5/16/2025
Last update
5/16/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.2
USERS' SCORE
Good
Based on 4 Reviews
8.1
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Vitamin B6 (as pyridoxine HCl and pyridoxal-5-phosphate)
50 mg
2,941%
Top Medical Research Studies
8
We explored the effects of pyridoxamine (PM), a form of vitamin B6, on heart health in a study involving male rats. These rats were divided into two groups: one received a standard diet, while the other was fed a Western diet known to induce prediabetes. To see how PM might help, we gave one group of rats on the Western diet an additional PM supplement through their drinking water for 18 weeks.
Throughout the study, we measured glucose levels and evaluated heart function using echocardiography, alongside analyzing heart tissue for any changes. Remarkably, the rats that received PM showed less increase in fasting blood glucose compared to those on the Western diet alone. Additionally, the PM treatment seemed to prevent some heart enlargement that typically occurs alongside unhealthy diets.
Furthermore, PM was effective in limiting collagen buildup within the heart tissue, which is often a marker of heart stress or damage. We also noted a reduction in substances related to oxidative stress, suggesting that PM might protect against heart damage by reducing harmful compounds. In summary, our findings suggest that pyridoxamine may help alleviate issues related to heart structure and stress in rats at risk of developing heart disease due to prediabetes.
Throughout the study, we measured glucose levels and evaluated heart function using echocardiography, alongside analyzing heart tissue for any changes. Remarkably, the rats that received PM showed less increase in fasting blood glucose compared to those on the Western diet alone. Additionally, the PM treatment seemed to prevent some heart enlargement that typically occurs alongside unhealthy diets.
Furthermore, PM was effective in limiting collagen buildup within the heart tissue, which is often a marker of heart stress or damage. We also noted a reduction in substances related to oxidative stress, suggesting that PM might protect against heart damage by reducing harmful compounds. In summary, our findings suggest that pyridoxamine may help alleviate issues related to heart structure and stress in rats at risk of developing heart disease due to prediabetes.
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7
We conducted an insightful study to understand how plasma vitamin B6, specifically its active form known as pyridoxal 5'-phosphate (PLP), might influence the risk of coronary heart disease (CHD). Our focus was on evaluating both overall effects and any notable differences between men and women.
In our research, we included 429 patients with diagnosed CHD and an equal number of controls, all matched for age, sex, and time of operation. By examining plasma PLP levels through sophisticated testing methods, we made some intriguing discoveries.
While we observed that higher levels of PLP were generally linked to a lower risk of CHD, this association strongly favored women. Specifically, each increase of 1 ng/mL in PLP was correlated with a 28% reduced risk of CHD in the overall group, and in women, this translated to a significant protection (odds ratio of 0.63). However, the same could not be said for men, where the results were not as clear-cut.
These findings reveal a noteworthy trend, suggesting that vitamin B6 may play a critical role in heart health for women, a connection that deserves further exploration. We believe this opens new avenues for understanding heart disease, especially among different genders.
In our research, we included 429 patients with diagnosed CHD and an equal number of controls, all matched for age, sex, and time of operation. By examining plasma PLP levels through sophisticated testing methods, we made some intriguing discoveries.
While we observed that higher levels of PLP were generally linked to a lower risk of CHD, this association strongly favored women. Specifically, each increase of 1 ng/mL in PLP was correlated with a 28% reduced risk of CHD in the overall group, and in women, this translated to a significant protection (odds ratio of 0.63). However, the same could not be said for men, where the results were not as clear-cut.
These findings reveal a noteworthy trend, suggesting that vitamin B6 may play a critical role in heart health for women, a connection that deserves further exploration. We believe this opens new avenues for understanding heart disease, especially among different genders.
Read More
9
We explored the effects of vitamin B6 (VB6) on heart recovery after an acute myocardial infarction (AMI). The study aimed to determine if VB6 could promote angiogenesis, the process of new blood vessel formation, which is crucial for healing the heart after such an event.
