Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 29 Researches
7.4
USERS' SCORE
Good
Based on 2 Reviews
8.3

Top Medical Research Studies

We explored how magnesium supplementation can help alleviate migraines, a condition that affects countless individuals and can be incredibly disabling. Research has shown a strong link between magnesium deficiency and various factors that contribute to migraines, such as neurological changes and inflammation.

Studies, including randomized controlled trials, indicate that magnesium can reduce the frequency and severity of migraine attacks, both in the short term and as a preventative measure. This effectiveness is thought to stem from magnesium's ability to influence nerve function and reduce stress responses in the body.

We've examined the accumulating evidence from case studies and clinical trials, and it clearly points to magnesium being a valuable option for those suffering from migraines. By addressing magnesium deficiency, we may offer a new avenue for relief and improved management of this challenging condition.
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8
Magnesium aids migraine prevention
We observed that magnesium plays a notable role in migraine prevention and treatment. Specifically, magnesium is recommended for both chronic migraine management and immediate intravenous relief during acute migraine episodes. The use of magnesium appears to be linked with mild gastrointestinal side effects, indicating that it is generally well-tolerated by those who use it.

Although individual responses may vary, magnesium has shown promising results for many people managing migraines. It's essential to consider this approach alongside other treatments, as magnesium supplementation might enhance overall migraine management. For those looking for alternative or complementary options, magnesium could be a viable choice worth exploring further.
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7
Docosahexaenoic acid reduces migraine duration
We aimed to understand how docosahexaenoic acid, a type of omega-3 fatty acid, affects migraines. Through a systematic review and meta-analysis of randomized controlled trials, we analyzed data from several studies on this topic.

After reviewing 13 trials, we found that only a few were eligible to evaluate docosahexaenoic acid's effectiveness on migraine frequency, duration, and severity. Our results indicated that while omega-3 intake made no significant difference in how often migraines occurred or their intensity, it did show a notable reduction in the duration of migraine attacks.

Specifically, participants who consumed omega-3 experienced a decrease in attack duration by about 3.44 hours. However, we recognized the need for further high-quality randomized controlled trials to strengthen these findings. Overall, while omega-3 may not improve every aspect of migraines, it does offer some relief in terms of how long the attacks last.
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Most Useful Reviews

7.5
Great for prevention
21 people found this helpful
Excellent! This is one of the best magnesium supplements I've tried. It didn't upset my stomach, even when taken without food. It's great for headaches, migraine prevention, insomnia, and general tension. I can even take it during the day without feeling excessively sleepy. This is my third bottle, and I'll definitely continue to reorder.
Read More
7
Helpful for migraines
4 people found this helpful
Seem very helpful. I got these for my girlfriend to help with her migraines. While she’s on other medication, she believes it has reduced the severity of her attacks. Additionally, she feels that the Ashwagandha has improved her sleep quality. For that alone, I'm pleased to have them on a monthly delivery schedule.
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 29 Researches
7.4
  • All Researches
9.5
Omega-3s effective for migraine
We dug into how docosahexaenoic acid (DHA), along with eicosapentaenoic acid (EPA), can help with migraine management. Through a comprehensive analysis of 40 randomized controlled trials involving over 6,600 participants, we compared various treatments for migraine prevention. Our focus was on the effectiveness and acceptability of high doses of DHA and EPA against other standard medications.

What we found was quite intriguing. Supplementing with high doses of EPA and DHA significantly reduced the frequency of migraines as compared to placebo treatments. In fact, our analysis revealed a notable decrease in migraine severity as well. Not only that, but those using high-dose omega-3s reported favorable experiences with treatment, showcasing a high level of acceptability.

