Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 2 Reviews
8.5
Supplement Facts
Serving Size: 2 Capsules
Amount Per Serving
%DV
Total Carbohydrate
<1 g
<1%†
Calcium (from calcium magnesium phytate)
131 mg
10%
Phosphorus (from calcium magnesium phytate)
192 mg
15%
Magnesium (from calcium magnesium phytate)
40 mg
10%
IP-6 (inositol hexaphosphate) (from calcium magnesium phytate)
800 mg
**
Inositol
220 mg
**
Top Medical Research Studies
7
We examined how INPP5E influences Sonic Hedgehog (SHH) signaling in medulloblastoma, a common pediatric brain tumor. By using a murine model, we found that deleting INPP5E reduced tumor growth, cell proliferation, and SHH signaling while causing a loss of cilia on tumor cells.
Our findings suggest that INPP5E is crucial for maintaining primary cilia and promoting tumor progression. Interestingly, we observed that lower levels of INPP5E in human samples correlated with better survival outcomes, highlighting its potential as a therapeutic target in combating SHH medulloblastoma.
Our findings suggest that INPP5E is crucial for maintaining primary cilia and promoting tumor progression. Interestingly, we observed that lower levels of INPP5E in human samples correlated with better survival outcomes, highlighting its potential as a therapeutic target in combating SHH medulloblastoma.
Read More
8
We explored the effects of inositol treatment on medulloblastoma, which is a leading cause of brain tumors in children. Specifically, we found that some medulloblastoma cells showed a unique sensitivity to changes in inositol metabolism due to the presence of the BMI1 gene.
Our research focused on a particular sub-group of this tumor that is characterized by a specific gene signature known as BMI1;CHD7. We discovered that treatment with a compound derived from inositol, called IP6, could effectively counteract the aggressive behaviors of these tumors, particularly through blocking the activation of a key metabolic pathway called mTOR.
Additionally, our findings revealed that IP6 does not just work in isolation. When combined with cisplatin, a common chemotherapy drug, IP6 enhanced the drug's ability to kill tumor cells in laboratory settings. This combination also proved beneficial in a pre-clinical model, where it extended survival in mice with tumors that mirrored human medulloblastoma.
Overall, our study suggests that inositol and its derivatives could offer a novel avenue for treatment, particularly for tumors that carry the BMI1;CHD7 signature. However, we emphasize the need for further research to fully understand the potential benefits and mechanisms at play.
Our research focused on a particular sub-group of this tumor that is characterized by a specific gene signature known as BMI1;CHD7. We discovered that treatment with a compound derived from inositol, called IP6, could effectively counteract the aggressive behaviors of these tumors, particularly through blocking the activation of a key metabolic pathway called mTOR.
Additionally, our findings revealed that IP6 does not just work in isolation. When combined with cisplatin, a common chemotherapy drug, IP6 enhanced the drug's ability to kill tumor cells in laboratory settings. This combination also proved beneficial in a pre-clinical model, where it extended survival in mice with tumors that mirrored human medulloblastoma.
Overall, our study suggests that inositol and its derivatives could offer a novel avenue for treatment, particularly for tumors that carry the BMI1;CHD7 signature. However, we emphasize the need for further research to fully understand the potential benefits and mechanisms at play.
Read More
Most Useful Reviews
9
Negative experience
15 people found this helpful
Bad product. I felt an increase in energy and digestion initially, but after that, I experienced strange tingling and sharp pain in my stomach, along with insomnia. Even after I stopped using this product, I sleep poorly, as if my brain is blocked from resting. Initially, I thought the symptoms might be typical die-off, but they were far worse than any I have experienced before. Even activated charcoal, which helped previously, did not work here.
Read More
7.5
Negative experience
19 people found this helpful
Bad product. I felt an increase in energy and digestion initially, but after that, I experienced strange tingling, sharp stomach pain, and insomnia. Even after ceasing use, I struggle to sleep, feeling as though my brain is blocked from rest. Initially, I thought these symptoms could be a typical die-off, but they were much more severe. I've experienced die-offs before and did not have symptoms like this. Even activated charcoal, which helped in the past, failed to alleviate these issues.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
- All Researches
8
We explored the effects of inositol treatment on medulloblastoma, which is a leading cause of brain tumors in children. Specifically, we found that some medulloblastoma cells showed a unique sensitivity to changes in inositol metabolism due to the presence of the BMI1 gene.
