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SCIENTIFIC SCORE
Moderately Effective
Based on 13 Researches
8
USERS' SCORE
Good
Based on 4 Reviews
8.5
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Vitamin B6 (as pyridoxine HCl and pyridoxal-5-phosphate)
50 mg
2,941%
Top Medical Research Studies
9
Vitamin B6 shows blood pressure benefits
Pyridoxal-5'-phosphate: A cost-effective treatment candidate for hypertensive patients?
Direct cardiovascular health impact
We investigated the potential of vitamin B6, in the form of pyridoxal-5'-phosphate (PLP), to influence blood pressure, particularly in the context of hypertension. Our focus was on how PLP modifies angiotensin II, a peptide that plays a critical role in blood vessel constriction, transforming it into a different form known as pyruvamide-Ang II (Ang P).
By examining this transformation, we looked into its effects on calcium entry in vascular smooth muscle cells (VSMCs) as well as its binding affinity to blood pressure receptors. Through laboratory experiments using both spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY), we found that those treated with PLP experienced a significant drop in blood pressure, while the control group showed an increase after receiving angiotensin II.
This suggests that PLP could be an effective, low-cost option for managing hypertension, potentially offering a new path for treatment. Increasing PLP intake could help hypertensive individuals manage their condition more effectively and affordably.
By examining this transformation, we looked into its effects on calcium entry in vascular smooth muscle cells (VSMCs) as well as its binding affinity to blood pressure receptors. Through laboratory experiments using both spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY), we found that those treated with PLP experienced a significant drop in blood pressure, while the control group showed an increase after receiving angiotensin II.
This suggests that PLP could be an effective, low-cost option for managing hypertension, potentially offering a new path for treatment. Increasing PLP intake could help hypertensive individuals manage their condition more effectively and affordably.
Read More
9
Pyridoxamine mitigates chemotherapy heart damage
Pyridoxamine Limits Cardiac Dysfunction in a Rat Model of Doxorubicin-Induced Cardiotoxicity.
High relevance to cardiovascular health
We examined the effects of pyridoxamine, a vitamin B6 derivative, on heart damage caused by doxorubicin (DOX), a common chemotherapy drug known for its harmful impact on the heart. In our study, we used a rat model where some rats received DOX while others received a combination of DOX and pyridoxamine. We also included control groups for comparison to ensure the effectiveness of the treatment could be clearly evaluated.
Our findings showed that pyridoxamine significantly reduced the heart-related harm often associated with DOX treatment. Specifically, it helped in preserving the heart's structure and function, limiting the development of conditions like dilated cardiomyopathy. Furthermore, pyridoxamine appeared to mitigate inflammation, fibrosis, and oxidative stress, all of which can worsen heart health over time.
The treatment notably protected against iron-related cell death, restoring healthier balance in iron levels and improving overall heart condition at the genetic level. This suggests that pyridoxamine could serve as a promising new strategy to protect against heart damage in patients undergoing chemotherapy.
Our findings showed that pyridoxamine significantly reduced the heart-related harm often associated with DOX treatment. Specifically, it helped in preserving the heart's structure and function, limiting the development of conditions like dilated cardiomyopathy. Furthermore, pyridoxamine appeared to mitigate inflammation, fibrosis, and oxidative stress, all of which can worsen heart health over time.
The treatment notably protected against iron-related cell death, restoring healthier balance in iron levels and improving overall heart condition at the genetic level. This suggests that pyridoxamine could serve as a promising new strategy to protect against heart damage in patients undergoing chemotherapy.
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8
Vitamin B6 supports heart recovery
Vitamin B6 allosterically activates AMPK to promote postischemic angiogenesis in mice.
Study directly investigates VB6 effects
We explored the potential of vitamin B6 (VB6) to boost heart recovery following acute myocardial infarction (AMI). Our research focused on how VB6 might promote angiogenesis, which is the process of forming new blood vessels, a crucial factor for improving heart function after a heart attack.
To investigate this, we conducted experiments measuring the effects of VB6 on human umbilical vein endothelial cells, a type of cell involved in blood vessel formation. We noticed that VB6 not only increased cell migration and tubule formation but also activated AMP-activated protein kinase (AMPK), a key player in cellular energy regulation. This activation led to a positive chain reaction that enhanced the production of vascular endothelial growth factor A, which aids in blood vessel growth.
Perhaps most exciting is our finding from in vivo studies, where long-term VB6 supplementation in mice significantly improved heart functions, increased new blood vessel formation, and reduced inflammatory cytokines after AMI. This suggests that VB6 serves as a strong ally in promoting heart recovery after ischemic injury. Our results indicate that adding VB6 to treatment plans could be beneficial in preventing cardiac dysfunction following heart attacks.
