Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.5
USERS' SCORE
Moderately Good
Based on 66 Reviews
7.6
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Milk Thistle extract (seed) standardized to 80% silymarin (140 mg)
175 mg
**
Top Medical Research Studies
9
We investigated the effects of silymarin on liver and heart health under oxidative stress from paracetamol. In a controlled study with 28 male mice, silymarin showed a strong potential to reduce liver injury markers and improve liver enzyme levels after treatment.
Histopathological assessments revealed less tissue damage and inflammation in mice treated with silymarin compared to those that only received paracetamol. Overall, these findings demonstrate that silymarin is a promising option to help protect the liver and heart from oxidative stress-related injury.
Histopathological assessments revealed less tissue damage and inflammation in mice treated with silymarin compared to those that only received paracetamol. Overall, these findings demonstrate that silymarin is a promising option to help protect the liver and heart from oxidative stress-related injury.
8
We explored how silybin A, a key ingredient from silybum marianum, impacts liver health. Through studies on liver cells and mice, we discovered that silybin A effectively lowers triglyceride levels while boosting essential phospholipids, supporting a healthy lipid balance.
Our findings suggest that silybin offers protective benefits against liver damage, particularly in cases of mild metabolic imbalance. However, its effectiveness seems limited in more severe liver disease scenarios, highlighting the nuances of its liver-protective properties.
Our findings suggest that silybin offers protective benefits against liver damage, particularly in cases of mild metabolic imbalance. However, its effectiveness seems limited in more severe liver disease scenarios, highlighting the nuances of its liver-protective properties.
8
Silymarin showed enhanced liver protection
We explored how different forms of silymarin, derived from milk thistle seeds, affect liver health in older hens. In a study with 70 hens, various treatments were given over 12 weeks, including control groups.
We found that higher doses of nano-silymarin and lecithinized silymarin showed significant benefits, such as improved liver enzyme activity and decreased fatty liver symptoms. However, silymarin was less effective at lower doses, which indicates that careful dosing is crucial for optimal results in managing liver issues.
We found that higher doses of nano-silymarin and lecithinized silymarin showed significant benefits, such as improved liver enzyme activity and decreased fatty liver symptoms. However, silymarin was less effective at lower doses, which indicates that careful dosing is crucial for optimal results in managing liver issues.
Most Useful Reviews
9
Normalised liver enzymes
24 people found this helpful
This product has helped my wife with liver disease more than any prescription drug. After her liver transplant, we struggled to manage high liver enzymes, but milk thistle significantly lowered them, surprising her transplant team.
9
Supports liver health
23 people found this helpful
The best product for maintaining a healthy liver! Milk Thistle, standardised to 80% Silymarin, in doses of around 600 mg per day provides therapeutic benefits, especially for liver disease conditions like alcohol-related liver disease and Hepatitis. It's crucial to consult a qualified physician for serious conditions. Standardised Milk Thistle is highly beneficial for those on prescription drugs or exposed to environmental toxins. I have used Nature's Way for five years, and although I believe they are top-notch, I often opt for Swanson due to its affordability. I take 3-4 capsules daily on an empty stomach to support my liver health.
9
Lowers cholesterol
15 people found this helpful
This great product for liver health contains milk thistle, which helps lower LDL cholesterol and reduces insulin resistance. It's also an antioxidant, antiviral, and anti-inflammatory.
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.5
- All Researches
9
We investigated the effects of silymarin on liver and heart health under oxidative stress from paracetamol. In a controlled study with 28 male mice, silymarin showed a strong potential to reduce liver injury markers and improve liver enzyme levels after treatment.
Histopathological assessments revealed less tissue damage and inflammation in mice treated with silymarin compared to those that only received paracetamol. Overall, these findings demonstrate that silymarin is a promising option to help protect the liver and heart from oxidative stress-related injury.
Histopathological assessments revealed less tissue damage and inflammation in mice treated with silymarin compared to those that only received paracetamol. Overall, these findings demonstrate that silymarin is a promising option to help protect the liver and heart from oxidative stress-related injury.