To investigate this, we looked at the ability of VB6 to enhance cell migration and tube formation in human umbilical vein endothelial cells, which are key players in the formation of blood vessels. Our results showed that VB6 not only encouraged these processes but also increased the phosphorylation of AMPK, a protein that plays a vital role in cellular energy regulation.
Importantly, these beneficial effects of VB6 on cell behavior were found to depend on AMPK activation. When we used specific inhibitors to block AMPK, the positive changes from VB6 were no longer observed. Additionally, in an animal model, long-term supplementing with VB6 led to significant improvements in heart function, more new blood vessel growth, and reduced inflammation markers in mice after AMI.
In summary, our findings suggest that vitamin B6 could be an effective support for heart recovery due to its role in promoting angiogenesis through AMPK activation following heart attacks. Given that VB6 shows promise in limiting ischemic heart injury, it could be a valuable addition to existing heart disease treatments.
To investigate this, we looked at the ability of VB6 to enhance cell migration and tube formation in human umbilical vein endothelial cells, which are key players in the formation of blood vessels. Our results showed that VB6 not only encouraged these processes but also increased the phosphorylation of AMPK, a protein that plays a vital role in cellular energy regulation.
Importantly, these beneficial effects of VB6 on cell behavior were found to depend on AMPK activation. When we used specific inhibitors to block AMPK, the positive changes from VB6 were no longer observed. Additionally, in an animal model, long-term supplementing with VB6 led to significant improvements in heart function, more new blood vessel growth, and reduced inflammation markers in mice after AMI.
In summary, our findings suggest that vitamin B6 could be an effective support for heart recovery due to its role in promoting angiogenesis through AMPK activation following heart attacks. Given that VB6 shows promise in limiting ischemic heart injury, it could be a valuable addition to existing heart disease treatments.
Read More
Most Useful Reviews
9
Prevents heart disease
Vitamin B6 plays a crucial role in the body's biochemical processes and cholesterol regulation. Its deficiency can lead to heart disease and anaemia. B6 supports the heart muscle, blood vessels, and immune function.
Read More
6
Supports heart health
1 people found this helpful
Inexpensive. Perfectly replenishes my vitamin B6 deficiency. I take it alongside vitamin B12 and folic acid from Solgar, as this combination supports the functioning of the heart and nervous system and aids in healthy blood formation.
Read More
7.5
Essential for heart
An indispensable vitamin for the heart alongside magnesium. The capsules are convenient and the dosage is easy to manage.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.2
- All Researches
9
We explored the effects of vitamin B6 (pyridoxine) on heart health, specifically looking at its protective qualities against angina provoked by vasopressin in a rat model. Vasopressin was administered to observe its impact on heart function, which included elevated stress on the heart indicated by changes on the electrocardiogram and increased cardiac enzymes.
The study found that when we gave rats pyridoxine in varying doses, it effectively reduced the ST elevation and heart rate changes caused by vasopressin. Notably, higher doses of pyridoxine (7 mg/kg) showed significant protective effects, outperforming both amlodipine and isosorbide. In addition, we observed that pyridoxine at these doses helped prevent cardiac tissue damage and improved heart structure.
Interestingly, while combining pyridoxine with amlodipine led to a trend of increased adverse cardiovascular events, the results underscored the potential of vitamin B6 in enhancing heart health. It appears vitamin B6 may work by improving certain functions in the body that support heart health, such as better blood vessel function and reduced levels of harmful substances.
Overall, our findings suggest that vitamin B6 could serve as a promising agent in preventing coronary heart disease, but more research is necessary to fully explore its benefits and practical applications in humans.
The study found that when we gave rats pyridoxine in varying doses, it effectively reduced the ST elevation and heart rate changes caused by vasopressin. Notably, higher doses of pyridoxine (7 mg/kg) showed significant protective effects, outperforming both amlodipine and isosorbide. In addition, we observed that pyridoxine at these doses helped prevent cardiac tissue damage and improved heart structure.
