Vitamin A supports immune responseEffect of oral vitamin A supplementation on host immune response to infectious bronchitis virus infection in specific pathogen-free chicken.
Focus on viral immune response
We conducted a study to investigate how vitamin A supplementation affects the immune response in chickens infected with the infectious bronchitis virus (IBV). In our approach, we used 40 one-day-old specific pathogen-free (SPF) chickens, dividing them into two groups. One group received an oral vitamin A treatment daily, while the other group was given a placebo until they were 21 days old.
Afterward, both groups were infected with a pathogenic strain of IBV. Our findings showed that while vitamin A supplementation didn't significantly alter the disease's clinical course or the chickens' overall growth, it had some notable effects on their immune response. Specifically, we observed increased levels of IBV-specific antibodies and a decrease in viral load in certain tissues among the vitamin A group.
Interestingly, vitamin A appeared to also suppress some immune responses, leading to lower expression levels of certain molecules related to inflammation and immune regulation. While vitamin A helped improve specific aspects of the immune response, it did not completely cure the chickens or prevent infection.
Overall, we can conclude that while vitamin A supplementation can offer some benefits in terms of boosting immunity and managing viral replication, it doesn't drastically change the outcome of IBV infections in chickens.
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