Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 17 Researches
7.5
USERS' SCORE
Good
Based on 9 Reviews
8.3
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Vitamin B6 (as pyridoxine HCl and pyridoxal-5-phosphate)
50 mg
2,941%
Top Medical Research Studies
9
We evaluated the effects of various treatments for nausea during early pregnancy, focusing on pyridoxine, or vitamin B6. Analyzing 28 trials, we found that pyridoxine showed promise in reducing nausea severity for those with milder symptoms. While anti-emetic medications overall helped reduce nausea significantly, we noted that more information is needed on their side effects and impact on fetal outcomes. Nevertheless, pyridoxine stands out as a useful option, with no evidence linking it to adverse fetal effects.
Read More
9
Vitamin B6 reduces pregnancy nausea
We assessed various methods for treating nausea and vomiting during early pregnancy, finding that vitamin B6 (pyridoxine) shows promise in easing nausea severity. Our analysis included 28 randomized trials, with many differing in quality. Among milder nausea cases, treatments like antihistamines and pyridoxine emerged as effective. Although we found consistent data supporting anti-emetic medication overall, some newer treatments like P6 acupressure were inconclusive. Importantly, no significant fetal risks were reported from these interventions.
Read More
8
B6 pyridoxine effective for nausea
We observed that high-quality research on over-the-counter medications during pregnancy, particularly for nausea, is somewhat scarce. However, vitamin B6, or pyridoxine, stands out as a safe and effective treatment for nausea and vomiting in pregnant women. Alongside this, H1 antihistamines and ginger are also recommended.
Nonpharmacologic approaches are usually advised as a first step. This is crucial since the safety of both maternal and fetal health needs to be prioritized when exploring treatment options during pregnancy.
Nonpharmacologic approaches are usually advised as a first step. This is crucial since the safety of both maternal and fetal health needs to be prioritized when exploring treatment options during pregnancy.
Read More
Most Useful Reviews
7.5
Effective against nausea
22 people found this helpful
Better than tablets. I take unisom and B6 to help with extreme pregnancy nausea. I cannot swallow B6 tablets because my gag reflex is too sensitive this pregnancy. Most of the time, I'm able to get these B6 capsules down easily. They are a standard size, flavourless, etc. They work well but are considerably more expensive than the tablets. However, it is better than continuing to vomit daily.
Read More
9
Morning sickness help
3 people found this helpful
Since taking unisom and vitamin B6 as prescribed by my midwife, I've not experienced any morning nausea at all, provided I have the right unisom!
Read More
9
Morning sickness relief
2 people found this helpful
I took it for nausea and dizziness during pregnancy, and I noticed an improvement from the first use; I no longer experience morning sickness. I also took it with magnesium to enhance absorption and improve sleep quality, taking it at night before bed.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 17 Researches
7.5
- All Researches
9
Pyridoxine alleviates pregnancy nausea
We delved into the effects of pyridoxine, or Vitamin B6, on nausea and vomiting during pregnancy, a common concern for many expectant mothers. By examining various studies, we found that out of 18 selected, eight showed clear benefits from using pyridoxine alone.
Furthermore, six additional studies indicated positive results when pyridoxine was combined with other treatments. Overall, our findings suggest that pyridoxine supplementation can significantly alleviate nausea symptoms during pregnancy.
Furthermore, six additional studies indicated positive results when pyridoxine was combined with other treatments. Overall, our findings suggest that pyridoxine supplementation can significantly alleviate nausea symptoms during pregnancy.
Read More
9
We evaluated the effects of various treatments for nausea during early pregnancy, focusing on pyridoxine, or vitamin B6. Analyzing 28 trials, we found that pyridoxine showed promise in reducing nausea severity for those with milder symptoms. While anti-emetic medications overall helped reduce nausea significantly, we noted that more information is needed on their side effects and impact on fetal outcomes. Nevertheless, pyridoxine stands out as a useful option, with no evidence linking it to adverse fetal effects.
Read More
9
Vitamin B6 reduces pregnancy nausea
We assessed various methods for treating nausea and vomiting during early pregnancy, finding that vitamin B6 (pyridoxine) shows promise in easing nausea severity. Our analysis included 28 randomized trials, with many differing in quality. Among milder nausea cases, treatments like antihistamines and pyridoxine emerged as effective. Although we found consistent data supporting anti-emetic medication overall, some newer treatments like P6 acupressure were inconclusive. Importantly, no significant fetal risks were reported from these interventions.
