We explored the impact of inositol on cold stress in rapeseed, an essential oilseed crop affected by low temperatures. Notably, we found that inositol plays a significant role in enhancing cold tolerance in these plants by boosting calcium ion (Ca) influx.
Our study involved identifying various genes associated with inositol and analyzing their expression under cold conditions. Interestingly, inositol appeared to inhibit the expression of calcineurin B-like genes, which are involved in regulating calcium flow, suggesting a unique pathway through which inositol aids in cold resilience.
Additionally, when we overexpressed certain genes linked to calcium flux, we noted a stronger response to cold stress, further emphasizing the importance of the inositol-Ca pathway in facilitating cold tolerance in rapeseed. These findings not only deepen our understanding of how rapeseed copes with cold conditions but also present a potential strategy for enhancing crop resilience in the face of climate challenges.
Read More
9
MIOX gene enhances cold tolerance
Genome-wide identification of the myo-inositol oxygenase gene family in alfalfa (Medicago sativa L.) and expression analysis under abiotic stress.
We explored how myo-inositol oxygenase (MIOX), an important enzyme, might help alfalfa, a type of forage crop, adapt to challenging cold conditions. The study identified ten MsMIOX genes in the alfalfa genome, which were found distributed across three chromosomes.
Through analysis, we noted that these genes exhibited similarities in structure and conserved features, hinting at a functional role important for the plant's survival under stress.
Our qRT-PCR tests showed that different MsMIOX genes could be triggered by cold and other abiotic stress factors like drought and salinity. Notably, the activity of MIOX in alfalfa significantly increased under these harsh conditions.
By overexpressing the MsMIOX2 gene in yeast, we found that it notably enhanced resistance to cold stresses. Additionally, when MsMIOX2 was overexpressed in alfalfa’s hairy roots, it reduced reactive oxygen species and improved the plant's resilience against cold.
This study provides valuable insights into how inositol plays a part in helping alfalfa thrive even in cold weather, presenting a candidate for future efforts to enhance the plant’s stress tolerance.
Read More
9
Myo-inositol boosts cold tolerance
SlFHY3 and SlHY5 act compliantly to enhance cold tolerance through the integration of myo-inositol and light signaling in tomato.
We explored how low red to far-red light ratios influence cold tolerance in tomato plants. The focus was on two key proteins, SlFHY3 and SlHY5, which play a role in increasing the accumulation of myo-inositol, a compound linked with cold resistance.
Our findings revealed that when tomato plants experienced low light ratios, it encouraged the production of SlFHY3 under cold stress. Knocking out this gene led to lower myo-inositol levels and made the plants more vulnerable to cold, while overexpressing it had the opposite effect.
Moreover, we found that SlFHY3 works closely with SlHY5 to boost writing activity for a particular gene involved in myo-inositol synthesis. This interaction is crucial, as it significantly enhances both myo-inositol levels and the plants' ability to withstand cold conditions. Without these proteins or the inositol synthesis gene, the cold resistance we observed was diminished.
Ultimately, our study shines a light on the important relationship between light signals, inositol accumulation, and cold tolerance in tomatoes, unveiling how plants manage environmental stress.
Read More
Most Useful Reviews
9
Normalises Ferritin levels
15 people found this helpful
IP6 has many benefits, including lowering Ferritin levels in my blood. Two years ago, my levels were at 1600, but after two months of taking IP6, they dropped below 100. I've maintained this regimen and have not experienced a cold since.
Read More
9
Stops cold effectively
1 people found this helpful
My saviour! The quality of the supplement is excellent. It has helped me several times to stop a cold at the very beginning, preventing me from getting fully ill. I took two capsules three times a day for a few days. The packaging is substantial, and I will continue to use it next winter.
Read More
9
Effective against colds
Having used this potent product for many years, I help those on the brink of getting a cold by giving them four capsules, and they’re often back in remission the next day.
We explored the effects of myo-inositol and corn steep liquor (CSL) on cucumber and tomato seedlings, particularly focusing on their ability to withstand cold temperatures. Through our research, we found that applying these substances led to noticeable improvements in seedling growth during low-temperature stress.