To investigate this, we conducted experiments measuring the effects of VB6 on human umbilical vein endothelial cells, a type of cell involved in blood vessel formation. We noticed that VB6 not only increased cell migration and tubule formation but also activated AMP-activated protein kinase (AMPK), a key player in cellular energy regulation. This activation led to a positive chain reaction that enhanced the production of vascular endothelial growth factor A, which aids in blood vessel growth.
Perhaps most exciting is our finding from in vivo studies, where long-term VB6 supplementation in mice significantly improved heart functions, increased new blood vessel formation, and reduced inflammatory cytokines after AMI. This suggests that VB6 serves as a strong ally in promoting heart recovery after ischemic injury. Our results indicate that adding VB6 to treatment plans could be beneficial in preventing cardiac dysfunction following heart attacks.
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Most Useful Reviews
9.5
Supports cardiovascular health
Nature's Way Vitamin B6 is a key supplement for various bodily functions, including amino acid metabolism and nerve system support. It aids in neurotransmitter production, which impacts mood and cognition, while also supporting hemoglobin formation. Additionally, it helps lower homocysteine levels, potentially reducing the risk of cardiovascular disease. This supplement boosts energy, improves cognitive function, and reduces stress.
Read More
8
Promising alternative treatment
I could not find a direct analogue of Milgamma Compositum, but I discovered excellent substitutes containing benfotiamine and pyridoxine hydrochloride. These supplements, taken as advised, can effectively address neurological issues like thoracalgia, which my friend was prescribed for. B vitamins are known for their sedative properties, aiding in pain relief. These medications work best when combined with treatments like massage. I recommend this combination for managing cardiovascular disease and ensuring a better quality of life.
Read More
8.8
Improved well-being
Vitamin B6 is essential for my nervous and cardiovascular systems. Since taking it upon my doctor's recommendation, I have experienced significant improvement in my overall health.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 13 Researches
8
9
Vitamin B6 shows heart protection
Protective effects of pyridoxine, amlodipine, and their combination in a vasopressin-induced angina model in rats.
Study addresses cardiovascular treatment
We examined how vitamin B6, or pyridoxine, might help protect against cardiovascular issues, specifically focusing on its effects in a model of angina in rats. The study involved administering vasopressin, which induced heart stress and ischemia, helping us assess the protective capabilities of pyridoxine.
During testing, we found that vitamin B6 effectively reduced ST-segment elevation on ECG and lowered heart rate related to the vasopressin-induced angina. Notably, it showed a dose-dependent response, with specific doses of 5 mg and 7 mg per kilogram proving particularly effective.
Interestingly, when we compared pyridoxine to amlodipine, another cardiovascular drug, we observed that pyridoxine not only performed better at reducing cardiac enzymes linked to heart damage but also suggests a novel approach to preventing coronary heart disease. However, combining pyridoxine with amlodipine raised concerns about increased adverse cardiovascular events, indicating that while pyridoxine may enhance heart protection, pairing it with certain medications could complicate treatment.
Given these findings, we believe that vitamin B6 at optimal doses may hold promise for heart disease prevention and deserves further exploration in clinical settings.
During testing, we found that vitamin B6 effectively reduced ST-segment elevation on ECG and lowered heart rate related to the vasopressin-induced angina. Notably, it showed a dose-dependent response, with specific doses of 5 mg and 7 mg per kilogram proving particularly effective.
Interestingly, when we compared pyridoxine to amlodipine, another cardiovascular drug, we observed that pyridoxine not only performed better at reducing cardiac enzymes linked to heart damage but also suggests a novel approach to preventing coronary heart disease. However, combining pyridoxine with amlodipine raised concerns about increased adverse cardiovascular events, indicating that while pyridoxine may enhance heart protection, pairing it with certain medications could complicate treatment.
Given these findings, we believe that vitamin B6 at optimal doses may hold promise for heart disease prevention and deserves further exploration in clinical settings.
Read More
9
Vitamin B6 shows blood pressure benefits
Pyridoxal-5'-phosphate: A cost-effective treatment candidate for hypertensive patients?
Direct cardiovascular health impact
We investigated the potential of vitamin B6, in the form of pyridoxal-5'-phosphate (PLP), to influence blood pressure, particularly in the context of hypertension. Our focus was on how PLP modifies angiotensin II, a peptide that plays a critical role in blood vessel constriction, transforming it into a different form known as pyruvamide-Ang II (Ang P).
