Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 22 Researches
7.7
USERS' SCORE
Moderately Good
Based on 10 Reviews
7.8
Top Medical Research Studies
9
In our recent study, we set out to explore the effectiveness of a 5% sodium L-ascorbyl-2-phosphate lotion, a stable form of vitamin C, for treating acne. We conducted a double-blind, controlled trial with 50 participants over 12 weeks, where half used the vitamin C lotion and the other half received a placebo.
Our findings revealed significant improvements in acne symptoms for those using the vitamin C lotion compared to the placebo group. We measured outcomes through various assessments, including a global evaluation by investigators and self-reported assessments by the subjects, along with lesion counts.
The results showed that the vitamin C lotion was not only effective but also well-tolerated, with side effects similar to those seen with the placebo. This adds a promising tool to the options available for acne treatment, suggesting that vitamin C might play a valuable role in skincare regimens aimed at combating acne.
Overall, our study supports the idea that vitamin C, in the form of sodium L-ascorbyl-2-phosphate, can help reduce acne, making it a noteworthy addition to acne treatment strategies.
Our findings revealed significant improvements in acne symptoms for those using the vitamin C lotion compared to the placebo group. We measured outcomes through various assessments, including a global evaluation by investigators and self-reported assessments by the subjects, along with lesion counts.
The results showed that the vitamin C lotion was not only effective but also well-tolerated, with side effects similar to those seen with the placebo. This adds a promising tool to the options available for acne treatment, suggesting that vitamin C might play a valuable role in skincare regimens aimed at combating acne.
Overall, our study supports the idea that vitamin C, in the form of sodium L-ascorbyl-2-phosphate, can help reduce acne, making it a noteworthy addition to acne treatment strategies.
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9
We explored the potential of sodium ascorbyl phosphate (SAP), a stable form of vitamin C, in preventing and treating acne vulgaris. The study included a time-kill analysis showing that a 1% SAP formulation reduced the harmful bacteria Propionibacterium acnes by a significant log reduction of 5 after 8 hours. This demonstrates the strong antimicrobial properties of SAP against acne-causing bacteria.
Additionally, we observed an in vivo study with 20 participants, where the SAP formulation effectively prevented up to 40% of UVA-induced sebum oxidation, suggesting it can help reduce inflammation associated with acne. In another open-label study involving 60 volunteers over 12 weeks, a 5% SAP lotion was rated as excellent or good in effectiveness by 76.9% of the participants, outperforming a commonly prescribed acne treatment.
Overall, our findings indicate that sodium ascorbyl phosphate could serve as an effective, non-antibiotic option for both the prevention and treatment of acne, making it an attractive addition to cosmetic products due to its lack of side effects.
Additionally, we observed an in vivo study with 20 participants, where the SAP formulation effectively prevented up to 40% of UVA-induced sebum oxidation, suggesting it can help reduce inflammation associated with acne. In another open-label study involving 60 volunteers over 12 weeks, a 5% SAP lotion was rated as excellent or good in effectiveness by 76.9% of the participants, outperforming a commonly prescribed acne treatment.
Overall, our findings indicate that sodium ascorbyl phosphate could serve as an effective, non-antibiotic option for both the prevention and treatment of acne, making it an attractive addition to cosmetic products due to its lack of side effects.
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9
In our exploration of treating atrophic acne scars, we focused on the effects of different microneedling depths using Dermapen. We designed a split-face study involving 14 individuals, where each side of their face received a different treatment depth over six sessions, spaced two weeks apart.
On one side, the needles penetrated 2.5 mm into the skin, while the other side used 1.5 mm. We observed a noticeable difference in the improvement of scars, with the deeper 2.5 mm treatment showing significantly better results both clinically and at a cellular level.
The findings suggest that deeper microneedling might foster better collagen induction, which is crucial for skin repair. Both treatments improved collagen and elastin fibers, but the more profound impact from the deeper needles highlights how penetration depth might be a key factor in achieving effective results in scar management.
On one side, the needles penetrated 2.5 mm into the skin, while the other side used 1.5 mm. We observed a noticeable difference in the improvement of scars, with the deeper 2.5 mm treatment showing significantly better results both clinically and at a cellular level.
