Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 17 Researches
7.9
USERS' SCORE
Good
Based on 3 Reviews
8.5
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Proprietary Probiotic BlendSaccharomyces boulardiiLactobacillus plantarum LP01, Bifidobacterium breve BR03Total Cultures
300 mg5 Billion CFU5 Billion CFU 10 Billion CFU
*
Digestive Support Blend (from ferment media)Organic Aloe (leaf), Organic Peppermint (leaf), Organic Coriander (seed), Organic Cardamom (fruit), Organic Artichoke (leaf)
82.5 mg
*
Organic Turmeric (Curcuma longa) (rhizome) (from ferment media)
31.4 mg
*
Top Medical Research Studies
9.5
Probiotic effectively reduces diarrhea
We investigated the effectiveness of the probiotic Saccharomyces boulardii CNCM I-745 in real-world settings for treating diarrhea. In a study involving over 30,000 patients, those treated with S. boulardii had a notable success rate of 77.8% in resolving their diarrhea, compared to just 15.8% in the control group.
This study showed that S. boulardii worked well even when patients were on antibiotics, outperforming traditional anti-diarrheal treatments.
Overall, S. boulardii demonstrates significant promise in managing diarrhea effectively.
This study showed that S. boulardii worked well even when patients were on antibiotics, outperforming traditional anti-diarrheal treatments.
Overall, S. boulardii demonstrates significant promise in managing diarrhea effectively.
Read More
9
Probiotics mitigate antibiotic-related diarrhea
We looked into how probiotics, especially Saccharomyces boulardii CNCM I-745, can impact antibiotic-associated diarrhea. Through systematic reviews and clinical trials, we found that this yeast is effective in preventing and resolving diarrhea linked to antibiotic use. Since it isn't affected by antibiotics, S. boulardii can safely be administered at the start of treatment or within the first couple of days. This shows that using the right probiotics can help restore gut health after antibiotics, which is crucial for overall well-being.
Read More
9
We explored the effects of Saccharomyces boulardii on diarrhea caused by the cancer drug abemaciclib in a study involving thirty rats. The rats were divided into three groups: a control group, a group receiving only abemaciclib, and a group receiving both abemaciclib and Saccharomyces boulardii.
Our results indicated that the group treated with Saccharomyces boulardii showed a significant reduction in diarrhea severity and weight loss compared to the group that only received abemaciclib. Furthermore, histopathological evaluations revealed less inflammation in the Saccharomyces boulardii group. Overall, this suggests that Saccharomyces boulardii might be a beneficial treatment option to alleviate chemotherapy-induced diarrhea.
Our results indicated that the group treated with Saccharomyces boulardii showed a significant reduction in diarrhea severity and weight loss compared to the group that only received abemaciclib. Furthermore, histopathological evaluations revealed less inflammation in the Saccharomyces boulardii group. Overall, this suggests that Saccharomyces boulardii might be a beneficial treatment option to alleviate chemotherapy-induced diarrhea.
Read More
Most Useful Reviews
9
Staunch chronic diarrhea
30 people found this helpful
Five Stars if You Have Chronic Loose Stools. New Chapter makes excellent supplements, and I’ve used many for long periods with great results. This probiotic is effective in addressing chronic diarrhea. Though I have lupus which complicates my gut health, for others who struggle with loose stools, this is the probiotic to try.
Read More
7
Quick relief after antibiotics
8 people found this helpful
Really helped after taking large doses of antibiotics. Post-diverticulitis, I experienced bloating and diarrhea. After consultation, my doctor recommended this probiotic, which greatly improved my gut health within 24 hours. I highly recommend it if you’ve taken antibiotics.
Read More
7.5
Beneficial for illness
5 people found this helpful
I like the addition of Cardamom and Saccharomyces boulardii. This probiotic’s blend includes ingredients known to assist with diarrhea and overall gut health. As a family member dealing with Ulcerative Colitis is introducing this, I find it beneficial without adverse effects. We will continue ordering, as it has proven helpful.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 17 Researches
7.9
- All Researches
9.5
Probiotic effectively reduces diarrhea
We investigated the effectiveness of the probiotic Saccharomyces boulardii CNCM I-745 in real-world settings for treating diarrhea. In a study involving over 30,000 patients, those treated with S. boulardii had a notable success rate of 77.8% in resolving their diarrhea, compared to just 15.8% in the control group.
