Reviewed By
Overview
SCIENTIFIC SCORE
Questionable
Based on 4 Researches
5.5
USERS' SCORE
Good
Based on 8 Reviews
8.7
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Zinc (as zinc oxide from ferment media)
15 mg
136%
Copper (as copper sulfate anhydrous from ferment media)
1.5 mg
167%
Cardio Support BlendOrganic Oregano (leaf) from ferment media, Organic Hawthorn (berry, leaf and flower) from ferment media, Grape Seed extract
12 mg
•
Immune System Blend (from ferment media)European Elder (berry) extract, OrganicEleuthero (root), Organic Astragalus (root)
11.2 mg
•
Digestive Support Blend (from ferment media)Organic Aloe (leaf), Organic Peppermint (leaf),Organic Coriander (seed), Organic Cardamom (fruit),Organic Artichoke (leaf)
11.2 mg
•
Ginger (rhizome) 1.2 mg aqueous extract and0.3 mg organic supercritical extract
1.5 mg
•
Organic Turmeric (rhizome)1 mg from ferment media and 0.3 mg supercritical extract
1.3 mg
•
Top Medical Research Studies
7
Zinc treatment reduces nausea risk
We conducted a study to evaluate how effective NPC-25, a new form of zinc, is compared to a well-known treatment, NOBELZIN™, for patients with low zinc levels. Participants in this trial had their zinc levels checked and were grouped to receive either NPC-25 or NOBELZIN™.
For a period of up to 24 weeks, we aimed to maintain their zinc levels within a specific target range while closely monitoring for side effects. One of our main goals was to see if NPC-25 could maintain these target zinc levels similarly to NOBELZIN™.
Our findings revealed that NPC-25 was indeed non-inferior to NOBELZIN™, meaning it worked just as well. Importantly, we also observed that those taking NPC-25 reported fewer digestive issues, like nausea and vomiting. This suggests that while both treatments were effective, NPC-25 might be the gentler option.
For a period of up to 24 weeks, we aimed to maintain their zinc levels within a specific target range while closely monitoring for side effects. One of our main goals was to see if NPC-25 could maintain these target zinc levels similarly to NOBELZIN™.
Our findings revealed that NPC-25 was indeed non-inferior to NOBELZIN™, meaning it worked just as well. Importantly, we also observed that those taking NPC-25 reported fewer digestive issues, like nausea and vomiting. This suggests that while both treatments were effective, NPC-25 might be the gentler option.
Read More
7
We explored the impact of zinc acetate dihydrate on several symptoms, including nausea, through a comprehensive study that assessed its safety and effectiveness for treating hypozincemia over a 52-week period. From the data collected, we observed an overall adverse reaction rate of 9.4%, with nausea reported in 1.4% of patients.
Despite nausea being a concern, the benefit of zinc acetate dihydrate for other indications was notable, with an efficacy rate of 83%. For patients experiencing symptoms such as pressure ulcers or stomatitis, the effectiveness was strikingly high. However, the specific effect of zinc on nausea is not definitively isolated within the study results, making it hard to gauge its direct and unique benefits.
In essence, while zinc acetate dihydrate shows promise for a variety of symptoms, including nausea, the evidence does not conclusively highlight its effectiveness for this particular issue on its own. Overall, it appears that zinc treatment can contribute positively to addressing several related health problems.
Despite nausea being a concern, the benefit of zinc acetate dihydrate for other indications was notable, with an efficacy rate of 83%. For patients experiencing symptoms such as pressure ulcers or stomatitis, the effectiveness was strikingly high. However, the specific effect of zinc on nausea is not definitively isolated within the study results, making it hard to gauge its direct and unique benefits.
In essence, while zinc acetate dihydrate shows promise for a variety of symptoms, including nausea, the evidence does not conclusively highlight its effectiveness for this particular issue on its own. Overall, it appears that zinc treatment can contribute positively to addressing several related health problems.
Read More
4
Zinc affects post-op nausea minimally
We explored the effectiveness of zinc-impregnated pharyngeal packs in reducing post-operative nausea and sore throat among patients undergoing septorhinoplasty. In this study, we divided 220 patients into four groups, each receiving different types of pharyngeal packs: normal saline-impregnated vibril, normal saline-impregnated gauze, zinc solution-impregnated vibril, and zinc solution-impregnated gauze.