Interestingly, while combining pyridoxine with amlodipine led to a trend of increased adverse cardiovascular events, the results underscored the potential of vitamin B6 in enhancing heart health. It appears vitamin B6 may work by improving certain functions in the body that support heart health, such as better blood vessel function and reduced levels of harmful substances.
Overall, our findings suggest that vitamin B6 could serve as a promising agent in preventing coronary heart disease, but more research is necessary to fully explore its benefits and practical applications in humans.
Read More
9
We explored the effects of vitamin B6 (VB6) on heart recovery after an acute myocardial infarction (AMI). The study aimed to determine if VB6 could promote angiogenesis, the process of new blood vessel formation, which is crucial for healing the heart after such an event.
To investigate this, we looked at the ability of VB6 to enhance cell migration and tube formation in human umbilical vein endothelial cells, which are key players in the formation of blood vessels. Our results showed that VB6 not only encouraged these processes but also increased the phosphorylation of AMPK, a protein that plays a vital role in cellular energy regulation.
Importantly, these beneficial effects of VB6 on cell behavior were found to depend on AMPK activation. When we used specific inhibitors to block AMPK, the positive changes from VB6 were no longer observed. Additionally, in an animal model, long-term supplementing with VB6 led to significant improvements in heart function, more new blood vessel growth, and reduced inflammation markers in mice after AMI.
In summary, our findings suggest that vitamin B6 could be an effective support for heart recovery due to its role in promoting angiogenesis through AMPK activation following heart attacks. Given that VB6 shows promise in limiting ischemic heart injury, it could be a valuable addition to existing heart disease treatments.
To investigate this, we looked at the ability of VB6 to enhance cell migration and tube formation in human umbilical vein endothelial cells, which are key players in the formation of blood vessels. Our results showed that VB6 not only encouraged these processes but also increased the phosphorylation of AMPK, a protein that plays a vital role in cellular energy regulation.
Importantly, these beneficial effects of VB6 on cell behavior were found to depend on AMPK activation. When we used specific inhibitors to block AMPK, the positive changes from VB6 were no longer observed. Additionally, in an animal model, long-term supplementing with VB6 led to significant improvements in heart function, more new blood vessel growth, and reduced inflammation markers in mice after AMI.
In summary, our findings suggest that vitamin B6 could be an effective support for heart recovery due to its role in promoting angiogenesis through AMPK activation following heart attacks. Given that VB6 shows promise in limiting ischemic heart injury, it could be a valuable addition to existing heart disease treatments.
Read More
9
We examined how vitamin B-6 might play a role in preventing heart failure with preserved ejection fraction (HFpEF), a condition that often results from changes in heart-related immune cells called macrophages. Our research was based on a mouse model that mimicked HFpEF through a high-fat diet paired with a specific supplement. By monitoring heart function using various imaging techniques, as well as examining heart tissue for changes, we gathered important insights into vitamin B-6's potential benefits.
We found that when vitamin B-6 was added to the diet of mice prone to HFpEF, it significantly improved several heart failure symptoms. There were notable enhancements in heart function, reducing pressure in the heart and allowing for better exercise capacity. However, we made a crucial discovery: the positive effects of vitamin B-6 were diminished when we examined mice lacking a specific protein called DOK3. This suggests that DOK3 is key to vitamin B-6’s success in mitigating heart failure symptoms.
Essentially, our findings indicate that vitamin B-6 might lower the risk of heart failure by halting harmful changes in cardiac macrophages thanks to its ability to boost DOK3 signaling. This research offers exciting possibilities for a new therapeutic approach aimed at improving heart health and managing HFpEF effectively.
We found that when vitamin B-6 was added to the diet of mice prone to HFpEF, it significantly improved several heart failure symptoms. There were notable enhancements in heart function, reducing pressure in the heart and allowing for better exercise capacity. However, we made a crucial discovery: the positive effects of vitamin B-6 were diminished when we examined mice lacking a specific protein called DOK3. This suggests that DOK3 is key to vitamin B-6’s success in mitigating heart failure symptoms.
