Last update
5/20/2025
Research Authors

Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 18 Researches
7.6
USERS' SCORE
Good
Based on 2 Reviews
8.5
Supplement Facts
Serving Size:  1 Softgel
Amount Per Serving
%DV
Vitamin A (from fish [liver] oil, retinyl palmitate)
3,000 mcg
333%

Top Medical Research Studies

We focused on the protective effects of vitamin A on stress-induced gastric lesions in piglets after experiencing hemorrhagic shock. In our study, piglets were subjected to low blood pressure and then treated with different doses of vitamin A. Remarkably, those receiving vitamin A showed no signs of gastric lesions.

This suggests that vitamin A plays a significant role in safeguarding the gastric lining against stress-related damage during critical conditions.

Overall, our findings highlight the potential benefits of vitamin A in both veterinary and human medicine for ulcer prevention under stress.
Read More
We explored the effects of dietary vitamin A on preventing duodenal ulcers in rats induced by cysteamine-HCl. In our study, we compared two groups of rats—one receiving a standard diet and the other supplemented with vitamin A.

After exposing them to cysteamine-HCl, we observed that only 32% of the vitamin A group developed ulcers, compared to 74% in the control group. This shows a significant protective effect of vitamin A on ulcer formation, although it did not influence gastric acid production.

Overall, our findings suggest vitamin A supplementation could be beneficial in reducing duodenal ulcer risk in this experimental model.
Read More
8
Beta-carotene shows ulcer benefits
We explored the effects of daily beta-carotene treatment on patients with duodenal ulcers and erosive gastritis. After administering 18 mg of beta-carotene in an oil solution, we observed a threefold increase in its blood serum levels.

Although the concentration of retinol remained unchanged, indicating no harmful effects, the treatment showed promising results. It improved the antioxidative system, reduced pain, helped heal ulcers, and led to the healing of erosions in the gastric mucosa.
Read More

Most Useful Reviews

9
Skin healing support
Vitamin A is effective in treating various skin conditions, including ulcers. It accelerates healing in cases of skin damage and stimulates collagen production. Additionally, it supports lung health and is useful for managing gastrointestinal issues like ulcers and colitis.
Read More
7.5
Treatment for ulcers
A nutritionist prescribed Vitamin A for healing the gastrointestinal tract. It is essential if you have mucosal damage or ulcers, especially after parasitic infection. It works best when combined with Vitamin E.
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 18 Researches
7.6
  • All Researches
We focused on the protective effects of vitamin A on stress-induced gastric lesions in piglets after experiencing hemorrhagic shock. In our study, piglets were subjected to low blood pressure and then treated with different doses of vitamin A. Remarkably, those receiving vitamin A showed no signs of gastric lesions.

This suggests that vitamin A plays a significant role in safeguarding the gastric lining against stress-related damage during critical conditions.

Overall, our findings highlight the potential benefits of vitamin A in both veterinary and human medicine for ulcer prevention under stress.
Read More
We explored the effects of dietary vitamin A on preventing duodenal ulcers in rats induced by cysteamine-HCl. In our study, we compared two groups of rats—one receiving a standard diet and the other supplemented with vitamin A.

After exposing them to cysteamine-HCl, we observed that only 32% of the vitamin A group developed ulcers, compared to 74% in the control group. This shows a significant protective effect of vitamin A on ulcer formation, although it did not influence gastric acid production.

Overall, our findings suggest vitamin A supplementation could be beneficial in reducing duodenal ulcer risk in this experimental model.
Read More
9
Vitamin A and beta-carotene prevent ulcers
In our investigation, we examined how vitamin A and beta-carotene impact gastric ulcers in rats. By administering these compounds before inducing gastric damage with ethanol or hydrochloric acid, we observed a notable reduction in both the number and severity of ulcers.

This suggests that both vitamin A and beta-carotene help protect the stomach lining. However, while they effectively prevent ulcers, they don't fully restore the activity of a crucial enzyme involved in gastric defense. Overall, we found that these vitamins play a key protective role, primarily due to their ability to act as antioxidants.
Read More
We examined a unique case of lip ulcers linked to the intravenous use of zoledronic acid (ZA) in a patient undergoing treatment for metastatic breast cancer. Despite managing the patient's anemia and an E. coli infection, the ulcers persisted until ZA was discontinued.

After halting the medication, the ulcers healed within three months with a treatment plan that included systemic antibiotics and vitamins A and E. However, upon resuming ZA, recurrence occurred, but follow-up treatment kept the patient clear of lesions for 18 months.

This case highlights how vitamin A can aid in the healing of severe oral mucosal ulcers related to bisphosphonate therapy.
Read More
8
Vitamin A protects against ARA-C damage
We investigated whether vitamin A could shield against intestinal damage caused by ARA-C, a common leukemia treatment known for its side effects like mucosal lesions. Mice in our study were divided into several groups, some receiving vitamin A alongside ARA-C.