Read More
9
We examined how well doxylamine and pyridoxine, known as Diclectin, help reduce nausea and vomiting during pregnancy. This condition impacts around 80% of pregnant women, making effective treatment crucial. Several randomized, controlled trials have demonstrated Diclectin's effectiveness, ensuring it is safe for use in this context. Our analysis aims to correct misconceptions about its safety, confirming it is a viable option for those struggling with pregnancy-related nausea.
Read More
8
B6 pyridoxine effective for nausea
We observed that high-quality research on over-the-counter medications during pregnancy, particularly for nausea, is somewhat scarce. However, vitamin B6, or pyridoxine, stands out as a safe and effective treatment for nausea and vomiting in pregnant women. Alongside this, H1 antihistamines and ginger are also recommended.
Nonpharmacologic approaches are usually advised as a first step. This is crucial since the safety of both maternal and fetal health needs to be prioritized when exploring treatment options during pregnancy.
Nonpharmacologic approaches are usually advised as a first step. This is crucial since the safety of both maternal and fetal health needs to be prioritized when exploring treatment options during pregnancy.
Read More
User Reviews
USERS' SCORE
Good
Based on 9 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Effective against nausea
22 people found this helpful
Better than tablets. I take unisom and B6 to help with extreme pregnancy nausea. I cannot swallow B6 tablets because my gag reflex is too sensitive this pregnancy. Most of the time, I'm able to get these B6 capsules down easily. They are a standard size, flavourless, etc. They work well but are considerably more expensive than the tablets. However, it is better than continuing to vomit daily.
Read More
9
Morning sickness help
3 people found this helpful
Since taking unisom and vitamin B6 as prescribed by my midwife, I've not experienced any morning nausea at all, provided I have the right unisom!
Read More
9
Morning sickness relief
2 people found this helpful
I took it for nausea and dizziness during pregnancy, and I noticed an improvement from the first use; I no longer experience morning sickness. I also took it with magnesium to enhance absorption and improve sleep quality, taking it at night before bed.
Read More
9
Nausea improvement
1 people found this helpful
I took Vitamin B6, recommended by Dr. Karim Ali, during my early pregnancy for nausea. Its quality was excellent and truly helped. I also combined it with magnesium glycinate for improved sleep quality and to calm my nervous system.
Read More
9
Nausea support
Excellent value. This was just what I needed to alleviate my nausea during the first trimester. I believe it’s worth the price for its quality and simple ingredients.
Read More
Frequently Asked Questions
9
Morning sickness relief
2 people found this helpful
I took it for nausea and dizziness during pregnancy, and I noticed an improvement from the first use; I no longer experience morning sickness. I also took it with magnesium to enhance absorption and improve sleep quality, taking it at night before bed.
9
Nausea improvement
1 people found this helpful
I took Vitamin B6, recommended by Dr. Karim Ali, during my early pregnancy for nausea. Its quality was excellent and truly helped. I also combined it with magnesium glycinate for improved sleep quality and to calm my nervous system.
9
Nausea support
Excellent value. This was just what I needed to alleviate my nausea during the first trimester. I believe it’s worth the price for its quality and simple ingredients.
7.5
Energy boost
Excellent. I took it to relieve pregnancy nausea. It contains folic acid, provides energy, and effectively supports the nervous system.
7.5
Nausea control
A very suitable dose to manage nausea.
7
Pyridoxine offers mild nausea relief
We assessed the effectiveness of pyridoxine (vitamin B6) in treating nausea and vomiting of pregnancy (NVP) compared to ginger and placebo. Our triple-blind clinical trial involved 77 pregnant women experiencing mild to moderate NVP. After four days of treatment, we saw significant reductions in nausea and vomiting for all groups.
However, while pyridoxine helped, ginger proved to be more effective overall. Importantly, there was no substantial difference in effectiveness between the ginger and vitamin B6 groups. Hence, both options can be considered useful, with ginger leading slightly in alleviating nausea.
However, while pyridoxine helped, ginger proved to be more effective overall. Importantly, there was no substantial difference in effectiveness between the ginger and vitamin B6 groups. Hence, both options can be considered useful, with ginger leading slightly in alleviating nausea.
