Last update
3/3/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.5
USERS' SCORE
Good
Based on 6 Reviews
8.5
Supplement Facts
Serving Size: 2 Capsules
Amount Per Serving
%DV
Total Carbohydrate
<1 g
<1%†
Calcium (from calcium magnesium phytate)
131 mg
10%
Phosphorus (from calcium magnesium phytate)
192 mg
15%
Magnesium (from calcium magnesium phytate)
40 mg
10%
IP-6 (inositol hexaphosphate) (from calcium magnesium phytate)
800 mg
**
Inositol
220 mg
**
Top Medical Research Studies
9
We explored how myo-inositol impacts breast cells, particularly in the context of a process called Epithelial-Mesenchymal Transition (EMT). This process, often triggered by factors like transforming growth factor beta 1 (TGF-β1), leads to changes in cells that can contribute to cancer progression.
Our study focused on non-tumorigenic MCF-10A breast cells, where we observed a remarkable transformation when these cells were exposed to TGF-β1. The cells lost their usual tight connections and took on a more flexible, mesenchymal shape, which is a hallmark of EMT.
However, when we applied myo-inositol, we saw an impressive reversal of these changes. The presence of myo-inositol helped restore the important cell connection proteins (E-cadherin-β-catenin complexes) and encouraged the re-expression of epithelial markers. This shift not only limited the cells' invasive capabilities but also reduced the release of proteins associated with cancer spread.
Our findings indicate that myo-inositol may offer a promising avenue for improving breast cancer treatment by counteracting the effects of EMT. It's encouraging to think about how this simple compound could play a critical role in fighting cancer progression.
Our study focused on non-tumorigenic MCF-10A breast cells, where we observed a remarkable transformation when these cells were exposed to TGF-β1. The cells lost their usual tight connections and took on a more flexible, mesenchymal shape, which is a hallmark of EMT.
However, when we applied myo-inositol, we saw an impressive reversal of these changes. The presence of myo-inositol helped restore the important cell connection proteins (E-cadherin-β-catenin complexes) and encouraged the re-expression of epithelial markers. This shift not only limited the cells' invasive capabilities but also reduced the release of proteins associated with cancer spread.
Our findings indicate that myo-inositol may offer a promising avenue for improving breast cancer treatment by counteracting the effects of EMT. It's encouraging to think about how this simple compound could play a critical role in fighting cancer progression.
Read More
8
Inositol delivery targeting breast cancer
We explored the role of inositol hexakisphosphate (InsP) in treating breast cancer. Our goal was to find a more effective way for InsP to enter cancerous cells, because its natural negative charge makes it hard for the cells to absorb. To tackle this, we encapsulated InsP in chitosan, a natural polysaccharide, using an ionic gelation technique.
Through various tests, we optimized the ratio of InsP to chitosan and confirmed its successful encapsulation using methods like gel electrophoresis and spectroscopy. The microscopic examination revealed significant changes in the structure after encapsulation.
We observed that the encapsulated InsP made its way into human breast cancer cells, specifically the MCF-7 line, much more effectively than free InsP. This internalization led to the triggering of apoptosis, or programmed cell death, in these cancer cells. The mechanism appeared to involve an increase in reactive oxygen species, which can lead to cell death.
Our findings suggest that using natural compounds like inositol, delivered via a chitosan framework, could offer promising therapeutic avenues for cancer treatment. This approach might help to reduce the severe side effects often seen with synthetic chemotherapy drugs.
Through various tests, we optimized the ratio of InsP to chitosan and confirmed its successful encapsulation using methods like gel electrophoresis and spectroscopy. The microscopic examination revealed significant changes in the structure after encapsulation.
We observed that the encapsulated InsP made its way into human breast cancer cells, specifically the MCF-7 line, much more effectively than free InsP. This internalization led to the triggering of apoptosis, or programmed cell death, in these cancer cells. The mechanism appeared to involve an increase in reactive oxygen species, which can lead to cell death.
Our findings suggest that using natural compounds like inositol, delivered via a chitosan framework, could offer promising therapeutic avenues for cancer treatment. This approach might help to reduce the severe side effects often seen with synthetic chemotherapy drugs.
Read More
Most Useful Reviews
9
Powerful tumour shrinker
319 people found this helpful
The best I-P6 product! There is no better solution for tumour reduction. I've used this product to beat cancer twice, taking 2 pills in the morning and at night. For active cancer, I recommend 4 pills twice daily. This product also promotes immune health and is fantastic for the whole family.
Read More
9
Tumour shrinkage
39 people found this helpful
Approximately two years ago, our miniature poodle was diagnosed with breast cancer. Following our vet's advice, we gave her two capsules twice daily. I'm delighted to report that she's doing well! The tumour has shrunk significantly, and her quality of life has improved immensely.