Our findings revealed that there was no significant difference between the groups regarding the occurrence of sore throat shortly after surgery and at various intervals thereafter. However, we did observe that those using zinc solution-impregnated gauze experienced significantly less severity of nausea two hours post-surgery compared to those using normal saline-impregnated gauze. Ultimately, while zinc did not help with sore throat, it showed promise in alleviating nausea.
Our findings revealed that there was no significant difference between the groups regarding the occurrence of sore throat shortly after surgery and at various intervals thereafter. However, we did observe that those using zinc solution-impregnated gauze experienced significantly less severity of nausea two hours post-surgery compared to those using normal saline-impregnated gauze. Ultimately, while zinc did not help with sore throat, it showed promise in alleviating nausea.
Read More
Most Useful Reviews
10
No nausea experienced
121 people found this helpful
Effective and does not cause nausea like most Zinc supplements. I have a zinc deficiency and must take these tablets daily for life. Previously, I took other forms of Zinc that caused severe nausea and discomfort, especially on an empty stomach. This product has been life-changing, allowing me to take my full daily dose without the previous fear of nausea.
Read More
9
Avoid nausea completely
60 people found this helpful
Tried and true. These are not processed with hexane, unlike other brands. You can take these vitamins without feeling nauseated. I have been taking New Chapter for quite a few years and really love them!
Read More
9
Perfectly absorbed
1 people found this helpful
Excellent Zinc Complex! This is one of the top zinc products available. The complex, including not just zinc but also all necessary components for optimal performance (copper and additional supporting mixtures), is outstanding. I consume it several times a year and have had no nausea or discomfort; it is perfectly absorbed!
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 4 Researches
5.5
- All Researches
7
Zinc treatment reduces nausea risk
We conducted a study to evaluate how effective NPC-25, a new form of zinc, is compared to a well-known treatment, NOBELZIN™, for patients with low zinc levels. Participants in this trial had their zinc levels checked and were grouped to receive either NPC-25 or NOBELZIN™.
For a period of up to 24 weeks, we aimed to maintain their zinc levels within a specific target range while closely monitoring for side effects. One of our main goals was to see if NPC-25 could maintain these target zinc levels similarly to NOBELZIN™.
Our findings revealed that NPC-25 was indeed non-inferior to NOBELZIN™, meaning it worked just as well. Importantly, we also observed that those taking NPC-25 reported fewer digestive issues, like nausea and vomiting. This suggests that while both treatments were effective, NPC-25 might be the gentler option.
For a period of up to 24 weeks, we aimed to maintain their zinc levels within a specific target range while closely monitoring for side effects. One of our main goals was to see if NPC-25 could maintain these target zinc levels similarly to NOBELZIN™.
Our findings revealed that NPC-25 was indeed non-inferior to NOBELZIN™, meaning it worked just as well. Importantly, we also observed that those taking NPC-25 reported fewer digestive issues, like nausea and vomiting. This suggests that while both treatments were effective, NPC-25 might be the gentler option.
Read More
7
We explored the impact of zinc acetate dihydrate on several symptoms, including nausea, through a comprehensive study that assessed its safety and effectiveness for treating hypozincemia over a 52-week period. From the data collected, we observed an overall adverse reaction rate of 9.4%, with nausea reported in 1.4% of patients.
Despite nausea being a concern, the benefit of zinc acetate dihydrate for other indications was notable, with an efficacy rate of 83%. For patients experiencing symptoms such as pressure ulcers or stomatitis, the effectiveness was strikingly high. However, the specific effect of zinc on nausea is not definitively isolated within the study results, making it hard to gauge its direct and unique benefits.
In essence, while zinc acetate dihydrate shows promise for a variety of symptoms, including nausea, the evidence does not conclusively highlight its effectiveness for this particular issue on its own. Overall, it appears that zinc treatment can contribute positively to addressing several related health problems.
