Overview

SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8.5
USERS' SCORE
Good
Based on 18 Reviews
8.5
Supplement Facts
Serving Size: 2 Capsules
Amount Per Serving
%DV
Total Carbohydrate
<1 g
<1%†
Calcium (from calcium magnesium phytate)
131 mg
10%
Phosphorus (from calcium magnesium phytate)
192 mg
15%
Magnesium (from calcium magnesium phytate)
40 mg
10%
IP-6 (inositol hexaphosphate) (from calcium magnesium phytate)
800 mg
**
Inositol
220 mg
**

Top Medical Research Studies

8
Inositol enhances rapeseed cold tolerance
We explored the impact of inositol on cold stress in rapeseed, an essential oilseed crop affected by low temperatures. Notably, we found that inositol plays a significant role in enhancing cold tolerance in these plants by boosting calcium ion (Ca) influx.

Our study involved identifying various genes associated with inositol and analyzing their expression under cold conditions. Interestingly, inositol appeared to inhibit the expression of calcineurin B-like genes, which are involved in regulating calcium flow, suggesting a unique pathway through which inositol aids in cold resilience.

Additionally, when we overexpressed certain genes linked to calcium flux, we noted a stronger response to cold stress, further emphasizing the importance of the inositol-Ca pathway in facilitating cold tolerance in rapeseed. These findings not only deepen our understanding of how rapeseed copes with cold conditions but also present a potential strategy for enhancing crop resilience in the face of climate challenges.
Read More
9
MIOX gene enhances cold tolerance
We explored how myo-inositol oxygenase (MIOX), an important enzyme, might help alfalfa, a type of forage crop, adapt to challenging cold conditions. The study identified ten MsMIOX genes in the alfalfa genome, which were found distributed across three chromosomes.

Through analysis, we noted that these genes exhibited similarities in structure and conserved features, hinting at a functional role important for the plant's survival under stress.

Our qRT-PCR tests showed that different MsMIOX genes could be triggered by cold and other abiotic stress factors like drought and salinity. Notably, the activity of MIOX in alfalfa significantly increased under these harsh conditions.

By overexpressing the MsMIOX2 gene in yeast, we found that it notably enhanced resistance to cold stresses. Additionally, when MsMIOX2 was overexpressed in alfalfa’s hairy roots, it reduced reactive oxygen species and improved the plant's resilience against cold.

This study provides valuable insights into how inositol plays a part in helping alfalfa thrive even in cold weather, presenting a candidate for future efforts to enhance the plant’s stress tolerance.
Read More
9
Myo-inositol boosts cold tolerance
We explored how low red to far-red light ratios influence cold tolerance in tomato plants. The focus was on two key proteins, SlFHY3 and SlHY5, which play a role in increasing the accumulation of myo-inositol, a compound linked with cold resistance.

Our findings revealed that when tomato plants experienced low light ratios, it encouraged the production of SlFHY3 under cold stress. Knocking out this gene led to lower myo-inositol levels and made the plants more vulnerable to cold, while overexpressing it had the opposite effect.

Moreover, we found that SlFHY3 works closely with SlHY5 to boost writing activity for a particular gene involved in myo-inositol synthesis. This interaction is crucial, as it significantly enhances both myo-inositol levels and the plants' ability to withstand cold conditions. Without these proteins or the inositol synthesis gene, the cold resistance we observed was diminished.

Ultimately, our study shines a light on the important relationship between light signals, inositol accumulation, and cold tolerance in tomatoes, unveiling how plants manage environmental stress.
Read More

Most Useful Reviews

9
Normalises Ferritin levels
15 people found this helpful
IP6 has many benefits, including lowering Ferritin levels in my blood. Two years ago, my levels were at 1600, but after two months of taking IP6, they dropped below 100. I've maintained this regimen and have not experienced a cold since.
Read More
9
Stops cold effectively
1 people found this helpful
My saviour! The quality of the supplement is excellent. It has helped me several times to stop a cold at the very beginning, preventing me from getting fully ill. I took two capsules three times a day for a few days. The packaging is substantial, and I will continue to use it next winter.
Read More
9
Effective against colds
Having used this potent product for many years, I help those on the brink of getting a cold by giving them four capsules, and they’re often back in remission the next day.
Read More

Medical Researches

SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8.5
  • All Researches
9
Myo-inositol boosts cold tolerance
We explored the effects of myo-inositol and corn steep liquor (CSL) on cucumber and tomato seedlings, particularly focusing on their ability to withstand cold temperatures. Through our research, we found that applying these substances led to noticeable improvements in seedling growth during low-temperature stress.

Our treatments not only increased the levels of photosynthetic pigments, enhancing photosynthesis, but also reduced harmful compounds like malondialdehyde (MDA) and electrolyte leakage. This suggests that the combination of inositol and CSL helps to protect plant cells under stress.

