Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.8
USERS' SCORE
Moderately Good
Based on 7 Reviews
7.9
Supplement Facts
Serving Size: 2 tablets
Amount Per Serving
%DV
Pancreatic EnzymesUsp Units Of Activity:Amylase 81,250 UspProtease 81,250 UspLipase 6,500 Usp
361 mg
**
Trypsin
75 mg
**
Papain
50 mg
**
Bromelain
16 mg
**
Amylase
10 mg
**
Lipase
10 mg
**
Chymotrypsin
2 mg
**
Top Medical Research Studies
9.5
Effective pancreatin in canine diarrhea
We investigated how pancreatin, derived from pigs, impacts diarrhea in a Maltese dog suffering from exocrine pancreatic insufficiency. The dog had chronic diarrhea, excessive hunger, weight loss, and foul-smelling feces. After beginning treatment with porcine pancreatin powder, we saw a complete resolution of the dog's clinical signs. This case highlights the potential effectiveness of oral pancreatic enzyme replacement therapy in managing similar gastrointestinal issues in dogs.
Read More
9
Pancreatin reliefs symptoms effectively
We observed how pancreatin, an enzyme replacement therapy, impacts patients suffering from diarrhea due to exocrine pancreatic insufficiency related to chronic pancreatitis. In a year-long, multicenter study, we evaluated symptom changes and quality of life in 294 patients, with some already on pancreatin and others newly diagnosed.
Both groups reported a significant reduction in gastrointestinal symptoms and pain after one year, alongside improved quality of life scores. The treatment was particularly effective for those who were new to pancreatin, showcasing a clear benefit in managing their symptoms.
Both groups reported a significant reduction in gastrointestinal symptoms and pain after one year, alongside improved quality of life scores. The treatment was particularly effective for those who were new to pancreatin, showcasing a clear benefit in managing their symptoms.
Read More
8
We looked into how exocrine pancreatic insufficiency (EPI) affects patients after esophagectomy. By measuring fecal elastase-1 in 63 postoperative patients, we found that 10 had significant EPI, all showing improvement when given pancreatic enzyme replacement therapy (PERT). In another group with mild EPI, some also reported symptom relief, though fewer experienced weight gain. Our findings suggest that EPI can worsen recovery after esophagectomy and point to the potential benefits of PERT, although further formal studies are needed to solidify these insights.
Read More
Most Useful Reviews
9
Diarrhea relief
63 people found this helpful
As far as I'm concerned, these digestive enzymes are the best quality available. I took prilosec for a long time but continued to suffer from what doctors called GERD. When I started taking these tablets with meals, my upset stomach, diarrhea, and acid reflux vanished within a week. These tablets may just be saving my life.
Read More
9
Stops chronic diarrhea
6 people found this helpful
This product works wonders for my digestive system. It has improved my digestion, stopping my chronic diarrhea and reducing inflammation throughout my body.
Read More
9
Effective treatment
1 people found this helpful
Mega-zyme has been a lifesaver for my husband. He frequently suffered from vomiting and diarrhea for no apparent reason. Since he began taking Mega-zyme, he has been thoroughly enjoying his meals!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.8
- All Researches
9.5
Effective pancreatin in canine diarrhea
We investigated how pancreatin, derived from pigs, impacts diarrhea in a Maltese dog suffering from exocrine pancreatic insufficiency. The dog had chronic diarrhea, excessive hunger, weight loss, and foul-smelling feces. After beginning treatment with porcine pancreatin powder, we saw a complete resolution of the dog's clinical signs. This case highlights the potential effectiveness of oral pancreatic enzyme replacement therapy in managing similar gastrointestinal issues in dogs.
Read More
9
Pancreatin reliefs symptoms effectively
We observed how pancreatin, an enzyme replacement therapy, impacts patients suffering from diarrhea due to exocrine pancreatic insufficiency related to chronic pancreatitis. In a year-long, multicenter study, we evaluated symptom changes and quality of life in 294 patients, with some already on pancreatin and others newly diagnosed.
Both groups reported a significant reduction in gastrointestinal symptoms and pain after one year, alongside improved quality of life scores. The treatment was particularly effective for those who were new to pancreatin, showcasing a clear benefit in managing their symptoms.
Both groups reported a significant reduction in gastrointestinal symptoms and pain after one year, alongside improved quality of life scores. The treatment was particularly effective for those who were new to pancreatin, showcasing a clear benefit in managing their symptoms.
Read More
8
We examined the case of a 50-year-old man with a long history of high blood sugar and diarrhea due to complications from pancreatitis and surgery. He was diagnosed with pancreatic diabetes and received insulin, along with pancreatin and micronutrient supplements.