9
Pyridoxine alleviates pregnancy nausea
We delved into the effects of pyridoxine, or Vitamin B6, on nausea and vomiting during pregnancy, a common concern for many expectant mothers. By examining various studies, we found that out of 18 selected, eight showed clear benefits from using pyridoxine alone.
Furthermore, six additional studies indicated positive results when pyridoxine was combined with other treatments. Overall, our findings suggest that pyridoxine supplementation can significantly alleviate nausea symptoms during pregnancy.
Furthermore, six additional studies indicated positive results when pyridoxine was combined with other treatments. Overall, our findings suggest that pyridoxine supplementation can significantly alleviate nausea symptoms during pregnancy.
7
We explored the effectiveness of pyridoxine, or Vitamin B6, as a preventive measure against postoperative nausea and vomiting (PONV) in patients undergoing gynecological laparoscopic surgery. In this randomized controlled trial, participants received either pyridoxine or a placebo along with standard anti-nausea medications.
Our findings indicated that those in the pyridoxine group experienced a lower incidence of PONV. However, further research across multiple centers is essential to confirm these promising results and establish broader applicability for diverse patient populations.
Our findings indicated that those in the pyridoxine group experienced a lower incidence of PONV. However, further research across multiple centers is essential to confirm these promising results and establish broader applicability for diverse patient populations.
8
We conducted a study assessing whether ginger can effectively treat nausea in pregnancy, similar to vitamin B6. In our research, we involved 291 women who were less than 16 weeks pregnant, comparing the effects of 1.05 g of ginger daily to 75 mg of vitamin B6 over three weeks.
The results showed that ginger and vitamin B6 were equally effective in reducing nausea, retching, and vomiting symptoms. This demonstrates that for those seeking relief during early pregnancy, both remedies can offer comparable benefits.
The results showed that ginger and vitamin B6 were equally effective in reducing nausea, retching, and vomiting symptoms. This demonstrates that for those seeking relief during early pregnancy, both remedies can offer comparable benefits.
7
We reviewed multiple studies to explore the effectiveness of B6 pyridoxine in treating nausea during pregnancy. Our analysis included 78 studies with nearly 9,000 participants, focusing on various remedies.
We found that B6 pyridoxine, along with ginger and antihistamines, showed a clear benefit for mild nausea symptoms compared to a placebo. For moderate symptoms, a combination of B6 and doxylamine was noted to potentially reduce recurrence rates when taken preemptively.
However, overall, the quality of evidence remains low, which suggests that while pyridoxine can help, more research is needed to fully understand its effects.
We found that B6 pyridoxine, along with ginger and antihistamines, showed a clear benefit for mild nausea symptoms compared to a placebo. For moderate symptoms, a combination of B6 and doxylamine was noted to potentially reduce recurrence rates when taken preemptively.
However, overall, the quality of evidence remains low, which suggests that while pyridoxine can help, more research is needed to fully understand its effects.
4
We investigated the use of vitamin B6 as a common treatment for nausea and vomiting during pregnancy. There has been an ongoing discussion about how effective high doses of this vitamin actually are, and we wanted to shed light on this issue.
Through a systematic review of literature, we examined various studies, focusing on reports that highlighted the effects of high doses of vitamin B6 on pregnant women experiencing nausea. While we found that many women do turn to vitamin B6 to alleviate their symptoms, particularly during the challenging first trimester, the data also raised serious concerns about potential side effects.
A significant portion of the studies reviewed documented adverse reactions in women taking excessive amounts of vitamin B6. These included neurological symptoms such as burning sensations, tingling, and coordination problems. Alarmingly, we also noted a few cases of miscarriage and intrauterine demise among those studied.
Overall, while vitamin B6 is a widely used treatment for nausea during pregnancy, we must exercise caution. The risks associated with high doses cannot be overlooked, particularly when it comes to the health of both the mother and the developing fetus.
Through a systematic review of literature, we examined various studies, focusing on reports that highlighted the effects of high doses of vitamin B6 on pregnant women experiencing nausea. While we found that many women do turn to vitamin B6 to alleviate their symptoms, particularly during the challenging first trimester, the data also raised serious concerns about potential side effects.
A significant portion of the studies reviewed documented adverse reactions in women taking excessive amounts of vitamin B6. These included neurological symptoms such as burning sensations, tingling, and coordination problems. Alarmingly, we also noted a few cases of miscarriage and intrauterine demise among those studied.
