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Supplement Facts
Serving Size: 2 Capsules
Amount Per Serving
%DV
Total Carbohydrate
<1 g
<1%†
Calcium (from calcium magnesium phytate)
131 mg
10%
Phosphorus (from calcium magnesium phytate)
192 mg
15%
Magnesium (from calcium magnesium phytate)
40 mg
10%
IP-6 (inositol hexaphosphate) (from calcium magnesium phytate)
800 mg
**
Inositol
220 mg
**
The product is found useful for the following medical conditions
Cancer
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Excellent
Based on 43 Reviews
9.1
9
Myo-inositol affects prostate cancer cells
Proteomic Analysis of Anticancer Effect of Myo-inositol in Human Prostate Cancer (DU-145) Cell Line.
Most Relevant Research
We investigated the potential benefits of Myo-inositol, a naturally occurring sugar alcohol, on DU-145 prostate cancer cells. By treating these cancer cells with various doses of Myo-inositol, we determined its half-maximal inhibitory concentration (IC50) using a simple method that measures cell viability.
Our findings revealed that Myo-inositol significantly decreased the viability of DU-145 cells, showing an IC50 of 0.06 mg/ml. This suggests that Myo-inositol may effectively inhibit cancer cell growth.
Furthermore, we performed a detailed proteomic analysis using advanced techniques to explore how Myo-inositol changes protein expression. We found notable differences in protein levels between treated and untreated cells, particularly in areas linked to key cellular functions like cytoskeletal regulation, apoptosis (cell death), and stress responses. For instance, certain proteins tied to tumor suppression were upregulated in response to Myo-inositol treatment.
Overall, these observations highlight Myo-inositol's potential as a therapeutic option. However, further studies are necessary to unravel the underlying mechanisms and assess its effectiveness in combination with other treatments for managing prostate cancer, especially castration-resistant prostate cancer (CRPC).
Our findings revealed that Myo-inositol significantly decreased the viability of DU-145 cells, showing an IC50 of 0.06 mg/ml. This suggests that Myo-inositol may effectively inhibit cancer cell growth.
Furthermore, we performed a detailed proteomic analysis using advanced techniques to explore how Myo-inositol changes protein expression. We found notable differences in protein levels between treated and untreated cells, particularly in areas linked to key cellular functions like cytoskeletal regulation, apoptosis (cell death), and stress responses. For instance, certain proteins tied to tumor suppression were upregulated in response to Myo-inositol treatment.
Overall, these observations highlight Myo-inositol's potential as a therapeutic option. However, further studies are necessary to unravel the underlying mechanisms and assess its effectiveness in combination with other treatments for managing prostate cancer, especially castration-resistant prostate cancer (CRPC).
10
Active cancer treatment
Most Useful Review
This is the best I-P6 product available. It works wonders to shrink tumours. I have effectively halted my cancer twice using this product – two pills in the morning and two at night for maintenance. Studies indicate it begins working at doses of 8 mg. It also benefits immune health and is suitable for the entire family; I highly recommend it.
Cold
SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8.5
USERS' SCORE
Good
Based on 8 Reviews
8.9
8
Inositol enhances rapeseed cold tolerance
Inositol Improves Cold Tolerance Through Inhibiting and Increasing Ca Influx in Rapeseed ( L.).
Most Relevant Research
We explored the impact of inositol on cold stress in rapeseed, an essential oilseed crop affected by low temperatures. Notably, we found that inositol plays a significant role in enhancing cold tolerance in these plants by boosting calcium ion (Ca) influx.
Our study involved identifying various genes associated with inositol and analyzing their expression under cold conditions. Interestingly, inositol appeared to inhibit the expression of calcineurin B-like genes, which are involved in regulating calcium flow, suggesting a unique pathway through which inositol aids in cold resilience.
Additionally, when we overexpressed certain genes linked to calcium flux, we noted a stronger response to cold stress, further emphasizing the importance of the inositol-Ca pathway in facilitating cold tolerance in rapeseed. These findings not only deepen our understanding of how rapeseed copes with cold conditions but also present a potential strategy for enhancing crop resilience in the face of climate challenges.
Our study involved identifying various genes associated with inositol and analyzing their expression under cold conditions. Interestingly, inositol appeared to inhibit the expression of calcineurin B-like genes, which are involved in regulating calcium flow, suggesting a unique pathway through which inositol aids in cold resilience.
Additionally, when we overexpressed certain genes linked to calcium flux, we noted a stronger response to cold stress, further emphasizing the importance of the inositol-Ca pathway in facilitating cold tolerance in rapeseed. These findings not only deepen our understanding of how rapeseed copes with cold conditions but also present a potential strategy for enhancing crop resilience in the face of climate challenges.
9.5
Normalises Ferritin levels
Most Useful Review
IP6 has many benefits, including lowering Ferritin levels in my blood. Two years ago, my levels were at 1600, but after two months of taking IP6, they dropped below 100. I've maintained this regimen and have not experienced a cold since.