Read More
7.5
Effective defence
77 people found this helpful
I have been taking this cancer-fighting supplement for over three years since my last episode with breast cancer. I feel great and was recommended this by my holistic practitioner. It is endorsed by Johns Hopkins as one of the best defences against cancer. I truly believe in its efficacy.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.5
- All Researches
9
We explored how myo-inositol impacts breast cells, particularly in the context of a process called Epithelial-Mesenchymal Transition (EMT). This process, often triggered by factors like transforming growth factor beta 1 (TGF-β1), leads to changes in cells that can contribute to cancer progression.
Our study focused on non-tumorigenic MCF-10A breast cells, where we observed a remarkable transformation when these cells were exposed to TGF-β1. The cells lost their usual tight connections and took on a more flexible, mesenchymal shape, which is a hallmark of EMT.
However, when we applied myo-inositol, we saw an impressive reversal of these changes. The presence of myo-inositol helped restore the important cell connection proteins (E-cadherin-β-catenin complexes) and encouraged the re-expression of epithelial markers. This shift not only limited the cells' invasive capabilities but also reduced the release of proteins associated with cancer spread.
Our findings indicate that myo-inositol may offer a promising avenue for improving breast cancer treatment by counteracting the effects of EMT. It's encouraging to think about how this simple compound could play a critical role in fighting cancer progression.
Our study focused on non-tumorigenic MCF-10A breast cells, where we observed a remarkable transformation when these cells were exposed to TGF-β1. The cells lost their usual tight connections and took on a more flexible, mesenchymal shape, which is a hallmark of EMT.
However, when we applied myo-inositol, we saw an impressive reversal of these changes. The presence of myo-inositol helped restore the important cell connection proteins (E-cadherin-β-catenin complexes) and encouraged the re-expression of epithelial markers. This shift not only limited the cells' invasive capabilities but also reduced the release of proteins associated with cancer spread.
Our findings indicate that myo-inositol may offer a promising avenue for improving breast cancer treatment by counteracting the effects of EMT. It's encouraging to think about how this simple compound could play a critical role in fighting cancer progression.
Read More
8
Inositol delivery targeting breast cancer
We explored the role of inositol hexakisphosphate (InsP) in treating breast cancer. Our goal was to find a more effective way for InsP to enter cancerous cells, because its natural negative charge makes it hard for the cells to absorb. To tackle this, we encapsulated InsP in chitosan, a natural polysaccharide, using an ionic gelation technique.
Through various tests, we optimized the ratio of InsP to chitosan and confirmed its successful encapsulation using methods like gel electrophoresis and spectroscopy. The microscopic examination revealed significant changes in the structure after encapsulation.
We observed that the encapsulated InsP made its way into human breast cancer cells, specifically the MCF-7 line, much more effectively than free InsP. This internalization led to the triggering of apoptosis, or programmed cell death, in these cancer cells. The mechanism appeared to involve an increase in reactive oxygen species, which can lead to cell death.
Our findings suggest that using natural compounds like inositol, delivered via a chitosan framework, could offer promising therapeutic avenues for cancer treatment. This approach might help to reduce the severe side effects often seen with synthetic chemotherapy drugs.
Through various tests, we optimized the ratio of InsP to chitosan and confirmed its successful encapsulation using methods like gel electrophoresis and spectroscopy. The microscopic examination revealed significant changes in the structure after encapsulation.
We observed that the encapsulated InsP made its way into human breast cancer cells, specifically the MCF-7 line, much more effectively than free InsP. This internalization led to the triggering of apoptosis, or programmed cell death, in these cancer cells. The mechanism appeared to involve an increase in reactive oxygen species, which can lead to cell death.
Our findings suggest that using natural compounds like inositol, delivered via a chitosan framework, could offer promising therapeutic avenues for cancer treatment. This approach might help to reduce the severe side effects often seen with synthetic chemotherapy drugs.
Read More
User Reviews
USERS' SCORE
Good
Based on 6 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Powerful tumour shrinker
319 people found this helpful
The best I-P6 product! There is no better solution for tumour reduction. I've used this product to beat cancer twice, taking 2 pills in the morning and at night. For active cancer, I recommend 4 pills twice daily. This product also promotes immune health and is fantastic for the whole family.
Read More
9
Tumour shrinkage
39 people found this helpful
Approximately two years ago, our miniature poodle was diagnosed with breast cancer. Following our vet's advice, we gave her two capsules twice daily. I'm delighted to report that she's doing well! The tumour has shrunk significantly, and her quality of life has improved immensely.
Read More
7.5
Effective defence
77 people found this helpful
I have been taking this cancer-fighting supplement for over three years since my last episode with breast cancer. I feel great and was recommended this by my holistic practitioner. It is endorsed by Johns Hopkins as one of the best defences against cancer. I truly believe in its efficacy.
