However, since taking this supplement, I've felt my immune system becoming stronger. I have PCOS and this product was recommended for me. Recently, I started to feel flu symptoms, mild fever and sore throat included. I doubled my dosage that day, and by the next morning, the symptoms had vanished—something that never happens for me. I would highly recommend it.
Read More
10
Long-term cold protection
13 people found this helpful
A LIFE SAVER. This product was recommended to me by a holistic healer and has kept me healthy for 13 years. I haven’t had a cold, flu, or virus since commencing Cell Forte w/IP6 & Inositol.
Read More
10
Illness-free season
8 people found this helpful
Zero illness during the cold/flu season since I started this supplement. I've been using this product for months, and despite my coworkers and boyfriend catching colds this fall/winter (I still kissed him!), I have remained healthy! Whoop!
We explored the effects of myo-inositol and corn steep liquor (CSL) on cucumber and tomato seedlings, particularly focusing on their ability to withstand cold temperatures. Through our research, we found that applying these substances led to noticeable improvements in seedling growth during low-temperature stress.
Our treatments not only increased the levels of photosynthetic pigments, enhancing photosynthesis, but also reduced harmful compounds like malondialdehyde (MDA) and electrolyte leakage. This suggests that the combination of inositol and CSL helps to protect plant cells under stress.
Additionally, we confirmed these findings by analyzing the expression of important genes that relate to cold tolerance in cucumbers. The most effective mix we identified was 0.6 mL L of CSL together with 72 mg L of myo-inositol. Overall, this study gives us valuable insights into how we can use inositol and maize leachate to foster early growth in crops and improve their resilience against cold weather.
Read More
9
MIOX gene enhances cold tolerance
Genome-wide identification of the myo-inositol oxygenase gene family in alfalfa (Medicago sativa L.) and expression analysis under abiotic stress.
We explored how myo-inositol oxygenase (MIOX), an important enzyme, might help alfalfa, a type of forage crop, adapt to challenging cold conditions. The study identified ten MsMIOX genes in the alfalfa genome, which were found distributed across three chromosomes.
Through analysis, we noted that these genes exhibited similarities in structure and conserved features, hinting at a functional role important for the plant's survival under stress.
Our qRT-PCR tests showed that different MsMIOX genes could be triggered by cold and other abiotic stress factors like drought and salinity. Notably, the activity of MIOX in alfalfa significantly increased under these harsh conditions.
By overexpressing the MsMIOX2 gene in yeast, we found that it notably enhanced resistance to cold stresses. Additionally, when MsMIOX2 was overexpressed in alfalfa’s hairy roots, it reduced reactive oxygen species and improved the plant's resilience against cold.
This study provides valuable insights into how inositol plays a part in helping alfalfa thrive even in cold weather, presenting a candidate for future efforts to enhance the plant’s stress tolerance.
Read More
9
Myo-inositol boosts cold tolerance
SlFHY3 and SlHY5 act compliantly to enhance cold tolerance through the integration of myo-inositol and light signaling in tomato.
We explored how low red to far-red light ratios influence cold tolerance in tomato plants. The focus was on two key proteins, SlFHY3 and SlHY5, which play a role in increasing the accumulation of myo-inositol, a compound linked with cold resistance.
Our findings revealed that when tomato plants experienced low light ratios, it encouraged the production of SlFHY3 under cold stress. Knocking out this gene led to lower myo-inositol levels and made the plants more vulnerable to cold, while overexpressing it had the opposite effect.
Moreover, we found that SlFHY3 works closely with SlHY5 to boost writing activity for a particular gene involved in myo-inositol synthesis. This interaction is crucial, as it significantly enhances both myo-inositol levels and the plants' ability to withstand cold conditions. Without these proteins or the inositol synthesis gene, the cold resistance we observed was diminished.
Ultimately, our study shines a light on the important relationship between light signals, inositol accumulation, and cold tolerance in tomatoes, unveiling how plants manage environmental stress.
Read More
8
Inositol transporter's role in cold
The Vacuolar Inositol Transporter BvINT1;1 Contributes to Raffinose Biosynthesis and Reactive Oxygen Species Scavenging During Cold Stress in Sugar Beet.