Breast Cancer
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.5
USERS' SCORE
Good
Based on 6 Reviews
8.8
9
Myo-inositol reverses EMT effects
Myo-Inositol Reverses TGF-β1-Induced EMT in MCF-10A Non-Tumorigenic Breast Cells.
Most Relevant Research
We explored how myo-inositol impacts breast cells, particularly in the context of a process called Epithelial-Mesenchymal Transition (EMT). This process, often triggered by factors like transforming growth factor beta 1 (TGF-β1), leads to changes in cells that can contribute to cancer progression.
Our study focused on non-tumorigenic MCF-10A breast cells, where we observed a remarkable transformation when these cells were exposed to TGF-β1. The cells lost their usual tight connections and took on a more flexible, mesenchymal shape, which is a hallmark of EMT.
However, when we applied myo-inositol, we saw an impressive reversal of these changes. The presence of myo-inositol helped restore the important cell connection proteins (E-cadherin-β-catenin complexes) and encouraged the re-expression of epithelial markers. This shift not only limited the cells' invasive capabilities but also reduced the release of proteins associated with cancer spread.
Our findings indicate that myo-inositol may offer a promising avenue for improving breast cancer treatment by counteracting the effects of EMT. It's encouraging to think about how this simple compound could play a critical role in fighting cancer progression.
Our study focused on non-tumorigenic MCF-10A breast cells, where we observed a remarkable transformation when these cells were exposed to TGF-β1. The cells lost their usual tight connections and took on a more flexible, mesenchymal shape, which is a hallmark of EMT.
However, when we applied myo-inositol, we saw an impressive reversal of these changes. The presence of myo-inositol helped restore the important cell connection proteins (E-cadherin-β-catenin complexes) and encouraged the re-expression of epithelial markers. This shift not only limited the cells' invasive capabilities but also reduced the release of proteins associated with cancer spread.
Our findings indicate that myo-inositol may offer a promising avenue for improving breast cancer treatment by counteracting the effects of EMT. It's encouraging to think about how this simple compound could play a critical role in fighting cancer progression.
9.5
Powerful tumour shrinker
Most Useful Review
The best I-P6 product! There is no better solution for tumour reduction. I've used this product to beat cancer twice, taking 2 pills in the morning and at night. For active cancer, I recommend 4 pills twice daily. This product also promotes immune health and is fantastic for the whole family.
Prostate Cancer
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8.5
USERS' SCORE
Good
Based on 4 Reviews
8.8
9
IP6 potentially prevents prostate cancer
Stage-Specific Effect of Inositol Hexaphosphate on Cancer Stem Cell Pool during Growth and Progression of Prostate Tumorigenesis in TRAMP Model.
Most Relevant Research
We evaluated how inositol hexaphosphate (IP6), a natural compound found in various foods, influences the growth and development of prostate cancer in a special group of mice known as TRAMP. The study involved feeding these male mice either regular water or water containing 2% IP6 at different stages of their growth – starting at 4, 12, 20, and 30 weeks of age – for a period of about 8 to 15 weeks.
Pathological evaluations at the end of the study revealed some encouraging results. The IP6 treatment seemed to halt tumor progression earlier on, and it significantly reduced the incidence of more severe forms of the disease by around 55% to 70%. This finding suggests that IP6 could have a crucial role in preventing prostate cancer from advancing in severity.
Furthermore, we explored the effects of IP6 on cancer stem cells (CSCs), a small group of cells within tumors that can drive cancer growth. The results indicated that IP6 might help in reducing these CSCs in prostate tumors. In laboratory tests, we also found that IP6 treatment dramatically decreased the number of floating prostate cancer stem cell clusters by approximately 90%.
Overall, these findings suggest that IP6 holds significant promise as a preventive measure against prostate cancer, particularly at earlier stages of the disease.
Pathological evaluations at the end of the study revealed some encouraging results. The IP6 treatment seemed to halt tumor progression earlier on, and it significantly reduced the incidence of more severe forms of the disease by around 55% to 70%. This finding suggests that IP6 could have a crucial role in preventing prostate cancer from advancing in severity.
Furthermore, we explored the effects of IP6 on cancer stem cells (CSCs), a small group of cells within tumors that can drive cancer growth. The results indicated that IP6 might help in reducing these CSCs in prostate tumors. In laboratory tests, we also found that IP6 treatment dramatically decreased the number of floating prostate cancer stem cell clusters by approximately 90%.
Overall, these findings suggest that IP6 holds significant promise as a preventive measure against prostate cancer, particularly at earlier stages of the disease.
9.5
Effective treatment
Most Useful Review
Cancer free. I take IP6 with finasteride (hormone) to maintain my PSA at 1; I have prostate cancer—it works for me and has for the past nine years.