This study showed that S. boulardii worked well even when patients were on antibiotics, outperforming traditional anti-diarrheal treatments.
Overall, S. boulardii demonstrates significant promise in managing diarrhea effectively.
This study showed that S. boulardii worked well even when patients were on antibiotics, outperforming traditional anti-diarrheal treatments.
Overall, S. boulardii demonstrates significant promise in managing diarrhea effectively.
Read More
9
Probiotic reduces antibiotic-associated diarrhea
We examined how a high-dose, multistrain probiotic mix called Sinquanon helps prevent antibiotic-associated diarrhea (AAD) in adults taking broad-spectrum antibiotics. This well-structured clinical trial involved 564 participants, half receiving the probiotic and half a placebo.
Results showed that fewer people in the probiotic group experienced AAD—only 9.2% compared to 25.3% in the placebo group. This promising improvement suggests that Sinquanon may significantly enhance gastrointestinal health during antibiotic treatment without causing harmful side effects.
Results showed that fewer people in the probiotic group experienced AAD—only 9.2% compared to 25.3% in the placebo group. This promising improvement suggests that Sinquanon may significantly enhance gastrointestinal health during antibiotic treatment without causing harmful side effects.
Read More
9
Probiotics mitigate antibiotic-related diarrhea
We looked into how probiotics, especially Saccharomyces boulardii CNCM I-745, can impact antibiotic-associated diarrhea. Through systematic reviews and clinical trials, we found that this yeast is effective in preventing and resolving diarrhea linked to antibiotic use. Since it isn't affected by antibiotics, S. boulardii can safely be administered at the start of treatment or within the first couple of days. This shows that using the right probiotics can help restore gut health after antibiotics, which is crucial for overall well-being.
Read More
9
We looked into how probiotics might help manage antibiotic-associated diarrhea (AAD) in children through a review of systematic reviews. Our review considered various databases and included 20 studies, evaluating their reporting quality and overall evidence strength. While we found that higher doses of probiotics show promise in preventing AAD, caution is needed as many studies had significant quality gaps. Overall, probiotics could benefit kids facing AAD, but more robust research is essential for clearer recommendations.
Read More
9
We explored the effects of Saccharomyces boulardii on diarrhea caused by the cancer drug abemaciclib in a study involving thirty rats. The rats were divided into three groups: a control group, a group receiving only abemaciclib, and a group receiving both abemaciclib and Saccharomyces boulardii.
Our results indicated that the group treated with Saccharomyces boulardii showed a significant reduction in diarrhea severity and weight loss compared to the group that only received abemaciclib. Furthermore, histopathological evaluations revealed less inflammation in the Saccharomyces boulardii group. Overall, this suggests that Saccharomyces boulardii might be a beneficial treatment option to alleviate chemotherapy-induced diarrhea.
Our results indicated that the group treated with Saccharomyces boulardii showed a significant reduction in diarrhea severity and weight loss compared to the group that only received abemaciclib. Furthermore, histopathological evaluations revealed less inflammation in the Saccharomyces boulardii group. Overall, this suggests that Saccharomyces boulardii might be a beneficial treatment option to alleviate chemotherapy-induced diarrhea.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Staunch chronic diarrhea
30 people found this helpful
Five Stars if You Have Chronic Loose Stools. New Chapter makes excellent supplements, and I’ve used many for long periods with great results. This probiotic is effective in addressing chronic diarrhea. Though I have lupus which complicates my gut health, for others who struggle with loose stools, this is the probiotic to try.
Read More
7
Quick relief after antibiotics
8 people found this helpful
Really helped after taking large doses of antibiotics. Post-diverticulitis, I experienced bloating and diarrhea. After consultation, my doctor recommended this probiotic, which greatly improved my gut health within 24 hours. I highly recommend it if you’ve taken antibiotics.
Read More
7.5
Beneficial for illness
5 people found this helpful
I like the addition of Cardamom and Saccharomyces boulardii. This probiotic’s blend includes ingredients known to assist with diarrhea and overall gut health. As a family member dealing with Ulcerative Colitis is introducing this, I find it beneficial without adverse effects. We will continue ordering, as it has proven helpful.