We examined how inositol, a key component in the production of raffinose, plays a role in helping sugar beet plants withstand cold stress. In the study, researchers identified the vacuolar inositol transporter BvINT1;1, which seems to be critical for the synthesis of raffinose under chilly conditions.
When plants were exposed to cold, BvINT1;1 was found to be highly active, ensuring adequate inositol was available for raffinose production. Interestingly, sugar beet mutants that lacked functional BvINT1;1 not only had higher levels of inositol but also lower amounts of raffinose when subjected to cold stress.
This reduction in raffinose was significant because raffinose can help neutralize harmful reactive oxygen species (ROS), which accumulate when plants are stressed. As a result, these mutants showed increased expression of genes related to ROS, pointing out a potential risk for them during cold weather.
Overall, our findings suggest that the transporter BvINT1;1 is not just about moving inositol; it plays a vital role in boosting the plant's cold resilience by facilitating raffinose biosynthesis and maintaining balance against oxidative stress.
Read More
8
Myo-inositol aids cold resistance
Multi-omic dissection of the cold resistance traits of white water lily.
We delved into the fascinating world of white water lilies and their remarkable ability to withstand cold temperatures. This study aimed to understand how certain compounds, particularly myo-inositol, contribute to the plant's cold resilience.
Through a comprehensive examination, we learned that the water lily effectively copes with winter by entering a state called ecodormancy. During this time, the plant reallocates resources and enhances its defenses against cold stress.
One of our key findings was the significance of myo-inositol. This compound helps bolster the plant’s cold tolerance, although it works alongside various other factors. It plays a role in regulating metabolic activities, especially in relation to amino acids, which are crucial for overcoming chilly conditions.
Although our study highlighted the importance of myo-inositol, it did not isolate its effects from other treatments, which limits our understanding of its specific impact. Nevertheless, the insights we gained about the water lily’s adaptive strategies provide valuable information for future agricultural practices in cold climates.
Excellent Product. I typically fall ill with flu or cold easily. However, since taking this supplement, I've felt my immune system becoming stronger. I have PCOS and this product was recommended for me. Recently, I started to feel flu symptoms, mild fever and sore throat included. I doubled my dosage that day, and by the next morning, the symptoms had vanished—something that never happens for me. I would highly recommend it.
Read More
10
Long-term cold protection
13 people found this helpful
A LIFE SAVER. This product was recommended to me by a holistic healer and has kept me healthy for 13 years. I haven’t had a cold, flu, or virus since commencing Cell Forte w/IP6 & Inositol.
Read More
10
Illness-free season
8 people found this helpful
Zero illness during the cold/flu season since I started this supplement. I've been using this product for months, and despite my coworkers and boyfriend catching colds this fall/winter (I still kissed him!), I have remained healthy! Whoop!
Read More
9
Stops cold effectively
1 people found this helpful
My saviour! The quality of the supplement is excellent. It has helped me several times to stop a cold at the very beginning, preventing me from getting fully ill. I took two capsules three times a day for a few days. The packaging is substantial, and I will continue to use it next winter.
Read More
9
Effective against colds
Having used this potent product for many years, I help those on the brink of getting a cold by giving them four capsules, and they’re often back in remission the next day.
Cold is a term that refers to a state of low temperature, often associated with a perceptibly chilly environment or the sensation of being cool to the touch. Scientifically, cold is relative to the presence and movement of heat, which is a measure of energy within matter. In everyday terms, we experience cold through weather changes, such as during winter months, and it can also be described in the context of specific temperature ranges – for example, temperatures below 32 degrees Fahrenheit (0 degrees Celsius) generally signify freezing conditions, which can impact outdoor activities, personal comfort, and various ecological systems.
Moreover, the sensation of cold is not solely dependent on temperature; factors like humidity and wind chill can enhance the feeling of coldness. When discussing cold in terms of human health, prolonged exposure to cold conditions can lead to hypothermia or frostbite if body heat is not effectively maintained. Hence, it's crucial to dress appropriately and take necessary precautions during colder months to prevent adverse effects. Understanding the concept of cold can help individuals better prepare for seasonal changes and ensure their comfort and safety.