Back Pain
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 4 Reviews
8.7
9.5
Improved back pain
Most Useful Review
This has really helped me. I suffer from chronic fatigue, brain fog, and muscle and joint pain. I've had cancer three times, and the chemotherapy has left me with long-term effects. This product has significantly reduced my fatigue, and I can actually organise and accomplish much more now. My back pain has improved tremendously. Initially, I took 2 pills twice a day without noticing a difference. However, I later discovered I could take up to ten per day, so I started taking 5 pills twice a day, and after the second dose, I felt a difference. I’m now on 4 twice daily and may cut back to 3 soon to see how that works. If you have similar issues, you owe it to yourself to give these a try.
Common Cold
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 4 Reviews
8.7
9.5
Cold prevention works
Most Useful Review
Excellent product! I have used this for years. If I ever feel a cold or sore throat, I immediately take two of these, and they’re gone! It also helps with an upset stomach from poor food combinations. Bottom line: I don’t get sick anymore. Moreover, I supplement my health with 4000 IU of vitamin D3 daily—my preferred brand is Mega Foods from iHerb, as it’s plant-based, not fish or lanolin.
Ear Infection
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.7
9.5
Fewer infections
Most Useful Review
I've taken these daily for three years and have no plans to stop. I rarely get sick; my colds and ear infections have decreased significantly, and I no longer suffer from migraines—I'm hooked.
Hives
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.7
10
No more hives
Most Useful Review
This product works wonders! I suffered from allergies for years with tests yielding no clear results, yet I continuously broke out in hives. After seeking to boost my immune response, I've been using this for nearly three years and I can happily say that I have not had any hives since. I'm still unsure of the trigger, but I’m incredibly thankful I stumbled upon this product. Amazon has the best prices and swift delivery.
Allergies
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.6
9.5
No more hives
Most Useful Review
This product has been outstanding! For years, allergies led to hives without clear triggers. After nearly three years of using this product, I am thrilled to report "no more hives." I'm unsure what was causing my reactions but am grateful for this find. Amazon offers the best prices and swift delivery.
Anxiety
SCIENTIFIC SCORE
Questionable
Based on 6 Researches
6.3
USERS' SCORE
Good
Based on 2 Reviews
8.6
8
Inositol reduces anxiety in hens
Dietary Inositol Reduces Fearfulness and Avoidance in Laying Hens.
Most Relevant Research
We conducted a study to understand how inositol, a naturally occurring sugar alcohol, influences anxiety levels in laying hens. Our focus was on the behavior of Lohmann LSL lite hens, which were fed two different diets—one rich and one deficient in protein—while receiving either pure inositol or high levels of phytase.
Throughout the experimental period from 19 to 59 weeks of age, we gathered data through multiple behavior assessments, which included observing their reactions to new objects and monitoring their overall health indicators like feather condition and mortality rates.
Interestingly, inositol appeared to help reduce fearfulness in these hens, which we observed through a decrease in the time it took for them to approach and peck at new objects. However, it's worth noting that while inositol also led to a drop in vent feather cover and was associated with a slight increase in mortality, its primary benefit was tied to its ability to lessen anxiety.
Phytase, on the other hand, did not yield similar effects on behavior or health. These findings point towards the potential of inositol as a useful dietary addition for improving the well-being of laying hens by reducing anxiety levels.
Throughout the experimental period from 19 to 59 weeks of age, we gathered data through multiple behavior assessments, which included observing their reactions to new objects and monitoring their overall health indicators like feather condition and mortality rates.
Interestingly, inositol appeared to help reduce fearfulness in these hens, which we observed through a decrease in the time it took for them to approach and peck at new objects. However, it's worth noting that while inositol also led to a drop in vent feather cover and was associated with a slight increase in mortality, its primary benefit was tied to its ability to lessen anxiety.
Phytase, on the other hand, did not yield similar effects on behavior or health. These findings point towards the potential of inositol as a useful dietary addition for improving the well-being of laying hens by reducing anxiety levels.
9.5
Improved mood
Most Useful Review
Inositol is my method of addressing the negative impacts of stress and anxiety. After taking it, I've noticed a better mood, reduced anxiety, and overall improved health. I'm very pleased with the results and will continue to use it.
Autoimmune Disorder
SCIENTIFIC SCORE
Questionable
Based on 5 Researches
5.6
USERS' SCORE
Good
Based on 9 Reviews
8.6
8
Myo-inositol enhances vitamin D effects
The impact of vitamin D on thyroid autoimmunity and hypothalamic-pituitary-thyroid axis activity in myo-inositol-treated and myo-inositol-naïve women with autoimmune thyroiditis: A pilot study.
Most Relevant Research
Our study aimed to explore the impact of myo-inositol treatment on thyroid autoimmunity in women with autoimmune thyroiditis. We included groups of women who had been on myo-inositol for a while and those who hadn’t. For six months, we observed how vitamin D supplementation interacted with myo-inositol in affecting thyroid health and immune responses.
We found that among participants taking myo-inositol, the addition of vitamin D significantly improved insulin sensitivity and led to better outcomes regarding thyroid antibodies. Specifically, women who were already on myo-inositol showed a greater reduction in thyroid peroxidase and thyroglobulin antibodies when vitamin D was added to their regimen.