Read More
Frequently Asked Questions
9.5
Probiotic effectively reduces diarrhea
We investigated the effectiveness of the probiotic Saccharomyces boulardii CNCM I-745 in real-world settings for treating diarrhea. In a study involving over 30,000 patients, those treated with S. boulardii had a notable success rate of 77.8% in resolving their diarrhea, compared to just 15.8% in the control group.
This study showed that S. boulardii worked well even when patients were on antibiotics, outperforming traditional anti-diarrheal treatments.
Overall, S. boulardii demonstrates significant promise in managing diarrhea effectively.
This study showed that S. boulardii worked well even when patients were on antibiotics, outperforming traditional anti-diarrheal treatments.
Overall, S. boulardii demonstrates significant promise in managing diarrhea effectively.
9
Probiotics mitigate antibiotic-related diarrhea
We looked into how probiotics, especially Saccharomyces boulardii CNCM I-745, can impact antibiotic-associated diarrhea. Through systematic reviews and clinical trials, we found that this yeast is effective in preventing and resolving diarrhea linked to antibiotic use. Since it isn't affected by antibiotics, S. boulardii can safely be administered at the start of treatment or within the first couple of days. This shows that using the right probiotics can help restore gut health after antibiotics, which is crucial for overall well-being.
8
We explored whether probiotics, particularly Saccharomyces boulardii, are effective for treating various digestive disorders in children. The findings suggest that S. boulardii is beneficial for acute gastroenteritis, antibiotic-associated diarrhea, and Clostridium difficile infections. However, its efficacy for conditions like functional constipation and gastroesophageal reflux disease remains questionable.
While S. boulardii shows promise for other conditions like infantile colic, evidence quality is inconsistent. The study emphasizes that while probiotics can aid in treatment, they should not replace core dietary management strategies.
While S. boulardii shows promise for other conditions like infantile colic, evidence quality is inconsistent. The study emphasizes that while probiotics can aid in treatment, they should not replace core dietary management strategies.
8
We analyzed data from six randomized controlled trials to see if the addition of a specific supplement boosts the effectiveness of bismuth quadruple therapy (BQT) in treating gastrointestinal issues. While our findings revealed that the supplement does not significantly increase eradication rates, it substantially reduces adverse events like diarrhea, constipation, and abdominal discomfort.
This reduction could ease patient experiences, potentially leading to better compliance with treatment. So, while the supplement might not enhance eradication rates, it has notable benefits in managing side effects.
This reduction could ease patient experiences, potentially leading to better compliance with treatment. So, while the supplement might not enhance eradication rates, it has notable benefits in managing side effects.
9
We looked into how probiotics might help manage antibiotic-associated diarrhea (AAD) in children through a review of systematic reviews. Our review considered various databases and included 20 studies, evaluating their reporting quality and overall evidence strength. While we found that higher doses of probiotics show promise in preventing AAD, caution is needed as many studies had significant quality gaps. Overall, probiotics could benefit kids facing AAD, but more robust research is essential for clearer recommendations.