The findings suggest that deeper microneedling might foster better collagen induction, which is crucial for skin repair. Both treatments improved collagen and elastin fibers, but the more profound impact from the deeper needles highlights how penetration depth might be a key factor in achieving effective results in scar management.
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Most Useful Reviews
9
Reduced acne issues
52 people found this helpful
I’ve been taking this collagen supplement for four years. At 44, I take between four to six pills each day. Working long shifts, I found it helps reduce my muscle aches and allows me to move better without pain. When I stopped for a week, I noticed my knee and shoulder hurt, emphasising how effective this supplement is. Additionally, as a smoker, collagen has cleared my acne significantly, and if I don’t take it, I will get a pimple! I love this product and cannot go without it!
Read More
9
Eliminated adult acne
10 people found this helpful
Goodbye adult acne! My skin is glowing, and the acne is gone. Although I dislike pills, I’ll gladly take these daily for the results. In my late 40s, I was horrified to find my chin and nose covered in bumpy, cystic acne. After trying Accutane and prescription creams with little success, my daughter-in-law suggested this product. The results have been remarkable!
Read More
7.5
Effective for acne
8 people found this helpful
I am already witnessing fantastic results without being finished with my first bottle of this supplement! I initiated my use mainly to tackle acne, strengthen my nails, and thicken my hair. Results took around two to three weeks, but the improvement in my skin has been notable.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 22 Researches
7.7
- All Researches
9
Vitamin C shows moderate efficacy
We explored the effectiveness of using vitamin C in treating persistent post-acne erythema, which often leaves visible redness after acne has cleared. In this study, participants received microneedling combined with either a 10% vitamin C solution or a tranexamic acid solution. The goal was to see which treatment worked better for reducing redness and improving overall skin appearance.
Four treatment sessions were spaced two weeks apart, followed by assessments two weeks after the final session. We measured improvements using clinical evaluations, 3D imaging technology to analyze blood flow in the skin, and patient feedback.
Our findings indicated that both treatments led to significant improvements in reducing skin redness. However, the tranexamic acid solution yielded even better results compared to vitamin C. Patients reported satisfaction on both sides, but they favored the effects of tranexamic acid more. Notably, any side effects were minimal and temporary.
This study suggests that while vitamin C can be helpful, using microneedling with tranexamic acid may deliver superior results for those struggling with post-acne redness.
Four treatment sessions were spaced two weeks apart, followed by assessments two weeks after the final session. We measured improvements using clinical evaluations, 3D imaging technology to analyze blood flow in the skin, and patient feedback.
Our findings indicated that both treatments led to significant improvements in reducing skin redness. However, the tranexamic acid solution yielded even better results compared to vitamin C. Patients reported satisfaction on both sides, but they favored the effects of tranexamic acid more. Notably, any side effects were minimal and temporary.
This study suggests that while vitamin C can be helpful, using microneedling with tranexamic acid may deliver superior results for those struggling with post-acne redness.
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9
We aimed to understand how a novel formulation combining vitamin C and quercetin can help treat acne. Our study focused on creating small liposomal structures called aspasomes that enhance the delivery of quercetin, a potent antioxidant, onto the skin.
Throughout our research, we thoroughly characterized these aspasomes for their size, stability, and how well they could penetrate the skin. One exciting finding was that these specialized nanovesicles not only preserved the antioxidant benefits of quercetin, but also demonstrated a stronger antibacterial effect against acne-causing bacteria compared to quercetin alone.
In an exploratory clinical trial involving 20 participants with acne, we observed considerable improvements. The results revealed a 77.9% reduction in inflammatory lesions and significant decreases in both non-inflammatory lesions and total acne lesions. These findings suggest that our vitamin C-based formula holds promise in managing acne and could potentially be used for other skin conditions in the future.
Throughout our research, we thoroughly characterized these aspasomes for their size, stability, and how well they could penetrate the skin. One exciting finding was that these specialized nanovesicles not only preserved the antioxidant benefits of quercetin, but also demonstrated a stronger antibacterial effect against acne-causing bacteria compared to quercetin alone.
In an exploratory clinical trial involving 20 participants with acne, we observed considerable improvements. The results revealed a 77.9% reduction in inflammatory lesions and significant decreases in both non-inflammatory lesions and total acne lesions. These findings suggest that our vitamin C-based formula holds promise in managing acne and could potentially be used for other skin conditions in the future.
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9
We conducted a study to explore the effectiveness of two forms of vitamin C—ascorbyl palmitate (AP) and sodium ascorbyl phosphate (SAP)—in managing sebum production on the skin. Through a single-blinded, placebo-controlled trial involving 11 healthy female volunteers, we compared the effects of a multiple emulsion containing these compounds with a control that lacked them.
Over 90 days, participants applied the vitamin C formulation to one cheek and the control to the other. We measured sebum levels using a non-invasive device called a Sebumeter at different time intervals. Our results demonstrated that the combination of AP and SAP achieved notable antioxidant activity and effectively reduced facial oiliness compared to the control.
Ultimately, we found that incorporating vitamin C into skincare routines can be a promising solution for controlling excess facial sebum, which is often linked to oily skin and acne. However, while the study highlights the role of these antioxidants in sebum regulation, it does not provide a definitive conclusion on their isolated effects solely for acne treatment.
Over 90 days, participants applied the vitamin C formulation to one cheek and the control to the other. We measured sebum levels using a non-invasive device called a Sebumeter at different time intervals. Our results demonstrated that the combination of AP and SAP achieved notable antioxidant activity and effectively reduced facial oiliness compared to the control.
Ultimately, we found that incorporating vitamin C into skincare routines can be a promising solution for controlling excess facial sebum, which is often linked to oily skin and acne. However, while the study highlights the role of these antioxidants in sebum regulation, it does not provide a definitive conclusion on their isolated effects solely for acne treatment.
Read More
9
We explored the effectiveness of a vitamin C derivative, zinc ascorbate, for treating acne. This study focused on its in vitro antimicrobial activity against Propionibacterium acnes, the bacteria often responsible for acne breakouts.
The researchers tested zinc ascorbate alone and in combination with popular antibiotics like clindamycin, widely used in Japan for acne treatment. They examined how these combinations worked against various strains of P. acnes, including those resistant to clindamycin.
Findings indicated that zinc ascorbate can effectively inhibit the growth of P. acnes, even in clindamycin-resistant strains. Notably, when combined with clindamycin, zinc ascorbate demonstrated an additive effect, enhancing its overall antimicrobial effectiveness.
Overall, this research suggests that incorporating zinc ascorbate could be a promising strategy for acne treatment, especially in conjunction with traditional antibiotics.
The researchers tested zinc ascorbate alone and in combination with popular antibiotics like clindamycin, widely used in Japan for acne treatment. They examined how these combinations worked against various strains of P. acnes, including those resistant to clindamycin.
Findings indicated that zinc ascorbate can effectively inhibit the growth of P. acnes, even in clindamycin-resistant strains. Notably, when combined with clindamycin, zinc ascorbate demonstrated an additive effect, enhancing its overall antimicrobial effectiveness.
Overall, this research suggests that incorporating zinc ascorbate could be a promising strategy for acne treatment, especially in conjunction with traditional antibiotics.
Read More
9
In our recent study, we set out to explore the effectiveness of a 5% sodium L-ascorbyl-2-phosphate lotion, a stable form of vitamin C, for treating acne. We conducted a double-blind, controlled trial with 50 participants over 12 weeks, where half used the vitamin C lotion and the other half received a placebo.
Our findings revealed significant improvements in acne symptoms for those using the vitamin C lotion compared to the placebo group. We measured outcomes through various assessments, including a global evaluation by investigators and self-reported assessments by the subjects, along with lesion counts.
The results showed that the vitamin C lotion was not only effective but also well-tolerated, with side effects similar to those seen with the placebo. This adds a promising tool to the options available for acne treatment, suggesting that vitamin C might play a valuable role in skincare regimens aimed at combating acne.
Overall, our study supports the idea that vitamin C, in the form of sodium L-ascorbyl-2-phosphate, can help reduce acne, making it a noteworthy addition to acne treatment strategies.
Our findings revealed significant improvements in acne symptoms for those using the vitamin C lotion compared to the placebo group. We measured outcomes through various assessments, including a global evaluation by investigators and self-reported assessments by the subjects, along with lesion counts.
The results showed that the vitamin C lotion was not only effective but also well-tolerated, with side effects similar to those seen with the placebo. This adds a promising tool to the options available for acne treatment, suggesting that vitamin C might play a valuable role in skincare regimens aimed at combating acne.
Overall, our study supports the idea that vitamin C, in the form of sodium L-ascorbyl-2-phosphate, can help reduce acne, making it a noteworthy addition to acne treatment strategies.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 10 Reviews
7.8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Reduced acne issues
52 people found this helpful
I’ve been taking this collagen supplement for four years. At 44, I take between four to six pills each day. Working long shifts, I found it helps reduce my muscle aches and allows me to move better without pain. When I stopped for a week, I noticed my knee and shoulder hurt, emphasising how effective this supplement is. Additionally, as a smoker, collagen has cleared my acne significantly, and if I don’t take it, I will get a pimple! I love this product and cannot go without it!
Read More
9
Eliminated adult acne
10 people found this helpful
Goodbye adult acne! My skin is glowing, and the acne is gone. Although I dislike pills, I’ll gladly take these daily for the results. In my late 40s, I was horrified to find my chin and nose covered in bumpy, cystic acne. After trying Accutane and prescription creams with little success, my daughter-in-law suggested this product. The results have been remarkable!
Read More
7.5
Effective for acne
8 people found this helpful
I am already witnessing fantastic results without being finished with my first bottle of this supplement! I initiated my use mainly to tackle acne, strengthen my nails, and thicken my hair. Results took around two to three weeks, but the improvement in my skin has been notable.
Read More
7.5
Balanced hormones effectively
74 people found this helpful
I have been taking this for a month now, and I’ve seen great results for my skin. After stopping birth control, my hormonal imbalance caused severe breakouts, but this product seems to help balance my hormones and improve my acne. My skin feels smoother and firmer, and it’s helpful for my oily complexion too. I take three tablets in the morning and three at bedtime. I love the results, especially on my skin!
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7.5
Improved skin elasticity
5 people found this helpful
My favourite collagen supplement! I have tried many different collagen supplements, and this is by far my favourite. I was gifted a bottle of another brand, and as soon as they were gone, I quickly reordered these because there is such a noticeable difference! While taking six pills a day may seem excessive, it is worth the difference they make. The elasticity of my skin has improved, and there’s less loose skin forming as I lose weight compared to when I’ve lost weight without collagen. Additionally, my acne scarring and fine lines have improved. I feel I have found the fountain of youth!
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Frequently Asked Questions
No FAQs are available for this product and symptom.
References
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- Golonka I, Łukasiewicz IW, Sebastiańczyk A, Greber KE, Sawicki W, et al. The Influence of the Amphiphilic Properties of Peptides on the Phosphatidylinositol Monolayer in the Presence of Ascorbic Acid. Int J Mol Sci. 2024;25. doi:10.3390/ijms252312484
- Hu JK, Quinonez RL, Antasiuk V, Waibel J. Treatment of Acne Vulgaris-Associated Post-Inflammatory Dyschromia With Combination of Non-Ablative Laser Therapy and Topical Antioxidants. J Drugs Dermatol. 2024;23:769. doi:10.36849/JDD.8309
- Abbas MAM, Elgamal EEAE, Zaky MS, Elsaie ML. Microneedling with topical vitamin C versus microneedling with topical insulin in the treatment of atrophic post-acne scars: A split-face study. Dermatol Ther. 2022;35:e15376. doi:10.1111/dth.15376