Interestingly, the effects of vitamin D were less noticeable in women who weren't on myo-inositol. These individuals did not exhibit the same improvements in thyroid function or antibodies. Overall, the findings suggest that myo-inositol might enhance the benefits of vitamin D, indicating a potential synergistic effect between these two agents in managing autoimmune thyroiditis.
We found that among participants taking myo-inositol, the addition of vitamin D significantly improved insulin sensitivity and led to better outcomes regarding thyroid antibodies. Specifically, women who were already on myo-inositol showed a greater reduction in thyroid peroxidase and thyroglobulin antibodies when vitamin D was added to their regimen.
Interestingly, the effects of vitamin D were less noticeable in women who weren't on myo-inositol. These individuals did not exhibit the same improvements in thyroid function or antibodies. Overall, the findings suggest that myo-inositol might enhance the benefits of vitamin D, indicating a potential synergistic effect between these two agents in managing autoimmune thyroiditis.
8.8
Quality support
Most Useful Review
I am very impressed with this product, which I had used before to help manage my cancer. After moving, I couldn't purchase it, and my cancer worsened, leading to two years of chemotherapy. Now, four years later, it's returning, so I ordered it as Iherb delivers here. This is a quality product that supports me at a good price. Very pleased with my purchase.
Chest Pain
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.6
9.5
Relieved sciatica pain
Most Useful Review
IP6 and inositol seem to be helping my sciatica pain. I have not experienced numbness, tingling, or chest pain since I started taking this.
Kidney Stones
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.5
USERS' SCORE
Good
Based on 2 Reviews
8.6
9.5
Inositol shows promise for nephropathies
Inhibitors of Calcium Oxalate Crystallization for the Treatment of Oxalate Nephropathies.
Most Relevant Research
We explored the potential of inositol hexakisphosphate (IP6) and its analogues as a treatment for calcium oxalate (CaOx) nephropathies, conditions often linked to kidney stones. Our study utilized a new machine learning approach that helped screen various chemical modifications of IP6 to find a particularly effective compound.
This innovative method led us to identify a divalent inositol phosphate that demonstrated remarkable activity. In our findings, this molecule completely inhibited the crystallization of CaOx crystals at very low concentrations. Additionally, it significantly reduced the interaction between crystals and kidney cells, preventing harmful changes in gene expression related to kidney damage.
We observed that, in a mouse model experiencing increased levels of oxalate, the IP6 analogue reduced crystal formation and subsequent kidney injury. With these promising results, we believe that these inositol analogues may offer a new therapeutic option for those suffering from calcium oxalate-related kidney issues.
This innovative method led us to identify a divalent inositol phosphate that demonstrated remarkable activity. In our findings, this molecule completely inhibited the crystallization of CaOx crystals at very low concentrations. Additionally, it significantly reduced the interaction between crystals and kidney cells, preventing harmful changes in gene expression related to kidney damage.
We observed that, in a mouse model experiencing increased levels of oxalate, the IP6 analogue reduced crystal formation and subsequent kidney injury. With these promising results, we believe that these inositol analogues may offer a new therapeutic option for those suffering from calcium oxalate-related kidney issues.
8.8
Supports kidney health
Most Useful Review
I purchased IP-6 for its benefits to kidney health, and I appreciate the inositol, which is said to aid brain function as well.
Menopause
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.7
USERS' SCORE
Good
Based on 1 Review
8.6
7
Myo-Inositol Support in Menopause
Tonsil-Derived Mesenchymal Stem Cell-Derived Small Extracellular Vesicles (sEVs) Restore Myo-Inositol Production in LPS-Treated Skeletal Muscle.
Most Relevant Research
We investigated whether small extracellular vesicles (sEVs) derived from human palatine tonsil mesenchymal stem cells could boost myo-inositol levels in the context of menopause. This was particularly interesting given that menopausal women are prone to chronic inflammation due to physiological changes and related issues like metabolic syndrome.
To explore this, we treated mice with lipopolysaccharides (LPS) to simulate inflammation and assessed how the inclusion of T-MSC sEVs influenced myo-inositol production. After treatment, we measured levels of proteins involved in inositol synthesis in skeletal muscle and checked the serum for inositol levels.
Our findings are encouraging and suggest that T-MSC sEVs might help mitigate some effects of chronic inflammation linked to menopause. By supporting skeletal muscle mass and maintaining myo-inositol levels, these sEVs could be an effective strategy for improving metabolic health in menopausal women. This study sheds light on a potential new approach to tackle metabolic disturbances during this life stage.
To explore this, we treated mice with lipopolysaccharides (LPS) to simulate inflammation and assessed how the inclusion of T-MSC sEVs influenced myo-inositol production. After treatment, we measured levels of proteins involved in inositol synthesis in skeletal muscle and checked the serum for inositol levels.
Our findings are encouraging and suggest that T-MSC sEVs might help mitigate some effects of chronic inflammation linked to menopause. By supporting skeletal muscle mass and maintaining myo-inositol levels, these sEVs could be an effective strategy for improving metabolic health in menopausal women. This study sheds light on a potential new approach to tackle metabolic disturbances during this life stage.