Our treatments not only increased the levels of photosynthetic pigments, enhancing photosynthesis, but also reduced harmful compounds like malondialdehyde (MDA) and electrolyte leakage. This suggests that the combination of inositol and CSL helps to protect plant cells under stress.
Additionally, we confirmed these findings by analyzing the expression of important genes that relate to cold tolerance in cucumbers. The most effective mix we identified was 0.6 mL L of CSL together with 72 mg L of myo-inositol. Overall, this study gives us valuable insights into how we can use inositol and maize leachate to foster early growth in crops and improve their resilience against cold weather.
Read More
9
MIOX gene enhances cold tolerance
Genome-wide identification of the myo-inositol oxygenase gene family in alfalfa (Medicago sativa L.) and expression analysis under abiotic stress.
We explored how myo-inositol oxygenase (MIOX), an important enzyme, might help alfalfa, a type of forage crop, adapt to challenging cold conditions. The study identified ten MsMIOX genes in the alfalfa genome, which were found distributed across three chromosomes.
Through analysis, we noted that these genes exhibited similarities in structure and conserved features, hinting at a functional role important for the plant's survival under stress.
Our qRT-PCR tests showed that different MsMIOX genes could be triggered by cold and other abiotic stress factors like drought and salinity. Notably, the activity of MIOX in alfalfa significantly increased under these harsh conditions.
By overexpressing the MsMIOX2 gene in yeast, we found that it notably enhanced resistance to cold stresses. Additionally, when MsMIOX2 was overexpressed in alfalfa’s hairy roots, it reduced reactive oxygen species and improved the plant's resilience against cold.
This study provides valuable insights into how inositol plays a part in helping alfalfa thrive even in cold weather, presenting a candidate for future efforts to enhance the plant’s stress tolerance.
Read More
9
Myo-inositol boosts cold tolerance
SlFHY3 and SlHY5 act compliantly to enhance cold tolerance through the integration of myo-inositol and light signaling in tomato.
We explored how low red to far-red light ratios influence cold tolerance in tomato plants. The focus was on two key proteins, SlFHY3 and SlHY5, which play a role in increasing the accumulation of myo-inositol, a compound linked with cold resistance.
Our findings revealed that when tomato plants experienced low light ratios, it encouraged the production of SlFHY3 under cold stress. Knocking out this gene led to lower myo-inositol levels and made the plants more vulnerable to cold, while overexpressing it had the opposite effect.
Moreover, we found that SlFHY3 works closely with SlHY5 to boost writing activity for a particular gene involved in myo-inositol synthesis. This interaction is crucial, as it significantly enhances both myo-inositol levels and the plants' ability to withstand cold conditions. Without these proteins or the inositol synthesis gene, the cold resistance we observed was diminished.
Ultimately, our study shines a light on the important relationship between light signals, inositol accumulation, and cold tolerance in tomatoes, unveiling how plants manage environmental stress.
Read More
8
Inositol transporter's role in cold
The Vacuolar Inositol Transporter BvINT1;1 Contributes to Raffinose Biosynthesis and Reactive Oxygen Species Scavenging During Cold Stress in Sugar Beet.
We examined how inositol, a key component in the production of raffinose, plays a role in helping sugar beet plants withstand cold stress. In the study, researchers identified the vacuolar inositol transporter BvINT1;1, which seems to be critical for the synthesis of raffinose under chilly conditions.
When plants were exposed to cold, BvINT1;1 was found to be highly active, ensuring adequate inositol was available for raffinose production. Interestingly, sugar beet mutants that lacked functional BvINT1;1 not only had higher levels of inositol but also lower amounts of raffinose when subjected to cold stress.
This reduction in raffinose was significant because raffinose can help neutralize harmful reactive oxygen species (ROS), which accumulate when plants are stressed. As a result, these mutants showed increased expression of genes related to ROS, pointing out a potential risk for them during cold weather.
Overall, our findings suggest that the transporter BvINT1;1 is not just about moving inositol; it plays a vital role in boosting the plant's cold resilience by facilitating raffinose biosynthesis and maintaining balance against oxidative stress.
Read More
8
Myo-inositol aids cold resistance
Multi-omic dissection of the cold resistance traits of white water lily.