References
- Li M, Xie Y. Efficacy and safety of as an adjuvant therapy for the eradication of : a meta-analysis. Front Cell Infect Microbiol. 2025;15:1441185. 10.3389/fcimb.2025.1441185
- Girard P, Verleye M, Castagné V. Serotoninergic Mechanisms of Action in the Relaxant Properties of Saccharomyces boulardii CNCM I-745 on the Intestine. Dig Dis Sci. 2025;70:191. 10.1007/s10620-024-08786-y
- Gwee KA, Lee WRW, Chua Q, Chiou FK, Aw MM, et al. The evidence for probiotics in the treatment of digestive disorders in the pediatric population. J Gastroenterol Hepatol. 2025;40:41. 10.1111/jgh.16809
- Hodzhev V, Dzhambazov K, Sapundziev N, Encheva M, Todorov S, et al. High-dose Probiotic Mix of spp., spp., , and to Prevent Antibiotic-associated Diarrhea in Adults: A Multicenter, Randomized, Double-blind, Placebo-controlled Trial (SPAADA). Open Forum Infect Dis. 2024;11:ofae615. 10.1093/ofid/ofae615
- Chen Y, Teng T, Su Y, Chen WZ. The effect of supplementing with on bismuth quadruple therapy for eradicating : a systematic review and meta-analysis of randomized controlled trials. Front Med (Lausanne). 2024;11:1344702. 10.3389/fmed.2024.1344702
- Pal BB, Bandagi RV, Pebbili KK, Rathod R, Kotak B, et al. Effectiveness of Saccharomyces boulardii CNCM I-745 in Adult Indian Patients with Diarrhoea: A Real-world, Multicentre, Retrospective, Comparative Study. Drugs Real World Outcomes. 2024;11:309. 10.1007/s40801-024-00424-3
- Alharbi BF, Alateek AA. Investigating the influence of probiotics in preventing Traveler's diarrhea: Meta-analysis based systematic review. Travel Med Infect Dis. 2024;59:102703. 10.1016/j.tmaid.2024.102703
- Waitzberg D, Guarner F, Hojsak I, Ianiro G, Polk DB, et al. Can the Evidence-Based Use of Probiotics (Notably Saccharomyces boulardii CNCM I-745 and Lactobacillus rhamnosus GG) Mitigate the Clinical Effects of Antibiotic-Associated Dysbiosis?. Adv Ther. 2024;41:901. 10.1007/s12325-024-02783-3
- Liu LH, Han B, Tao J, Zhang K, Wang XK, et al. The effect of Saccharomyces boulardii supplementation on Helicobacter pylori eradication in children: a systematic review and meta-analysis of Randomized controlled trials. BMC Infect Dis. 2023;23:878. 10.1186/s12879-023-08896-4
- Sjomina O, Poļaka I, Suhorukova J, Vangravs R, Paršutins S, et al. Randomised clinical trial: efficacy and safety of H. pylori eradication treatment with and without Saccharomyces boulardii supplementation. Eur J Cancer Prev. 2024;33:217. 10.1097/CEJ.0000000000000858
- Gopalan S, Ganapathy S, Mitra M, Kumar Joshi D, Veligandla KC, et al. Unique Properties of Yeast Probiotic Saccharomyces boulardii CNCM I-745: A Narrative Review. Cureus. 2023;15:e46314. 10.7759/cureus.46314
- Yang Q, Hu Z, Lei Y, Li X, Xu C, et al. Overview of systematic reviews of probiotics in the prevention and treatment of antibiotic-associated diarrhea in children. Front Pharmacol. 2023;14:1153070. 10.3389/fphar.2023.1153070
- Salazar-Parra MA, Cruz-Neri RU, Trujillo-Trujillo XA, Dominguez-Mora JJ, Cruz-Neri HI, et al. Effectiveness of Saccharomyces Boulardii CNCM I-745 probiotic in acute inflammatory viral diarrhoea in adults: results from a single-centre randomized trial. BMC Gastroenterol. 2023;23:229. 10.1186/s12876-023-02863-8
- Cakcak İE, Aytın YE, Sayın S, Küçükarda A, Gökyer A, et al. An experimental study: the effect of S. boulardii on abemaciclibinduced diarrhea. Turk J Med Sci. 2023;53:51. 10.55730/1300-0144.5557
- He XJ, Wang XL, Sun DJ, Huang XY, Liu G, et al. The efficacy and safety of in addition to antofloxacin-based bismuth quadruple therapy for eradication: a single-center, prospective randomized-control study. Therap Adv Gastroenterol. 2023;16:17562848221147763. 10.1177/17562848221147763
- Bustos Fernández LM, Man F, Lasa JS. Impact of Saccharomyces boulardii CNCM I-745 on Bacterial Overgrowth and Composition of Intestinal Microbiota in Diarrhea-Predominant Irritable Bowel Syndrome Patients: Results of a Randomized Pilot Study. Dig Dis. 2023;41:798. 10.1159/000528954
- Dang X, Choi SY, Choi YJ, Lee JH, Castex M, et al. Probiotic, Paraprobiotic, and Hydrolyzed Yeast Mixture Supplementation Has Comparable Effects to Zinc Oxide in Improving Growth Performance and Ameliorating Post-weaning Diarrhea in Weaned Piglets. Probiotics Antimicrob Proteins. 2024;16:249. 10.1007/s12602-022-10008-8