- Sawutdeechaikul P, Kanokrungsee S, Sahaspot T, Thadvibun K, Banlunara W, et al. Detachable dissolvable microneedles: intra-epidermal and intradermal diffusion, effect on skin surface, and application in hyperpigmentation treatment. Sci Rep. 2021;11:24114. doi:10.1038/s41598-021-03503-5
- Amer SS, Nasr M, Abdel-Aziz RTA, Moftah NH, El Shaer A, et al. Cosm-nutraceutical nanovesicles for acne treatment: Physicochemical characterization and exploratory clinical experimentation. Int J Pharm. 2020;577:119092. doi:10.1016/j.ijpharm.2020.119092
- Vasanth S, Dubey A, G S R, Lewis SA, Ghate VM, et al. Development and Investigation of Vitamin C-Enriched Adapalene-Loaded Transfersome Gel: a Collegial Approach for the Treatment of Acne Vulgaris. AAPS PharmSciTech. 2020;21:61. doi:10.1208/s12249-019-1518-5
- Khan H, Akhtar N, Ali A. Assessment of Combined Ascorbyl Palmitate (AP) and Sodium Ascorbyl Phosphate (SAP) on Facial Skin Sebum Control in Female Healthy Volunteers. Drug Res (Stuttg). 2017;67:52. doi:10.1055/s-0042-118171
- Jain A, Garg NK, Jain A, Kesharwani P, Jain AK, et al. A synergistic approach of adapalene-loaded nanostructured lipid carriers, and vitamin C co-administration for treating acne. Drug Dev Ind Pharm. 2016;42:897. doi:10.3109/03639045.2015.1104343
- Lee WJ, Kim SL, Choe YS, Jang YH, Lee SJ, et al. Magnesium Ascorbyl Phosphate Regulates the Expression of Inflammatory Biomarkers in Cultured Sebocytes. Ann Dermatol. 2015;27:376. doi:10.5021/ad.2015.27.4.376
- Ikeno H, Apel M, Zouboulis C, Luger TA, Böhm M. L-Ascorbyl-2-phosphate attenuates NF-κB signaling in SZ95 sebocytes without affecting IL-6 and IL-8 secretion. Arch Dermatol Res. 2015;307:595. doi:10.1007/s00403-015-1565-z
- Chawla S. Split Face Comparative Study of Microneedling with PRP Versus Microneedling with Vitamin C in Treating Atrophic Post Acne Scars. J Cutan Aesthet Surg. 2014;7:209. doi:10.4103/0974-2077.150742
- Iinuma K, Noguchi N, Nakaminami H, Sasatsu M, Nishijima S, et al. Susceptibility of Propionibacterium acnes isolated from patients with acne vulgaris to zinc ascorbate and antibiotics. Clin Cosmet Investig Dermatol. 2011;4:161. doi:10.2147/CCID.S23840
- Woolery-Lloyd H, Baumann L, Ikeno H. Sodium L-ascorbyl-2-phosphate 5% lotion for the treatment of acne vulgaris: a randomized, double-blind, controlled trial. J Cosmet Dermatol. 2010;9:22. doi:10.1111/j.1473-2165.2010.00480.x
- Burgess C. Topical vitamins. J Drugs Dermatol. 2008;7:s2.
- Klock J, Ikeno H, Ohmori K, Nishikawa T, Vollhardt J, et al. Sodium ascorbyl phosphate shows in vitro and in vivo efficacy in the prevention and treatment of acne vulgaris. Int J Cosmet Sci. 2005;27:171. doi:10.1111/j.1467-2494.2005.00263.x
- Huang Y, Liu C, Fu Z, Li C, Wu Y, et al. The combination of RL-QN15 and OH-CATH30 promotes the repair of acne via the TLR2/NF-κB pathway. Eur J Pharmacol. 2025;989:177233. doi:10.1016/j.ejphar.2024.177233
- Lyu J, Jiang L, Tang M, Zheng L, Liu S. Microneedle fractional radiofrequency associated with drug delivery for facial atrophic acne scars and skin rejuvenation. J Cosmet Laser Ther. 2024;26:61. doi:10.1080/14764172.2024.2372342
- Barone M, De Bernardis R, Persichetti P. Minimally Invasive Post-Acne Scars Treatment with the Hybrid Filler HArmonyCa™. Aesthetic Plast Surg. 2024. doi:10.1007/s00266-024-04046-6
- Ozer K, Gunes D. Comment on "A Split-Face Study to Evaluate Efficacy of Autologous Injectable Platelet-Rich Fibrin With Microneedling Against Microneedling With Normal Saline (Placebo Control) in Atrophic Acne Scars". Dermatol Surg. 2024;50:693. doi:10.1097/DSS.0000000000004150
- El-Domyati M, Moftah NH, Ahmed AM, Ibrahim MR. Evaluation of microneedling depth of penetration in management of atrophic acne scars: a split-face comparative study. Int J Dermatol. 2024;63:632. doi:10.1111/ijd.17006
- Khattab FM, Samir MA, El Khouly SS, Atwa EM. Efficacy of Polycaprolactone Threads in Treating Atrophic Acne Scars: A Split-face Comparative Study. J Clin Aesthet Dermatol. 2023;16:33.