Essentially, our findings indicate that vitamin B-6 might lower the risk of heart failure by halting harmful changes in cardiac macrophages thanks to its ability to boost DOK3 signaling. This research offers exciting possibilities for a new therapeutic approach aimed at improving heart health and managing HFpEF effectively.
Read More
9
We focused on how pyridoxamine, a form of vitamin B6, impacts heart health during treatment with doxorubicin, a common cancer drug. In an experimental setup with Sprague Dawley rats, we observed that those receiving doxorubicin experienced a decrease in heart function, specifically a reduced left ventricular ejection fraction, and an increase in heart volume.
Notably, when we added pyridoxamine to the treatment, these harmful effects were significantly lessened. The rats that took pyridoxamine alongside doxorubicin maintained better heart function compared to those who only received doxorubicin. This suggests that pyridoxamine acts as a protective agent for the heart, countering some of the negative impacts caused by doxorubicin.
However, we also investigated how doxorubicin and pyridoxamine affected breast cancer cells in the lab. While doxorubicin effectively reduced cancer cell viability and increased cell death, pyridoxamine didn’t change these outcomes. This indicates that while pyridoxamine can preserve heart health during chemotherapy, it doesn’t interfere with the cancer-fighting effects of doxorubicin.
Overall, this research highlights pyridoxamine's promising role as a cardioprotectant during cancer treatment, allowing for heart preservation without diminishing the effectiveness of anticancer therapies.
Notably, when we added pyridoxamine to the treatment, these harmful effects were significantly lessened. The rats that took pyridoxamine alongside doxorubicin maintained better heart function compared to those who only received doxorubicin. This suggests that pyridoxamine acts as a protective agent for the heart, countering some of the negative impacts caused by doxorubicin.
However, we also investigated how doxorubicin and pyridoxamine affected breast cancer cells in the lab. While doxorubicin effectively reduced cancer cell viability and increased cell death, pyridoxamine didn’t change these outcomes. This indicates that while pyridoxamine can preserve heart health during chemotherapy, it doesn’t interfere with the cancer-fighting effects of doxorubicin.
Overall, this research highlights pyridoxamine's promising role as a cardioprotectant during cancer treatment, allowing for heart preservation without diminishing the effectiveness of anticancer therapies.
Read More
We explored the potential benefits of a special compound that combines a vitamin B6 analog and another substance known for releasing nitric oxide. This research aimed to understand how this compound, known as 2-ethyl-3-hydroxy-6-methylpyridinium 2-nitroxysuccinate, could protect the heart during episodes of ischemia, which is when blood flow to the heart is reduced.
We conducted our study using a mouse model of myocardial ischemia, assessing how well this compound could reduce damage to heart cells. Our results showed that it had the ability to release nitric oxide, which is essential for heart health, while also combating oxidative stress—a harmful process that can worsen heart disease.
Furthermore, we noticed that this compound helped protect heart cells from damage caused by ischemia. The compound appeared to work by inhibiting reactive oxygen species, which can harm cells, and stabilizing mitochondrial function. This indicates that it may provide a dual action that both facilitates healthy blood flow and protects the heart from harm.
In summary, while our research focused on a vitamin B6 derivative, it ultimately suggests promising avenues for developing new treatments for cardiovascular diseases by harnessing the therapeutic potential of nitric oxide and reducing oxidative stress within heart tissue.
We conducted our study using a mouse model of myocardial ischemia, assessing how well this compound could reduce damage to heart cells. Our results showed that it had the ability to release nitric oxide, which is essential for heart health, while also combating oxidative stress—a harmful process that can worsen heart disease.
Furthermore, we noticed that this compound helped protect heart cells from damage caused by ischemia. The compound appeared to work by inhibiting reactive oxygen species, which can harm cells, and stabilizing mitochondrial function. This indicates that it may provide a dual action that both facilitates healthy blood flow and protects the heart from harm.