9
Silymarin improves liver health in mice
We investigated how silymarin, along with other natural compounds, affects non-alcoholic fatty liver disease (NAFLD) in mice. Over 16 weeks, mice on a high-fat diet received silymarin supplements, which significantly improved liver health and reduced fat buildup.
Notably, these changes were linked to beneficial shifts in gut bacteria and their metabolites. The study shows that silymarin may play a key role in enhancing liver function through its positive influence on gut microbiota, offering promising insights for NAFLD treatment.
Notably, these changes were linked to beneficial shifts in gut bacteria and their metabolites. The study shows that silymarin may play a key role in enhancing liver function through its positive influence on gut microbiota, offering promising insights for NAFLD treatment.
9
We investigated the potential of a specially formulated version of Silybum marianum, known as nano-SM, to combat liver damage caused by a compound called 17α-ethinylestradiol (EE).
In an experiment involving female rats, we discovered that nano-SM significantly reduced harmful liver enzymes and improved antioxidant levels compared to untreated rats.
This suggests that nano-SM could effectively protect the liver from cholestasis-related injury by enhancing the removal of bile acids and reducing inflammation.
In an experiment involving female rats, we discovered that nano-SM significantly reduced harmful liver enzymes and improved antioxidant levels compared to untreated rats.
This suggests that nano-SM could effectively protect the liver from cholestasis-related injury by enhancing the removal of bile acids and reducing inflammation.
8
We explored how silybin A, a key ingredient from silybum marianum, impacts liver health. Through studies on liver cells and mice, we discovered that silybin A effectively lowers triglyceride levels while boosting essential phospholipids, supporting a healthy lipid balance.
Our findings suggest that silybin offers protective benefits against liver damage, particularly in cases of mild metabolic imbalance. However, its effectiveness seems limited in more severe liver disease scenarios, highlighting the nuances of its liver-protective properties.
Our findings suggest that silybin offers protective benefits against liver damage, particularly in cases of mild metabolic imbalance. However, its effectiveness seems limited in more severe liver disease scenarios, highlighting the nuances of its liver-protective properties.
8
Silybum marianum aids liver health
We conducted a randomized, double-blind trial to explore the impact of a Silybum marianum (SM) and alpha-lipoic acid (ALA) formulation, combined with a Mediterranean diet, on liver health in those with metabolic dysfunction-associated steatosis.
Our findings showed that this combination can successfully reduce visceral fat and liver fat content over 24 weeks.
Although some patients experienced mild side effects, both treatment and control groups had similar results in this regard. Ultimately, SM-ALA alongside a Mediterranean diet may bring significant benefits to managing liver damage associated with metabolic disorders.
Our findings showed that this combination can successfully reduce visceral fat and liver fat content over 24 weeks.
Although some patients experienced mild side effects, both treatment and control groups had similar results in this regard. Ultimately, SM-ALA alongside a Mediterranean diet may bring significant benefits to managing liver damage associated with metabolic disorders.
User Reviews
USERS' SCORE
Moderately Good
Based on 66 Reviews
7.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Normalised liver enzymes
24 people found this helpful
This product has helped my wife with liver disease more than any prescription drug. After her liver transplant, we struggled to manage high liver enzymes, but milk thistle significantly lowered them, surprising her transplant team.
9
Supports liver health
23 people found this helpful
The best product for maintaining a healthy liver! Milk Thistle, standardised to 80% Silymarin, in doses of around 600 mg per day provides therapeutic benefits, especially for liver disease conditions like alcohol-related liver disease and Hepatitis. It's crucial to consult a qualified physician for serious conditions. Standardised Milk Thistle is highly beneficial for those on prescription drugs or exposed to environmental toxins. I have used Nature's Way for five years, and although I believe they are top-notch, I often opt for Swanson due to its affordability. I take 3-4 capsules daily on an empty stomach to support my liver health.
9
Lowers cholesterol
15 people found this helpful
This great product for liver health contains milk thistle, which helps lower LDL cholesterol and reduces insulin resistance. It's also an antioxidant, antiviral, and anti-inflammatory.