This compelling evidence suggests that high doses of DHA and EPA can serve as a premier option for preventing migraines. Their effectiveness and tolerability make them an attractive choice for those seeking relief. The potential of omega-3 supplementation in this context opens new avenues for migraine management that are worth exploring further.
Read More
We explored how magnesium supplementation can help alleviate migraines, a condition that affects countless individuals and can be incredibly disabling. Research has shown a strong link between magnesium deficiency and various factors that contribute to migraines, such as neurological changes and inflammation.

Studies, including randomized controlled trials, indicate that magnesium can reduce the frequency and severity of migraine attacks, both in the short term and as a preventative measure. This effectiveness is thought to stem from magnesium's ability to influence nerve function and reduce stress responses in the body.

We've examined the accumulating evidence from case studies and clinical trials, and it clearly points to magnesium being a valuable option for those suffering from migraines. By addressing magnesium deficiency, we may offer a new avenue for relief and improved management of this challenging condition.
Read More
9
Magnesium significantly alleviates migraines
We explored how magnesium supplementation affects the frequency and intensity of migraine attacks. The study relied on evidence gathered from twenty-two randomized controlled trials, providing a solid foundation for our findings.

Through a detailed analysis, we found that magnesium supplementation significantly reduced migraine attacks, with a marked decrease in severity and the number of days afflicted each month. Specifically, magnesium showed a mean difference of -2.51 in attack frequency and -0.88 in severity compared to those who did not receive the supplement.

This promising outcome suggests that magnesium could be an effective option for individuals seeking migraine relief. As we delved deeper into the study, it became clear that while additional research is needed to establish long-term effects, magnesium’s immediate benefits in reducing migraines are noteworthy.
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We examined how magnesium oxide (MgO), both alone and with riboflavin, helps prevent migraines in pregnant individuals. This retrospective study included 203 patients treated between 2015 and 2020, analyzing outcomes such as migraine frequency, severity, and duration.

We found that both treatment options reduced migraines significantly, with 77% of participants experiencing improvement in associated symptoms. The results indicate that magnesium oxide can be an effective option for managing migraines during pregnancy, making it a potential consideration for expectant mothers suffering from this condition.
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9
Dietary intervention alleviates headaches
We conducted a thorough investigation into how dietary adjustments, particularly focusing on the balance of omega-3 and omega-6 fatty acids, can help reduce the frequency and intensity of chronic headaches, which are often debilitating for many individuals. Our study involved a randomized, controlled trial with participants who were experiencing chronic daily headaches. After a four-week pre-intervention phase, we divided them into two groups, one receiving a high omega-3 plus low omega-6 dietary intervention and the other following a lower omega-6 intake only.

Throughout the 12-week intervention, we observed that those in the high omega-3 group not only reported significant improvements in their headache impact scores but also experienced fewer headache days and reduced headache hours per day. One of the key findings was the increased levels of specific antinociceptive biomarkers related to omega-3 fatty acids, which suggests that enhancing omega-3 intake can alter pain-relieving pathways in the body.

Although the study highlighted the benefits of this dietary approach, it’s important to note that isolating the specific impact of docosahexaenoic acid (DHA) alone was challenging due to the combined dietary changes implemented. Nevertheless, the general evidence suggests that shifting towards more omega-3 fatty acids while lowering omega-6 can lead to meaningful relief from chronic headaches, enhancing not only physical comfort but also the quality of life for individuals suffering from migraines.
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User Reviews

USERS' SCORE
Good
Based on 2 Reviews
8.3
  • All Reviews
  • Positive Reviews
  • Negative Reviews
7.5
Great for prevention
21 people found this helpful
Excellent! This is one of the best magnesium supplements I've tried. It didn't upset my stomach, even when taken without food. It's great for headaches, migraine prevention, insomnia, and general tension. I can even take it during the day without feeling excessively sleepy. This is my third bottle, and I'll definitely continue to reorder.
Read More
7
Helpful for migraines
4 people found this helpful
Seem very helpful. I got these for my girlfriend to help with her migraines. While she’s on other medication, she believes it has reduced the severity of her attacks. Additionally, she feels that the Ashwagandha has improved her sleep quality. For that alone, I'm pleased to have them on a monthly delivery schedule.
Read More

Frequently Asked Questions

No FAQs are available for this product and symptom.

