Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 23 Researches
7.8
USERS' SCORE
Good
Based on 1 Review
8.5
Top Medical Research Studies
8
We explored how vitamin D plays a role in managing rheumatoid arthritis (RA), a condition that causes joint inflammation and discomfort. It's been found that many people with RA often suffer from vitamin D deficiency, which may worsen their symptoms and overall disease severity.
Our review indicates that vitamin D could help modulate immune responses and lower inflammation levels. Supplementing with vitamin D has shown potential in improving various disease activity markers, signaling that it could be a valuable addition to treatment strategies for RA.
Besides vitamin D, we also looked at other important vitamins like B12, C, and K. While vitamin D stands out for its immune benefits, B12 supports energy and neurological health, C helps with collagen production and inflammation reduction, and K contributes to bone health.
Together, these vitamins create a comprehensive approach to managing RA, emphasizing the need for further research to determine the best ways to use them effectively.
Our review indicates that vitamin D could help modulate immune responses and lower inflammation levels. Supplementing with vitamin D has shown potential in improving various disease activity markers, signaling that it could be a valuable addition to treatment strategies for RA.
Besides vitamin D, we also looked at other important vitamins like B12, C, and K. While vitamin D stands out for its immune benefits, B12 supports energy and neurological health, C helps with collagen production and inflammation reduction, and K contributes to bone health.
Together, these vitamins create a comprehensive approach to managing RA, emphasizing the need for further research to determine the best ways to use them effectively.
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We set out to explore the potential benefits of vitamin D supplementation for people suffering from end-stage knee osteoarthritis (OA). Our research took the form of a double-blinded, randomized controlled trial involving 56 patients with vitamin D insufficiency. This careful design allowed us to compare the effects of vitamin D against a placebo, ensuring that neither the patients nor the assessors knew who received what treatment.
Over six months, participants in the vitamin D group took capsules containing 4,000 IU daily, while the others received a placebo. We measured muscle strength, pain levels, physical function, and signs of sarcopenia at several points: at the start, after three months, and again at the six-month mark.
We aimed to see whether this cost-effective and well-tolerated supplement could improve quality of life by boosting muscle strength and reducing pain for knee OA patients. Given the growing number of people waiting for knee replacements in Hong Kong, our findings could have significant implications for patient care.
Our study's findings may help clarify whether vitamin D supplementation is a viable option for alleviating some symptoms associated with knee osteoarthritis. With ongoing interest in non-surgical therapies, understanding the role of vitamin D (particularly in muscle health) is more relevant than ever.
Over six months, participants in the vitamin D group took capsules containing 4,000 IU daily, while the others received a placebo. We measured muscle strength, pain levels, physical function, and signs of sarcopenia at several points: at the start, after three months, and again at the six-month mark.
We aimed to see whether this cost-effective and well-tolerated supplement could improve quality of life by boosting muscle strength and reducing pain for knee OA patients. Given the growing number of people waiting for knee replacements in Hong Kong, our findings could have significant implications for patient care.
Our study's findings may help clarify whether vitamin D supplementation is a viable option for alleviating some symptoms associated with knee osteoarthritis. With ongoing interest in non-surgical therapies, understanding the role of vitamin D (particularly in muscle health) is more relevant than ever.
Read More
9
We explored how vitamin D (VD) affects osteoarthritis (OA), a condition that commonly leads to joint pain and stiffness. Our research focused on the idea that vitamin D might help reduce inflammation and tissue damage driven by the NF-κB pathway, a crucial player in OA development.
To investigate this, we examined the effects of vitamin D on chondrocytes—cells responsible for cartilage health. By observing how vitamin D influences these cells, we found that it does indeed help maintain cartilage integrity. The study highlighted that vitamin D stabilizes the NF-κB pathway, which normally promotes inflammation, and by doing so, it encourages cellular processes like autophagy that are essential for keeping the cartilage healthy.
We observed significant changes in cartilage condition when vitamin D's role was emphasized, suggesting that vitamin D could be a valuable ally in managing OA symptoms. These findings recommend vitamin D as a potential therapeutic strategy for arthritis, opening new avenues for treatment options that could improve joint health and function for people dealing with this challenging condition.