9
Liver enzymes stabilised
11 people found this helpful
I have autoimmune hepatitis, so keeping my liver enzymes controlled is essential. After taking three of these and combining them with ALA and turmeric, my liver enzymes have stabilised and are now perfectly healthy.
9
Maintained liver health
7 people found this helpful
I began taking Thisilyn to combat the side effects of antibiotics for Lyme disease. Since starting it, my liver tests have returned to normal. I’ve continued for over 10 years to maintain liver health.
Frequently Asked Questions
9
Rapid skin improvement
4 people found this helpful
I have a skin condition linked to liver disease, and no other product has matched the effectiveness of this one. I see results within a few days, taking two tablets each morning.
9
Protective effects
This milk thistle extract supports normal liver function and its antioxidant properties protect the liver. I recommend it to everyone.
9
Maintained liver health
7 people found this helpful
I began taking Thisilyn to combat the side effects of antibiotics for Lyme disease. Since starting it, my liver tests have returned to normal. I’ve continued for over 10 years to maintain liver health.
9
Normalised liver enzymes
24 people found this helpful
This product has helped my wife with liver disease more than any prescription drug. After her liver transplant, we struggled to manage high liver enzymes, but milk thistle significantly lowered them, surprising her transplant team.
9
Normal liver tests
2 people found this helpful
Thisilyn, made in Germany, has been crucial in keeping my liver disease tests within a normal range for years. I received fresh caplets from iHerb, though it's a bit pricey.
7.5
Improved liver function
1 people found this helpful
I feel much better since I began taking this supplement, and my liver enzyme profile has improved.
9
Digestive improvement
1 people found this helpful
I'm pleased with my purchase! Recommended by my doctor, I've noticed improvements in my gastrointestinal function after a week, which has alleviated my liver disease symptoms.
7.5
Improved digestion
2 people found this helpful
I took Thisilyn, following a nutritionist's guidance, alongside other medications. I've seen a decrease in swelling and rashes, and my digestion has improved significantly.
9
Heartburn relief
1 people found this helpful
This milk thistle extract has greatly supported my liver. It has improved my liver detox, aided skin health, and even relieved my heartburn. Highly recommend!
7.5
Liver function protection
2 people found this helpful
I purchased this for my sister post-gallbladder removal. Together with other detox products, silymarin protects liver function. I take two daily with lecithin to enhance absorption.
7.5
Liver improvement
2 people found this helpful
This milk thistle, recommended by my doctor, has been helpful. I take two tablets with each meal. The supplement is tasteless and easy to swallow. I plan to take a blood test to gauge my liver improvement due to my liver disease, specifically Gilbert's syndrome. Overall, I feel much better! Thank you!
7
We explored the therapeutic potential of silibinin, a key component of milk thistle extract, for treating liver disorders. Research has shown that silibinin can protect liver cells from damage and support tissue regeneration due to its antioxidant properties.
However, its effectiveness is limited by poor solubility and bioavailability. Innovative derivatives like silibinin-C-2',3-dihydrogen succinate and silibinin-phosphatidylcholine are being developed to enhance its effects. Despite promising initial findings, a thorough understanding of how silibinin works is still needed before it can be fully harnessed for liver disease treatment.
However, its effectiveness is limited by poor solubility and bioavailability. Innovative derivatives like silibinin-C-2',3-dihydrogen succinate and silibinin-phosphatidylcholine are being developed to enhance its effects. Despite promising initial findings, a thorough understanding of how silibinin works is still needed before it can be fully harnessed for liver disease treatment.
7
We explored the effects of silymarin, a natural compound derived from milk thistle, on various liver diseases like cirrhosis and fatty liver. Through extensive clinical trials, we observed that silymarin has impressive antioxidant and hepatoprotective properties, which can help prevent further liver damage and reduce symptoms in patients. This herbal remedy shows promise in improving liver function and has a good safety record with mild side effects. Overall, silymarin stands out as a beneficial option in managing liver health.