Read More
7.5
Supportive supplement
41 people found this helpful
I use it against breast cancer recurrence. I am a breast cancer survivor of four years. I bought this product for its cancer-fighting attributes. Although IP-6 is not well-known among mainstream doctors, it has been beneficial for cancer patients. I take it daily along with Essiac tea, Resveratrol, and other supplements. I also maintain a mostly vegan diet rich in fresh vegetable juices. Since I started taking IP-6 a few weeks back, I hope it aids others too.
Read More
7.5
Prostate cancer prevention
33 people found this helpful
It keeps away prostate cancer. After my treatment, I was advised to take this product every morning. Fifteen years later, my prostate cancer has not returned. When my wife experienced breast pain, I recommended the same dosage, and the pain subsided. I'm thoroughly convinced of its efficacy!
Read More
Frequently Asked Questions
9
We explored how myo-inositol impacts breast cells, particularly in the context of a process called Epithelial-Mesenchymal Transition (EMT). This process, often triggered by factors like transforming growth factor beta 1 (TGF-β1), leads to changes in cells that can contribute to cancer progression.
Our study focused on non-tumorigenic MCF-10A breast cells, where we observed a remarkable transformation when these cells were exposed to TGF-β1. The cells lost their usual tight connections and took on a more flexible, mesenchymal shape, which is a hallmark of EMT.
However, when we applied myo-inositol, we saw an impressive reversal of these changes. The presence of myo-inositol helped restore the important cell connection proteins (E-cadherin-β-catenin complexes) and encouraged the re-expression of epithelial markers. This shift not only limited the cells' invasive capabilities but also reduced the release of proteins associated with cancer spread.
Our findings indicate that myo-inositol may offer a promising avenue for improving breast cancer treatment by counteracting the effects of EMT. It's encouraging to think about how this simple compound could play a critical role in fighting cancer progression.
Our study focused on non-tumorigenic MCF-10A breast cells, where we observed a remarkable transformation when these cells were exposed to TGF-β1. The cells lost their usual tight connections and took on a more flexible, mesenchymal shape, which is a hallmark of EMT.
However, when we applied myo-inositol, we saw an impressive reversal of these changes. The presence of myo-inositol helped restore the important cell connection proteins (E-cadherin-β-catenin complexes) and encouraged the re-expression of epithelial markers. This shift not only limited the cells' invasive capabilities but also reduced the release of proteins associated with cancer spread.
Our findings indicate that myo-inositol may offer a promising avenue for improving breast cancer treatment by counteracting the effects of EMT. It's encouraging to think about how this simple compound could play a critical role in fighting cancer progression.
8
Inositol delivery targeting breast cancer
We explored the role of inositol hexakisphosphate (InsP) in treating breast cancer. Our goal was to find a more effective way for InsP to enter cancerous cells, because its natural negative charge makes it hard for the cells to absorb. To tackle this, we encapsulated InsP in chitosan, a natural polysaccharide, using an ionic gelation technique.
Through various tests, we optimized the ratio of InsP to chitosan and confirmed its successful encapsulation using methods like gel electrophoresis and spectroscopy. The microscopic examination revealed significant changes in the structure after encapsulation.
We observed that the encapsulated InsP made its way into human breast cancer cells, specifically the MCF-7 line, much more effectively than free InsP. This internalization led to the triggering of apoptosis, or programmed cell death, in these cancer cells. The mechanism appeared to involve an increase in reactive oxygen species, which can lead to cell death.
Our findings suggest that using natural compounds like inositol, delivered via a chitosan framework, could offer promising therapeutic avenues for cancer treatment. This approach might help to reduce the severe side effects often seen with synthetic chemotherapy drugs.
Through various tests, we optimized the ratio of InsP to chitosan and confirmed its successful encapsulation using methods like gel electrophoresis and spectroscopy. The microscopic examination revealed significant changes in the structure after encapsulation.
We observed that the encapsulated InsP made its way into human breast cancer cells, specifically the MCF-7 line, much more effectively than free InsP. This internalization led to the triggering of apoptosis, or programmed cell death, in these cancer cells. The mechanism appeared to involve an increase in reactive oxygen species, which can lead to cell death.
Our findings suggest that using natural compounds like inositol, delivered via a chitosan framework, could offer promising therapeutic avenues for cancer treatment. This approach might help to reduce the severe side effects often seen with synthetic chemotherapy drugs.
References
- Kadhim IH, Oluremi AS, Chhetri BP, Ghosh A, Ali N. Encapsulation of Inositol Hexakisphosphate with Chitosan via Gelation to Facilitate Cellular Delivery and Programmed Cell Death in Human Breast Cancer Cells. Bioengineering (Basel). 2024;11. 10.3390/bioengineering11090931
- Monti N, Dinicola S, Querqui A, Fabrizi G, Fedeli V, et al. Myo-Inositol Reverses TGF-β1-Induced EMT in MCF-10A Non-Tumorigenic Breast Cells. Cancers (Basel). 2023;15. 10.3390/cancers15082317
Data last updated:
