Medical Researches
Moderately Effective
Based on 13 Researches
Probiotic reduces side effectsEffectiveness of 7-Day and 14-Day Moxifloxacin-Dexlansoprazole Based Triple Therapy and Probiotic Supplement for Helicobacter Pylori Eradication in Thai Patients with Non-Ulcer Dyspepsia: A Double-Blind Randomized Placebo-Controlled Study.
Highly relevant probiotic findings
We looked into how the probiotic Saccharomyces boulardii affects the treatment of Helicobacter pylori in Thai patients. In a double-blind study, participants received either a probiotic or placebo with a moxifloxacin-dexlansoprazole therapy.
While the treatment achieved high eradication rates of H. pylori, we found that the addition of the probiotic significantly reduced side effects like nausea and diarrhea compared to those on placebo. This suggests that Saccharomyces boulardii could enhance patient comfort during an effective antibiotic regimen.
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This study examined how Saccharomyces boulardii supernatant (SbS) impacts ulcerative colitis (UC) by activating the FXR-NLRP3 signaling pathway. We used a murine model to assess the effects of SbS compared to a control group.
Our findings showed that SbS not only activated FXR but also suppressed the NLRP3 inflammasome in colonic tissues. It reduced macrophage pyroptosis, a process linked to inflammation. However, the benefits were reversed by an FXR inhibitor, indicating that FXR’s activation is crucial for SbS's effects.
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We investigated the impact of a targeted delivery system for Saccharomyces boulardii, a probiotic yeast, aimed at treating ulcerative colitis. In our preclinical studies on female mice, we found that this engineered strain significantly improved gut retention time, increasing it by an extra 24-48 hours.
This enhanced delivery led to a dramatic boost in the concentration of the probiotic in the colon, which resulted in notable improvements in colon health markers. Key indicators like colon length and inflammation scores returned to healthier levels, suggesting promising potential for this targeted treatment strategy in managing inflammatory bowel diseases.
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We explored the effects of Saccharomyces boulardii (Sb) in mice with NSAID-induced enteropathy. Through various assessments, including clinical scores and intestinal analyses, we compared four groups: Control, Indomethacin, Sb, and Sb with Indomethacin.
Mice treated with Sb demonstrated significant improvements in their health compared to those only on indomethacin. Sb not only enhanced the intestinal barrier but also positively influenced gut bacteria, reducing inflammation and damage caused by NSAIDs.
Our findings suggest that Sb could serve as a protective agent against NSAID-related intestinal issues.
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We explored how the probiotic yeast, Saccharomyces boulardii, impacts ulcerative colitis in mice. Through a careful setup, C57BL/6 mice received the treatment for three weeks and were later exposed to a harmful substance to induce the condition.
The results were promising; we observed that Saccharomyces boulardii significantly improved various symptoms. It helped prevent weight loss, diarrhea, and inflammation while strengthening the intestinal barrier. Furthermore, it demonstrated an ability to counteract oxidative damage effectively.
However, we also noted that while these findings are positive, further research is needed to fully understand the comprehensive benefits of this treatment in humans.
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