9.5
Eases menopause symptoms
Most Useful Review
Good, I ordered this for my friend, who is 45, and she asks for more. She claims it effectively alleviates menopause symptoms. The composition is excellent, and the form is convenient. The quality is high, and I'm impressed by the company.
Anemia
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.6
9.5
Improved dog health
Most Useful Review
I started my 60-pound dog on this after her cancer diagnosis, and she had severe anemia despite taking iron drops. Once I began using these capsules, her energy and anemia improved significantly. Her gums are now pink, indicating better health, and she has returned to her pre-diagnosis energy level. These products have truly enhanced her quality of life.
Bladder Cancer
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.6
9.5
Improved Quality of Life
Most Useful Review
After my 60-pound dog was diagnosed with bladder and urethra cancer, I started her on these capsules, administering 4 in the morning and 4 at bedtime. She had severe anaemia, and while iron drops provided some help, it wasn't sufficient. Once I introduced IP6, her energy and gum colour improved significantly. Despite her disease progressing, causing more frequent urination and bleeding, I added Piroxicam to her regimen. Together, these products have kept her quality of life intact. She was given a prognosis of four to six months but is thriving nearly ten months later. I highly recommend this product!
Chemotherapy
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.6
9.5
Improves blood counts
Most Useful Review
Great Supplement. My boyfriend has aggressive stage IV prostate cancer and is undergoing intense chemotherapy. His blood counts dropped drastically, leading to mouth sores. After starting IP 6 twice daily, conditions improved significantly. His blood counts remained stable, and he felt much better. His PSA dropped over 10 points within four weeks. I’m ordering the powdered form for convenience and highly recommend this product, particularly with added B vitamins, magnesium and inositol.
Leukemia
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.6
9.5
Cancer treatment
Most Useful Review
This is excellent at killing and reducing abnormal cell growth, including tumours, both malignant and benign. I've purchased it for an ex who had leukemia and for my younger brother. It's beneficial for both pets and loved ones. When paired with exercise and a healthy diet, you're likely to see a happier, healthier being.
Migraine
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.6
10
No more migraines
Most Useful Review
I’ve been taking these every day for three years and won’t stop if I can help it. I’m rarely sick, my colds and ear infections have significantly decreased, and I no longer experience migraines. I’m completely hooked.
Neuropathy
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.6
9.5
Dramatic relief
Most Useful Review
Five stars. This has significantly helped my husband’s neuropathy pain; he swears by it.
Ovarian Cancer
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.6
9.5
Survivor's benefit
Most Useful Review
I've been taking Cell Forte IP6 & Inositol for nearly three years as an ovarian cancer survivor. Following my surgery and chemotherapy, I've taken this daily, and my CA125 tests consistently come back at 5.5, which is within the normal range of 0-35.
Pots
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.6
9.5
Improved skin appearance
Most Useful Review
I think it actually makes my skin look better, with much fewer brown spots. I began taking this supplement about 9 years ago to enhance my immune system. It has made a significant difference. Soon after starting, I noticed my skin's improvement, which has continued. I take two each morning on an empty stomach, and with 240 capsules in a bottle, it's very economical. I certainly recommend this product!
Skin Cancer
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.6
10
Cured skin cancer
Most Useful Review
I've been using this for almost a decade now and I love it! I know they don't appreciate such claims, but I cured my own skin cancer with high doses of this product. It also makes my skin look wonderful and keeps me appearing considerably younger than my actual age. I can't speak highly enough about it.
Thrush
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.6
9.5
Significant improvement noticed.
Most Useful Review
Great supplement. My boyfriend has aggressive stage IV prostate cancer and is undergoing intense chemotherapy. His blood counts dropped significantly, and he developed mouth sores from thrush after just a week of treatment. After starting IP 6, taking six capsules daily, his next treatment went much better, with blood counts remaining stable and no infections. He feels better too, with his PSA dropping more than 10 points in the last four weeks. I'm ordering the powdered form for convenience. Highly recommended!
Warts
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.6
9.5
Warts healing well
Most Useful Review
Worth it - Cancer & Virus Fighter! This supplement is great. I originally purchased it for my mum, who is battling esophageal cancer. I also began taking 6-8 a day and noticed the three warts on my hands have disappeared. The plantar warts on my feet are almost healed too. It’s an amazing miracle formula!
Arthritis
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Good
Based on 1 Review
8.5
9
SHIP1 inhibition may relieve RA
Inhibition of lipid phosphatase SHIP1 expands myeloid-derived suppressor cells and attenuates rheumatoid arthritis in mice.
Most Relevant Research
We explored how inhibiting a specific lipid phosphatase known as SHIP1 could potentially help in treating rheumatoid arthritis (RA). This study primarily investigated the impact of using a SHIP1 inhibitor on the expansion of myeloid-derived suppressor cells (MDSCs) in a mouse model that mimics the symptoms of RA. By employing a small molecule called 3α-aminocholestane (3AC), we observed a significant increase in MDSCs within the treated mice. This increase seemed to correlate with a noticeable reduction in both the severity and incidence of arthritis symptoms.
