' 
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Good
Based on 1 Review
8.5
Supplement Facts
Serving Size: 2 Capsules
Amount Per Serving
%DV
Total Carbohydrate
<1 g
<1%†
Calcium (from calcium magnesium phytate)
131 mg
10%
Phosphorus (from calcium magnesium phytate)
192 mg
15%
Magnesium (from calcium magnesium phytate)
40 mg
10%
IP-6 (inositol hexaphosphate) (from calcium magnesium phytate)
800 mg
**
Inositol
220 mg
**
Top Medical Research Studies
9
SHIP1 inhibition may relieve RA
Inhibition of lipid phosphatase SHIP1 expands myeloid-derived suppressor cells and attenuates rheumatoid arthritis in mice.
Limited relevance to inositol treatment
We explored how inhibiting a specific lipid phosphatase known as SHIP1 could potentially help in treating rheumatoid arthritis (RA). This study primarily investigated the impact of using a SHIP1 inhibitor on the expansion of myeloid-derived suppressor cells (MDSCs) in a mouse model that mimics the symptoms of RA. By employing a small molecule called 3α-aminocholestane (3AC), we observed a significant increase in MDSCs within the treated mice. This increase seemed to correlate with a noticeable reduction in both the severity and incidence of arthritis symptoms.
Notably, our results indicated that transferring MDSCs from 3AC-treated mice into those with CIA provided a significant therapeutic effect, suggesting that these induced cells played a crucial role in suppressing the adverse immune responses associated with arthritis. However, it’s important to mention that while the study highlights the potential of SHIP1 inhibition in benefiting RA treatment, it does not specifically evaluate the direct effects of inositol treatment alone. This could limit the broader applicability of findings concerning inositol’s role in managing arthritis.
Overall, the study indicates that targeting SHIP1 and subsequently expanding MDSCs may offer a promising new strategy for managing RA and other autoimmune conditions.
Notably, our results indicated that transferring MDSCs from 3AC-treated mice into those with CIA provided a significant therapeutic effect, suggesting that these induced cells played a crucial role in suppressing the adverse immune responses associated with arthritis. However, it’s important to mention that while the study highlights the potential of SHIP1 inhibition in benefiting RA treatment, it does not specifically evaluate the direct effects of inositol treatment alone. This could limit the broader applicability of findings concerning inositol’s role in managing arthritis.
Overall, the study indicates that targeting SHIP1 and subsequently expanding MDSCs may offer a promising new strategy for managing RA and other autoimmune conditions.
Read More
Most Useful Reviews
8.8
Reduced arthritis pain
I was sceptical after reading the reviews, but this product has improved my very old dog’s condition significantly. His breathing has improved and his skin is healing from repeated staph infections. He appears to have less pain from arthritis now and his eyes are clearer. I give him one pill daily, and it seems suitable for a 25 lb dog. I'm intrigued to see how it might work for people!
Read More
Medical Researches
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
- All Researches
9
SHIP1 inhibition may relieve RA
Inhibition of lipid phosphatase SHIP1 expands myeloid-derived suppressor cells and attenuates rheumatoid arthritis in mice.
Limited relevance to inositol treatment
We explored how inhibiting a specific lipid phosphatase known as SHIP1 could potentially help in treating rheumatoid arthritis (RA). This study primarily investigated the impact of using a SHIP1 inhibitor on the expansion of myeloid-derived suppressor cells (MDSCs) in a mouse model that mimics the symptoms of RA. By employing a small molecule called 3α-aminocholestane (3AC), we observed a significant increase in MDSCs within the treated mice. This increase seemed to correlate with a noticeable reduction in both the severity and incidence of arthritis symptoms.
Notably, our results indicated that transferring MDSCs from 3AC-treated mice into those with CIA provided a significant therapeutic effect, suggesting that these induced cells played a crucial role in suppressing the adverse immune responses associated with arthritis. However, it’s important to mention that while the study highlights the potential of SHIP1 inhibition in benefiting RA treatment, it does not specifically evaluate the direct effects of inositol treatment alone. This could limit the broader applicability of findings concerning inositol’s role in managing arthritis.
Overall, the study indicates that targeting SHIP1 and subsequently expanding MDSCs may offer a promising new strategy for managing RA and other autoimmune conditions.
Notably, our results indicated that transferring MDSCs from 3AC-treated mice into those with CIA provided a significant therapeutic effect, suggesting that these induced cells played a crucial role in suppressing the adverse immune responses associated with arthritis. However, it’s important to mention that while the study highlights the potential of SHIP1 inhibition in benefiting RA treatment, it does not specifically evaluate the direct effects of inositol treatment alone. This could limit the broader applicability of findings concerning inositol’s role in managing arthritis.
Overall, the study indicates that targeting SHIP1 and subsequently expanding MDSCs may offer a promising new strategy for managing RA and other autoimmune conditions.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
8.8
Reduced arthritis pain
I was sceptical after reading the reviews, but this product has improved my very old dog’s condition significantly. His breathing has improved and his skin is healing from repeated staph infections. He appears to have less pain from arthritis now and his eyes are clearer. I give him one pill daily, and it seems suitable for a 25 lb dog. I'm intrigued to see how it might work for people!
Read More