In summary, while our research focused on a vitamin B6 derivative, it ultimately suggests promising avenues for developing new treatments for cardiovascular diseases by harnessing the therapeutic potential of nitric oxide and reducing oxidative stress within heart tissue.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Prevents heart disease
Vitamin B6 plays a crucial role in the body's biochemical processes and cholesterol regulation. Its deficiency can lead to heart disease and anaemia. B6 supports the heart muscle, blood vessels, and immune function.
Read More
6
Supports heart health
1 people found this helpful
Inexpensive. Perfectly replenishes my vitamin B6 deficiency. I take it alongside vitamin B12 and folic acid from Solgar, as this combination supports the functioning of the heart and nervous system and aids in healthy blood formation.
Read More
7.5
Essential for heart
An indispensable vitamin for the heart alongside magnesium. The capsules are convenient and the dosage is easy to manage.
Read More
6
Enhances heart quality
A great quality product, B6 has increased my energy levels and improved my sleep. It’s beneficial for heart health and has also addressed my greasy hair issue.
Read More
Frequently Asked Questions
6
Enhances heart quality
A great quality product, B6 has increased my energy levels and improved my sleep. It’s beneficial for heart health and has also addressed my greasy hair issue.
6
Supports heart health
1 people found this helpful
Inexpensive. Perfectly replenishes my vitamin B6 deficiency. I take it alongside vitamin B12 and folic acid from Solgar, as this combination supports the functioning of the heart and nervous system and aids in healthy blood formation.
7.5
Essential for heart
An indispensable vitamin for the heart alongside magnesium. The capsules are convenient and the dosage is easy to manage.
9
Prevents heart disease
Vitamin B6 plays a crucial role in the body's biochemical processes and cholesterol regulation. Its deficiency can lead to heart disease and anaemia. B6 supports the heart muscle, blood vessels, and immune function.
8
We aimed to uncover the relationship between Vitamin B6 and coronary heart disease (CHD). Using data from the National Health and Nutrition Examination Survey (NHANES) from 2003 to 2020, we analyzed samples from over 33,000 individuals. Our focus was on whether Vitamins B6 and E could provide some form of protection against heart disease, alongside the exploration of Vitamin B12’s role.
Our analysis highlighted that both Vitamins B6 and E were associated with lower rates of CHD, suggesting they may offer protective benefits. Interestingly, we found that the most significant effects were seen in people who were women, had a BMI in the overweight range, and were smokers. Conversely, Vitamin B12 didn’t show a clear connection with heart disease, indicating it might not play a major role in this context.
Overall, we observed that incorporating higher levels of Vitamins B6 and E into our diets might be helpful, particularly for specific groups of individuals at higher risk of heart disease. By remaining mindful of dietary intake, especially for those who are obese or smoke, we can potentially influence our heart health positively. Watching factors like income and education can also help us understand this complex interaction better.
Our analysis highlighted that both Vitamins B6 and E were associated with lower rates of CHD, suggesting they may offer protective benefits. Interestingly, we found that the most significant effects were seen in people who were women, had a BMI in the overweight range, and were smokers. Conversely, Vitamin B12 didn’t show a clear connection with heart disease, indicating it might not play a major role in this context.
Overall, we observed that incorporating higher levels of Vitamins B6 and E into our diets might be helpful, particularly for specific groups of individuals at higher risk of heart disease. By remaining mindful of dietary intake, especially for those who are obese or smoke, we can potentially influence our heart health positively. Watching factors like income and education can also help us understand this complex interaction better.
9
We explored the effects of vitamin B6 (VB6) on heart recovery after an acute myocardial infarction (AMI). The study aimed to determine if VB6 could promote angiogenesis, the process of new blood vessel formation, which is crucial for healing the heart after such an event.
To investigate this, we looked at the ability of VB6 to enhance cell migration and tube formation in human umbilical vein endothelial cells, which are key players in the formation of blood vessels. Our results showed that VB6 not only encouraged these processes but also increased the phosphorylation of AMPK, a protein that plays a vital role in cellular energy regulation.
