Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 38 Researches
7.4
USERS' SCORE
Good
Based on 2 Reviews
8.5
Supplement Facts
Serving Size: 2 Soft Gels
Amount Per Serving
%DV
Calories
10
Total Fat
1 g
1%
Saturated Fat
0 g
0%
Trans Fat
0 g
†
Vitamin D3 (cholecalciferol)
10 mcg (400 IU)
67%
Total Omega-3s♦
830 mg
†
EPA (Eicosapentaenoic Acid)
205 mg
†
DHA (Docosahexaenoic Acid)
480 mg
†
Top Medical Research Studies
8
We explored the effects of eicosapentaenoic acid (EPA), a key component of omega-3 fatty acids, on patients with rheumatoid arthritis (RA). This analysis gathered data from eighteen randomized controlled trials involving over a thousand RA patients, ensuring a comprehensive look at its impact.
Our findings revealed that EPA supplementation significantly increased levels of both eicosapentaenoic acid and docosahexaenoic acid (DHA). Additionally, we noted a reduction in the omega-6 to omega-3 fatty acid ratio, which is beneficial for overall health.
Moreover, we observed that EPA led to a decrease in triglyceride levels and tender joint counts among RA patients. However, while there were slight decreases in markers of inflammation, such as erythrocyte sedimentation rate and C-reactive protein, these changes were not statistically significant.
Overall, our analysis supports the idea that EPA has positive effects on lipid profiles and joint tenderness for those with RA, although not all inflammatory markers showed significant improvement.
Our findings revealed that EPA supplementation significantly increased levels of both eicosapentaenoic acid and docosahexaenoic acid (DHA). Additionally, we noted a reduction in the omega-6 to omega-3 fatty acid ratio, which is beneficial for overall health.
Moreover, we observed that EPA led to a decrease in triglyceride levels and tender joint counts among RA patients. However, while there were slight decreases in markers of inflammation, such as erythrocyte sedimentation rate and C-reactive protein, these changes were not statistically significant.
Overall, our analysis supports the idea that EPA has positive effects on lipid profiles and joint tenderness for those with RA, although not all inflammatory markers showed significant improvement.
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9
We explored the link between vitamin D3 and knee osteoarthritis (OA) by examining both young and older mice. Our findings revealed that a deficiency in vitamin D3, specifically the active form known as 1,25(OH)D, significantly sped up the development of age-related OA. This included issues such as cartilage damage and increased chondrocyte senescence.
When we supplemented with vitamin D3, we were pleased to see a reversal of these negative changes in OA phenotypes among the test mice. It not only improved cartilage health but also countered oxidative stress and cell aging associated with OA.
Our research highlights the important role of vitamin D3 in maintaining joint health and its potential to help prevent or slow down the onset of OA through mechanisms involving Sirt1, a gene linked to aging and cellular health. This suggests that ensuring sufficient levels of vitamin D3 could be a useful strategy for those at risk of developing arthritis.
When we supplemented with vitamin D3, we were pleased to see a reversal of these negative changes in OA phenotypes among the test mice. It not only improved cartilage health but also countered oxidative stress and cell aging associated with OA.
Our research highlights the important role of vitamin D3 in maintaining joint health and its potential to help prevent or slow down the onset of OA through mechanisms involving Sirt1, a gene linked to aging and cellular health. This suggests that ensuring sufficient levels of vitamin D3 could be a useful strategy for those at risk of developing arthritis.
Read More
9
We set out to investigate how docosahexaenoic acid (DHA), a fatty acid known for its health benefits, can affect osteoarthritis (OA), a common degenerative joint disease, particularly among older adults. Using both human chondrocyte models stimulated by IL-1β and rat models created through surgical methods, we aimed to understand DHA's potential to impact chondrocyte behavior and cartilage health.
Our observations revealed that DHA significantly promotes the growth of chondrocytes while reducing cell death, which is a key concern in OA. Notably, we found an increase in autophagosomes—structures that help break down cellular waste—within cells treated with DHA, suggesting enhanced cell health.