References

  1. Dominguez LJ, Veronese N, Sabico S, Al-Daghri NM, Barbagallo M. Magnesium and Migraine. Nutrients. 2025;17. 10.3390/nu17040725
  2. Tepper SJ, Tepper K. Nutraceuticals and Headache 2024: Riboflavin, Coenzyme Q10, Feverfew, Magnesium, Melatonin, and Butterbur. Curr Pain Headache Rep. 2025;29:33. 10.1007/s11916-025-01358-3
  3. Hajhashemy Z, Golpour-Hamedani S, Eshaghian N, Sadeghi O, Khorvash F, et al. Practical supplements for prevention and management of migraine attacks: a narrative review. Front Nutr. 2024;11:1433390. 10.3389/fnut.2024.1433390
  4. Talandashti MK, Shahinfar H, Delgarm P, Jazayeri S. Effects of selected dietary supplements on migraine prophylaxis: A systematic review and dose-response meta-analysis of randomized controlled trials. Neurol Sci. 2025;46:651. 10.1007/s10072-024-07794-0
  5. Gazerani P, Papetti L, Dalkara T, Cook CL, Webster C, et al. The Brain, the Eating Plate, and the Gut Microbiome: Partners in Migraine Pathogenesis. Nutrients. 2024;16. 10.3390/nu16142222
  6. Hannigan IP, Rosengren SM, Di Tanna GL, Watson SRD, Welgampola MS. Effects of nonprescription therapies on vestibular migraine: a questionnaire-based observational study. Intern Med J. 2024;54:916. 10.1111/imj.16314
  7. Kurhade PI, Kodape SM, Das A, Bansod PG. Synergistic action of sumatriptan delivery and targeting magnesium deficiency using green, pH-responsive MgO nanoparticles synthesized from mahua flower extracts. Environ Sci Pollut Res Int. 2023. 10.1007/s11356-023-30648-9
  8. Umemoto KK, Tawk K, Mazhari N, Abouzari M, Djalilian HR. Management of Migraine-Associated Vestibulocochlear Disorders. Audiol Res. 2023;13:528. 10.3390/audiolres13040047
  9. Gaul C, Zaranek L, Goßrau G. [Complementary and supplementary procedures in the treatment of headache]. Schmerz. 2023;37:448. 10.1007/s00482-023-00738-1
  10. Shenoy NN, Gheewala GK, Kedambadi R, Pai S, Zulfikli KM, et al. Can Serum Magnesium Level and Visual Evoked Potentials (P100) be a Predictive in Migraineurs?: Evidence Based Study. Neurol India. 2023;71:463. 10.4103/0028-3886.378668
  11. Frank M, Abouzari M, Djalilian HR. Meniere's disease is a manifestation of migraine. Curr Opin Otolaryngol Head Neck Surg. 2023;31:313. 10.1097/MOO.0000000000000908
  12. Pawar V, Ashraf H, Dorsala S, Mary P, Hameed N, et al. Motorist's Vestibular Disorientation Syndrome (MVDS)-Proposed Diagnostic Criteria. J Pers Med. 2023;13. 10.3390/jpm13050732
  13. Hoshino MT, Bochio MG, Spagnol Bonache J, Ludwig L, Leandro de Campos M, et al. Plasma and erythrocyte magnesium levels: from validation of the method to analysis in volunteers diagnosed to migraine. Magnes Res. 2022;35:51. 10.1684/mrh.2022.0502
  14. Mahajan R, Anand KS, Mahajan RK, Garg J, Juneja A. Serum Magnesium Levels During the Ictal and Interictal Phase in Patients of Migraine: A Prospective Observational Study. Neurol India. 2022;70:1852. 10.4103/0028-3886.359247
  15. Bhurat R, Premkumar S, Manokaran RK. Serum Magnesium Levels in Children With and Without Migraine: A Cross-Sectional Study. Indian Pediatr. 2022;59:623.
