Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 25 Researches
7.3
USERS' SCORE
Good
Based on 2 Reviews
8.6
Top Medical Research Studies
9
We explored how Vitamin D3 impacts autoimmune thyroiditis, a specific autoimmune disorder. In this study, researchers established a mouse model of experimental autoimmune thyroiditis (EAT) to see how Vitamin D3 could influence this condition. After eight weeks of treatment, they assessed thyroid health and immune response through various methods, including staining tissues and measuring hormone levels.
Our observations revealed that administering Vitamin D3 helped reduce damage to the thyroid and decreased the presence of inflammatory cells within the thyroid. This treatment also led to lower levels of thyroid hormones and autoimmune antibodies in the blood, highlighting its positive effect on thyroid function. Additionally, Vitamin D3 appeared to promote the regulatory T cell (Treg) subset while decreasing the levels of Th17 cells, which are often involved in autoimmune processes.
Mechanistically, the study found that Vitamin D3 triggered specific pathways that influence Treg cell activity and survival. Notably, it activated a signaling pathway involving YAP and JAK/STAT, which are crucial for immune cell regulation. These findings suggest that Vitamin D3 could play a significant role in balancing immune responses in autoimmune thyroiditis, making it a promising candidate for further research and potential treatment strategies.
Our observations revealed that administering Vitamin D3 helped reduce damage to the thyroid and decreased the presence of inflammatory cells within the thyroid. This treatment also led to lower levels of thyroid hormones and autoimmune antibodies in the blood, highlighting its positive effect on thyroid function. Additionally, Vitamin D3 appeared to promote the regulatory T cell (Treg) subset while decreasing the levels of Th17 cells, which are often involved in autoimmune processes.
Mechanistically, the study found that Vitamin D3 triggered specific pathways that influence Treg cell activity and survival. Notably, it activated a signaling pathway involving YAP and JAK/STAT, which are crucial for immune cell regulation. These findings suggest that Vitamin D3 could play a significant role in balancing immune responses in autoimmune thyroiditis, making it a promising candidate for further research and potential treatment strategies.
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9.5
Vitamin D3 aids autoimmune thyroiditis
We observed that vitamin D3 supplementation may play a significant role in managing autoimmune thyroiditis, a condition often marked by thyroid inflammation. In this study, researchers induced autoimmune thyroiditis in female mice and administered vitamin D3 to evaluate its effects on the disease.
After eight weeks of treatment, the results showed a notable reduction in thyroid damage and lower levels of thyroid autoantibodies in the mice receiving vitamin D3. Specifically, the vitamin appeared to inhibit the activity of certain inflammatory immune cells, which are typically elevated in autoimmune conditions. At the same time, it seemed to support the activity of regulatory immune cells that help keep inflammation in check.
This study highlights the potential of vitamin D3 as a therapeutic option to mitigate the effects of autoimmune thyroiditis, suggesting that it could help balance the immune response in affected individuals. As researchers continue to delve into the role of vitamin D in autoimmune disorders, findings like these support the notion that maintaining adequate vitamin D levels might be crucial for immune health.
After eight weeks of treatment, the results showed a notable reduction in thyroid damage and lower levels of thyroid autoantibodies in the mice receiving vitamin D3. Specifically, the vitamin appeared to inhibit the activity of certain inflammatory immune cells, which are typically elevated in autoimmune conditions. At the same time, it seemed to support the activity of regulatory immune cells that help keep inflammation in check.
This study highlights the potential of vitamin D3 as a therapeutic option to mitigate the effects of autoimmune thyroiditis, suggesting that it could help balance the immune response in affected individuals. As researchers continue to delve into the role of vitamin D in autoimmune disorders, findings like these support the notion that maintaining adequate vitamin D levels might be crucial for immune health.
Read More
9
We aimed to understand how vitamin D3, specifically its active form 1,25(OH)D, affects autoimmune hepatitis (AIH), a complex autoimmune disease that causes liver damage. Researchers focused on the role of a special type of immune cell known as dendritic cells (DCs), which are influenced by vitamin D3 to promote a more balanced immune response.
Through our investigation using a mouse model, we observed that injecting these vitamin D3-modulated dendritic cells, which overexpress a molecule called PD-L1, significantly lessened liver injury and severity of autoimmune hepatitis. This treatment appeared to correct the imbalance between two types of T cells: regulatory T cells (TFR) and follicular helper T cells (TFH).
By increasing the TFR population and restoring their balance with TFH cells, vitamin D3 treatment helped regulate this immune response. Additionally, the infusion boosted the production of anti-inflammatory substances while decreasing those linked to inflammation, suggesting a potential new avenue for treating autoimmune hepatitis. Overall, these findings indicate that vitamin D3-modulated dendritic cells could be a promising strategy for managing autoimmune conditions like AIH.
Through our investigation using a mouse model, we observed that injecting these vitamin D3-modulated dendritic cells, which overexpress a molecule called PD-L1, significantly lessened liver injury and severity of autoimmune hepatitis. This treatment appeared to correct the imbalance between two types of T cells: regulatory T cells (TFR) and follicular helper T cells (TFH).
By increasing the TFR population and restoring their balance with TFH cells, vitamin D3 treatment helped regulate this immune response. Additionally, the infusion boosted the production of anti-inflammatory substances while decreasing those linked to inflammation, suggesting a potential new avenue for treating autoimmune hepatitis. Overall, these findings indicate that vitamin D3-modulated dendritic cells could be a promising strategy for managing autoimmune conditions like AIH.
Read More
Most Useful Reviews
9
Life-changing discovery
70 people found this helpful
Having suffered from rheumatoid arthritis for nearly a decade, I was on Enbrel but still experiencing pain daily. Learning about the Coimbra protocol and Vitamin D changed everything for me. After boosting my intake to 10,000 IUs daily, I noticed a significant reduction in pain and improved mental clarity. I can now run and play with my kids, feeling alive again. I wholeheartedly recommend this product!
Read More
7.5
Clean ingredients matter
8 people found this helpful
I appreciate this Vitamin D for its clean ingredients, crucial as I have autoimmune disorders and intolerances to soy and dairy. I discovered many vitamins use soybean oil, preventing my body from absorbing them. I’ve begun regulating the ingredients in products I buy to ensure they are clean and non-GMO. This product gets a thumbs up from me, and I've been taking it for about a year.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 25 Researches
7.3
- All Researches
9.5
Vitamin D3 aids autoimmune thyroiditis
We observed that vitamin D3 supplementation may play a significant role in managing autoimmune thyroiditis, a condition often marked by thyroid inflammation. In this study, researchers induced autoimmune thyroiditis in female mice and administered vitamin D3 to evaluate its effects on the disease.
After eight weeks of treatment, the results showed a notable reduction in thyroid damage and lower levels of thyroid autoantibodies in the mice receiving vitamin D3. Specifically, the vitamin appeared to inhibit the activity of certain inflammatory immune cells, which are typically elevated in autoimmune conditions. At the same time, it seemed to support the activity of regulatory immune cells that help keep inflammation in check.
This study highlights the potential of vitamin D3 as a therapeutic option to mitigate the effects of autoimmune thyroiditis, suggesting that it could help balance the immune response in affected individuals. As researchers continue to delve into the role of vitamin D in autoimmune disorders, findings like these support the notion that maintaining adequate vitamin D levels might be crucial for immune health.
After eight weeks of treatment, the results showed a notable reduction in thyroid damage and lower levels of thyroid autoantibodies in the mice receiving vitamin D3. Specifically, the vitamin appeared to inhibit the activity of certain inflammatory immune cells, which are typically elevated in autoimmune conditions. At the same time, it seemed to support the activity of regulatory immune cells that help keep inflammation in check.
This study highlights the potential of vitamin D3 as a therapeutic option to mitigate the effects of autoimmune thyroiditis, suggesting that it could help balance the immune response in affected individuals. As researchers continue to delve into the role of vitamin D in autoimmune disorders, findings like these support the notion that maintaining adequate vitamin D levels might be crucial for immune health.
Read More
9
We explored an intriguing instance of IgG4-related disease (IgG4-RD) manifesting as Mikulicz syndrome in an 85-year-old male patient. This condition usually involves significant systemic symptoms, yet our patient exhibited primarily local manifestations, specifically bilateral dacryoadenitis and orbital pseudotumor, without major organ complications.
Interestingly, despite normal serum IgG4 levels, which were below 135 mg/dL, the clinical and imaging findings strongly suggested the diagnosis of IgG4-RD. This scenario underscores the importance of undertaking a biopsy for accurate diagnosis. Histopathological examination revealed notable signs, such as a dense lymphoplasmacytic infiltrate and storiform fibrosis, with a considerable percentage of IgG4-positive cells, ultimately confirming our diagnosis.
We observed that treatment with prednisone, alongside azathioprine for long-term control, was effective. To mitigate the risk of glucocorticoid-induced osteoporosis, we added calcium and vitamin D3 supplementation. Remarkably, the patient showed significant clinical improvement within just 24 hours, with resolution of orbital and glandular symptoms over the following year. There was a complete recovery of vision and no relapses, with only minor dry eye as a long-term concern.
This case demonstrates the necessity of considering IgG4-RD even when serum IgG4 levels are normal and highlights the role of histopathology in diagnosis. Furthermore, it showcases the effectiveness of corticosteroids as a first-line treatment in managing this condition.
Interestingly, despite normal serum IgG4 levels, which were below 135 mg/dL, the clinical and imaging findings strongly suggested the diagnosis of IgG4-RD. This scenario underscores the importance of undertaking a biopsy for accurate diagnosis. Histopathological examination revealed notable signs, such as a dense lymphoplasmacytic infiltrate and storiform fibrosis, with a considerable percentage of IgG4-positive cells, ultimately confirming our diagnosis.
We observed that treatment with prednisone, alongside azathioprine for long-term control, was effective. To mitigate the risk of glucocorticoid-induced osteoporosis, we added calcium and vitamin D3 supplementation. Remarkably, the patient showed significant clinical improvement within just 24 hours, with resolution of orbital and glandular symptoms over the following year. There was a complete recovery of vision and no relapses, with only minor dry eye as a long-term concern.
This case demonstrates the necessity of considering IgG4-RD even when serum IgG4 levels are normal and highlights the role of histopathology in diagnosis. Furthermore, it showcases the effectiveness of corticosteroids as a first-line treatment in managing this condition.
Read More
9
We aimed to understand how vitamin D3, specifically its active form 1,25(OH)D, affects autoimmune hepatitis (AIH), a complex autoimmune disease that causes liver damage. Researchers focused on the role of a special type of immune cell known as dendritic cells (DCs), which are influenced by vitamin D3 to promote a more balanced immune response.
Through our investigation using a mouse model, we observed that injecting these vitamin D3-modulated dendritic cells, which overexpress a molecule called PD-L1, significantly lessened liver injury and severity of autoimmune hepatitis. This treatment appeared to correct the imbalance between two types of T cells: regulatory T cells (TFR) and follicular helper T cells (TFH).
By increasing the TFR population and restoring their balance with TFH cells, vitamin D3 treatment helped regulate this immune response. Additionally, the infusion boosted the production of anti-inflammatory substances while decreasing those linked to inflammation, suggesting a potential new avenue for treating autoimmune hepatitis. Overall, these findings indicate that vitamin D3-modulated dendritic cells could be a promising strategy for managing autoimmune conditions like AIH.
Through our investigation using a mouse model, we observed that injecting these vitamin D3-modulated dendritic cells, which overexpress a molecule called PD-L1, significantly lessened liver injury and severity of autoimmune hepatitis. This treatment appeared to correct the imbalance between two types of T cells: regulatory T cells (TFR) and follicular helper T cells (TFH).
By increasing the TFR population and restoring their balance with TFH cells, vitamin D3 treatment helped regulate this immune response. Additionally, the infusion boosted the production of anti-inflammatory substances while decreasing those linked to inflammation, suggesting a potential new avenue for treating autoimmune hepatitis. Overall, these findings indicate that vitamin D3-modulated dendritic cells could be a promising strategy for managing autoimmune conditions like AIH.
Read More
9
We investigated the effects of Vitamin D modulation on autoimmune prostatitis using a mouse model. In this study, we focused on how changes in gut microbiota influence the immune response, specifically looking at how vitamin D can help shift macrophage polarization—key players in the immune system—from a pro-inflammatory state (M1) to a more healing state (M2).
We observed that treatment with Eriocalyxin B (EriB), known for its anti-inflammatory properties, significantly reduced prostate inflammation in these mice. Our findings indicate that EriB not only altered the gut microbiome but also enhanced the absorption of vitamin D, contributing to a shift in macrophage phenotype. This suggests that the immune state of macrophages, altered through gut bacteria and vitamin D levels, plays a crucial role in managing autoimmune prostatitis.
Notably, fecal transplantation from EriB-treated mice resulted in a marked reduction in inflammatory markers and further supported the macrophage polarization effect. This is the first time we connected gut microbiota and vitamin D as pivotal factors in the treatment of autoimmune disorders like chronic prostatitis, highlighting a new therapeutic pathway. Overall, our research emphasizes the importance of vitamin D in modulating autoimmune responses through gut health.
We observed that treatment with Eriocalyxin B (EriB), known for its anti-inflammatory properties, significantly reduced prostate inflammation in these mice. Our findings indicate that EriB not only altered the gut microbiome but also enhanced the absorption of vitamin D, contributing to a shift in macrophage phenotype. This suggests that the immune state of macrophages, altered through gut bacteria and vitamin D levels, plays a crucial role in managing autoimmune prostatitis.
Notably, fecal transplantation from EriB-treated mice resulted in a marked reduction in inflammatory markers and further supported the macrophage polarization effect. This is the first time we connected gut microbiota and vitamin D as pivotal factors in the treatment of autoimmune disorders like chronic prostatitis, highlighting a new therapeutic pathway. Overall, our research emphasizes the importance of vitamin D in modulating autoimmune responses through gut health.
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9
We observed a fascinating interplay between vitamin D3 and immune responses in patients with multiple sclerosis (MS), an autoimmune disorder that leads to significant neurological damage. Our focus was on a type of immune cell called tolerogenic dendritic cells (tolDCs), which help maintain a balance in the immune system. In our study, we used monocytes from both healthy donors and treatment-naive MS patients to assess how these cells behaved under different conditions.
Our findings revealed that tolDCs derived from MS patients had reduced tolerogenic properties when compared to their healthy counterparts. To our surprise, we found that direct activation of the aryl hydrocarbon receptor (AhR), a key player in immune regulation, could restore the tolerogenic features of MS patient-derived tolDCs. Furthermore, when we combined this approach with a treatment known as dimethyl fumarate (DMF), the results were even more promising.
The combination therapy of DMF and vitamin D3-tolDCs not only improved the tolerogenic effects but also showed better results in an experimental model of MS than using either treatment alone. This suggests that we may have a novel and effective strategy for enhancing immune tolerance in autoimmune diseases like MS.
Overall, our research indicates that vitamin D3, when used alongside DMF, could offer a new pathway for treatment, potentially minimizing the need for broader immunosuppression. This discovery opens up exciting possibilities for better management of autoimmune conditions in the future.
Our findings revealed that tolDCs derived from MS patients had reduced tolerogenic properties when compared to their healthy counterparts. To our surprise, we found that direct activation of the aryl hydrocarbon receptor (AhR), a key player in immune regulation, could restore the tolerogenic features of MS patient-derived tolDCs. Furthermore, when we combined this approach with a treatment known as dimethyl fumarate (DMF), the results were even more promising.
The combination therapy of DMF and vitamin D3-tolDCs not only improved the tolerogenic effects but also showed better results in an experimental model of MS than using either treatment alone. This suggests that we may have a novel and effective strategy for enhancing immune tolerance in autoimmune diseases like MS.
Overall, our research indicates that vitamin D3, when used alongside DMF, could offer a new pathway for treatment, potentially minimizing the need for broader immunosuppression. This discovery opens up exciting possibilities for better management of autoimmune conditions in the future.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Life-changing discovery
70 people found this helpful
Having suffered from rheumatoid arthritis for nearly a decade, I was on Enbrel but still experiencing pain daily. Learning about the Coimbra protocol and Vitamin D changed everything for me. After boosting my intake to 10,000 IUs daily, I noticed a significant reduction in pain and improved mental clarity. I can now run and play with my kids, feeling alive again. I wholeheartedly recommend this product!
Read More
7.5
Clean ingredients matter
8 people found this helpful
I appreciate this Vitamin D for its clean ingredients, crucial as I have autoimmune disorders and intolerances to soy and dairy. I discovered many vitamins use soybean oil, preventing my body from absorbing them. I’ve begun regulating the ingredients in products I buy to ensure they are clean and non-GMO. This product gets a thumbs up from me, and I've been taking it for about a year.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Vernerová L, Vokurková M, Laiferová NA, Nemec M, Špiritović M, et al. Vitamin D and its receptor in skeletal muscle are associated with muscle disease manifestation, lipid metabolism and physical fitness of patients with myositis. Arthritis Res Ther. 2025;27:48. doi:10.1186/s13075-025-03516-9
- Wang CM, Chen YJ, Yang BC, Yang JW, Wang W, et al. Supplementation with active vitamin D3 ameliorates experimental autoimmune thyroiditis in mice by modulating the differentiation and functionality of intrathyroidal T-cell subsets. Front Immunol. 2025;16:1528707. doi:10.3389/fimmu.2025.1528707
- Chen X, Zhang Y, Lin L, Chen Y, Shen X, et al. A beneficial levels of 25-hydroxyvitamin D for a decrease in thyrotropin receptor antibody (TRAB) in patients with Graves' disease: a real-world study. BMC Endocr Disord. 2025;25:14. doi:10.1186/s12902-024-01823-x
- Rafati A, Ramezani R, Esmaeili Gouvarchin Ghaleh H, Bahrami S, Alvanegh AG, et al. Calcitriol Treated Mesenchymal Stem Cells Modulated Immune Response in Collagen-Induced Rheumatoid Arthritis in BALB/c Mice. Transplant Proc. 2025;57:355. doi:10.1016/j.transproceed.2024.12.020
- Casas R, Tompa A, Åkesson K, Teixeira PF, Lindqvist A, et al. Redosing with Intralymphatic GAD-Alum in the Treatment of Type 1 Diabetes: The DIAGNODE-B Pilot Trial. Int J Mol Sci. 2025;26. doi:10.3390/ijms26010374
- Rasheed A, Khan G. Epstein-Barr virus, vitamin D and the immune response: connections with consequences for multiple sclerosis. Front Immunol. 2024;15:1503808. doi:10.3389/fimmu.2024.1503808
- Wu R, Li Y, Peng H, Yang Z, Wang Y, et al. Association Between Serum Trace Elements Level and Alopecia Areata: A Systematic Review and Meta-Analysis. J Cosmet Dermatol. 2025;24:e16740. doi:10.1111/jocd.16740
- Hijjawi N, Tout FS, Azaizeh B, Aljaafreh B. The role of vitamins D, B12, C, and K in modulating inflammation and disease management in rheumatoid arthritis: a comprehensive review. Clin Rheumatol. 2025;44:591. doi:10.1007/s10067-024-07285-9
- Peng B, Wang W, Gu Q, Wang P, Teng W, et al. Effects of different supplements on Hashimoto's thyroiditis: a systematic review and network meta-analysis. Front Endocrinol (Lausanne). 2024;15:1445878. doi:10.3389/fendo.2024.1445878
- Balshi A, Leuenberger G, Dempsey J, Baber U, Sloane JA. Glucagon-like peptide-1 agonist safety and efficacy in a multiple sclerosis cohort. Mult Scler Relat Disord. 2025;93:106229. doi:10.1016/j.msard.2024.106229
- Mourelatou NG, Kounatidis D, Jude EB, Rebelos E. Vitamin D Supplementation as a Therapeutic Strategy in Autoimmune Diabetes: Insights and Implications for LADA Management. Nutrients. 2024;16. doi:10.3390/nu16234072
- Huo R, Yang Y, Wei C, Huo X, Meng D, et al. Vitamin D affects antiphospholipid syndrome by regulating T cells (Review). Int J Mol Med. 2025;55. doi:10.3892/ijmm.2024.5471