To investigate this, we examined the effects of vitamin D on chondrocytes—cells responsible for cartilage health. By observing how vitamin D influences these cells, we found that it does indeed help maintain cartilage integrity. The study highlighted that vitamin D stabilizes the NF-κB pathway, which normally promotes inflammation, and by doing so, it encourages cellular processes like autophagy that are essential for keeping the cartilage healthy.
We observed significant changes in cartilage condition when vitamin D's role was emphasized, suggesting that vitamin D could be a valuable ally in managing OA symptoms. These findings recommend vitamin D as a potential therapeutic strategy for arthritis, opening new avenues for treatment options that could improve joint health and function for people dealing with this challenging condition.
Read More
Most Useful Reviews
9
Life-changing treatment
70 people found this helpful
Gave me my life back - rheumatoid arthritis. After almost a decade of rheumatoid arthritis and being on Enbrel, I found myself still in pain daily. I researched and tried 10,000 IU of vitamin D daily. Surprisingly, within two weeks, I noticed a significant reduction in pain and even forgot I had arthritis! My anxiety decreased, and I regained energy to engage with my children. I am now living fully, running, dancing, and playing with them, something I thought I had lost. Though I still take Enbrel, my goal is to transition to the vitamin D approach fully under medical supervision. I am thrilled with the results!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 23 Researches
7.8
- All Researches
9
We explored how vitamin D (VD) affects osteoarthritis (OA), a condition that commonly leads to joint pain and stiffness. Our research focused on the idea that vitamin D might help reduce inflammation and tissue damage driven by the NF-κB pathway, a crucial player in OA development.
To investigate this, we examined the effects of vitamin D on chondrocytes—cells responsible for cartilage health. By observing how vitamin D influences these cells, we found that it does indeed help maintain cartilage integrity. The study highlighted that vitamin D stabilizes the NF-κB pathway, which normally promotes inflammation, and by doing so, it encourages cellular processes like autophagy that are essential for keeping the cartilage healthy.
We observed significant changes in cartilage condition when vitamin D's role was emphasized, suggesting that vitamin D could be a valuable ally in managing OA symptoms. These findings recommend vitamin D as a potential therapeutic strategy for arthritis, opening new avenues for treatment options that could improve joint health and function for people dealing with this challenging condition.
To investigate this, we examined the effects of vitamin D on chondrocytes—cells responsible for cartilage health. By observing how vitamin D influences these cells, we found that it does indeed help maintain cartilage integrity. The study highlighted that vitamin D stabilizes the NF-κB pathway, which normally promotes inflammation, and by doing so, it encourages cellular processes like autophagy that are essential for keeping the cartilage healthy.
We observed significant changes in cartilage condition when vitamin D's role was emphasized, suggesting that vitamin D could be a valuable ally in managing OA symptoms. These findings recommend vitamin D as a potential therapeutic strategy for arthritis, opening new avenues for treatment options that could improve joint health and function for people dealing with this challenging condition.
Read More
9
We conducted an insightful study to explore how vitamin D3 supplementation might affect rheumatoid arthritis (RA) symptoms, particularly focusing on disease activity and fatigue. This research involved a total of 68 RA patients who were monitored over a period of 12 weeks.
Our participants were divided into two groups. One group received a weekly dose of 50,000 IU of vitamin D3 alongside their conventional arthritis medications. The other group continued with their standard treatment regimen without any vitamin D3.
As we evaluated the outcomes, we found that the group receiving vitamin D3 exhibited significant improvements. Specifically, they showed enhanced levels of vitamin D and reported lower fatigue, as measured by the FACIT-F score. While both groups initially presented similar health characteristics, those on vitamin D3 achieved a normal range in fatigue levels compared to the continued struggle within the other group.
Interestingly, we observed a positive correlation between higher vitamin D levels and improved fatigue scores, indicating that vitamin D3 could indeed play a beneficial role in managing symptoms associated with rheumatoid arthritis. However, disease activity scores did not show a strong significant correlation with vitamin D levels, suggesting that more research may be necessary to understand this relationship fully.
Our participants were divided into two groups. One group received a weekly dose of 50,000 IU of vitamin D3 alongside their conventional arthritis medications. The other group continued with their standard treatment regimen without any vitamin D3.