  16. Mazza GR, Solorio C, Stek AM, Kalayjian LA, Wilson ML, et al. Assessing the efficacy of magnesium oxide and riboflavin as preventative treatment of migraines in pregnancy. Arch Gynecol Obstet. 2023;308:1749. 10.1007/s00404-022-06872-y
  17. Ariyanfar S, Razeghi Jahromi S, Togha M, Ghorbani Z. Review on Headache Related to Dietary Supplements. Curr Pain Headache Rep. 2022;26:193. 10.1007/s11916-022-01019-9
  18. Guerrero-Toro C, Koroleva K, Ermakova E, Gafurov O, Abushik P, et al. Testing the Role of Glutamate NMDA Receptors in Peripheral Trigeminal Nociception Implicated in Migraine Pain. Int J Mol Sci. 2022;23. 10.3390/ijms23031529
  19. Matin H, Taghian F, Chitsaz A. Artificial intelligence analysis to explore synchronize exercise, cobalamin, and magnesium as new actors to therapeutic of migraine symptoms: a randomized, placebo-controlled trial. Neurol Sci. 2022;43:4413. 10.1007/s10072-021-05843-6
  20. Karim MR, Bhattacharjee M, Islam MS, Banerjee S, Hossain S, et al. Relation between Serum Magnesium Level and Migraine. Mymensingh Med J. 2021;30:301.
  21. Tseng PT, Zeng BY, Chen JJ, Kuo CH, Zeng BS, et al. High Dosage Omega-3 Fatty Acids Outperform Existing Pharmacological Options for Migraine Prophylaxis: A Network Meta-Analysis. Adv Nutr. 2024;15:100163. 10.1016/j.advnut.2023.100163
  22. Faurot KR, Cole WR, MacIntosh BA, Dunlap M, Moore CB, et al. Targeted dietary interventions to reduce pain in persistent post-traumatic headache among service members: Protocol for a randomized, controlled parallel-group trial. Contemp Clin Trials. 2022;119:106851. 10.1016/j.cct.2022.106851
  23. Ramsden CE, Zamora D, Faurot KR, MacIntosh B, Horowitz M, et al. Dietary alteration of n-3 and n-6 fatty acids for headache reduction in adults with migraine: randomized controlled trial. BMJ. 2021;374:n1448. 10.1136/bmj.n1448
  24. Sanders AE, Shaikh SR, Slade GD. Long-chain omega-3 fatty acids and headache in the U.S. population. Prostaglandins Leukot Essent Fatty Acids. 2018;135:47. 10.1016/j.plefa.2018.06.008
  25. Maghsoumi-Norouzabad L, Mansoori A, Abed R, Shishehbor F. Effects of omega-3 fatty acids on the frequency, severity, and duration of migraine attacks: A systematic review and meta-analysis of randomized controlled trials. Nutr Neurosci. 2018;21:614. 10.1080/1028415X.2017.1344371
  26. Sadeghi O, Maghsoudi Z, Khorvash F, Ghiasvand R, Askari G. The relationship between different fatty acids intake and frequency of migraine attacks. Iran J Nurs Midwifery Res. 2015;20:334.
  27. Ramsden CE, Faurot KR, Zamora D, Suchindran CM, MacIntosh BA, et al. Targeted alteration of dietary n-3 and n-6 fatty acids for the treatment of chronic headaches: a randomized trial. Pain. 2013;154:2441. 10.1016/j.pain.2013.07.028
  28. Pradalier A, Bakouche P, Baudesson G, Delage A, Cornaille-Lafage G, et al. Failure of omega-3 polyunsaturated fatty acids in prevention of migraine: a double-blind study versus placebo. Cephalalgia. 2001;21:818.
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