Despite nausea being a concern, the benefit of zinc acetate dihydrate for other indications was notable, with an efficacy rate of 83%. For patients experiencing symptoms such as pressure ulcers or stomatitis, the effectiveness was strikingly high. However, the specific effect of zinc on nausea is not definitively isolated within the study results, making it hard to gauge its direct and unique benefits.
In essence, while zinc acetate dihydrate shows promise for a variety of symptoms, including nausea, the evidence does not conclusively highlight its effectiveness for this particular issue on its own. Overall, it appears that zinc treatment can contribute positively to addressing several related health problems.
Read More
4
Zinc affects post-op nausea minimally
We explored the effectiveness of zinc-impregnated pharyngeal packs in reducing post-operative nausea and sore throat among patients undergoing septorhinoplasty. In this study, we divided 220 patients into four groups, each receiving different types of pharyngeal packs: normal saline-impregnated vibril, normal saline-impregnated gauze, zinc solution-impregnated vibril, and zinc solution-impregnated gauze.
Our findings revealed that there was no significant difference between the groups regarding the occurrence of sore throat shortly after surgery and at various intervals thereafter. However, we did observe that those using zinc solution-impregnated gauze experienced significantly less severity of nausea two hours post-surgery compared to those using normal saline-impregnated gauze. Ultimately, while zinc did not help with sore throat, it showed promise in alleviating nausea.
Our findings revealed that there was no significant difference between the groups regarding the occurrence of sore throat shortly after surgery and at various intervals thereafter. However, we did observe that those using zinc solution-impregnated gauze experienced significantly less severity of nausea two hours post-surgery compared to those using normal saline-impregnated gauze. Ultimately, while zinc did not help with sore throat, it showed promise in alleviating nausea.
Read More
4
Zinc's tolerability in diarrhoea treatment
We aimed to understand how zinc tablets, often recommended for treating diarrhoea in young children, affect nausea and overall treatment adherence. In this open-label study, we involved children aged 3 to 59 months who visited the outpatient department at Dhaka Hospital.
Our findings revealed that a significant number of children, about 92.7%, tolerated the modified zinc tablets well. However, we also noted that 32.8% of the children experienced vomiting, and 19.5% had regurgitation, while a smaller number, 7.4%, reported nausea. Interestingly, despite these side effects, a remarkable 99.3% of caregivers expressed their willingness to continue using this zinc formulation in the future.
Overall, while our study demonstrated that the modified zinc formulation was generally well-tolerated, we cannot overlook the considerable instances of nausea and vomiting experienced by the children. Balancing these side effects with the willingness of caregivers offers a complex view of zinc's role in diarrhoea management.
Our findings revealed that a significant number of children, about 92.7%, tolerated the modified zinc tablets well. However, we also noted that 32.8% of the children experienced vomiting, and 19.5% had regurgitation, while a smaller number, 7.4%, reported nausea. Interestingly, despite these side effects, a remarkable 99.3% of caregivers expressed their willingness to continue using this zinc formulation in the future.
Overall, while our study demonstrated that the modified zinc formulation was generally well-tolerated, we cannot overlook the considerable instances of nausea and vomiting experienced by the children. Balancing these side effects with the willingness of caregivers offers a complex view of zinc's role in diarrhoea management.
Read More
User Reviews
USERS' SCORE
Good
Based on 8 Reviews
8.7
- All Reviews
- Positive Reviews
- Negative Reviews
10
No nausea experienced
121 people found this helpful
Effective and does not cause nausea like most Zinc supplements. I have a zinc deficiency and must take these tablets daily for life. Previously, I took other forms of Zinc that caused severe nausea and discomfort, especially on an empty stomach. This product has been life-changing, allowing me to take my full daily dose without the previous fear of nausea.
Read More
9
Avoid nausea completely
60 people found this helpful
Tried and true. These are not processed with hexane, unlike other brands. You can take these vitamins without feeling nauseated. I have been taking New Chapter for quite a few years and really love them!
Read More
9
Perfectly absorbed
1 people found this helpful
Excellent Zinc Complex! This is one of the top zinc products available. The complex, including not just zinc but also all necessary components for optimal performance (copper and additional supporting mixtures), is outstanding. I consume it several times a year and have had no nausea or discomfort; it is perfectly absorbed!