As we evaluated the outcomes, we found that the group receiving vitamin D3 exhibited significant improvements. Specifically, they showed enhanced levels of vitamin D and reported lower fatigue, as measured by the FACIT-F score. While both groups initially presented similar health characteristics, those on vitamin D3 achieved a normal range in fatigue levels compared to the continued struggle within the other group.
Interestingly, we observed a positive correlation between higher vitamin D levels and improved fatigue scores, indicating that vitamin D3 could indeed play a beneficial role in managing symptoms associated with rheumatoid arthritis. However, disease activity scores did not show a strong significant correlation with vitamin D levels, suggesting that more research may be necessary to understand this relationship fully.
Read More
9
We explored the link between vitamin D3 and knee osteoarthritis (OA) by examining both young and older mice. Our findings revealed that a deficiency in vitamin D3, specifically the active form known as 1,25(OH)D, significantly sped up the development of age-related OA. This included issues such as cartilage damage and increased chondrocyte senescence.
When we supplemented with vitamin D3, we were pleased to see a reversal of these negative changes in OA phenotypes among the test mice. It not only improved cartilage health but also countered oxidative stress and cell aging associated with OA.
Our research highlights the important role of vitamin D3 in maintaining joint health and its potential to help prevent or slow down the onset of OA through mechanisms involving Sirt1, a gene linked to aging and cellular health. This suggests that ensuring sufficient levels of vitamin D3 could be a useful strategy for those at risk of developing arthritis.
When we supplemented with vitamin D3, we were pleased to see a reversal of these negative changes in OA phenotypes among the test mice. It not only improved cartilage health but also countered oxidative stress and cell aging associated with OA.
Our research highlights the important role of vitamin D3 in maintaining joint health and its potential to help prevent or slow down the onset of OA through mechanisms involving Sirt1, a gene linked to aging and cellular health. This suggests that ensuring sufficient levels of vitamin D3 could be a useful strategy for those at risk of developing arthritis.
Read More
8
We explored the effects of vitamin D supplementation on adults with rheumatoid arthritis (RA), an inflammatory condition affecting millions worldwide. By examining clinical studies that compared vitamin D to either a placebo or standard care, we focused on how these supplements might influence various health outcomes for those suffering from RA.
Our analysis included 11 studies, highlighting several noteworthy findings. We observed a significant improvement in key measures: the Disease Activity Score 28 (DAS-28) showed a meaningful reduction, while levels of C-reactive protein (CRP) and the erythrocyte sedimentation rate (ESR) also decreased. Furthermore, vitamin D supplementation led to an increase in serum vitamin D levels.
Despite these positive results, vitamin D supplementation did not appear to significantly impact the health assessment questionnaire (HAQ) and visual analog scale for pain (VAS-pain) scores. Consequently, while vitamin D can help reduce inflammation and improve specific health parameters in RA patients, the optimal dosage and duration of treatment remain unclear.
Overall, our findings suggest that boosting vitamin D levels might offer benefits for managing RA, and further research may help refine treatment strategies for optimal outcomes.
Our analysis included 11 studies, highlighting several noteworthy findings. We observed a significant improvement in key measures: the Disease Activity Score 28 (DAS-28) showed a meaningful reduction, while levels of C-reactive protein (CRP) and the erythrocyte sedimentation rate (ESR) also decreased. Furthermore, vitamin D supplementation led to an increase in serum vitamin D levels.
Despite these positive results, vitamin D supplementation did not appear to significantly impact the health assessment questionnaire (HAQ) and visual analog scale for pain (VAS-pain) scores. Consequently, while vitamin D can help reduce inflammation and improve specific health parameters in RA patients, the optimal dosage and duration of treatment remain unclear.
Overall, our findings suggest that boosting vitamin D levels might offer benefits for managing RA, and further research may help refine treatment strategies for optimal outcomes.
Read More
8
We aimed to understand how vitamin D deficiency impacts elderly people suffering from osteoarthritis (OA) in their hips and knees. Our study involved 105 OA patients and 152 healthy individuals to compare their vitamin D levels and functional abilities, using criteria like the WOMAC questionnaire to assess pain and functional impairment.