We delved into the fascinating world of white water lilies and their remarkable ability to withstand cold temperatures. This study aimed to understand how certain compounds, particularly myo-inositol, contribute to the plant's cold resilience.
Through a comprehensive examination, we learned that the water lily effectively copes with winter by entering a state called ecodormancy. During this time, the plant reallocates resources and enhances its defenses against cold stress.
One of our key findings was the significance of myo-inositol. This compound helps bolster the plant’s cold tolerance, although it works alongside various other factors. It plays a role in regulating metabolic activities, especially in relation to amino acids, which are crucial for overcoming chilly conditions.
Although our study highlighted the importance of myo-inositol, it did not isolate its effects from other treatments, which limits our understanding of its specific impact. Nevertheless, the insights we gained about the water lily’s adaptive strategies provide valuable information for future agricultural practices in cold climates.
IP6 has many benefits, including lowering Ferritin levels in my blood. Two years ago, my levels were at 1600, but after two months of taking IP6, they dropped below 100. I've maintained this regimen and have not experienced a cold since.
Read More
9
Stops cold effectively
1 people found this helpful
My saviour! The quality of the supplement is excellent. It has helped me several times to stop a cold at the very beginning, preventing me from getting fully ill. I took two capsules three times a day for a few days. The packaging is substantial, and I will continue to use it next winter.
Read More
9
Effective against colds
Having used this potent product for many years, I help those on the brink of getting a cold by giving them four capsules, and they’re often back in remission the next day.
Read More
9
Boosted Immune System
126 people found this helpful
Useful product! Having recently been diagnosed with cancer that was successfully removed via surgery, I wanted to provide my body with all the healing support possible. When I came across this product in a cancer-related book, I decided to try it. Cell Forte was affordable and appears to be enhancing my immune system. For years, I've battled cold-like symptoms each March due to oak pollen in Florida. This year has been particularly challenging, yet while those around me caught colds and flu, I remained well. That had never happened before! I first thank the Lord and am also grateful for His guidance to this product.
Read More
7.5
Minimises cold impact
100 people found this helpful
I'm still undecided about this product. I purchased it due to the rave reviews about how it helps during cold and flu season. After using it for myself and my children, I haven’t noticed a significant difference, but our flu experience was mild compared to others. It's possible this contributed to our minor symptoms. Increasing the dose for everyone when the flu hit appeared to help, as those who refused to take it experienced more severe symptoms. It seems to make a difference!
Cold is a term that refers to a state of low temperature, often associated with a perceptibly chilly environment or the sensation of being cool to the touch. Scientifically, cold is relative to the presence and movement of heat, which is a measure of energy within matter. In everyday terms, we experience cold through weather changes, such as during winter months, and it can also be described in the context of specific temperature ranges – for example, temperatures below 32 degrees Fahrenheit (0 degrees Celsius) generally signify freezing conditions, which can impact outdoor activities, personal comfort, and various ecological systems.
Moreover, the sensation of cold is not solely dependent on temperature; factors like humidity and wind chill can enhance the feeling of coldness. When discussing cold in terms of human health, prolonged exposure to cold conditions can lead to hypothermia or frostbite if body heat is not effectively maintained. Hence, it's crucial to dress appropriately and take necessary precautions during colder months to prevent adverse effects. Understanding the concept of cold can help individuals better prepare for seasonal changes and ensure their comfort and safety.
Inositol is a naturally occurring sugar alcohol that plays a crucial role in cellular signaling and the structural integrity of cell membranes. It is a member of the B-vitamin complex and exists in several forms, with myo-inositol being the most prevalent in the human body. Inositol is found in various foods, including fruits, beans, grains, and nuts, and it can also be synthesized by the body from glucose. It is often marketed as a supplement for various health benefits, including mental health support, particularly for conditions like anxiety and depression, and is studied for its potential role in managing polycystic ovary syndrome (PCOS).
Research suggests that inositol may help in alleviating symptoms associated with these health issues by enhancing insulin sensitivity and regulating hormonal balance. While it is generally considered safe for consumption, individuals should consult with healthcare professionals before starting any new supplement regimen, especially if they have existing health conditions or are taking other medications. As with any supplement, the effectiveness can vary from person to person, and understanding the underlying scientific evidence can guide informed choices.