Notably, our results indicated that transferring MDSCs from 3AC-treated mice into those with CIA provided a significant therapeutic effect, suggesting that these induced cells played a crucial role in suppressing the adverse immune responses associated with arthritis. However, it’s important to mention that while the study highlights the potential of SHIP1 inhibition in benefiting RA treatment, it does not specifically evaluate the direct effects of inositol treatment alone. This could limit the broader applicability of findings concerning inositol’s role in managing arthritis.
Overall, the study indicates that targeting SHIP1 and subsequently expanding MDSCs may offer a promising new strategy for managing RA and other autoimmune conditions.
Notably, our results indicated that transferring MDSCs from 3AC-treated mice into those with CIA provided a significant therapeutic effect, suggesting that these induced cells played a crucial role in suppressing the adverse immune responses associated with arthritis. However, it’s important to mention that while the study highlights the potential of SHIP1 inhibition in benefiting RA treatment, it does not specifically evaluate the direct effects of inositol treatment alone. This could limit the broader applicability of findings concerning inositol’s role in managing arthritis.
Overall, the study indicates that targeting SHIP1 and subsequently expanding MDSCs may offer a promising new strategy for managing RA and other autoimmune conditions.
8.8
Reduced arthritis pain
Most Useful Review
I was sceptical after reading the reviews, but this product has improved my very old dog’s condition significantly. His breathing has improved and his skin is healing from repeated staph infections. He appears to have less pain from arthritis now and his eyes are clearer. I give him one pill daily, and it seems suitable for a 25 lb dog. I'm intrigued to see how it might work for people!
Blood Clot
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Good
Based on 1 Review
8.5
9
SCI offers safe anticoagulant potential
A synthetic heparin mimetic that allosterically inhibits factor XIa and reduces thrombosis in vivo without enhanced risk of bleeding.
Most Relevant Research
We explored the effects of a synthetic heparin mimetic known as sulfated chiro-inositol (SCI) on blood clotting mechanisms. This innovative treatment aims to inhibit human factor XIa (FXIa), a key player in the clotting process, while minimizing bleeding risks typically associated with anticoagulants.
In our study, we synthesized SCI to engage FXIa specifically by targeting its heparin-binding sites. Through various blood coagulation assays and in vivo models, we observed that SCI effectively inhibited FXIa, leading to reduced clot formation without significant safety concerns. In particular, SCI demonstrated potent anticoagulant properties, matching the performance of existing treatments like enoxaparin but at a much lower dosage.
Importantly, our investigations revealed that SCI's effects could be reversed by common antidotes, which adds an important layer of safety. While we noted no major bleeding risks or toxicity in the studies, further research is needed to ensure SCI's efficacy across broader clinical scenarios. Overall, our findings highlight SCI as a promising candidate for safer anticoagulation therapies.
In our study, we synthesized SCI to engage FXIa specifically by targeting its heparin-binding sites. Through various blood coagulation assays and in vivo models, we observed that SCI effectively inhibited FXIa, leading to reduced clot formation without significant safety concerns. In particular, SCI demonstrated potent anticoagulant properties, matching the performance of existing treatments like enoxaparin but at a much lower dosage.
Importantly, our investigations revealed that SCI's effects could be reversed by common antidotes, which adds an important layer of safety. While we noted no major bleeding risks or toxicity in the studies, further research is needed to ensure SCI's efficacy across broader clinical scenarios. Overall, our findings highlight SCI as a promising candidate for safer anticoagulation therapies.
8.3
Effective iron chelation
Most Useful Review
An excellent product for chelating iron and reducing blood hematocrit levels.
Food Poisoning
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.5
8
Food poisoning relief
Most Useful Review
Excellent product! I've used this for years. Whenever I sense a cold or sore throat coming on, I take two of these, and they work wonders. They’re also effective for food poisoning. Essentially, I hardly ever get ill now. Additionally, I take 4000 units of vitamin D3 daily, specifically from the Mega Foods brand, as it's plant-based rather than derived from fish or lanolin.
Heart Attack
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Good
Based on 1 Review
8.5
9
ITPP enhances heart attack recovery
Treatment of hypoxia-dependent cardiovascular diseases by myo-inositol trispyrophosphate (ITPP)-enhancement of oxygen delivery by red blood cells.
Most Relevant Research
We explored the potential of myo-inositol trispyrophosphate (ITPP) as a treatment for heart attacks and its effect on heart tissue injured by low oxygen levels. This research indicates ITPP modifies hemoglobin in red blood cells, enhancing the delivery of oxygen throughout the body.
Using an animal model for myocardial infarction, we observed that ITPP administration provided significant protection against heart failure and aided in recovery from left ventricular remodeling following the heart attack.