After treatment, he experienced relief from diarrhea and improved blood glucose control. This highlights the importance of recognizing pancreatic diabetes and the potential benefits of pancreatin in managing related symptoms.
Proper intervention and monitoring are crucial to avoid further complications.
After treatment, he experienced relief from diarrhea and improved blood glucose control. This highlights the importance of recognizing pancreatic diabetes and the potential benefits of pancreatin in managing related symptoms.
Proper intervention and monitoring are crucial to avoid further complications.
Read More
8
We looked into how exocrine pancreatic insufficiency (EPI) affects patients after esophagectomy. By measuring fecal elastase-1 in 63 postoperative patients, we found that 10 had significant EPI, all showing improvement when given pancreatic enzyme replacement therapy (PERT). In another group with mild EPI, some also reported symptom relief, though fewer experienced weight gain. Our findings suggest that EPI can worsen recovery after esophagectomy and point to the potential benefits of PERT, although further formal studies are needed to solidify these insights.
Read More
8
Combizym significantly reduces dyspepsia symptoms
This study evaluated how well Combizym works to relieve dyspepsia symptoms in Chinese patients, using a randomized, placebo-controlled design.
We observed 151 participants split into two groups for treatments, with significant symptom reduction in the group receiving Combizym.
The results showed an impressive efficacy rate of about 90% for Combizym compared to just 22% for the placebo. Symptoms like diarrhea, abdominal pain, and belching were notably improved.
Notably, no adverse effects were reported, highlighting the safety of Combizym for dyspepsia relief.
We observed 151 participants split into two groups for treatments, with significant symptom reduction in the group receiving Combizym.
The results showed an impressive efficacy rate of about 90% for Combizym compared to just 22% for the placebo. Symptoms like diarrhea, abdominal pain, and belching were notably improved.
Notably, no adverse effects were reported, highlighting the safety of Combizym for dyspepsia relief.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 7 Reviews
7.9
- All Reviews
- Positive Reviews
- Negative Reviews
9
Diarrhea relief
63 people found this helpful
As far as I'm concerned, these digestive enzymes are the best quality available. I took prilosec for a long time but continued to suffer from what doctors called GERD. When I started taking these tablets with meals, my upset stomach, diarrhea, and acid reflux vanished within a week. These tablets may just be saving my life.
Read More
9
Stops chronic diarrhea
6 people found this helpful
This product works wonders for my digestive system. It has improved my digestion, stopping my chronic diarrhea and reducing inflammation throughout my body.
Read More
9
Effective treatment
1 people found this helpful
Mega-zyme has been a lifesaver for my husband. He frequently suffered from vomiting and diarrhea for no apparent reason. Since he began taking Mega-zyme, he has been thoroughly enjoying his meals!
Read More
0
Unnecessary side effects
1 people found this helpful
The product may reduce antibodies, but experiencing diarrhoea every time is unnecessary. I cannot justify the price when I'm encountering similar discomfort and side effects. I plan to stop using it before the weekend.
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0
Severe stomach issues
1 people found this helpful
I take this product as advised by my nutritionist, but sadly, I suffer from terrible diarrhea and stomach pain regardless of whether I take it before or after meals. I haven’t conducted any tests, so I can’t guarantee any improvement in my condition, but the cost is too high for the adverse effects.
Read More
Frequently Asked Questions
9
Effective treatment
1 people found this helpful
Mega-zyme has been a lifesaver for my husband. He frequently suffered from vomiting and diarrhea for no apparent reason. Since he began taking Mega-zyme, he has been thoroughly enjoying his meals!
0
Severe stomach issues
1 people found this helpful
I take this product as advised by my nutritionist, but sadly, I suffer from terrible diarrhea and stomach pain regardless of whether I take it before or after meals. I haven’t conducted any tests, so I can’t guarantee any improvement in my condition, but the cost is too high for the adverse effects.
0
Caused diarrhea
3 people found this helpful
I didn’t realise that digestive enzymes could cause stomach pains and diarrhea, but this one certainly did. I experienced intermittent diarrhea for a month while using it. Upon stopping, my gastrointestinal issues resolved, but they returned upon resuming. I’d recommend avoiding this if you have GI problems.
9
Pancreatin reliefs symptoms effectively
We observed how pancreatin, an enzyme replacement therapy, impacts patients suffering from diarrhea due to exocrine pancreatic insufficiency related to chronic pancreatitis. In a year-long, multicenter study, we evaluated symptom changes and quality of life in 294 patients, with some already on pancreatin and others newly diagnosed.