Read More
9
Definitely recommended
1 people found this helpful
No nausea! Zinc generally makes me feel nauseous, but not this one. It goes down gently and I'm now on my second bottle. I definitely recommend it!
Read More
8
No nausea
6 people found this helpful
Excellent zinc + copper. I plan to take a course for two months, 1 tablet along with 1 tablet of quercetin for better zinc absorption. I started four days ago, and I’ve experienced no nausea. Previously, I took zinc from MegaFood with the same approach, and it was equally well tolerated. Zinc and copper are vital for both immunity and promoting healthy hair while preventing greys!
Read More
Frequently Asked Questions
8
No nausea
6 people found this helpful
Excellent zinc + copper. I plan to take a course for two months, 1 tablet along with 1 tablet of quercetin for better zinc absorption. I started four days ago, and I’ve experienced no nausea. Previously, I took zinc from MegaFood with the same approach, and it was equally well tolerated. Zinc and copper are vital for both immunity and promoting healthy hair while preventing greys!
9
Definitely recommended
1 people found this helpful
No nausea! Zinc generally makes me feel nauseous, but not this one. It goes down gently and I'm now on my second bottle. I definitely recommend it!
2
Caused severe nausea
Good balanced composition of zinc and copper. I couldn’t take it on an empty stomach as it caused severe nausea, so I only take it during meals.
9
Perfectly absorbed
1 people found this helpful
Excellent Zinc Complex! This is one of the top zinc products available. The complex, including not just zinc but also all necessary components for optimal performance (copper and additional supporting mixtures), is outstanding. I consume it several times a year and have had no nausea or discomfort; it is perfectly absorbed!
7
Zinc treatment reduces nausea risk
We conducted a study to evaluate how effective NPC-25, a new form of zinc, is compared to a well-known treatment, NOBELZIN™, for patients with low zinc levels. Participants in this trial had their zinc levels checked and were grouped to receive either NPC-25 or NOBELZIN™.
For a period of up to 24 weeks, we aimed to maintain their zinc levels within a specific target range while closely monitoring for side effects. One of our main goals was to see if NPC-25 could maintain these target zinc levels similarly to NOBELZIN™.
Our findings revealed that NPC-25 was indeed non-inferior to NOBELZIN™, meaning it worked just as well. Importantly, we also observed that those taking NPC-25 reported fewer digestive issues, like nausea and vomiting. This suggests that while both treatments were effective, NPC-25 might be the gentler option.
For a period of up to 24 weeks, we aimed to maintain their zinc levels within a specific target range while closely monitoring for side effects. One of our main goals was to see if NPC-25 could maintain these target zinc levels similarly to NOBELZIN™.
Our findings revealed that NPC-25 was indeed non-inferior to NOBELZIN™, meaning it worked just as well. Importantly, we also observed that those taking NPC-25 reported fewer digestive issues, like nausea and vomiting. This suggests that while both treatments were effective, NPC-25 might be the gentler option.
4
Zinc affects post-op nausea minimally
We explored the effectiveness of zinc-impregnated pharyngeal packs in reducing post-operative nausea and sore throat among patients undergoing septorhinoplasty. In this study, we divided 220 patients into four groups, each receiving different types of pharyngeal packs: normal saline-impregnated vibril, normal saline-impregnated gauze, zinc solution-impregnated vibril, and zinc solution-impregnated gauze.
Our findings revealed that there was no significant difference between the groups regarding the occurrence of sore throat shortly after surgery and at various intervals thereafter. However, we did observe that those using zinc solution-impregnated gauze experienced significantly less severity of nausea two hours post-surgery compared to those using normal saline-impregnated gauze. Ultimately, while zinc did not help with sore throat, it showed promise in alleviating nausea.
Our findings revealed that there was no significant difference between the groups regarding the occurrence of sore throat shortly after surgery and at various intervals thereafter. However, we did observe that those using zinc solution-impregnated gauze experienced significantly less severity of nausea two hours post-surgery compared to those using normal saline-impregnated gauze. Ultimately, while zinc did not help with sore throat, it showed promise in alleviating nausea.