8
Silybum marianum aids liver health
We conducted a randomized, double-blind trial to explore the impact of a Silybum marianum (SM) and alpha-lipoic acid (ALA) formulation, combined with a Mediterranean diet, on liver health in those with metabolic dysfunction-associated steatosis.
Our findings showed that this combination can successfully reduce visceral fat and liver fat content over 24 weeks.
Although some patients experienced mild side effects, both treatment and control groups had similar results in this regard. Ultimately, SM-ALA alongside a Mediterranean diet may bring significant benefits to managing liver damage associated with metabolic disorders.
Our findings showed that this combination can successfully reduce visceral fat and liver fat content over 24 weeks.
Although some patients experienced mild side effects, both treatment and control groups had similar results in this regard. Ultimately, SM-ALA alongside a Mediterranean diet may bring significant benefits to managing liver damage associated with metabolic disorders.
8
We explored how silybin A, a key ingredient from silybum marianum, impacts liver health. Through studies on liver cells and mice, we discovered that silybin A effectively lowers triglyceride levels while boosting essential phospholipids, supporting a healthy lipid balance.
Our findings suggest that silybin offers protective benefits against liver damage, particularly in cases of mild metabolic imbalance. However, its effectiveness seems limited in more severe liver disease scenarios, highlighting the nuances of its liver-protective properties.
Our findings suggest that silybin offers protective benefits against liver damage, particularly in cases of mild metabolic imbalance. However, its effectiveness seems limited in more severe liver disease scenarios, highlighting the nuances of its liver-protective properties.
8
We explored the role of silymarin, a compound from milk thistle, as an antioxidant treatment for chronic liver diseases like hepatitis and cirrhosis. Through a thorough review of clinical studies, we found that silymarin shows promise for protecting the liver and may help improve liver function in patients with these conditions.
However, while the results are hopeful, more research is necessary to determine the best dosage, long-term safety, and potential interactions with other medications. This review highlights silymarin's potential and sets the stage for future research on its clinical application.
However, while the results are hopeful, more research is necessary to determine the best dosage, long-term safety, and potential interactions with other medications. This review highlights silymarin's potential and sets the stage for future research on its clinical application.
8
Silymarin showed enhanced liver protection
We explored how different forms of silymarin, derived from milk thistle seeds, affect liver health in older hens. In a study with 70 hens, various treatments were given over 12 weeks, including control groups.
We found that higher doses of nano-silymarin and lecithinized silymarin showed significant benefits, such as improved liver enzyme activity and decreased fatty liver symptoms. However, silymarin was less effective at lower doses, which indicates that careful dosing is crucial for optimal results in managing liver issues.
We found that higher doses of nano-silymarin and lecithinized silymarin showed significant benefits, such as improved liver enzyme activity and decreased fatty liver symptoms. However, silymarin was less effective at lower doses, which indicates that careful dosing is crucial for optimal results in managing liver issues.