Importantly, these beneficial effects of VB6 on cell behavior were found to depend on AMPK activation. When we used specific inhibitors to block AMPK, the positive changes from VB6 were no longer observed. Additionally, in an animal model, long-term supplementing with VB6 led to significant improvements in heart function, more new blood vessel growth, and reduced inflammation markers in mice after AMI.
In summary, our findings suggest that vitamin B6 could be an effective support for heart recovery due to its role in promoting angiogenesis through AMPK activation following heart attacks. Given that VB6 shows promise in limiting ischemic heart injury, it could be a valuable addition to existing heart disease treatments.
To investigate this, we looked at the ability of VB6 to enhance cell migration and tube formation in human umbilical vein endothelial cells, which are key players in the formation of blood vessels. Our results showed that VB6 not only encouraged these processes but also increased the phosphorylation of AMPK, a protein that plays a vital role in cellular energy regulation.
Importantly, these beneficial effects of VB6 on cell behavior were found to depend on AMPK activation. When we used specific inhibitors to block AMPK, the positive changes from VB6 were no longer observed. Additionally, in an animal model, long-term supplementing with VB6 led to significant improvements in heart function, more new blood vessel growth, and reduced inflammation markers in mice after AMI.
In summary, our findings suggest that vitamin B6 could be an effective support for heart recovery due to its role in promoting angiogenesis through AMPK activation following heart attacks. Given that VB6 shows promise in limiting ischemic heart injury, it could be a valuable addition to existing heart disease treatments.
9
We examined how vitamin B-6 might play a role in preventing heart failure with preserved ejection fraction (HFpEF), a condition that often results from changes in heart-related immune cells called macrophages. Our research was based on a mouse model that mimicked HFpEF through a high-fat diet paired with a specific supplement. By monitoring heart function using various imaging techniques, as well as examining heart tissue for changes, we gathered important insights into vitamin B-6's potential benefits.
We found that when vitamin B-6 was added to the diet of mice prone to HFpEF, it significantly improved several heart failure symptoms. There were notable enhancements in heart function, reducing pressure in the heart and allowing for better exercise capacity. However, we made a crucial discovery: the positive effects of vitamin B-6 were diminished when we examined mice lacking a specific protein called DOK3. This suggests that DOK3 is key to vitamin B-6’s success in mitigating heart failure symptoms.
Essentially, our findings indicate that vitamin B-6 might lower the risk of heart failure by halting harmful changes in cardiac macrophages thanks to its ability to boost DOK3 signaling. This research offers exciting possibilities for a new therapeutic approach aimed at improving heart health and managing HFpEF effectively.
We found that when vitamin B-6 was added to the diet of mice prone to HFpEF, it significantly improved several heart failure symptoms. There were notable enhancements in heart function, reducing pressure in the heart and allowing for better exercise capacity. However, we made a crucial discovery: the positive effects of vitamin B-6 were diminished when we examined mice lacking a specific protein called DOK3. This suggests that DOK3 is key to vitamin B-6’s success in mitigating heart failure symptoms.
Essentially, our findings indicate that vitamin B-6 might lower the risk of heart failure by halting harmful changes in cardiac macrophages thanks to its ability to boost DOK3 signaling. This research offers exciting possibilities for a new therapeutic approach aimed at improving heart health and managing HFpEF effectively.
7
We explored the link between vitamin B6 and heart disease, particularly how it may influence conditions like myocardial infarction (MI) and heart failure (HF). The research highlights that homocysteine, an amino acid, can indicate cardiovascular risk. When we have low levels of vitamin B6 or folate, homocysteine levels can rise, leading to potential damage to our blood vessels and heart.
Vitamin B6 plays a crucial role in the metabolism of homocysteine, helping to convert it into other beneficial compounds. This reaction is vital because elevated homocysteine can contribute to oxidative stress and inflammation, making heart problems worse. The study underscores the importance of vitamin B6 in managing these processes, suggesting that it can help reduce oxidative stress, affect gasotransmitter function, and improve blood flow in cases of MI and HF.