7
We explored the impact of zinc acetate dihydrate on several symptoms, including nausea, through a comprehensive study that assessed its safety and effectiveness for treating hypozincemia over a 52-week period. From the data collected, we observed an overall adverse reaction rate of 9.4%, with nausea reported in 1.4% of patients.
Despite nausea being a concern, the benefit of zinc acetate dihydrate for other indications was notable, with an efficacy rate of 83%. For patients experiencing symptoms such as pressure ulcers or stomatitis, the effectiveness was strikingly high. However, the specific effect of zinc on nausea is not definitively isolated within the study results, making it hard to gauge its direct and unique benefits.
In essence, while zinc acetate dihydrate shows promise for a variety of symptoms, including nausea, the evidence does not conclusively highlight its effectiveness for this particular issue on its own. Overall, it appears that zinc treatment can contribute positively to addressing several related health problems.
Despite nausea being a concern, the benefit of zinc acetate dihydrate for other indications was notable, with an efficacy rate of 83%. For patients experiencing symptoms such as pressure ulcers or stomatitis, the effectiveness was strikingly high. However, the specific effect of zinc on nausea is not definitively isolated within the study results, making it hard to gauge its direct and unique benefits.
In essence, while zinc acetate dihydrate shows promise for a variety of symptoms, including nausea, the evidence does not conclusively highlight its effectiveness for this particular issue on its own. Overall, it appears that zinc treatment can contribute positively to addressing several related health problems.
4
Zinc's tolerability in diarrhoea treatment
We aimed to understand how zinc tablets, often recommended for treating diarrhoea in young children, affect nausea and overall treatment adherence. In this open-label study, we involved children aged 3 to 59 months who visited the outpatient department at Dhaka Hospital.
Our findings revealed that a significant number of children, about 92.7%, tolerated the modified zinc tablets well. However, we also noted that 32.8% of the children experienced vomiting, and 19.5% had regurgitation, while a smaller number, 7.4%, reported nausea. Interestingly, despite these side effects, a remarkable 99.3% of caregivers expressed their willingness to continue using this zinc formulation in the future.
Overall, while our study demonstrated that the modified zinc formulation was generally well-tolerated, we cannot overlook the considerable instances of nausea and vomiting experienced by the children. Balancing these side effects with the willingness of caregivers offers a complex view of zinc's role in diarrhoea management.
Our findings revealed that a significant number of children, about 92.7%, tolerated the modified zinc tablets well. However, we also noted that 32.8% of the children experienced vomiting, and 19.5% had regurgitation, while a smaller number, 7.4%, reported nausea. Interestingly, despite these side effects, a remarkable 99.3% of caregivers expressed their willingness to continue using this zinc formulation in the future.
Overall, while our study demonstrated that the modified zinc formulation was generally well-tolerated, we cannot overlook the considerable instances of nausea and vomiting experienced by the children. Balancing these side effects with the willingness of caregivers offers a complex view of zinc's role in diarrhoea management.
References
- Asaoka D, Ishihara T, Ezoe S, Hamada I, Kitamura M, et al. Randomized, multicenter, active-controlled open-label study of NPC-25, zinc histidine hydrate, (non-inferiority to NOBELZIN™, zinc acetate dihydrate) for patients with hypozincemia. J Trace Elem Med Biol. 2025;87:127558. 10.1016/j.jtemb.2024.127558
- Ezoe S, Ishihara T, Hosogai T, Kokubo T. Post-marketing surveillance of zinc acetate dihydrate for hypozincemia in Japan. Pharmazie. 2024;79:29. 10.1691/ph.2024.3630
- Parvizi A, Haddadi S, Akbari M, Akbarpour M, Taghipour Rudsari F, et al. Comparing the Effect of Zinc-impregnated Pharyngeal Packs with Conventional Methods on the Level of Sore Throat Among Patients Undergoing Septorhinoplasty. Anesth Pain Med. 2022;12:e127262. 10.5812/aapm-127262
- Nuzhat S, Ahmed T, Alam J, Billal SM, Khan AI, et al. New formulation zinc sulphate acceptability and adherence in children with acute diarrhoea: A prospective, open-label, interventional study in Bangladesh. J Paediatr Child Health. 2022;58:1215. 10.1111/jpc.15953