Based on user reviews, many individuals report experiencing noticeable results after just a few doses of this supplement. For example, one user mentioned they take two capsules three times a day for several days and find it effective at stopping a cold right at the onset Read Review. Another reviewer highlighted that after giving the product to friends on the brink of a cold, they often return to normal within just one day Read Review.
Overall, it seems that many users typically begin to see improvements in their cold symptoms within one to two days of usage. Consistent short-term use at the first sign of illness is a common theme among testimonials, indicating that early intervention may lead to quicker recovery Read Review.
The scientific research on the role of inositol in enhancing cold tolerance in various plants suggests a promising link between this compound and resilience against cold stress. Studies have shown that inositol plays a crucial role in the synthesis of raffinose, which helps plants manage oxidative stress during chilly conditions. For instance, research on sugar beet indicated that the vacuolar inositol transporter BvINT1;1 is vital for supplying inositol necessary for raffinose production under cold stress, thereby improving cold tolerance [1]. Similarly, myo-inositol application has demonstrated significant benefits in growth during low temperatures in crops like cucumbers and tomatoes, indicating its protective role against cellular stress due to cold [2].
Moreover, inositol's importance extends to various mechanisms within different species. In rapeseed, for example, inositol's influence on calcium ion influx pathways enhances cold tolerance by regulating gene expression related to stress response [5]. Additional findings also highlight myo-inositol's contributions to the cold resilience of alfalfa and water lilies by modulating metabolic processes vital for survival during low temperatures [4], [3]. This body of research collectively supports the idea that inositol supplements may provide beneficial effects, particularly for agricultural practices focused on crops vulnerable to cold stress.
Users have reported significant improvements in their symptoms, particularly in the context of cold and immune support. Many individuals note a remarkable ability to fend off colds at their onset. For instance, one reviewer shared how they were able to stop a cold in its tracks by taking two capsules three times a day, highlighting the supplement’s effectiveness in early intervention Read Review. Similarly, another long-time user mentioned that they have successfully helped friends avoid colds entirely, often resulting in a return to normal health the very next day after taking the recommended dosage Read Review.
Moreover, numerous reviews indicate that consistent use of the supplement leads to a noticeable reduction in the frequency of illnesses. For example, a parent remarked that their child, who started taking the supplement regularly, managed to avoid any colds for over a year, even amidst peers who were falling ill Read Review. Other users have expressed similar sentiments, reporting fewer colds and an overall improved sense of health and resilience against infections Read Review. However, it's essential to note that individual results may vary.
Based on user reviews, many individuals report successfully combining this supplement with other approaches to enhance their effectiveness in handling colds. One user mentioned they not only take the recommended dosage of the supplement but also benefit from a daily intake of 4000 IU of vitamin D3, which they believe supports their immune health significantly Read Review. Similarly, another user shared that they regularly incorporate inositol, alongside this supplement, into their routine to boost their child's immune system effectively, noting that their child has remained healthy without falling ill for an extended period Read Review.
Users have also highlighted how the unique formulation of the supplement, paired with their proactive health strategies, improves their overall immune function. One reviewer noted that by supporting their immune system with the combination of IP-6 and inositol found in the supplement, they often avoid illnesses altogether, demonstrating a collective sentiment that pairing it with other healthy practices can yield even better results against colds Read Review.
Based on user reviews, the right dose of Inositol for treating colds varies, but many users recommend taking two capsules multiple times throughout the day. For instance, one user reported taking two capsules three times daily when feeling a cold coming on, which they found effective in preventing more severe symptoms from developing Read Review. Another user mentioned that their child takes two capsules on an empty stomach each morning, ensuring that their immune system remains strong and helping to prevent any illnesses Read Review.
Additionally, some users have found success with a slightly higher dosage; one reviewer shared that they often give friends on the verge of a cold four capsules, suggesting this amount can lead to improvement by the following day Read Review. Overall, common dosages reported by users range from two to four capsules a day, tailored to individuals' needs and responses to the supplement.
9
Stops cold effectively
1 people found this helpful
My saviour! The quality of the supplement is excellent. It has helped me several times to stop a cold at the very beginning, preventing me from getting fully ill. I took two capsules three times a day for a few days. The packaging is substantial, and I will continue to use it next winter.