Additionally, we confirmed these findings by analyzing the expression of important genes that relate to cold tolerance in cucumbers. The most effective mix we identified was 0.6 mL L of CSL together with 72 mg L of myo-inositol. Overall, this study gives us valuable insights into how we can use inositol and maize leachate to foster early growth in crops and improve their resilience against cold weather.
Read More
9
MIOX gene enhances cold tolerance
We explored how myo-inositol oxygenase (MIOX), an important enzyme, might help alfalfa, a type of forage crop, adapt to challenging cold conditions. The study identified ten MsMIOX genes in the alfalfa genome, which were found distributed across three chromosomes.

Through analysis, we noted that these genes exhibited similarities in structure and conserved features, hinting at a functional role important for the plant's survival under stress.

Our qRT-PCR tests showed that different MsMIOX genes could be triggered by cold and other abiotic stress factors like drought and salinity. Notably, the activity of MIOX in alfalfa significantly increased under these harsh conditions.

By overexpressing the MsMIOX2 gene in yeast, we found that it notably enhanced resistance to cold stresses. Additionally, when MsMIOX2 was overexpressed in alfalfa’s hairy roots, it reduced reactive oxygen species and improved the plant's resilience against cold.

This study provides valuable insights into how inositol plays a part in helping alfalfa thrive even in cold weather, presenting a candidate for future efforts to enhance the plant’s stress tolerance.
Read More
9
Myo-inositol boosts cold tolerance
We explored how low red to far-red light ratios influence cold tolerance in tomato plants. The focus was on two key proteins, SlFHY3 and SlHY5, which play a role in increasing the accumulation of myo-inositol, a compound linked with cold resistance.

Our findings revealed that when tomato plants experienced low light ratios, it encouraged the production of SlFHY3 under cold stress. Knocking out this gene led to lower myo-inositol levels and made the plants more vulnerable to cold, while overexpressing it had the opposite effect.

Moreover, we found that SlFHY3 works closely with SlHY5 to boost writing activity for a particular gene involved in myo-inositol synthesis. This interaction is crucial, as it significantly enhances both myo-inositol levels and the plants' ability to withstand cold conditions. Without these proteins or the inositol synthesis gene, the cold resistance we observed was diminished.

Ultimately, our study shines a light on the important relationship between light signals, inositol accumulation, and cold tolerance in tomatoes, unveiling how plants manage environmental stress.
Read More
8
Inositol transporter's role in cold
We examined how inositol, a key component in the production of raffinose, plays a role in helping sugar beet plants withstand cold stress. In the study, researchers identified the vacuolar inositol transporter BvINT1;1, which seems to be critical for the synthesis of raffinose under chilly conditions.

When plants were exposed to cold, BvINT1;1 was found to be highly active, ensuring adequate inositol was available for raffinose production. Interestingly, sugar beet mutants that lacked functional BvINT1;1 not only had higher levels of inositol but also lower amounts of raffinose when subjected to cold stress.

This reduction in raffinose was significant because raffinose can help neutralize harmful reactive oxygen species (ROS), which accumulate when plants are stressed. As a result, these mutants showed increased expression of genes related to ROS, pointing out a potential risk for them during cold weather.

Overall, our findings suggest that the transporter BvINT1;1 is not just about moving inositol; it plays a vital role in boosting the plant's cold resilience by facilitating raffinose biosynthesis and maintaining balance against oxidative stress.
Read More
We delved into the fascinating world of white water lilies and their remarkable ability to withstand cold temperatures. This study aimed to understand how certain compounds, particularly myo-inositol, contribute to the plant's cold resilience.

Through a comprehensive examination, we learned that the water lily effectively copes with winter by entering a state called ecodormancy. During this time, the plant reallocates resources and enhances its defenses against cold stress.

One of our key findings was the significance of myo-inositol. This compound helps bolster the plant’s cold tolerance, although it works alongside various other factors. It plays a role in regulating metabolic activities, especially in relation to amino acids, which are crucial for overcoming chilly conditions.