In comparing groups, those treated with DHA exhibited healthier cartilage characterized by thickened tissue and a decrease in degeneration when compared to the untreated OA group. We also noted an increase in collagen production, vital for maintaining joint structure. The biochemical analysis indicated that DHA potentially exerts its effects by inhibiting certain pathways associated with cell growth and stress responses, thus enhancing chondrocyte proliferation and survival.
Overall, our findings contribute valuable insights into how DHA can be leveraged as a therapeutic approach for OA, emphasizing its role in protecting and restoring cartilage health.
Our observations revealed that DHA significantly promotes the growth of chondrocytes while reducing cell death, which is a key concern in OA. Notably, we found an increase in autophagosomes—structures that help break down cellular waste—within cells treated with DHA, suggesting enhanced cell health.
In comparing groups, those treated with DHA exhibited healthier cartilage characterized by thickened tissue and a decrease in degeneration when compared to the untreated OA group. We also noted an increase in collagen production, vital for maintaining joint structure. The biochemical analysis indicated that DHA potentially exerts its effects by inhibiting certain pathways associated with cell growth and stress responses, thus enhancing chondrocyte proliferation and survival.
Overall, our findings contribute valuable insights into how DHA can be leveraged as a therapeutic approach for OA, emphasizing its role in protecting and restoring cartilage health.
Read More
Most Useful Reviews
9
Relief for arthritis
Omega strengthens the immune system, normalises metabolism, and helps manage mental stress. It has also prevented osteoporosis, supported joint health, and alleviated pain during flare-ups. Omega-3 fatty acids reduce inflammation, fight bone loss, and alleviate symptoms of arthritis while preserving cartilage during arthrosis. The quality is excellent, the capsules are small, and the taste is pleasant with no unpleasant odour.
Read More
7.5
Supports joint health
This omega is fantastic for pregnant women as it supports joint health while alleviating arthritis symptoms. Omega-3s reduce inflammation and help combat bone loss, which is essential during this period. They also effectively ease joint pain and slow the progression of arthritis.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 38 Researches
7.4
- All Researches
9
We conducted an insightful study to explore how vitamin D3 supplementation might affect rheumatoid arthritis (RA) symptoms, particularly focusing on disease activity and fatigue. This research involved a total of 68 RA patients who were monitored over a period of 12 weeks.
Our participants were divided into two groups. One group received a weekly dose of 50,000 IU of vitamin D3 alongside their conventional arthritis medications. The other group continued with their standard treatment regimen without any vitamin D3.
As we evaluated the outcomes, we found that the group receiving vitamin D3 exhibited significant improvements. Specifically, they showed enhanced levels of vitamin D and reported lower fatigue, as measured by the FACIT-F score. While both groups initially presented similar health characteristics, those on vitamin D3 achieved a normal range in fatigue levels compared to the continued struggle within the other group.
Interestingly, we observed a positive correlation between higher vitamin D levels and improved fatigue scores, indicating that vitamin D3 could indeed play a beneficial role in managing symptoms associated with rheumatoid arthritis. However, disease activity scores did not show a strong significant correlation with vitamin D levels, suggesting that more research may be necessary to understand this relationship fully.
Our participants were divided into two groups. One group received a weekly dose of 50,000 IU of vitamin D3 alongside their conventional arthritis medications. The other group continued with their standard treatment regimen without any vitamin D3.
As we evaluated the outcomes, we found that the group receiving vitamin D3 exhibited significant improvements. Specifically, they showed enhanced levels of vitamin D and reported lower fatigue, as measured by the FACIT-F score. While both groups initially presented similar health characteristics, those on vitamin D3 achieved a normal range in fatigue levels compared to the continued struggle within the other group.
Interestingly, we observed a positive correlation between higher vitamin D levels and improved fatigue scores, indicating that vitamin D3 could indeed play a beneficial role in managing symptoms associated with rheumatoid arthritis. However, disease activity scores did not show a strong significant correlation with vitamin D levels, suggesting that more research may be necessary to understand this relationship fully.
Read More
9
We explored the link between vitamin D3 and knee osteoarthritis (OA) by examining both young and older mice. Our findings revealed that a deficiency in vitamin D3, specifically the active form known as 1,25(OH)D, significantly sped up the development of age-related OA. This included issues such as cartilage damage and increased chondrocyte senescence.