Our findings revealed that patients with low vitamin D levels experienced more severe OA symptoms. They reported higher pain levels and greater difficulties in daily activities compared to those with normal vitamin D levels. Furthermore, their vitamin D deficiency was associated with increased levels of inflammatory markers, TNF-α and IL-6, suggesting a link between inflammation and vitamin D status.
Ultimately, the evidence indicates that maintaining adequate vitamin D levels may be crucial in managing the symptoms of hip and knee osteoarthritis. While further research is necessary to fully understand these relationships, our results hint at the potential benefits of vitamin D supplementation to help alleviate OA symptoms and slow disease progression.
Our findings revealed that patients with low vitamin D levels experienced more severe OA symptoms. They reported higher pain levels and greater difficulties in daily activities compared to those with normal vitamin D levels. Furthermore, their vitamin D deficiency was associated with increased levels of inflammatory markers, TNF-α and IL-6, suggesting a link between inflammation and vitamin D status.
Ultimately, the evidence indicates that maintaining adequate vitamin D levels may be crucial in managing the symptoms of hip and knee osteoarthritis. While further research is necessary to fully understand these relationships, our results hint at the potential benefits of vitamin D supplementation to help alleviate OA symptoms and slow disease progression.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Life-changing treatment
70 people found this helpful
Gave me my life back - rheumatoid arthritis. After almost a decade of rheumatoid arthritis and being on Enbrel, I found myself still in pain daily. I researched and tried 10,000 IU of vitamin D daily. Surprisingly, within two weeks, I noticed a significant reduction in pain and even forgot I had arthritis! My anxiety decreased, and I regained energy to engage with my children. I am now living fully, running, dancing, and playing with them, something I thought I had lost. Though I still take Enbrel, my goal is to transition to the vitamin D approach fully under medical supervision. I am thrilled with the results!
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Ranjbar M, Rahimlou M, Fallah M, Djafarian K, Mohammadi H. Effects of vitamin D supplementation in patients with rheumatoid arthritis: A systematic review and meta-analysis. Heliyon. 2025;11:e42463. doi:10.1016/j.heliyon.2025.e42463
- Montemor CN, Fernandes MTP, Marquez AS, Bignardi PR, Poli RC, et al. Impact of Reduced Vitamin D Levels on Pain, Function, and Severity in Knee or Hip Osteoarthritis. Nutrients. 2025;17. doi:10.3390/nu17030447
- Mende LK, Kuthati Y, Wong CS. Curcumin and Vitamin D Supplement Attenuates Knee Osteoarthritis Progression in ACLT + MMx Rat Model: Effect on Cartilage Protection and Pain Reduction. Nutrients. 2025;17. doi:10.3390/nu17020349
- Arellano Pérez Vertti RD, Arellano Ramírez DO, González Galarza FF, Prieto Hinojosa AI, Méndez Hernández A, et al. "Association of vitamin D blood deficiency and the rs731236 polymorphism vitamin D receptor with primary knee osteoarthritis in subjects from Mexico". Clin Rheumatol. 2025;44:1329. doi:10.1007/s10067-025-07332-z
- Rafati A, Ramezani R, Esmaeili Gouvarchin Ghaleh H, Bahrami S, Alvanegh AG, et al. Calcitriol Treated Mesenchymal Stem Cells Modulated Immune Response in Collagen-Induced Rheumatoid Arthritis in BALB/c Mice. Transplant Proc. 2025;57:355. doi:10.1016/j.transproceed.2024.12.020
- Liu P, Zhou J, Cui H, Xu J, Ruan G, et al. 1,25(OH)D induces chondrocyte autophagy and reduces the loss of proteoglycans in osteoarthritis through inhibiting the NF-κB pathway. Clin Rheumatol. 2025;44:811. doi:10.1007/s10067-024-07281-z