Overall, while vitamin B6 is a widely used treatment for nausea during pregnancy, we must exercise caution. The risks associated with high doses cannot be overlooked, particularly when it comes to the health of both the mother and the developing fetus.
References
- Zhang Q, Ye X, Shi S, Zhou S, Ma D, et al. Pyridoxine Prevents Postoperative Nausea and Vomiting in Gynecological Laparoscopic Surgery: A Double-blind Randomized Controlled Trial. Anesthesiology. 2024. doi:10.1097/ALN.0000000000005354
- Powers EA, Tewell R, Bayard M. Over-the-Counter Medications in Pregnancy. Am Fam Physician. 2023;108:360.
- Jayawardena R, Majeed S, Sooriyaarachchi P, Abeywarne U, Ranaweera P. The effects of pyridoxine (vitamin B6) supplementation in nausea and vomiting during pregnancy: a systematic review and meta-analysis. Arch Gynecol Obstet. 2023;308:1075. doi:10.1007/s00404-023-06925-w
- Ostby SA, Smith HJ, Leath CA. Pyridoxine for prevention and treatment of PARP inhibitor induced nausea and vomiting. Gynecol Oncol Rep. 2019;29:123. doi:10.1016/j.gore.2019.07.005
- Khorasani F, Aryan H, Sobhi A, Aryan R, Abavi-Sani A, et al. A systematic review of the efficacy of alternative medicine in the treatment of nausea and vomiting of pregnancy. J Obstet Gynaecol. 2020;40:10. doi:10.1080/01443615.2019.1587392
- Sharifzadeh F, Kashanian M, Koohpayehzadeh J, Rezaian F, Sheikhansari N, et al. A comparison between the effects of ginger, pyridoxine (vitamin B6) and placebo for the treatment of the first trimester nausea and vomiting of pregnancy (NVP). J Matern Fetal Neonatal Med. 2018;31:2509. doi:10.1080/14767058.2017.1344965
- McParlin C, O'Donnell A, Robson SC, Beyer F, Moloney E, et al. Treatments for Hyperemesis Gravidarum and Nausea and Vomiting in Pregnancy: A Systematic Review. JAMA. 2016;316:1392. doi:10.1001/jama.2016.14337
- Boelig RC, Barton SJ, Saccone G, Kelly AJ, Edwards SJ, et al. Interventions for treating hyperemesis gravidarum. Cochrane Database Syst Rev. 2016;2016:CD010607. doi:10.1002/14651858.CD010607.pub2
- Jewell D, Young G. WITHDRAWN: Interventions for nausea and vomiting in early pregnancy. Cochrane Database Syst Rev. 2010;2010:CD000145. doi:10.1002/14651858.CD000145.pub2
- Smith C, Crowther C, Willson K, Hotham N, McMillian V. A randomized controlled trial of ginger to treat nausea and vomiting in pregnancy. Obstet Gynecol. 2004;103:639.
- Jewell D, Young G. Interventions for nausea and vomiting in early pregnancy. Cochrane Database Syst Rev. 2003.
- Boskovic R, Einarson A, Maltepe C, Wolpin J, Koren G. Diclectin therapy for nausea and vomiting of pregnancy: effects of optimal dosing. J Obstet Gynaecol Can. 2003;25:830.
- Jewell D, Young G. Interventions for nausea and vomiting in early pregnancy. Cochrane Database Syst Rev. 2002.
- Bishai R, Mazzotta P, Atanackovic G, Levichek Z, Pole M, et al. Critical appraisal of drug therapy for nausea and vomiting of pregnancy: II. Efficacy and safety of diclectin (doxylamine-B6). Can J Clin Pharmacol. 2000;7:138.
- Jewell D, Young G. Interventions for nausea and vomiting in early pregnancy. Cochrane Database Syst Rev. 2000.
- Boneva RS, Moore CA, Botto L, Wong LY, Erickson JD. Nausea during pregnancy and congenital heart defects: a population-based case-control study. Am J Epidemiol. 1999;149:717.
- He L, Fan Y, Hu Y, Tian C, Tian Y, et al. The potential hazards of high doses of vitamin B6 in treating nausea and vomiting in pregnancy: A systematic review. Int J Gynaecol Obstet. 2024. doi:10.1002/ijgo.16032