9
Effective against colds
Having used this potent product for many years, I help those on the brink of getting a cold by giving them four capsules, and they’re often back in remission the next day.
9
Stops cold symptoms
5 people found this helpful
I have been using this excellent product for years. Whenever I feel a cold or sore throat coming on, I immediately take 2 of these, and the symptoms disappear. It also helps with an upset stomach from poor food combinations. The bottom line is that I rarely get sick anymore; my health has also benefitted from a daily intake of 4000 IU of vitamin D3, particularly from Mega Foods brand, which is plant-based rather than fish or lanolin.
9
Prevents colds effectively
5 people found this helpful
This supplement is my favourite! I'm delighted to have found one that boosts my son's immune system and is safe for long-term use. This remedy can be taken continuously. My child began this supplement in September 2020, and since then, up until February 2022, he’s not caught a cold or any new viruses, despite sickness among classmates. Each morning, we start the day with inositol. He takes 2 capsules on an empty stomach before breakfast. This amount is sufficient for him to remain healthy and not miss school.
7.5
Strengthens resistance
My resistance seems to have strengthened, resulting in fewer colds!
7.5
Increases immunity significantly
2 people found this helpful
This product is a saviour for frequent colds. The IP-6 and inositol in Cell Forté’s unique formulation supports natural killer cells and immune function. After taking it, my immunity improves significantly, so I often avoid illness. The packaging is excellent, and the quality is commendable.
8
Inositol transporter's role in cold
The Vacuolar Inositol Transporter BvINT1;1 Contributes to Raffinose Biosynthesis and Reactive Oxygen Species Scavenging During Cold Stress in Sugar Beet.
We examined how inositol, a key component in the production of raffinose, plays a role in helping sugar beet plants withstand cold stress. In the study, researchers identified the vacuolar inositol transporter BvINT1;1, which seems to be critical for the synthesis of raffinose under chilly conditions.
When plants were exposed to cold, BvINT1;1 was found to be highly active, ensuring adequate inositol was available for raffinose production. Interestingly, sugar beet mutants that lacked functional BvINT1;1 not only had higher levels of inositol but also lower amounts of raffinose when subjected to cold stress.
This reduction in raffinose was significant because raffinose can help neutralize harmful reactive oxygen species (ROS), which accumulate when plants are stressed. As a result, these mutants showed increased expression of genes related to ROS, pointing out a potential risk for them during cold weather.
Overall, our findings suggest that the transporter BvINT1;1 is not just about moving inositol; it plays a vital role in boosting the plant's cold resilience by facilitating raffinose biosynthesis and maintaining balance against oxidative stress.
9
Myo-inositol boosts cold tolerance
Combined application of myo-inositol and corn steep liquor enhances seedling growth and cold tolerance in cucumber and tomato.
We explored the effects of myo-inositol and corn steep liquor (CSL) on cucumber and tomato seedlings, particularly focusing on their ability to withstand cold temperatures. Through our research, we found that applying these substances led to noticeable improvements in seedling growth during low-temperature stress.
Our treatments not only increased the levels of photosynthetic pigments, enhancing photosynthesis, but also reduced harmful compounds like malondialdehyde (MDA) and electrolyte leakage. This suggests that the combination of inositol and CSL helps to protect plant cells under stress.
Additionally, we confirmed these findings by analyzing the expression of important genes that relate to cold tolerance in cucumbers. The most effective mix we identified was 0.6 mL L of CSL together with 72 mg L of myo-inositol. Overall, this study gives us valuable insights into how we can use inositol and maize leachate to foster early growth in crops and improve their resilience against cold weather.
8
Inositol enhances rapeseed cold tolerance
Inositol Improves Cold Tolerance Through Inhibiting and Increasing Ca Influx in Rapeseed ( L.).
We explored the impact of inositol on cold stress in rapeseed, an essential oilseed crop affected by low temperatures. Notably, we found that inositol plays a significant role in enhancing cold tolerance in these plants by boosting calcium ion (Ca) influx.
Our study involved identifying various genes associated with inositol and analyzing their expression under cold conditions. Interestingly, inositol appeared to inhibit the expression of calcineurin B-like genes, which are involved in regulating calcium flow, suggesting a unique pathway through which inositol aids in cold resilience.