In our laboratory studies, heart muscle cells exposed to low oxygen levels reacted quickly to ITPP treatment, showing increased activity of a protein known as HIF-1. Interestingly, this overactivity was countered by ITPP when it was in the red blood cells, which suggests a strong connection between shear stress from blood flow and oxygen release facilitated by the modified hemoglobin.
Overall, the findings indicate that ITPP could be a game-changer in treating injuries to heart tissues related to low oxygen or ischemia. This approach may open new avenues for effectively managing damage caused by heart attacks.
Using an animal model for myocardial infarction, we observed that ITPP administration provided significant protection against heart failure and aided in recovery from left ventricular remodeling following the heart attack.
In our laboratory studies, heart muscle cells exposed to low oxygen levels reacted quickly to ITPP treatment, showing increased activity of a protein known as HIF-1. Interestingly, this overactivity was countered by ITPP when it was in the red blood cells, which suggests a strong connection between shear stress from blood flow and oxygen release facilitated by the modified hemoglobin.
Overall, the findings indicate that ITPP could be a game-changer in treating injuries to heart tissues related to low oxygen or ischemia. This approach may open new avenues for effectively managing damage caused by heart attacks.
8
Immune function boost
Most Useful Review
IP-6 enhances immune function, lowers the risk of heart attack, and reduces cholesterol levels. It may also decrease the risk of cancer.
Hypothyroidism
SCIENTIFIC SCORE
Moderately Effective
Based on 11 Researches
8.4
USERS' SCORE
Good
Based on 1 Review
8.5
9
Myo-inositol reduces thyroid nodule size
Evaluation of thyroid nodule characteristics in subclinical hypothyroid patients under a myo-inositol plus selenium treatment.
Most Relevant Research
We conducted an observational study to explore how myo-inositol (MI) combined with selenium (Se) impacts patients with subclinical hypothyroidism (SCH) and associated thyroid nodules (TNs).
Our research involved 642 patients suspected of having hypothyroidism, focusing on a subset with SCH. We divided them into two groups: one that received the MI plus Se treatment for six months and a control group that did not receive any treatment.
Among the received results, we found that the treatment group showed a significant reduction in the size and number of mixed TNs, alongside an improved elasticity score. Remarkably, TSH levels also dropped significantly after treatment, indicating a positive response. In contrast, the control group experienced an increase in TSH levels, highlighting the potential benefits of MI plus Se for managing symptoms of hypothyroidism.
These findings suggest promising avenues for further research, particularly regarding the role of inositol in thyroid health. While we observed substantial benefits in the treated group, we also emphasize the need for more extensive studies to confirm these effects and their mechanisms.
Our research involved 642 patients suspected of having hypothyroidism, focusing on a subset with SCH. We divided them into two groups: one that received the MI plus Se treatment for six months and a control group that did not receive any treatment.
Among the received results, we found that the treatment group showed a significant reduction in the size and number of mixed TNs, alongside an improved elasticity score. Remarkably, TSH levels also dropped significantly after treatment, indicating a positive response. In contrast, the control group experienced an increase in TSH levels, highlighting the potential benefits of MI plus Se for managing symptoms of hypothyroidism.
These findings suggest promising avenues for further research, particularly regarding the role of inositol in thyroid health. While we observed substantial benefits in the treated group, we also emphasize the need for more extensive studies to confirm these effects and their mechanisms.
8.8
Improved immune regulation
Most Useful Review
The quality of the product is excellent. I alternate it with Beta Glucan or Fucoidan, which work as immunomodulators, gently regulating my immune system—crucial for my hypothyroidism.
Influenza
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.5
8.8
No cold symptoms
Most Useful Review
Poor intestinal environment with heavy metal pollution. Since I began taking the supplement in late October 2014, during this cold wave influenza pandemic, I haven’t caught a cold. I take two tablets in the morning and evening, but if you're not accustomed to the size, it might be difficult to swallow.
Lung Cancer
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.7
USERS' SCORE
Good
Based on 14 Reviews
8.5
9
IP shows potential in lung cancer
Intrathecal pemetrexed improves survival outcomes in previously treated EGFR-mutant advanced non-small-cell lung cancer with leptomeningeal metastases.
Most Relevant Research
We explored the effects of intrathecal pemetrexed (IP) on lung cancer patients facing leptomeningeal metastases (LM), particularly after they had not responded to previous treatments with EGFR-TKIs. The study analyzed 50 patients who received a 50 mg dose of IP after their cancer progressed, looking closely at their clinical responses and survival outcomes over two years.
Remarkably, we observed a 64% clinical response rate, indicating that many patients saw improvements in their neurological symptoms and overall performance. The median intracranial progression-free survival was 5.3 months, while overall survival reached up to 12 months for these patients. Those who responded positively to the treatment experienced significantly longer survival compared to non-responders, which is encouraging for both patients and doctors seeking options after traditional therapies fail.