Although our study highlighted the importance of myo-inositol, it did not isolate its effects from other treatments, which limits our understanding of its specific impact. Nevertheless, the insights we gained about the water lily’s adaptive strategies provide valuable information for future agricultural practices in cold climates.
Read More

User Reviews

USERS' SCORE
Good
Based on 18 Reviews
8.5
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Normalises Ferritin levels
15 people found this helpful
IP6 has many benefits, including lowering Ferritin levels in my blood. Two years ago, my levels were at 1600, but after two months of taking IP6, they dropped below 100. I've maintained this regimen and have not experienced a cold since.
Read More
9
Stops cold effectively
1 people found this helpful
My saviour! The quality of the supplement is excellent. It has helped me several times to stop a cold at the very beginning, preventing me from getting fully ill. I took two capsules three times a day for a few days. The packaging is substantial, and I will continue to use it next winter.
Read More
9
Effective against colds
Having used this potent product for many years, I help those on the brink of getting a cold by giving them four capsules, and they’re often back in remission the next day.
Read More
9
Boosted Immune System
126 people found this helpful
Useful product! Having recently been diagnosed with cancer that was successfully removed via surgery, I wanted to provide my body with all the healing support possible. When I came across this product in a cancer-related book, I decided to try it. Cell Forte was affordable and appears to be enhancing my immune system. For years, I've battled cold-like symptoms each March due to oak pollen in Florida. This year has been particularly challenging, yet while those around me caught colds and flu, I remained well. That had never happened before! I first thank the Lord and am also grateful for His guidance to this product.
Read More
7.5
Minimises cold impact
100 people found this helpful
I'm still undecided about this product. I purchased it due to the rave reviews about how it helps during cold and flu season. After using it for myself and my children, I haven’t noticed a significant difference, but our flu experience was mild compared to others. It's possible this contributed to our minor symptoms. Increasing the dose for everyone when the flu hit appeared to help, as those who refused to take it experienced more severe symptoms. It seems to make a difference!
Read More

Frequently Asked Questions

9
Stops cold effectively
1 people found this helpful
My saviour! The quality of the supplement is excellent. It has helped me several times to stop a cold at the very beginning, preventing me from getting fully ill. I took two capsules three times a day for a few days. The packaging is substantial, and I will continue to use it next winter.
9
Effective against colds
Having used this potent product for many years, I help those on the brink of getting a cold by giving them four capsules, and they’re often back in remission the next day.
9
Stops cold symptoms
5 people found this helpful
I have been using this excellent product for years. Whenever I feel a cold or sore throat coming on, I immediately take 2 of these, and the symptoms disappear. It also helps with an upset stomach from poor food combinations. The bottom line is that I rarely get sick anymore; my health has also benefitted from a daily intake of 4000 IU of vitamin D3, particularly from Mega Foods brand, which is plant-based rather than fish or lanolin.
9
Prevents colds effectively
5 people found this helpful
This supplement is my favourite! I'm delighted to have found one that boosts my son's immune system and is safe for long-term use. This remedy can be taken continuously. My child began this supplement in September 2020, and since then, up until February 2022, he’s not caught a cold or any new viruses, despite sickness among classmates. Each morning, we start the day with inositol. He takes 2 capsules on an empty stomach before breakfast. This amount is sufficient for him to remain healthy and not miss school.
7.5
Strengthens resistance
My resistance seems to have strengthened, resulting in fewer colds!
7.5
Increases immunity significantly
2 people found this helpful
This product is a saviour for frequent colds. The IP-6 and inositol in Cell Forté’s unique formulation supports natural killer cells and immune function. After taking it, my immunity improves significantly, so I often avoid illness. The packaging is excellent, and the quality is commendable.
8
Inositol transporter's role in cold
We examined how inositol, a key component in the production of raffinose, plays a role in helping sugar beet plants withstand cold stress. In the study, researchers identified the vacuolar inositol transporter BvINT1;1, which seems to be critical for the synthesis of raffinose under chilly conditions.

When plants were exposed to cold, BvINT1;1 was found to be highly active, ensuring adequate inositol was available for raffinose production. Interestingly, sugar beet mutants that lacked functional BvINT1;1 not only had higher levels of inositol but also lower amounts of raffinose when subjected to cold stress.

This reduction in raffinose was significant because raffinose can help neutralize harmful reactive oxygen species (ROS), which accumulate when plants are stressed. As a result, these mutants showed increased expression of genes related to ROS, pointing out a potential risk for them during cold weather.

Overall, our findings suggest that the transporter BvINT1;1 is not just about moving inositol; it plays a vital role in boosting the plant's cold resilience by facilitating raffinose biosynthesis and maintaining balance against oxidative stress.
9
Myo-inositol boosts cold tolerance
We explored the effects of myo-inositol and corn steep liquor (CSL) on cucumber and tomato seedlings, particularly focusing on their ability to withstand cold temperatures. Through our research, we found that applying these substances led to noticeable improvements in seedling growth during low-temperature stress.

Our treatments not only increased the levels of photosynthetic pigments, enhancing photosynthesis, but also reduced harmful compounds like malondialdehyde (MDA) and electrolyte leakage. This suggests that the combination of inositol and CSL helps to protect plant cells under stress.