By examining this transformation, we looked into its effects on calcium entry in vascular smooth muscle cells (VSMCs) as well as its binding affinity to blood pressure receptors. Through laboratory experiments using both spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY), we found that those treated with PLP experienced a significant drop in blood pressure, while the control group showed an increase after receiving angiotensin II.
This suggests that PLP could be an effective, low-cost option for managing hypertension, potentially offering a new path for treatment. Increasing PLP intake could help hypertensive individuals manage their condition more effectively and affordably.
By examining this transformation, we looked into its effects on calcium entry in vascular smooth muscle cells (VSMCs) as well as its binding affinity to blood pressure receptors. Through laboratory experiments using both spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY), we found that those treated with PLP experienced a significant drop in blood pressure, while the control group showed an increase after receiving angiotensin II.
This suggests that PLP could be an effective, low-cost option for managing hypertension, potentially offering a new path for treatment. Increasing PLP intake could help hypertensive individuals manage their condition more effectively and affordably.
Read More
9
Vitamin B-6 supports heart health
Vitamin B-6 Prevents Heart Failure with Preserved Ejection Fraction Through Downstream of Kinase 3 in a Mouse Model.
Well-researched but moderately complex
We set out to understand whether vitamin B-6 has preventive effects on heart failure with preserved ejection fraction (HFpEF), a condition often associated with changes in heart macrophages. To test this, we used a mouse model where we induced HFpEF through a combination of a high-fat diet and a specific supplement.
By assessing the cardiac function using echocardiography, we were able to track how the inclusion of vitamin B-6 impacted various heart issues related to HFpEF. Our findings were quite promising: when vitamin B-6 was administered alongside the HFpEF diet, we saw significant improvements in several key areas.
The E/E' ratio—a measure of heart function—dropped considerably, from 42.0 down to 21.6, while the E/A ratio improved, indicating better heart operation. Moreover, the mice displayed enhanced exercise capacity. However, it was interesting to note that these positive outcomes vanished in mice lacking the DOK3 protein, suggesting that vitamin B-6 plays a role in regulating signaling pathways that affect the function of heart macrophages.
Overall, our study indicates that vitamin B-6 could be a valuable therapeutic approach to mitigate the effects of HFpEF by preventing harmful changes in macrophage function, thereby supporting heart health.
By assessing the cardiac function using echocardiography, we were able to track how the inclusion of vitamin B-6 impacted various heart issues related to HFpEF. Our findings were quite promising: when vitamin B-6 was administered alongside the HFpEF diet, we saw significant improvements in several key areas.
The E/E' ratio—a measure of heart function—dropped considerably, from 42.0 down to 21.6, while the E/A ratio improved, indicating better heart operation. Moreover, the mice displayed enhanced exercise capacity. However, it was interesting to note that these positive outcomes vanished in mice lacking the DOK3 protein, suggesting that vitamin B-6 plays a role in regulating signaling pathways that affect the function of heart macrophages.
Overall, our study indicates that vitamin B-6 could be a valuable therapeutic approach to mitigate the effects of HFpEF by preventing harmful changes in macrophage function, thereby supporting heart health.
Read More
9
Vitamin B6 shows uncertain cardiovascular effects
Effect of Methylfolate, Pyridoxal-5'-Phosphate, and Methylcobalamin (Soloways) Supplementation on Homocysteine and Low-Density Lipoprotein Cholesterol Levels in Patients with Methylenetetrahydrofolate Reductase, Methionine Synthase, and Methionine Synthase Reductase Polymorphisms: A Randomized Controlled Trial.
Low relevance due to mixed effects
We conducted a study to assess the potential benefits of vitamin B6, along with other B vitamins, in lowering homocysteine levels and reducing bad cholesterol (LDL-C) in individuals at risk for cardiovascular disease due to specific genetic polymorphisms.
Our research included a randomized, double-blind, placebo-controlled trial with 54 participants aged between 40 and 75, all of whom had elevated homocysteine and moderate LDL-C levels. Over a six-month period, those receiving a combination of methylfolate, pyridoxal-5'-phosphate (vitamin B6), and methylcobalamin showed a significant reduction in both homocysteine by 30% and LDL-C by 7.5%, compared to those who received a placebo.
Particularly interesting were the findings regarding the subgroup of participants with homozygous minor allele polymorphisms, who experienced even larger decreases in homocysteine levels and LDL-C compared to mixed allele carriers. While vitamin B6 was part of the effective combination, we must note that its individual effect on cardiovascular disease remains uncertain, as the study primarily evaluates the combined effect of the B vitamins.