Our results revealed that mice treated with vitamin A showed significantly improved gut health compared to those who did not receive it. They exhibited better mucosal integrity and less tissue damage, suggesting that vitamin A can indeed play a protective role against the harmful effects of ARA-C.
Read More

User Reviews

USERS' SCORE
Good
Based on 2 Reviews
8.5
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Skin healing support
Vitamin A is effective in treating various skin conditions, including ulcers. It accelerates healing in cases of skin damage and stimulates collagen production. Additionally, it supports lung health and is useful for managing gastrointestinal issues like ulcers and colitis.
Read More
7.5
Treatment for ulcers
A nutritionist prescribed Vitamin A for healing the gastrointestinal tract. It is essential if you have mucosal damage or ulcers, especially after parasitic infection. It works best when combined with Vitamin E.
Read More

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References

  1. Elli M, Aydin O, Bilge S, Bozkurt A, Dagdemir A, et al. Protective effect of vitamin A on ARA-C induced intestinal damage in mice. Tumori. 2009;95:87.
  2. Ryan-Harshman M, Aldoori W. How diet and lifestyle affect duodenal ulcers. Review of the evidence. Can Fam Physician. 2004;50:727.
  3. Pimenov LT, Balobanov VIu, Pushina LN, Shemiakina TV. [The clinico-endoscopic, psychological and physical characteristics of duodenal peptic ulcer patients using piracetam and aevit]. Ter Arkh. 1997;69:10.
  4. Aldoori WH, Giovannucci EL, Stampfer MJ, Rimm EB, Wing AL, et al. Prospective study of diet and the risk of duodenal ulcer in men. Am J Epidemiol. 1997;145:42.
  5. Stanislavchuk NA, Pentiuk AA, Vovk OG, Ostapchuk EI. [The influence of retinol, tocopherol and cimetidine on the ulcerogenic effect of Orthofen, indomethacin and naproxen]. Eksp Klin Farmakol. 1995;58:33.
  6. Mózsik G, Hunyady B, Garamszegi M, Németh A, Pakodi F, et al. Dynamism of cytoprotective and antisecretory drugs in patients with unhealed gastric and duodenal ulcers. J Gastroenterol Hepatol. 1994;9 Suppl 1:S88.
  7. Spirichev VB, Levachev MM, Rymarenko TV, Iakushina LM, Kharitonchik LA, et al. [The effect of administration of beta-carotene in an oil solution on its blood serum level and antioxidant status of patients with duodenal ulcer and erosive gastritis]. Vopr Med Khim. 1992;38:44.
  8. Király A, Sütö G, Vincze A, Tóth G, Matus Z, et al. Correlation between the cytoprotective effect of beta-carotene and its gastric mucosal level in indomethacin (IND) treated rats with or without acute surgical vagotomy. Acta Physiol Hung. 1992;80:213.
  9. Granov AM, Aiskhanov SK, Nikolaev LI, Smirnova NA. [Clinico-endoscopic evaluation of the effectiveness of the treatment of uncomplicated gastroduodenal ulcers after local administration of solcoseryl and aevit]. Vestn Khir Im I I Grek. 1989;144:12.
  10. Mahmood T, Tenenbaum S, Niu XT, Levenson SM, Seifter E, et al. Prevention of duodenal ulcer formation in the rat by dietary vitamin A supplementation. JPEN J Parenter Enteral Nutr. 1986;10:74.
  11. Mózsik G, Jávor T, Tóth G, Zsoldos T, Tigyi A. Interrelationships between the gastric cytoprotective effects of vitamin A and beta-carotene and the gastric mucosal superoxide dismutase activity in rats. Acta Physiol Hung. 1984;64:315.
  12. Patty I, Tárnok F, Simon L, Jávor T, Deák G, et al. A comparative dynamic study of the effectiveness of gastric cytoprotection by vitamin A, De-Nol, sucralfate and ulcer healing by pirenzepine in patients with chronic gastric ulcer (a multiclinical and randomized study). Acta Physiol Hung. 1984;64:379.
  13. Patty I, Benedek S, Deák G, Jávor T, Kenéz P, et al. Cytoprotective effect of vitamin A and its clinical importance in the treatment of patients with chronic gastric ulcer. Int J Tissue React. 1983;5:301.
  14. von Gerstenbergk L, Büsing M, Seufert RM, Doertenbach J, Hottenrott C. [Lose-dose treatment with vitamin A in prevention of stress ulcer in swine]. Langenbecks Arch Chir. 1976;Suppl:224.
  15. Schumpelick V, Farthmann E. [Study on the protective effect of vitamin A on stress ulcer of the rat (author's transl)]. Arzneimittelforschung. 1976;26:386.
  16. Kivilaakso E, Kalima TV, Lempinen M. Modification of procine stress ulceration by methylprednisolone, vitaminA and methysergide treatment. Eur Surg Res. 1976;8:281.
  17. Andreadis D, Mauroudis S, Poulopoulos A, Markopoulos A, Epivatianos A. Lip ulceration associated with intravenous administration of zoledronic acid: report of a case. Head Neck Pathol. 2012;6:275. 10.1007/s12105-011-0313-8
  18. Lischer CJ, Dietrich-Hunkeler A, Geyer H, Schulze J, Ossent P. [Healing process of uncomplicated sole ulcers in dairy cows kept in tie stalls: clinical description and blood chemical investigations]. Schweiz Arch Tierheilkd. 2001;143:125.
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