We explored the effects of all-trans retinoic acid (atRA) on atherosclerosis in rabbits fed a high-fat diet. In an experiment where rabbits were divided into groups, some received atRA while others received atorvastatin or both.
We found that atRA effectively reduced plaque size, comparable to atorvastatin, and their combination was even more effective. Additionally, atRA improved the serum lipid profile, suggesting it could be a valuable tool in managing cholesterol levels.
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9
Vitamin A may help cholesterol levels
Chronic vitamin A-enriched diet feeding regulates hypercholesterolaemia through transcriptional regulation of reverse cholesterol transport pathway genes in obese rat model of WNIN/GR-Ob strain.
We examined the effects of a vitamin A-enriched diet on cholesterol levels in glucose-intolerant obese rats. Over a 14-week period, we fed two groups of ratsāone received a standard diet, while the other enjoyed the vitamin A boost.
Our findings revealed that the vitamin A diet successfully lowered high cholesterol levels and improved HDL cholesterol, but it worked through different mechanisms than previously thought. Importantly, while we did see positive changes, the study indicates that the benefits may vary based on individual factors.
Read More
8
Vitamin A lowers cholesterol in rats
Vitamin A-enriched diet modulates reverse cholesterol transport in hypercholesterolemic obese rats of the WNIN/Ob strain.
We explored how vitamin A affects cholesterol levels in obese rats with high cholesterol. By administering different doses of vitamin A, we found that a dose of 52 mg/kg significantly decreased the unhealthy HDL-cholesterol levels after 20 weeks. This feeding regimen increased the expression of proteins that help with cholesterol transport. However, the lean rats didnāt show similar benefits. The findings suggest that vitamin A might offer a way to improve cholesterol metabolism in obese individuals, but more research is needed before making any human recommendations.
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Most Useful Reviews
6
Vision and health boost
1 people found this helpful
The high CP value of vitamin A is crucial for eye health. Regular supplementation can alleviate minor issues and help to prevent diseases. The packaging is attractive, and the quality of the product is commendable.
Read More
2
Disappointment expressed
I had high hopes for this product, but unfortunately, it did not meet my expectations.
We explored the effects of all-trans retinoic acid (atRA) on atherosclerosis in rabbits fed a high-fat diet. In an experiment where rabbits were divided into groups, some received atRA while others received atorvastatin or both.
We found that atRA effectively reduced plaque size, comparable to atorvastatin, and their combination was even more effective. Additionally, atRA improved the serum lipid profile, suggesting it could be a valuable tool in managing cholesterol levels.
Read More
9
Vitamin A may help cholesterol levels
Chronic vitamin A-enriched diet feeding regulates hypercholesterolaemia through transcriptional regulation of reverse cholesterol transport pathway genes in obese rat model of WNIN/GR-Ob strain.
We examined the effects of a vitamin A-enriched diet on cholesterol levels in glucose-intolerant obese rats. Over a 14-week period, we fed two groups of ratsāone received a standard diet, while the other enjoyed the vitamin A boost.
Our findings revealed that the vitamin A diet successfully lowered high cholesterol levels and improved HDL cholesterol, but it worked through different mechanisms than previously thought. Importantly, while we did see positive changes, the study indicates that the benefits may vary based on individual factors.
Read More
8
Vitamin A lowers cholesterol in rats
Vitamin A-enriched diet modulates reverse cholesterol transport in hypercholesterolemic obese rats of the WNIN/Ob strain.
We explored how vitamin A affects cholesterol levels in obese rats with high cholesterol. By administering different doses of vitamin A, we found that a dose of 52 mg/kg significantly decreased the unhealthy HDL-cholesterol levels after 20 weeks. This feeding regimen increased the expression of proteins that help with cholesterol transport. However, the lean rats didnāt show similar benefits. The findings suggest that vitamin A might offer a way to improve cholesterol metabolism in obese individuals, but more research is needed before making any human recommendations.
Read More
7
Vitamin A helps improve cholesterol
THE EFFECT OF APPLICATION OF ANTIOXIDANT THERAPY IN THE TREATMENT OF NON-ALKOHOLIC STEATOHEPATATIS IN CHORNOBYL NPP ACCIDENT SUFFERERS IN THE REMOTE PERIOD AFTER IRRADIATION.
We investigated how antioxidant therapy, including vitamins A and E, affects patients with non-alcoholic steatohepatitis (NASH) who were involved in the Chernobyl disaster.
By studying 72 patients through blood tests and ultrasounds before and after treatment, we found that this combined treatment improved antioxidant levels in the body.
It also resulted in lower cholesterol levels and better liver health overall. Thus, vitamin A therapy showed promise in managing cholesterol and other metabolic issues in these patients.
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4
Vitamin A shows limited cholesterol effects
A comparative study of antioxidant vitamins and simvastatin in hypercholesterolimic rabbits.
We explored how antioxidant vitamins, particularly vitamin A, vitamin C, and vitamin E, impact cholesterol levels in rabbits fed high cholesterol diets.
In our research, we noted that while all treatment groups saw a reduction in total cholesterol and triglycerides, vitamin A did not perform as well as vitamin C, vitamin E, or simvastatin.
Ultimately, simvastatin stood out for significantly increasing beneficial HDL-C levels, while vitamin A showed limited effectiveness in comparison.
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USERS' SCORE
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Based on 2 Reviews
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Negative Reviews
6
Vision and health boost
1 people found this helpful
The high CP value of vitamin A is crucial for eye health. Regular supplementation can alleviate minor issues and help to prevent diseases. The packaging is attractive, and the quality of the product is commendable.
Read More
2
Disappointment expressed
I had high hopes for this product, but unfortunately, it did not meet my expectations.
Read More
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References
Sarkisova EA, Chumak AA, Ovsyannikova LM, Alekhina LM, Nosach OV, et al. THE EFFECT OF APPLICATION OF ANTIOXIDANT THERAPY IN THE TREATMENT OF NON-ALKOHOLIC STEATOHEPATATIS IN CHORNOBYL NPP ACCIDENT SUFFERERS IN THE REMOTE PERIOD AFTER IRRADIATION. Probl Radiac Med Radiobiol. 2018;23:452. 10.33145/2304-8336-2018-23-452-461
Zarei L, Bahrami M, Farhad N, Froushani SMA, Abbasi A. All-trans retinoic acid effectively reduces atheroma plaque size in a rabbit model of high-fat-induced atherosclerosis. Adv Clin Exp Med. 2018;27:1631. 10.17219/acem/74552
Jeyakumar SM, Sheril A, Vajreswari A. Chronic vitamin A-enriched diet feeding regulates hypercholesterolaemia through transcriptional regulation of reverse cholesterol transport pathway genes in obese rat model of WNIN/GR-Ob strain. Indian J Med Res. 2016;144:238. 10.4103/0971-5916.195038
Prashanth A, Jeyakumar SM, Giridharan NV, Vajreswari A. Vitamin A-enriched diet modulates reverse cholesterol transport in hypercholesterolemic obese rats of the WNIN/Ob strain. J Atheroscler Thromb. 2014;21:1197. PubMed
Syed NI, Arshad S, Syed AA, Ahmad M, Khan FZ, et al. A comparative study of antioxidant vitamins and simvastatin in hypercholesterolimic rabbits. Pak J Pharm Sci. 2011;24:479. PubMed