Our research included a randomized, double-blind, placebo-controlled trial with 54 participants aged between 40 and 75, all of whom had elevated homocysteine and moderate LDL-C levels. Over a six-month period, those receiving a combination of methylfolate, pyridoxal-5'-phosphate (vitamin B6), and methylcobalamin showed a significant reduction in both homocysteine by 30% and LDL-C by 7.5%, compared to those who received a placebo.
Particularly interesting were the findings regarding the subgroup of participants with homozygous minor allele polymorphisms, who experienced even larger decreases in homocysteine levels and LDL-C compared to mixed allele carriers. While vitamin B6 was part of the effective combination, we must note that its individual effect on cardiovascular disease remains uncertain, as the study primarily evaluates the combined effect of the B vitamins.
Read More
9
Pyridoxamine may protect heart health
Pyridoxamine Attenuates Doxorubicin-Induced Cardiomyopathy without Affecting Its Antitumor Effect on Rat Mammary Tumor Cells.
Moderate relevance to B6 effects
We investigated the potential of pyridoxamine, a derivative of vitamin B6, to protect the heart from the effects of doxorubicin, a common chemotherapy drug associated with heart problems. In this study, we treated Sprague Dawley rats with doxorubicin and monitored their heart function over eight weeks. We also administered pyridoxamine to some of the rats to see if it could counteract the drug’s harmful effects.
Our findings revealed that pyridoxamine significantly improved heart function in the rats treated with doxorubicin. Specifically, the left ventricular ejection fraction, which indicates how well the heart pumps blood, was notably higher in rats receiving pyridoxamine. Additionally, we found that pyridoxamine reduced the heart's end-systolic volume, suggesting it helped maintain heart health during doxorubicin treatment.
On the other hand, when we looked at the effects of doxorubicin on cancer cells in the lab, pyridoxamine did not change the drug's effectiveness. Doxorubicin still reduced cell viability and increased cell death in the tumor cells, which indicates that while pyridoxamine may protect the heart, it does not interfere with the drug's ability to fight cancer.
In conclusion, pyridoxamine appears to be a promising option for safeguarding heart health during cancer treatments with doxorubicin, without affecting the drug's anticancer properties.
Our findings revealed that pyridoxamine significantly improved heart function in the rats treated with doxorubicin. Specifically, the left ventricular ejection fraction, which indicates how well the heart pumps blood, was notably higher in rats receiving pyridoxamine. Additionally, we found that pyridoxamine reduced the heart's end-systolic volume, suggesting it helped maintain heart health during doxorubicin treatment.
On the other hand, when we looked at the effects of doxorubicin on cancer cells in the lab, pyridoxamine did not change the drug's effectiveness. Doxorubicin still reduced cell viability and increased cell death in the tumor cells, which indicates that while pyridoxamine may protect the heart, it does not interfere with the drug's ability to fight cancer.
In conclusion, pyridoxamine appears to be a promising option for safeguarding heart health during cancer treatments with doxorubicin, without affecting the drug's anticancer properties.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.5
9.5
Supports cardiovascular health
Nature's Way Vitamin B6 is a key supplement for various bodily functions, including amino acid metabolism and nerve system support. It aids in neurotransmitter production, which impacts mood and cognition, while also supporting hemoglobin formation. Additionally, it helps lower homocysteine levels, potentially reducing the risk of cardiovascular disease. This supplement boosts energy, improves cognitive function, and reduces stress.
Read More
8.8
Improved well-being
Vitamin B6 is essential for my nervous and cardiovascular systems. Since taking it upon my doctor's recommendation, I have experienced significant improvement in my overall health.
8
Promising alternative treatment
I could not find a direct analogue of Milgamma Compositum, but I discovered excellent substitutes containing benfotiamine and pyridoxine hydrochloride. These supplements, taken as advised, can effectively address neurological issues like thoracalgia, which my friend was prescribed for. B vitamins are known for their sedative properties, aiding in pain relief. These medications work best when combined with treatments like massage. I recommend this combination for managing cardiovascular disease and ensuring a better quality of life.
Read More
7.8
Prevention of diseases
Vitamin B6 plays a vital role in biochemical processes, regulating fat and protein exchange and maintaining cholesterol levels. Its deficiency can cause anaemia and adversely affect the cardiovascular system. Regular intake supports heart muscle function and helps prevent serious conditions such as thrombosis and hypertension. Overall, Vitamin B6 enhances immune response and plays a significant role in preventing cardiovascular disease.
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