Inositol is a naturally occurring sugar alcohol that plays a crucial role in cellular signaling and the structural integrity of cell membranes. It is a member of the B-vitamin complex and exists in several forms, with myo-inositol being the most prevalent in the human body. Inositol is found in various foods, including fruits, beans, grains, and nuts, and it can also be synthesized by the body from glucose. It is often marketed as a supplement for various health benefits, including mental health support, particularly for conditions like anxiety and depression, and is studied for its potential role in managing polycystic ovary syndrome (PCOS).
Research suggests that inositol may help in alleviating symptoms associated with these health issues by enhancing insulin sensitivity and regulating hormonal balance. While it is generally considered safe for consumption, individuals should consult with healthcare professionals before starting any new supplement regimen, especially if they have existing health conditions or are taking other medications. As with any supplement, the effectiveness can vary from person to person, and understanding the underlying scientific evidence can guide informed choices.
Based on user reviews, the time it takes to see results from this supplement for cold relief can vary. Some users report that they notice a difference almost immediately after taking the supplement. For instance, one user mentioned that when they feel a cold coming on and take two capsules, their symptoms disappear quickly (Read Review). Another user indicated that by giving four capsules to someone on the brink of a cold, they often see improvement the very next day (Read Review).
However, individual results can vary based on factors such as the severity of the illness and the specific health condition of each user. Some reviews also highlight long-term benefits, indicating that regular use of the supplement contributes to a more robust immune response, resulting in fewer colds overall (Read Review). Overall, while some users report immediate relief, the cumulative effect of consistent use appears to strengthen immunity and reduce the frequency of colds over time.
The role of inositol in enhancing cold tolerance has been well-documented in various plant species. Research indicates that inositol, particularly myo-inositol, plays a crucial part in helping plants cope with low temperatures by regulating metabolic processes and increasing resilience against cold stress. For instance, studies have shown that myo-inositol contributes significantly to cold tolerance in crops like cucumber, tomato, and rapeseed by bolstering specific genetic expressions and pathways that mitigate stress effects [2], [5]. Additionally, it aids in the synthesis of raffinose, which protects cells from oxidative damage during cold exposure [1].
Moreover, investigations into specific gene families related to inositol, such as myo-inositol oxygenase (MIOX) in alfalfa, reveal that increased activity of these genes under cold conditions can enhance the plant's survival prospects [4]. Overall, the accumulating evidence suggests that inositol is not only supported by scientific research for its role in cold resistance but also presents a vital avenue for enhancing plant resilience in changing climatic conditions.
Based on user reviews, many individuals have reported significant improvements in their cold symptoms and overall immune function. For instance, one user described the supplement as their "saviour," stating that it effectively halted a cold at its onset when taken in higher doses for a few days (Read Review). Another long-time user mentioned that providing four capsules to someone on the brink of a cold usually leads to rapid recovery, often within just a day (Read Review). Many have noted a reduction in the frequency of colds, with some stating they rarely get sick anymore after incorporating the supplement into their daily routine (Read Review).
Moreover, several reviews highlight the long-term benefits of the supplement, indicating that consistent use significantly strengthens the immune system and leads to fewer illnesses overall (Read Review). One parent even reported their child’s prolonged absence of colds despite exposure to many germs, crediting the supplement's immune-boosting properties (Read Review). However, it's important to keep in mind that individual results can vary, and what works for one person may not yield the same effects for another.
Based on user reviews, many individuals have found that combining this supplement with others can enhance their effectiveness in managing cold symptoms. Some users report that taking this supplement alongside vitamin D3 contributes to improved overall health and a more robust immune system, resulting in fewer instances of illness (Read Review). Additionally, one user specifically mentioned that taking inositol on an empty stomach has been beneficial for their child, as it seemed to provide excellent immune support throughout the school year, while minimizing the risk of colds and infections (Read Review).
Moreover, several reviewers noted that this supplement serves as a foundational component in their regimen, emphasizing the potential benefits of simultaneous use with other immune-boosting supplements. For instance, one user highlighted that the unique formulation, which includes IP-6 and inositol, supports natural killer cells and overall immune function, thereby providing additional protection against frequent colds (Read Review). Overall, while the combination of this supplement with others appears to substantially affect immunity, individual experiences may vary.
According to user reviews, the optimal dose of Inositol for effectively preventing or treating colds varies, with several users finding success at different amounts. One reviewer mentioned taking two capsules three times a day at the onset of a cold, reporting that this regimen helped prevent the cold from escalating further ({review id='6702cf96-4d76-4858-a31f-9ddbeff9227c'}). Another user has recommended four capsules, noting that this dose often leads to a rapid return to health within a day ({review id='68d2dbb5-7c48-4419-9ae2-b9bb32b52b20'}).
