Can New Chapter Magnesium + Ashwagandha Supplement Help with Headache?

Reviewed By

🩺 Dr. Talia Klein

Reviewed By

🩺 Kety Ben David, B.Sn.

Overview

New Chapter Magnesium + Ashwagandha Supplement

SCIENTIFIC SCORE

Possibly Effective

Based on 21 Researches

7.4

USERS' SCORE

Good

Based on 2 Reviews

8.6

Top Medical Research Studies

Magnesium aids migraine management

Dominguez LJ, Veronese N, Sabico S, Al-Daghri NM, Barbagallo M. Magnesium and Migraine. Nutrients. 2025;17. doi:10.3390/nu17040725

We explored the impact of magnesium on migraine headaches, focusing on its potential benefits based on various studies. Magnesium deficiency is quite common and can arise from different factors, such as not consuming enough through diet or losing more through bodily systems.

A wealth of research, including case reports and controlled trials, suggests that magnesium supplementation can effectively alleviate migraines, both in the short term and long term. The proposed reasons for this effectiveness range from magnesium's role in preventing spreading cortical depression to its ability to manage oxidative stress and inflammation.

This evidence leads us to consider magnesium not just as a dietary supplement but as an important player in migraine management. Understanding these links helps us contemplate magnesium’s role in prevention and treatment, promising a potential path for those who suffer from this debilitating condition.

Network meta-analysis on tocolytics

Wilson A, Hodgetts-Morton VA, Marson EJ, Markland AD, Larkai E, et al. Tocolytics for delaying preterm birth: a network meta-analysis (0924). Cochrane Database Syst Rev. 2022;8:CD014978. doi:10.1002/14651858.CD014978.pub2

We examined how various tocolytic drugs delay preterm birth, analyzing data from 122 trials involving nearly 13,700 women.

Our findings suggest that all classes of tocolytics, including magnesium sulfate, are likely effective for delaying birth up to 7 days compared to no treatment.

While these treatments showed promise, they also carried risks of side effects, such as nausea and headaches, particularly with betamimetics and calcium channel blockers. We found no definitive conclusions on their impact on neonatal outcomes, leaving room for further research.

Omega-3s may reduce headaches

Sanders AE, Shaikh SR, Slade GD. Long-chain omega-3 fatty acids and headache in the U.S. population. Prostaglandins Leukot Essent Fatty Acids. 2018;135:47. doi:10.1016/j.plefa.2018.06.008

We aimed to explore the link between dietary intake of long-chain omega-3 fatty acids, specifically docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), and their potential impact on headache prevalence in the U.S. Using data from the National Health and Nutrition Examination Surveys conducted between 1999 and 2004, we looked at a diverse group of over 12,000 adults aged 20 and older.

Through interviews, participants reported experiences of severe headaches or migraines in the past three months. We also measured dietary EPA and DHA from their food intake and assessed levels of C-reactive protein, which is an indicator of inflammation. Our analysis suggested that increased intake of omega-3 fatty acids correlated with a lower prevalence of severe headaches or migraines. Specifically, each log unit increase in EPA was linked to a 6% reduction in the prevalence—while DHA showed a similar reduction.

Interestingly, we found that this effect was more pronounced among non-Mexican Hispanic participants compared to others. Importantly, our results remained robust even after considering inflammation levels. Thus, this study supports the idea that omega-3 fatty acids may be beneficial in helping to prevent or alleviate headaches.

Most Useful Reviews

Great for headaches

21 people found this helpful

Excellent! This is one of the best magnesium supplements I've tried. It has not upset my stomach at all, even when taken with little or no food. It’s great for headaches, migraine prevention, insomnia, and general tension. I can take it during the day without becoming excessively drowsy, unlike other magnesium pills. This is my third bottle, and I shall definitely keep reordering.

No more headaches

10 people found this helpful

Magnesium. Since taking this pill, I have been sleeping soundly and have had no headaches. I'm uncertain if this is solely due to the vitamins, but I feel I am benefitting from them. They are large, so if you struggle with swallowing pills, that could be an issue. Otherwise, I am enjoying this product and have ordered another bottle.