The treatment was generally well tolerated, with manageable side effects mostly related to myelosuppression and liver functions. Additionally, genetic testing revealed consistency between the tumors and the cerebrospinal fluid, which opens up further investigation into the underlying mechanisms of treatment resistance. Overall, our findings suggest that IP could be a promising option for patients battling advanced lung cancer with LM after existing therapies have stopped working.
Remarkably, we observed a 64% clinical response rate, indicating that many patients saw improvements in their neurological symptoms and overall performance. The median intracranial progression-free survival was 5.3 months, while overall survival reached up to 12 months for these patients. Those who responded positively to the treatment experienced significantly longer survival compared to non-responders, which is encouraging for both patients and doctors seeking options after traditional therapies fail.
The treatment was generally well tolerated, with manageable side effects mostly related to myelosuppression and liver functions. Additionally, genetic testing revealed consistency between the tumors and the cerebrospinal fluid, which opens up further investigation into the underlying mechanisms of treatment resistance. Overall, our findings suggest that IP could be a promising option for patients battling advanced lung cancer with LM after existing therapies have stopped working.
9.5
Cancer-free status
Most Useful Review
This product was recommended to my husband and is excellent for strengthening the cells that fight disease. We use it to support his lung cancer battle, and after a year of treatment, he is now cancer-free. We believe this product has played a role in his recovery and tumour shrinkage.
Pneumonia
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.5
8.8
Effective recovery support
Most Useful Review
Excellent preparation for recovery from pneumonia and Covid.
Bursitis
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.5
8.8
Pain bothers me less
Most Useful Review
I purchased these for my sister who passed away, unsure if they could have helped her. However, I've been taking them since and realised that over three years, I haven’t suffered from colds or flu, and my nagging bursitis is now hardly bothersome at all.
Flu
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 7 Reviews
8.5
9.5
No flu recurrence
Most Useful Review
I've used this product for years and my cancer has never returned. Doctors now take it and encourage their staff to do the same, especially during flu season. You either don’t get the flu, or if you do, it lasts only a couple of days rather than the typical 10.
Sore Throat
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.5
8.8
Preventative support noted
Most Useful Review
This is the only immune supplement I've used that genuinely appears effective. It works well both preventatively and once I start feeling unwell. When I sense congestion or a sore throat, I take three capsules three times daily. I either avoid getting sick or don’t remain ill for long. My family swears by this product!
Sleep Apnea
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.4
7.5
Helps with sleep
Most Useful Review
I recently started taking this at night on an empty stomach, and it seems to help me sleep. I am hopeful for the additional health benefits related to sleep apnea to emerge soon. I deducted one star due to magnesium stearate.
Headache
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.4
7.5
Initial headaches present
Most Useful Review
Very good value for money. I experienced headaches in the first few days, but after three days of taking it, I felt much better.
Acne
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.9
USERS' SCORE
Good
Based on 1 Review
8.2
9
Myo-inositol improves acne symptoms
Efficacy of myo-inositol in the treatment of cutaneous disorders in young women with polycystic ovary syndrome.
Most Relevant Research
We explored the effects of myo-inositol (MYO) on acne among young women diagnosed with polycystic ovary syndrome (PCOS). The study included 50 participants who underwent treatment with MYO for six months, focusing on its potential to improve the often frustrating skin issues linked to PCOS.
At the beginning and after the treatment period, we measured various factors including levels of hormones and insulin, as well as the severity of acne.
Remarkably, after three months of MYO therapy, we observed significant reductions in hormone levels associated with PCOS, particularly testosterone and insulin. After six months, both hirsutism and acne symptoms showed notable improvement among the participants.
This research highlights MYO as a promising, safe treatment option for alleviating acne symptoms in individuals with PCOS. Its ability to improve metabolic conditions while managing acne is a fascinating development for women seeking effective solutions for their skin concerns.
At the beginning and after the treatment period, we measured various factors including levels of hormones and insulin, as well as the severity of acne.
Remarkably, after three months of MYO therapy, we observed significant reductions in hormone levels associated with PCOS, particularly testosterone and insulin. After six months, both hirsutism and acne symptoms showed notable improvement among the participants.
This research highlights MYO as a promising, safe treatment option for alleviating acne symptoms in individuals with PCOS. Its ability to improve metabolic conditions while managing acne is a fascinating development for women seeking effective solutions for their skin concerns.
5
Adult acne issue
Most Useful Review
I'm unsure about the results yet, but I've had issues due to weak immunity that led to shingles. I sought nutritional supplements to enhance my immunity, but while taking 2 tablets twice daily, I developed adult acne on my nose and forehead. After 7-10 years without any pimples during puberty, I paused the tablets. I'm sensitive but have typically healthy skin. Perhaps a smaller dosage would be beneficial! I haven’t observed the effects yet, but I give it 5 stars for others' reference.
Knee Pain
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 1 Review
7.8
1.3
Tumour growth noted
Most Useful Review
I began taking IP-6 and Inositol, but my tumour started to grow faster, and my knee pain intensified. Different reactions are possible, and I cannot predict them. I give it 2 stars for the quick delivery.