Additionally, users seem to appreciate a more moderate approach, with some finding that taking two capsules daily sufficiently supports their immune system and reduces the frequency of colds ({review id='02b671d0-70f9-43d0-94c7-518d16b478e6'}). This aligns with feedback from parents who administer two capsules daily to their children, establishing a routine that has reportedly kept them healthy amidst common school viruses ({review id='e5b88c84-63b8-4bbf-9ece-e4766d5ceb9e'}). Ultimately, while there is no consensus on a singular 'correct' dose for Inositol, users highlight a range of dosing strategies that effectively bolster immune responses against colds.
9
Stops cold symptoms
5 people found this helpful
I have been using this excellent product for years. Whenever I feel a cold or sore throat coming on, I immediately take 2 of these, and the symptoms disappear. It also helps with an upset stomach from poor food combinations. The bottom line is that I rarely get sick anymore; my health has also benefitted from a daily intake of 4000 IU of vitamin D3, particularly from Mega Foods brand, which is plant-based rather than fish or lanolin.
9
Effective against colds
Having used this potent product for many years, I help those on the brink of getting a cold by giving them four capsules, and they’re often back in remission the next day.
7.5
Strengthens resistance
My resistance seems to have strengthened, resulting in fewer colds!
9
Stops cold effectively
1 people found this helpful
My saviour! The quality of the supplement is excellent. It has helped me several times to stop a cold at the very beginning, preventing me from getting fully ill. I took two capsules three times a day for a few days. The packaging is substantial, and I will continue to use it next winter.
9
Prevents colds effectively
5 people found this helpful
This supplement is my favourite! I'm delighted to have found one that boosts my son's immune system and is safe for long-term use. This remedy can be taken continuously. My child began this supplement in September 2020, and since then, up until February 2022, he’s not caught a cold or any new viruses, despite sickness among classmates. Each morning, we start the day with inositol. He takes 2 capsules on an empty stomach before breakfast. This amount is sufficient for him to remain healthy and not miss school.
7.5
Increases immunity significantly
2 people found this helpful
This product is a saviour for frequent colds. The IP-6 and inositol in Cell Forté’s unique formulation supports natural killer cells and immune function. After taking it, my immunity improves significantly, so I often avoid illness. The packaging is excellent, and the quality is commendable.
9
Myo-inositol boosts cold tolerance
Combined application of myo-inositol and corn steep liquor enhances seedling growth and cold tolerance in cucumber and tomato.
We explored the effects of myo-inositol and corn steep liquor (CSL) on cucumber and tomato seedlings, particularly focusing on their ability to withstand cold temperatures. Through our research, we found that applying these substances led to noticeable improvements in seedling growth during low-temperature stress.
Our treatments not only increased the levels of photosynthetic pigments, enhancing photosynthesis, but also reduced harmful compounds like malondialdehyde (MDA) and electrolyte leakage. This suggests that the combination of inositol and CSL helps to protect plant cells under stress.
Additionally, we confirmed these findings by analyzing the expression of important genes that relate to cold tolerance in cucumbers. The most effective mix we identified was 0.6 mL L of CSL together with 72 mg L of myo-inositol. Overall, this study gives us valuable insights into how we can use inositol and maize leachate to foster early growth in crops and improve their resilience against cold weather.
8
Inositol enhances rapeseed cold tolerance
Inositol Improves Cold Tolerance Through Inhibiting and Increasing Ca Influx in Rapeseed ( L.).
We explored the impact of inositol on cold stress in rapeseed, an essential oilseed crop affected by low temperatures. Notably, we found that inositol plays a significant role in enhancing cold tolerance in these plants by boosting calcium ion (Ca) influx.
Our study involved identifying various genes associated with inositol and analyzing their expression under cold conditions. Interestingly, inositol appeared to inhibit the expression of calcineurin B-like genes, which are involved in regulating calcium flow, suggesting a unique pathway through which inositol aids in cold resilience.