- Hijjawi N, Tout FS, Azaizeh B, Aljaafreh B. The role of vitamins D, B12, C, and K in modulating inflammation and disease management in rheumatoid arthritis: a comprehensive review. Clin Rheumatol. 2025;44:591. doi:10.1007/s10067-024-07285-9
- Gottreich JR, Katz JN, Jones MH. Nonsurgical Knee Osteoarthritis Treatments for Reducing Inflammation as Measured on MRI Scans: A Systematic Review of Randomized Controlled Trials. Orthop J Sports Med. 2024;12:23259671241272667. doi:10.1177/23259671241272667
- Zuo A, Jia Q, Zhang M, Zhou X, Li T, et al. The association of vitamin D with knee osteoarthritis pain: an analysis from the Osteoarthritis Initiative database. Sci Rep. 2024;14:30176. doi:10.1038/s41598-024-81845-6
- Wielińska J, Górna K, Świerkot J, Bugaj B, Kolossa K, et al. Polymorphic Variants in the Vitamin D Receptor and Clinical Parameters of Rheumatoid Arthritis Patients Undergoing Anti-TNF Treatment. Arch Immunol Ther Exp (Warsz). 2024;72. doi:10.2478/aite-2024-0023
- Cai Z, Zhang Z, Leng J, Xie M, Zhang K, et al. β-Hydroxybutyrate ameliorates osteoarthritis through activation of the ERBB3 signaling pathway in mice. J Bone Miner Res. 2024;40:140. doi:10.1093/jbmr/zjae176
- Luo H, Zhang Y, Meng C, Li C, Jia D, et al. The effect of copper and vitamin D on osteoarthritis outcomes: A Mendelian randomization study. Medicine (Baltimore). 2024;103:e39828. doi:10.1097/MD.0000000000039828
- Zang K, Bhatia R, Xue E, Bennett KJ, Luo KH, et al. Vitamin D as a Modifiable Risk Factor for Juvenile Idiopathic Arthritis: A Systematic Review and Meta-analysis of Observational Studies Comparing Baseline Vitamin D in Children with JIA to Individuals Without. Nutr Rev. 2024. doi:10.1093/nutrit/nuae148
- Kirikovich SS, Levites EV, Proskurina AS, Ritter GS, Dolgova EV, et al. Production of GcMAF with Anti-Inflammatory Properties and Its Effect on Models of Induced Arthritis in Mice and Cystitis in Rats. Curr Issues Mol Biol. 2024;46:10934. doi:10.3390/cimb46100650
- Feng Y, Zhu P, Yan D, Wang X, Chen C, et al. Implications of vitamin D levels or status for mortality in rheumatoid arthritis: analysis of 2001-2018 data from the National Health and Nutrition Examination Survey. Front Immunol. 2024;15:1425119. doi:10.3389/fimmu.2024.1425119
- Wang QW, Ong MT, Man GC, Yeung YM, He X, et al. The effectiveness of vitamin D supplementation in patients with end-stage knee osteoarthritis: Study protocol for a double-blinded, randomized controlled trial. PLoS One. 2024;19:e0309610. doi:10.1371/journal.pone.0309610
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- Tekeli SÖ, Köse Ö, Yapar D, Tekeli FY, Asoğlu MM, et al. Relationship between serum vitamin D levels and the prevalence of knee osteoarthritis: A retrospective study on 3424 subjects. Technol Health Care. 2024;32:3649. doi:10.3233/THC-230802
- Huovinen J, Palosaari S, Pesonen P, Huhtakangas JA, Lehenkari P. 1,25(OH)D and its analogue calcipotriol inhibit the migration of human synovial and mesenchymal stromal cells in a wound healing model - A comparison with glucocorticoids. J Steroid Biochem Mol Biol. 2023;233:106373. doi:10.1016/j.jsbmb.2023.106373
- Zhu W, Zhu Y, Zhang S, Zhang W, Si Z, et al. 1,25-Dihydroxyvitamin D regulates macrophage activation through FBP1/PKR and ameliorates arthritis in TNF-transgenic mice. J Steroid Biochem Mol Biol. 2023;228:106251. doi:10.1016/j.jsbmb.2023.106251
- Chen J, Zhang J, Li J, Qin R, Lu N, et al. 1,25-Dihydroxyvitamin D Deficiency Accelerates Aging-related Osteoarthritis via Downregulation of Sirt1 in Mice. Int J Biol Sci. 2023;19:610. doi:10.7150/ijbs.78785
- Divjak A, Jovanovic I, Matic A, Lucic AT, Gajovic N, et al. The influence of vitamin D supplementation on the expression of mediators of inflammation in knee osteoarthritis. Immunol Res. 2023;71:442. doi:10.1007/s12026-022-09354-0