Additionally, when we overexpressed certain genes linked to calcium flux, we noted a stronger response to cold stress, further emphasizing the importance of the inositol-Ca pathway in facilitating cold tolerance in rapeseed. These findings not only deepen our understanding of how rapeseed copes with cold conditions but also present a potential strategy for enhancing crop resilience in the face of climate challenges.
9
MIOX gene enhances cold tolerance
Genome-wide identification of the myo-inositol oxygenase gene family in alfalfa (Medicago sativa L.) and expression analysis under abiotic stress.
We explored how myo-inositol oxygenase (MIOX), an important enzyme, might help alfalfa, a type of forage crop, adapt to challenging cold conditions. The study identified ten MsMIOX genes in the alfalfa genome, which were found distributed across three chromosomes.
Through analysis, we noted that these genes exhibited similarities in structure and conserved features, hinting at a functional role important for the plant's survival under stress.
Our qRT-PCR tests showed that different MsMIOX genes could be triggered by cold and other abiotic stress factors like drought and salinity. Notably, the activity of MIOX in alfalfa significantly increased under these harsh conditions.
By overexpressing the MsMIOX2 gene in yeast, we found that it notably enhanced resistance to cold stresses. Additionally, when MsMIOX2 was overexpressed in alfalfa’s hairy roots, it reduced reactive oxygen species and improved the plant's resilience against cold.
This study provides valuable insights into how inositol plays a part in helping alfalfa thrive even in cold weather, presenting a candidate for future efforts to enhance the plant’s stress tolerance.
8
Myo-inositol aids cold resistance
Multi-omic dissection of the cold resistance traits of white water lily.
We delved into the fascinating world of white water lilies and their remarkable ability to withstand cold temperatures. This study aimed to understand how certain compounds, particularly myo-inositol, contribute to the plant's cold resilience.
Through a comprehensive examination, we learned that the water lily effectively copes with winter by entering a state called ecodormancy. During this time, the plant reallocates resources and enhances its defenses against cold stress.
One of our key findings was the significance of myo-inositol. This compound helps bolster the plant’s cold tolerance, although it works alongside various other factors. It plays a role in regulating metabolic activities, especially in relation to amino acids, which are crucial for overcoming chilly conditions.
Although our study highlighted the importance of myo-inositol, it did not isolate its effects from other treatments, which limits our understanding of its specific impact. Nevertheless, the insights we gained about the water lily’s adaptive strategies provide valuable information for future agricultural practices in cold climates.
References
Berg J, Rodrigues CM, Scheid C, Pirrotte Y, Picco C, et al. The Vacuolar Inositol Transporter BvINT1;1 Contributes to Raffinose Biosynthesis and Reactive Oxygen Species Scavenging During Cold Stress in Sugar Beet. Plant Cell Environ. 2025. 10.1111/pce.15367
Sun S, Zhang X, Wang C, Yu Q, Yang H, et al. Combined application of myo-inositol and corn steep liquor enhances seedling growth and cold tolerance in cucumber and tomato. Physiol Plant. 2024;176:e14422. 10.1111/ppl.14422
Qiu P, Liu T, Xu Y, Ye C, Zhang R, et al. Multi-omic dissection of the cold resistance traits of white water lily. Hortic Res. 2024;11:uhae093. 10.1093/hr/uhae093
Guo W, Yu D, Zhang R, Zhao W, Zhang L, et al. Genome-wide identification of the myo-inositol oxygenase gene family in alfalfa (Medicago sativa L.) and expression analysis under abiotic stress. Plant Physiol Biochem. 2023;200:107787. 10.1016/j.plaphy.2023.107787
Yan L, Zeng L, Raza A, Lv Y, Ding X, et al. Inositol Improves Cold Tolerance Through Inhibiting and Increasing Ca Influx in Rapeseed ( L.). Front Plant Sci. 2022;13:775692. 10.3389/fpls.2022.775692
Wang F, Wang X, Zhang Y, Yan J, Ahammed GJ, et al. SlFHY3 and SlHY5 act compliantly to enhance cold tolerance through the integration of myo-inositol and light signaling in tomato. New Phytol. 2022;233:2127. 10.1111/nph.17934