Our research focused on a particular sub-group of this tumor that is characterized by a specific gene signature known as BMI1;CHD7. We discovered that treatment with a compound derived from inositol, called IP6, could effectively counteract the aggressive behaviors of these tumors, particularly through blocking the activation of a key metabolic pathway called mTOR.
Additionally, our findings revealed that IP6 does not just work in isolation. When combined with cisplatin, a common chemotherapy drug, IP6 enhanced the drug's ability to kill tumor cells in laboratory settings. This combination also proved beneficial in a pre-clinical model, where it extended survival in mice with tumors that mirrored human medulloblastoma.
Overall, our study suggests that inositol and its derivatives could offer a novel avenue for treatment, particularly for tumors that carry the BMI1;CHD7 signature. However, we emphasize the need for further research to fully understand the potential benefits and mechanisms at play.
Our research focused on a particular sub-group of this tumor that is characterized by a specific gene signature known as BMI1;CHD7. We discovered that treatment with a compound derived from inositol, called IP6, could effectively counteract the aggressive behaviors of these tumors, particularly through blocking the activation of a key metabolic pathway called mTOR.
Additionally, our findings revealed that IP6 does not just work in isolation. When combined with cisplatin, a common chemotherapy drug, IP6 enhanced the drug's ability to kill tumor cells in laboratory settings. This combination also proved beneficial in a pre-clinical model, where it extended survival in mice with tumors that mirrored human medulloblastoma.
Overall, our study suggests that inositol and its derivatives could offer a novel avenue for treatment, particularly for tumors that carry the BMI1;CHD7 signature. However, we emphasize the need for further research to fully understand the potential benefits and mechanisms at play.
Read More
7
We examined how INPP5E influences Sonic Hedgehog (SHH) signaling in medulloblastoma, a common pediatric brain tumor. By using a murine model, we found that deleting INPP5E reduced tumor growth, cell proliferation, and SHH signaling while causing a loss of cilia on tumor cells.
Our findings suggest that INPP5E is crucial for maintaining primary cilia and promoting tumor progression. Interestingly, we observed that lower levels of INPP5E in human samples correlated with better survival outcomes, highlighting its potential as a therapeutic target in combating SHH medulloblastoma.
Our findings suggest that INPP5E is crucial for maintaining primary cilia and promoting tumor progression. Interestingly, we observed that lower levels of INPP5E in human samples correlated with better survival outcomes, highlighting its potential as a therapeutic target in combating SHH medulloblastoma.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Negative experience
15 people found this helpful
Bad product. I felt an increase in energy and digestion initially, but after that, I experienced strange tingling and sharp pain in my stomach, along with insomnia. Even after I stopped using this product, I sleep poorly, as if my brain is blocked from resting. Initially, I thought the symptoms might be typical die-off, but they were far worse than any I have experienced before. Even activated charcoal, which helped previously, did not work here.
Read More
7.5
Negative experience
19 people found this helpful
Bad product. I felt an increase in energy and digestion initially, but after that, I experienced strange tingling, sharp stomach pain, and insomnia. Even after ceasing use, I struggle to sleep, feeling as though my brain is blocked from rest. Initially, I thought these symptoms could be a typical die-off, but they were much more severe. I've experienced die-offs before and did not have symptoms like this. Even activated charcoal, which helped in the past, failed to alleviate these issues.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Badodi S, Pomella N, Zhang X, Rosser G, Whittingham J, et al. Inositol treatment inhibits medulloblastoma through suppression of epigenetic-driven metabolic adaptation. Nat Commun. 2021;12:2148. doi:10.1038/s41467-021-22379-7
- Conduit SE, Ramaswamy V, Remke M, Watkins DN, Wainwright BJ, et al. A compartmentalized phosphoinositide signaling axis at cilia is regulated by INPP5E to maintain cilia and promote Sonic Hedgehog medulloblastoma. Oncogene. 2017;36:5969. doi:10.1038/onc.2017.208