- Kilani Y, Alsakarneh S, Madi MY, Mosquera DAG, Ferreira MN, et al. Autoimmune Hepatitis and Vitamin D Deficiency: A Nationwide Perspective. Aliment Pharmacol Ther. 2025;61:682. doi:10.1111/apt.18438
- Mendoza-Vargas LÁ, Sevilla-Fuentes S, Bautista-Becerril B, Berthaúd-González B, Falfán-Valencia R, et al. IgG4-RD-Associated Mikulicz Syndrome Without Classic Systemic Involvement-A Case Report. J Clin Med. 2025;14. doi:10.3390/jcm14030958
- Dai J, Song J, Chen X, Ding F, Ding Y, et al. 1,25(OH)D-treated mouse bone marrow-derived dendritic cells alleviate autoimmune hepatitis in mice by improving TFR/TFH imbalance. Immunopharmacol Immunotoxicol. 2025;47:59. doi:10.1080/08923973.2024.2435314
- Wielińska J, Górna K, Świerkot J, Bugaj B, Kolossa K, et al. Polymorphic Variants in the Vitamin D Receptor and Clinical Parameters of Rheumatoid Arthritis Patients Undergoing Anti-TNF Treatment. Arch Immunol Ther Exp (Warsz). 2024;72. doi:10.2478/aite-2024-0023
- Yu ZQ, Du HX, Gao S, Liang CZ. Eriocalyxin B ameliorated experimental autoimmune prostatitis via modulation of macrophage polarization through gut microbiota-mediated vitamin D alteration. Phytomedicine. 2024;135:156191. doi:10.1016/j.phymed.2024.156191
- Fondelli F, Willemyns J, Domenech-Garcia R, Mansilla MJ, Godoy-Tena G, et al. Targeting aryl hydrocarbon receptor functionally restores tolerogenic dendritic cells derived from patients with multiple sclerosis. J Clin Invest. 2024;134. doi:10.1172/JCI178949
- Grove-Laugesen D, Ebbehoj E, Watt T, Hansen KW, Rejnmark L. Changes in bone density and microarchitecture following treatment of Graves' disease and the effects of vitamin D supplementation. A randomized clinical trial. Osteoporos Int. 2024;35:2153. doi:10.1007/s00198-024-07241-y
- Zhang Q, He X, Chen W, Jiu J, Gao C, et al. Vitamin D3 attenuates autoimmune thyroiditis by regulating Th17/Treg cell differentiation via YAP/JAK1/STAT1 axis. Immunol Lett. 2024;269:106890. doi:10.1016/j.imlet.2024.106890
- Rodi M, de Lastic AL, Panagoulias I, Aggeletopoulou I, Kelaidonis K, et al. Myelin Oligodendrocyte Glycoprotein (MOG)35-55 Mannan Conjugate Induces Human T-Cell Tolerance and Can Be Used as a Personalized Therapy for Multiple Sclerosis. Int J Mol Sci. 2024;25. doi:10.3390/ijms25116092
- Maghbooli Z, Shirvani A, Moghadasi AN, Varzandi T, Hamtaei Ghashti S, et al. Investigating the effects of 25-hydroxyvitamin D3 on clinical outcomes in multiple sclerosis patients: A randomized, double-blind clinical trial- a pilot study. Mult Scler Relat Disord. 2024;87:105673. doi:10.1016/j.msard.2024.105673
- Fasihi M, Samimi-Badabi M, Robat-Jazi B, Bitarafan S, Moghadasi AN, et al. Immunoregulatory Effects of the Active Form of Vitamin D (Calcitriol), Individually and in Combination with Curcumin, on Peripheral Blood Mononuclear Cells (PBMCs) of Multiple Sclerosis (MS) Patients. Antiinflamm Antiallergy Agents Med Chem. 2024;23:138. doi:10.2174/0118715230293847240314073359
- Durá-Travé T, Gallinas-Victoriano F. Autoimmune Thyroiditis and Vitamin D. Int J Mol Sci. 2024;25. doi:10.3390/ijms25063154
- Qu F, Zhang M, Weinstock-Guttman B, Zivadinov R, Qu J, et al. An ultra-sensitive and high-throughput trapping-micro-LC-MS method for quantification of circulating vitamin D metabolites and application in multiple sclerosis patients. Sci Rep. 2024;14:5545. doi:10.1038/s41598-024-55939-0