Both groups reported a significant reduction in gastrointestinal symptoms and pain after one year, alongside improved quality of life scores. The treatment was particularly effective for those who were new to pancreatin, showcasing a clear benefit in managing their symptoms.
Both groups reported a significant reduction in gastrointestinal symptoms and pain after one year, alongside improved quality of life scores. The treatment was particularly effective for those who were new to pancreatin, showcasing a clear benefit in managing their symptoms.
8
We looked into how exocrine pancreatic insufficiency (EPI) affects patients after esophagectomy. By measuring fecal elastase-1 in 63 postoperative patients, we found that 10 had significant EPI, all showing improvement when given pancreatic enzyme replacement therapy (PERT). In another group with mild EPI, some also reported symptom relief, though fewer experienced weight gain. Our findings suggest that EPI can worsen recovery after esophagectomy and point to the potential benefits of PERT, although further formal studies are needed to solidify these insights.
8
We explored a rare condition known as isolated congenital enterokinase deficiency, particularly in a 13-month-old patient. This condition caused significant issues, including failure to thrive, diarrhea, and low protein levels. By reviewing all eight reported cases, we found that all patients, including ours, showed improvement with pancreatic enzyme replacement therapy. This suggests that pancreatin can play a crucial role in managing the symptoms, particularly diarrhea, linked to this deficiency.
7
Pancreatin shows partial efficacy
We evaluate pancreatin's effectiveness in addressing diarrhea associated with pancreatic insufficiency. Using eight tablets of pancreatin during meals rich in fat typically eliminates azotorrhea and provides improved nutritional status and symptom relief.
However, while diarrhea often improves, steatorrhea may persist. For patients who still struggle with weight loss and diarrhea despite dietary adjustments, adding cimetidine can further help. In challenging cases, adjusting the dosage schedule or using specialized formulations may be necessary to optimize results.
However, while diarrhea often improves, steatorrhea may persist. For patients who still struggle with weight loss and diarrhea despite dietary adjustments, adding cimetidine can further help. In challenging cases, adjusting the dosage schedule or using specialized formulations may be necessary to optimize results.
References
- Song A, Zhang R, Chi Y, Zhang HB. [The 501st case: elevated blood glucose, chronic pancreatitis, and post- pancreatoduodenectomy malnutrition]. Zhonghua Nei Ke Za Zhi. 2023;62:891. 10.3760/cma.j.cn112138-20221120-00870
- D'Haese JG, Ceyhan GO, Demir IE, Layer P, Uhl W, et al. Pancreatic enzyme replacement therapy in patients with exocrine pancreatic insufficiency due to chronic pancreatitis: a 1-year disease management study on symptom control and quality of life. Pancreas. 2014;43:834. 10.1097/MPA.0000000000000131
- Huddy JR, Macharg FM, Lawn AM, Preston SR. Exocrine pancreatic insufficiency following esophagectomy. Dis Esophagus. 2013;26:594. 10.1111/dote.12004
- Ran ZH, Yuan YZ, Li ZS, Wang JY, Zong CH, et al. The efficacy of Combizym in the treatment of Chinese patients with dyspepsia: a multicenter, randomized, placebo-controlled and cross-over study: Shanghai Combizym Clinical Cooperative Group. J Dig Dis. 2009;10:41. 10.1111/j.1751-2980.2008.00361.x
- Kim JW, Jung DI, Kang BT, Kim HJ, Park C, et al. Canine exocrine pancreatic insufficiency treated with porcine pancreatic extract. J Vet Sci. 2005;6:263.
- Mohamed AE, Ghandour ZM, Al-Karawi MA. Spasmocanulase in irritable bowel syndrome. Saudi Med J. 2002;23:1074.
- Lechowski R, Pisarski J, Gosławski J, Lenarcik M. Exocrine pancreatic insufficiency-like syndrome in giraffe. J Wildl Dis. 1991;27:728.
- Ghishan FK, Lee PC, Lebenthal E, Johnson P, Bradley CA, et al. Isolated congenital enterokinase deficiency. Recent findings and review of the literature. Gastroenterology. 1983;85:727.
- Krieger I, Evans GW, Zelkowitz PS. Zinc dependency as a cause of chronic diarrhea in variant acrodermatitis enteropathica. Pediatrics. 1982;69:773.
- DiMagno EP. Medical treatment of pancreatic insufficiency. Mayo Clin Proc. 1979;54:435.
- Moosauer M. [High-dose enzyme-substitution therapy in digestive disorders]. Fortschr Med. 1976;94:1815.