However, while the research indicates that vitamin B6 may have protective effects, it does not delve into specific results that would confirm its overall effectiveness for heart disease. The findings suggest a potential benefit, but we should approach them with caution until further comparative studies are conducted.
Vitamin B6 plays a crucial role in the metabolism of homocysteine, helping to convert it into other beneficial compounds. This reaction is vital because elevated homocysteine can contribute to oxidative stress and inflammation, making heart problems worse. The study underscores the importance of vitamin B6 in managing these processes, suggesting that it can help reduce oxidative stress, affect gasotransmitter function, and improve blood flow in cases of MI and HF.
However, while the research indicates that vitamin B6 may have protective effects, it does not delve into specific results that would confirm its overall effectiveness for heart disease. The findings suggest a potential benefit, but we should approach them with caution until further comparative studies are conducted.
7
We have explored the impact of vitamin B6 on heart health, particularly its potential benefits for those suffering from cardiovascular diseases. Although outright vitamin B6 deficiency is uncommon, many individuals experience marginal deficiency that could increase their risk for heart-related issues and cancers.
The focus of our review was on how vitamin B6 could protect the heart. We observed that this vitamin can elevate levels of important substances in the heart such as imidazole dipeptides—specifically carnosine, anserine, and homocarnosine—as well as histamine and γ-aminobutyric acid (GABA). Additionally, vitamin B6 appears to help suppress the NLRP3 inflammasome, which is activated through P2X7 receptor signaling.
These findings tentatively suggest that vitamin B6 may play a role in combating oxidative stress and inflammation, two factors closely tied to heart diseases. As we summarize our current understanding, it becomes clear that more research is needed to fully uncover vitamin B6's cardioprotective effects, but the preliminary data is promising.
The focus of our review was on how vitamin B6 could protect the heart. We observed that this vitamin can elevate levels of important substances in the heart such as imidazole dipeptides—specifically carnosine, anserine, and homocarnosine—as well as histamine and γ-aminobutyric acid (GABA). Additionally, vitamin B6 appears to help suppress the NLRP3 inflammasome, which is activated through P2X7 receptor signaling.
These findings tentatively suggest that vitamin B6 may play a role in combating oxidative stress and inflammation, two factors closely tied to heart diseases. As we summarize our current understanding, it becomes clear that more research is needed to fully uncover vitamin B6's cardioprotective effects, but the preliminary data is promising.
9
We explored the effects of vitamin B6 (pyridoxine) on heart health, specifically looking at its protective qualities against angina provoked by vasopressin in a rat model. Vasopressin was administered to observe its impact on heart function, which included elevated stress on the heart indicated by changes on the electrocardiogram and increased cardiac enzymes.
The study found that when we gave rats pyridoxine in varying doses, it effectively reduced the ST elevation and heart rate changes caused by vasopressin. Notably, higher doses of pyridoxine (7 mg/kg) showed significant protective effects, outperforming both amlodipine and isosorbide. In addition, we observed that pyridoxine at these doses helped prevent cardiac tissue damage and improved heart structure.
Interestingly, while combining pyridoxine with amlodipine led to a trend of increased adverse cardiovascular events, the results underscored the potential of vitamin B6 in enhancing heart health. It appears vitamin B6 may work by improving certain functions in the body that support heart health, such as better blood vessel function and reduced levels of harmful substances.
Overall, our findings suggest that vitamin B6 could serve as a promising agent in preventing coronary heart disease, but more research is necessary to fully explore its benefits and practical applications in humans.
The study found that when we gave rats pyridoxine in varying doses, it effectively reduced the ST elevation and heart rate changes caused by vasopressin. Notably, higher doses of pyridoxine (7 mg/kg) showed significant protective effects, outperforming both amlodipine and isosorbide. In addition, we observed that pyridoxine at these doses helped prevent cardiac tissue damage and improved heart structure.
Interestingly, while combining pyridoxine with amlodipine led to a trend of increased adverse cardiovascular events, the results underscored the potential of vitamin B6 in enhancing heart health. It appears vitamin B6 may work by improving certain functions in the body that support heart health, such as better blood vessel function and reduced levels of harmful substances.