Medical Researches

SCIENTIFIC SCORE

Possibly Effective

Based on 21 Researches

7.4

9.5

Omega-3s effectively reduce headaches

Ramsden CE, Faurot KR, Zamora D, Suchindran CM, MacIntosh BA, et al. Targeted alteration of dietary n-3 and n-6 fatty acids for the treatment of chronic headaches: a randomized trial. Pain. 2013;154:2441. doi:10.1016/j.pain.2013.07.028

We conducted a clinical trial to see how dietary changes targeting omega-3 and omega-6 fatty acids could help people dealing with chronic headaches. Over 12 weeks, we divided participants into two groups: one that increased their omega-3 intake while reducing omega-6 and another that just focused on lowering omega-6.

Our findings were quite promising! Those in the group increasing their omega-3 levels experienced a greater reduction in headache severity and frequency compared to those simply lowering omega-6. Specifically, the high omega-3 group had a significant drop in both daily headache hours and pain impact, while altering levels of important headache-relief mediators in the body.

This suggests that increasing omega-3, particularly docosahexaenoic acid, can be an effective strategy for reducing headache symptoms and improving overall quality of life among chronic headache sufferers. These dietary adjustments could provide a new avenue for managing headaches more effectively.

Magnesium aids migraine management

Dominguez LJ, Veronese N, Sabico S, Al-Daghri NM, Barbagallo M. Magnesium and Migraine. Nutrients. 2025;17. doi:10.3390/nu17040725

Magnesium's role in headache treatment

Mirzaeva LM, Lobzina AS, Akhmedova KN, Shvartsman GI, Kula II, et al. [Therapeutic approaches to comorbid pathology in episodic migraine and tension-type headache]. Zh Nevrol Psikhiatr Im S S Korsakova. 2023;123:52. doi:10.17116/jnevro202312309152

We examined the effects of magnesium treatment on individuals suffering from episodic migraine and tension-type headache, aiming to understand its potential benefits alongside other therapeutic approaches. The study involved 104 participants, who were assessed for anxiety, depression, insomnia, and fatigue before and after receiving various treatments, including magnesium.

Our findings indicated that a significant portion of patients reported anxiety and depression, affecting their headache severity. After treatment, we noticed a marked decrease in headache intensity, along with improvements in anxiety and depressive symptoms. However, the specific impact of magnesium alone couldn’t be isolated in this study, as we looked at it alongside other medications like anxiolytics and antidepressants.

Overall, while magnesium was part of the treatment plan and showed potential benefits, we must acknowledge that its individual effectiveness cannot be clearly determined from our research. It appears to contribute to an overall improvement in managing headaches when combined with other treatments.

Multimodal therapy shows promise

Martin BR. Multimodal Care for Headaches, Lumbopelvic Pain, and Dysmenorrhea in a Woman With Endometriosis: A Case Report. J Chiropr Med. 2021;20:148. doi:10.1016/j.jcm.2021.10.002

We explored a case involving a 36-year-old woman with endometriosis suffering from frequent headaches and debilitating pain. While traditional medications didn't work for her, she started a new treatment plan that included acupuncture and supplements like magnesium and turmeric.

After this multimodal approach, her headache frequency decreased significantly, along with improvements in her lumbopelvic pain, sleep quality, and overall focus. This case indicates that integrating various alternative therapies can provide significant relief for those with challenging symptoms.

Omega-3 diet reduces headache pain

Ramsden CE, Zamora D, Makriyannis A, Wood JT, Mann JD, et al. Diet-induced changes in n-3- and n-6-derived endocannabinoids and reductions in headache pain and psychological distress. J Pain. 2015;16:707. doi:10.1016/j.jpain.2015.04.007

We explored how dietary changes, specifically increasing omega-3 fatty acids like docosahexaenoic acid (DHA) while lowering omega-6 fatty acids, can influence headache pain. In a trial involving 55 chronic headache patients, we observed significant benefits from this targeted dietary intervention.

Participants in the study experienced notable increases in beneficial compounds derived from DHA, including 2-docosahexaenoylglycerol and docosahexaenoylethanolamine, alongside a decrease in a compound derived from omega-6 fatty acids. Our findings indicate that these changes in endocannabinoids are linked to reductions in both physical pain and psychological distress related to headaches.

The results suggest that adopting a diet rich in omega-3 fatty acids could be a promising way to manage headaches and related psychological issues effectively. This highlights the potential relevance of diet in addressing chronic pain, opening the door for further exploration into personalized nutrition as a valuable strategy for headache relief.

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