When we supplemented with vitamin D3, we were pleased to see a reversal of these negative changes in OA phenotypes among the test mice. It not only improved cartilage health but also countered oxidative stress and cell aging associated with OA.
Our research highlights the important role of vitamin D3 in maintaining joint health and its potential to help prevent or slow down the onset of OA through mechanisms involving Sirt1, a gene linked to aging and cellular health. This suggests that ensuring sufficient levels of vitamin D3 could be a useful strategy for those at risk of developing arthritis.
When we supplemented with vitamin D3, we were pleased to see a reversal of these negative changes in OA phenotypes among the test mice. It not only improved cartilage health but also countered oxidative stress and cell aging associated with OA.
Our research highlights the important role of vitamin D3 in maintaining joint health and its potential to help prevent or slow down the onset of OA through mechanisms involving Sirt1, a gene linked to aging and cellular health. This suggests that ensuring sufficient levels of vitamin D3 could be a useful strategy for those at risk of developing arthritis.
Read More
9
We conducted a study to examine the effects of eicosapentaenoic acid (EPA) combined with l-serine on individuals suffering from chronic low-back and knee pain. This was a randomized, double-blind, placebo-controlled trial, ensuring rigorous evaluation of the treatment's impact.
Over the course of 12 weeks, we assessed participants using well-structured questionnaires to measure their pain levels and overall experience. Our group comprised 120 adults who, despite enduring persistent pain for more than three months, showed promising results from the active treatment.
It appears that EPA, known for its anti-inflammatory properties, alongside l-serine, which supports nerve function, provided noticeable relief from pain. By the end of the study, many participants experienced significant improvements in their pain scores, suggesting that this combination could be a valuable option for those managing arthritis-related discomfort.
It's encouraging to see how l-serine and EPA can help enhance the quality of life for individuals struggling with painful conditions, reinforcing their importance as potential treatments for arthritis-related pain.
Over the course of 12 weeks, we assessed participants using well-structured questionnaires to measure their pain levels and overall experience. Our group comprised 120 adults who, despite enduring persistent pain for more than three months, showed promising results from the active treatment.
It appears that EPA, known for its anti-inflammatory properties, alongside l-serine, which supports nerve function, provided noticeable relief from pain. By the end of the study, many participants experienced significant improvements in their pain scores, suggesting that this combination could be a valuable option for those managing arthritis-related discomfort.
It's encouraging to see how l-serine and EPA can help enhance the quality of life for individuals struggling with painful conditions, reinforcing their importance as potential treatments for arthritis-related pain.
Read More
9
We investigated the impact of eicosapentaenoic acid (EPA) on osteoarthritis (OA) progression through an innovative approach involving gelatin hydrogels. In our study, we divided ten-week-old male mice into six different groups, each receiving various treatments after undergoing surgery that mimicked OA. This design allowed us to effectively compare the benefits of EPA delivered directly and through hydrogels.
Our findings revealed that when EPA was delivered in gelatin hydrogels, it significantly outperformed EPA injection alone in slowing down OA progression. Specifically, we measured several inflammatory markers and found that the group receiving the gelatin hydrogels exhibited lower levels of harmful proteins linked to inflammation and cartilage damage compared to those receiving just the EPA injections.
This suggests that the controlled release of EPA from these hydrogels can be a promising new strategy for treating OA. The potential benefits of gelatin hydrogels in enhancing the effectiveness of EPA treatment present a valuable insight for future therapeutic approaches addressing arthritis.
Our findings revealed that when EPA was delivered in gelatin hydrogels, it significantly outperformed EPA injection alone in slowing down OA progression. Specifically, we measured several inflammatory markers and found that the group receiving the gelatin hydrogels exhibited lower levels of harmful proteins linked to inflammation and cartilage damage compared to those receiving just the EPA injections.
This suggests that the controlled release of EPA from these hydrogels can be a promising new strategy for treating OA. The potential benefits of gelatin hydrogels in enhancing the effectiveness of EPA treatment present a valuable insight for future therapeutic approaches addressing arthritis.