References
- Koeberle SC, Thürmer M, Su F, Werner M, Grander J, et al. Silybin A from reprograms lipid metabolism to induce a cell fate-dependent class switch from triglycerides to phospholipids. Theranostics. 2025;15:2006. doi:10.7150/thno.99562
- Cano Contreras AD, Del Rocío Francisco M, Vargas Basurto JL, Gonzalez-Gomez KD, Amieva-Balmori M, et al. Effect of alpha-lipoic acid and supplementation with a Mediterranean diet on metabolic dysfunction-associated steatosis. World J Hepatol. 2025;17:101704. doi:10.4254/wjh.v17.i1.101704
- Shaker MK, Hassany M, Eysa B, Adel A, Zidan A, et al. The activity of a herbal medicinal product of Phyllanthus niruri and Silybum marianum powdered extracts (Heptex®) in patients with apparent risk factors for nonalcoholic steatohepatitis: a phase II, multicentered, randomized, double-blind, placebo-controlled clinical trial. BMC Complement Med Ther. 2025;25:8. doi:10.1186/s12906-024-04692-y
- Selc M, Macova R, Babelova A. Novel Strategies Enhancing Bioavailability and Therapeutical Potential of Silibinin for Treatment of Liver Disorders. Drug Des Devel Ther. 2024;18:4629. doi:10.2147/DDDT.S483140
- Faryadi S, Sheikhahmadi A, Farhadi A, Nourbakhsh H. Evaluating the therapeutic effect of different forms of silymarin on liver status and expression of some genes involved in fat metabolism, antioxidants and anti-inflammatory in older laying hens. Vet Med Sci. 2024;10:e70025. doi:10.1002/vms3.70025
- Dhande D, Dhok A, Anjankar A, Nagpure S. Silymarin as an Antioxidant Therapy in Chronic Liver Diseases: A Comprehensive Review. Cureus. 2024;16:e67083. doi:10.7759/cureus.67083
- Li BY, Xi Y, Liu YP, Wang D, Wang C, et al. Effects of Silybum marianum, Pueraria lobate, combined with Salvia miltiorrhiza tablets on non-alcoholic fatty liver disease in adults: A triple-blind, randomized, placebo-controlled clinical trial. Clin Nutr ESPEN. 2024;63:2. doi:10.1016/j.clnesp.2024.06.003
- Jaffar HM, Al-Asmari F, Khan FA, Rahim MA, Zongo E. Silymarin: Unveiling its pharmacological spectrum and therapeutic potential in liver diseases-A comprehensive narrative review. Food Sci Nutr. 2024;12:3097. doi:10.1002/fsn3.4010
- Okiljević B, Martić N, Govedarica S, Andrejić Višnjić B, Bosanac M, et al. Cardioprotective and Hepatoprotective Potential of Silymarin in Paracetamol-Induced Oxidative Stress. Pharmaceutics. 2024;16. doi:10.3390/pharmaceutics16040520
- Wang X, Jin Y, Di C, Zeng Y, Zhou Y, et al. Supplementation of Silymarin Alone or in Combination with Salvianolic Acids B and Puerarin Regulates Gut Microbiota and Its Metabolism to Improve High-Fat Diet-Induced NAFLD in Mice. Nutrients. 2024;16. doi:10.3390/nu16081169
- Salem MB, Mohammed DM, Hammam OA, Elzallat M. Mitigation of intrahepatic cholestasis induced by 17α-ethinylestradiol via nanoformulation of Silybum marianum L. BMC Complement Med Ther. 2024;24:51. doi:10.1186/s12906-024-04351-2
- Singla RK, Singh D, Verma R, Kaushik D, Echeverría J, et al. Fermented formulation of Silybum marianum seeds: Optimization, heavy metal analysis, and hepatoprotective assessment. Phytomedicine. 2024;124:155286. doi:10.1016/j.phymed.2023.155286
- Calderon Martinez E, Herrera D, Mogan S, Hameed Z, Jangda AA, et al. Impact of Silymarin Supplements on Liver Enzyme Levels: A Systematic Review. Cureus. 2023;15:e47608. doi:10.7759/cureus.47608
- Ma X, Yu X, Li R, Cui J, Yu H, et al. Berberine-silybin salt achieves improved anti-nonalcoholic fatty liver disease effect through regulating lipid metabolism. J Ethnopharmacol. 2024;319:117238. doi:10.1016/j.jep.2023.117238
- Talebi A, Soltani R, Khorvash F, Jouabadi SM. The Effectiveness of Silymarin in the Prevention of Anti-tuberculosis Drug-induced Hepatotoxicity: A Randomized Controlled Clinical Trial. Int J Prev Med. 2023;14:48. doi:10.4103/ijpvm.ijpvm_81_22
- Ghodousi M, Karbasforooshan H, Arabi L, Elyasi S. Silymarin as a preventive or therapeutic measure for chemotherapy and radiotherapy-induced adverse reactions: a comprehensive review of preclinical and clinical data. Eur J Clin Pharmacol. 2023;79:15. doi:10.1007/s00228-022-03434-8