Additionally, we confirmed these findings by analyzing the expression of important genes that relate to cold tolerance in cucumbers. The most effective mix we identified was 0.6 mL L of CSL together with 72 mg L of myo-inositol. Overall, this study gives us valuable insights into how we can use inositol and maize leachate to foster early growth in crops and improve their resilience against cold weather.
8
Inositol enhances rapeseed cold tolerance
We explored the impact of inositol on cold stress in rapeseed, an essential oilseed crop affected by low temperatures. Notably, we found that inositol plays a significant role in enhancing cold tolerance in these plants by boosting calcium ion (Ca) influx.

Our study involved identifying various genes associated with inositol and analyzing their expression under cold conditions. Interestingly, inositol appeared to inhibit the expression of calcineurin B-like genes, which are involved in regulating calcium flow, suggesting a unique pathway through which inositol aids in cold resilience.

Additionally, when we overexpressed certain genes linked to calcium flux, we noted a stronger response to cold stress, further emphasizing the importance of the inositol-Ca pathway in facilitating cold tolerance in rapeseed. These findings not only deepen our understanding of how rapeseed copes with cold conditions but also present a potential strategy for enhancing crop resilience in the face of climate challenges.
9
MIOX gene enhances cold tolerance
We explored how myo-inositol oxygenase (MIOX), an important enzyme, might help alfalfa, a type of forage crop, adapt to challenging cold conditions. The study identified ten MsMIOX genes in the alfalfa genome, which were found distributed across three chromosomes.

Through analysis, we noted that these genes exhibited similarities in structure and conserved features, hinting at a functional role important for the plant's survival under stress.

Our qRT-PCR tests showed that different MsMIOX genes could be triggered by cold and other abiotic stress factors like drought and salinity. Notably, the activity of MIOX in alfalfa significantly increased under these harsh conditions.

By overexpressing the MsMIOX2 gene in yeast, we found that it notably enhanced resistance to cold stresses. Additionally, when MsMIOX2 was overexpressed in alfalfa’s hairy roots, it reduced reactive oxygen species and improved the plant's resilience against cold.

This study provides valuable insights into how inositol plays a part in helping alfalfa thrive even in cold weather, presenting a candidate for future efforts to enhance the plant’s stress tolerance.
We delved into the fascinating world of white water lilies and their remarkable ability to withstand cold temperatures. This study aimed to understand how certain compounds, particularly myo-inositol, contribute to the plant's cold resilience.

Through a comprehensive examination, we learned that the water lily effectively copes with winter by entering a state called ecodormancy. During this time, the plant reallocates resources and enhances its defenses against cold stress.

One of our key findings was the significance of myo-inositol. This compound helps bolster the plant’s cold tolerance, although it works alongside various other factors. It plays a role in regulating metabolic activities, especially in relation to amino acids, which are crucial for overcoming chilly conditions.

Although our study highlighted the importance of myo-inositol, it did not isolate its effects from other treatments, which limits our understanding of its specific impact. Nevertheless, the insights we gained about the water lily’s adaptive strategies provide valuable information for future agricultural practices in cold climates.

References

  1. Berg J, Rodrigues CM, Scheid C, Pirrotte Y, Picco C, et al. The Vacuolar Inositol Transporter BvINT1;1 Contributes to Raffinose Biosynthesis and Reactive Oxygen Species Scavenging During Cold Stress in Sugar Beet. Plant Cell Environ. 2025. 10.1111/pce.15367
  2. Sun S, Zhang X, Wang C, Yu Q, Yang H, et al. Combined application of myo-inositol and corn steep liquor enhances seedling growth and cold tolerance in cucumber and tomato. Physiol Plant. 2024;176:e14422. 10.1111/ppl.14422
  3. Qiu P, Liu T, Xu Y, Ye C, Zhang R, et al. Multi-omic dissection of the cold resistance traits of white water lily. Hortic Res. 2024;11:uhae093. 10.1093/hr/uhae093
  4. Guo W, Yu D, Zhang R, Zhao W, Zhang L, et al. Genome-wide identification of the myo-inositol oxygenase gene family in alfalfa (Medicago sativa L.) and expression analysis under abiotic stress. Plant Physiol Biochem. 2023;200:107787. 10.1016/j.plaphy.2023.107787
  5. Yan L, Zeng L, Raza A, Lv Y, Ding X, et al. Inositol Improves Cold Tolerance Through Inhibiting and Increasing Ca Influx in Rapeseed ( L.). Front Plant Sci. 2022;13:775692. 10.3389/fpls.2022.775692
  6. Wang F, Wang X, Zhang Y, Yan J, Ahammed GJ, et al. SlFHY3 and SlHY5 act compliantly to enhance cold tolerance through the integration of myo-inositol and light signaling in tomato. New Phytol. 2022;233:2127. 10.1111/nph.17934
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