Overall, our findings suggest that vitamin B6 could serve as a promising agent in preventing coronary heart disease, but more research is necessary to fully explore its benefits and practical applications in humans.
References
- Al-Khawlani MA, Al-Madhagi WM, Sabati AM, ALomaisi SAMA, Al-Najar M. Protective effects of pyridoxine, amlodipine, and their combination in a vasopressin-induced angina model in rats. Naunyn Schmiedebergs Arch Pharmacol. 2025. 10.1007/s00210-025-03905-6
- Wang XQ, Yin S, Wang QW, Bai WW, Tan RH, et al. Vitamin B6 allosterically activates AMPK to promote postischemic angiogenesis in mice. Eur J Pharmacol. 2025;993:177413. 10.1016/j.ejphar.2025.177413
- Li B, Hu M, Ma Y, Sun X, Wu D, et al. Association between Vitamin E, Vitamin B6, and Vitamin B12 with coronary heart disease. Sci Rep. 2024;14:19960. 10.1038/s41598-024-68413-8
- Song JW, Zhang ZS, Chen L, Wang QW, Xu JY, et al. Vitamin B-6 Prevents Heart Failure with Preserved Ejection Fraction Through Downstream of Kinase 3 in a Mouse Model. J Nutr. 2024;154:3031. 10.1016/j.tjnut.2024.08.006
- Agraib LM, Al-Shami I, Alkhatib B, Hasan H. The impact of energy releasing B-vitamin intake on indices of obesity and cardiac function: a cross-sectional study. F1000Res. 2023;12:1382.
- D'Haese S, Claes L, Jaeken E, Deluyker D, Evens L, et al. Pyridoxamine Alleviates Cardiac Fibrosis and Oxidative Stress in Western Diet-Induced Prediabetic Rats. Int J Mol Sci. 2024;25. 10.3390/ijms25158508
- Haesen S, Verghote E, Heeren E, Wolfs E, Deluyker D, et al. Pyridoxamine Attenuates Doxorubicin-Induced Cardiomyopathy without Affecting Its Antitumor Effect on Rat Mammary Tumor Cells. Cells. 2024;13. 10.3390/cells13020120
- Faingold II, Smolina AV, Soldatova YV, Poletaeva DA, Balakina AA, et al. Cardioprotective Effect of 2-Ethyl-3-Hydroxy-6-Methylpyridinium 2-Nitroxysuccinate Against Adrenaline/Hydrocortisone-Induced Myocardial Ischemia in Mice: Modulation of Free-Radical Processes in Biomembranes and Monoamine Oxidase A Activity. Cell Biochem Biophys. 2024;82:235. 10.1007/s12013-023-01203-7
- Sun RL, Wang HH, Gui ZC, Lin LB, Fan JX, et al. Protective effect of vitamin B against doxorubicin-induced cardiotoxicity by modulating NHE1 expression. J Biochem Mol Toxicol. 2023;37:e23403. 10.1002/jbt.23403
- Hanssen NMJ, Tikellis C, Pickering RJ, Dragoljevic D, Lee MKS, et al. Pyridoxamine prevents increased atherosclerosis by intermittent methylglyoxal spikes in the aortic arches of ApoE mice. Biomed Pharmacother. 2023;158:114211. 10.1016/j.biopha.2022.114211
- Bajic Z, Sobot T, Skrbic R, Stojiljkovic MP, Ponorac N, et al. Homocysteine, Vitamins B6 and Folic Acid in Experimental Models of Myocardial Infarction and Heart Failure-How Strong Is That Link?. Biomolecules. 2022;12. 10.3390/biom12040536
- Hu L, Li Y, Liu Z, Fan F, Xu B, et al. Association of Plasma Vitamin B6 With Coronary Heart Disease in Patients Undergoing Diagnostic Coronary Angiography: New Insight on Sex Differences. Front Cardiovasc Med. 2021;8:789669. 10.3389/fcvm.2021.789669
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