Additionally, when we overexpressed certain genes linked to calcium flux, we noted a stronger response to cold stress, further emphasizing the importance of the inositol-Ca pathway in facilitating cold tolerance in rapeseed. These findings not only deepen our understanding of how rapeseed copes with cold conditions but also present a potential strategy for enhancing crop resilience in the face of climate challenges.
8
Inositol transporter's role in cold
The Vacuolar Inositol Transporter BvINT1;1 Contributes to Raffinose Biosynthesis and Reactive Oxygen Species Scavenging During Cold Stress in Sugar Beet.
We examined how inositol, a key component in the production of raffinose, plays a role in helping sugar beet plants withstand cold stress. In the study, researchers identified the vacuolar inositol transporter BvINT1;1, which seems to be critical for the synthesis of raffinose under chilly conditions.
When plants were exposed to cold, BvINT1;1 was found to be highly active, ensuring adequate inositol was available for raffinose production. Interestingly, sugar beet mutants that lacked functional BvINT1;1 not only had higher levels of inositol but also lower amounts of raffinose when subjected to cold stress.
This reduction in raffinose was significant because raffinose can help neutralize harmful reactive oxygen species (ROS), which accumulate when plants are stressed. As a result, these mutants showed increased expression of genes related to ROS, pointing out a potential risk for them during cold weather.
Overall, our findings suggest that the transporter BvINT1;1 is not just about moving inositol; it plays a vital role in boosting the plant's cold resilience by facilitating raffinose biosynthesis and maintaining balance against oxidative stress.
9
MIOX gene enhances cold tolerance
Genome-wide identification of the myo-inositol oxygenase gene family in alfalfa (Medicago sativa L.) and expression analysis under abiotic stress.
We explored how myo-inositol oxygenase (MIOX), an important enzyme, might help alfalfa, a type of forage crop, adapt to challenging cold conditions. The study identified ten MsMIOX genes in the alfalfa genome, which were found distributed across three chromosomes.
Through analysis, we noted that these genes exhibited similarities in structure and conserved features, hinting at a functional role important for the plant's survival under stress.
Our qRT-PCR tests showed that different MsMIOX genes could be triggered by cold and other abiotic stress factors like drought and salinity. Notably, the activity of MIOX in alfalfa significantly increased under these harsh conditions.
By overexpressing the MsMIOX2 gene in yeast, we found that it notably enhanced resistance to cold stresses. Additionally, when MsMIOX2 was overexpressed in alfalfa’s hairy roots, it reduced reactive oxygen species and improved the plant's resilience against cold.
This study provides valuable insights into how inositol plays a part in helping alfalfa thrive even in cold weather, presenting a candidate for future efforts to enhance the plant’s stress tolerance.
References
Berg J, Rodrigues CM, Scheid C, Pirrotte Y, Picco C, et al. The Vacuolar Inositol Transporter BvINT1;1 Contributes to Raffinose Biosynthesis and Reactive Oxygen Species Scavenging During Cold Stress in Sugar Beet. Plant Cell Environ. 2025. 10.1111/pce.15367
Sun S, Zhang X, Wang C, Yu Q, Yang H, et al. Combined application of myo-inositol and corn steep liquor enhances seedling growth and cold tolerance in cucumber and tomato. Physiol Plant. 2024;176:e14422. 10.1111/ppl.14422
Qiu P, Liu T, Xu Y, Ye C, Zhang R, et al. Multi-omic dissection of the cold resistance traits of white water lily. Hortic Res. 2024;11:uhae093. 10.1093/hr/uhae093
Guo W, Yu D, Zhang R, Zhao W, Zhang L, et al. Genome-wide identification of the myo-inositol oxygenase gene family in alfalfa (Medicago sativa L.) and expression analysis under abiotic stress. Plant Physiol Biochem. 2023;200:107787. 10.1016/j.plaphy.2023.107787
Yan L, Zeng L, Raza A, Lv Y, Ding X, et al. Inositol Improves Cold Tolerance Through Inhibiting and Increasing Ca Influx in Rapeseed ( L.). Front Plant Sci. 2022;13:775692. 10.3389/fpls.2022.775692
Wang F, Wang X, Zhang Y, Yan J, Ahammed GJ, et al. SlFHY3 and SlHY5 act compliantly to enhance cold tolerance through the integration of myo-inositol and light signaling in tomato. New Phytol. 2022;233:2127. 10.1111/nph.17934