Read More
9
Docosahexaenoic acid reduces arthritis
We examined the effects of lipid mediators derived from docosahexaenoic acid (DHA) on arthritis, particularly focusing on rheumatoid arthritis (RA). The study utilized a model involving mice with collagen antibody-induced arthritis (CAIA) and RAW264.7 cells to investigate the role of these mediators in reducing inflammation and joint damage.
The lipid mediators were produced by soybean lipoxygenase from DHA and included substances known for their anti-inflammatory properties. We found that these mediators significantly reduced symptoms in CAIA mice, evidenced by decreased paw swelling and reduced progression of arthritis. In the cellular studies, these mediators inhibited the formation of bone-resorbing cells called osteoclasts, while also downregulating key inflammatory markers.
Following treatment, there were notable improvements in serum cytokine levels, with a decrease in pro-inflammatory cytokines like TNF-α and IL-6, and an increase in the anti-inflammatory cytokine IL-10. Additionally, joint inflammation and damage were reduced, hinting at a complex relationship involving various signaling pathways.
These findings indicate that lipid mediators derived from DHA may offer a promising approach to alleviating symptoms of RA, though the precise individual contributions of DHA alone are difficult to isolate due to the presence of other components in the intervention.
The lipid mediators were produced by soybean lipoxygenase from DHA and included substances known for their anti-inflammatory properties. We found that these mediators significantly reduced symptoms in CAIA mice, evidenced by decreased paw swelling and reduced progression of arthritis. In the cellular studies, these mediators inhibited the formation of bone-resorbing cells called osteoclasts, while also downregulating key inflammatory markers.
Following treatment, there were notable improvements in serum cytokine levels, with a decrease in pro-inflammatory cytokines like TNF-α and IL-6, and an increase in the anti-inflammatory cytokine IL-10. Additionally, joint inflammation and damage were reduced, hinting at a complex relationship involving various signaling pathways.
These findings indicate that lipid mediators derived from DHA may offer a promising approach to alleviating symptoms of RA, though the precise individual contributions of DHA alone are difficult to isolate due to the presence of other components in the intervention.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Relief for arthritis
Omega strengthens the immune system, normalises metabolism, and helps manage mental stress. It has also prevented osteoporosis, supported joint health, and alleviated pain during flare-ups. Omega-3 fatty acids reduce inflammation, fight bone loss, and alleviate symptoms of arthritis while preserving cartilage during arthrosis. The quality is excellent, the capsules are small, and the taste is pleasant with no unpleasant odour.
Read More
7.5
Supports joint health
This omega is fantastic for pregnant women as it supports joint health while alleviating arthritis symptoms. Omega-3s reduce inflammation and help combat bone loss, which is essential during this period. They also effectively ease joint pain and slow the progression of arthritis.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
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- Deng C, Presle N, Pizard A, Guillaume C, Bianchi A, et al. Beneficial Impact of Eicosapentaenoic Acid on the Adverse Effects Induced by Palmitate and Hyperglycemia on Healthy Rat Chondrocyte. Int J Mol Sci. 2024;25. doi:10.3390/ijms25031810
- Poggioli R, Hirani K, Jogani VG, Ricordi C. Modulation of inflammation and immunity by omega-3 fatty acids: a possible role for prevention and to halt disease progression in autoimmune, viral, and age-related disorders. Eur Rev Med Pharmacol Sci. 2023;27:7380. doi:10.26355/eurrev_202308_33310
- Wadell AT, Bärebring L, Hulander E, Gjertsson I, Landberg R, et al. Dietary biomarkers and food records indicate compliance to study diets in the ADIRA (Anti-inflammatory Diet In Rheumatoid Arthritis) trial. Front Nutr. 2023;10:1209787. doi:10.3389/fnut.2023.1209787
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- Lindqvist HM, Winkvist A, Gjertsson I, Calder PC, Armando AM, et al. Influence of Dietary n-3 Long Chain Polyunsaturated Fatty Acid Intake on Oxylipins in Erythrocytes of Women with Rheumatoid Arthritis. Molecules. 2023;28. doi:10.3390/molecules28020717
- Kuang X, Shao X, Li H, Jiang D, Gao T, et al. Lipid extract from blue mussel (Mytilus edulis) improves glycemic traits in Chinese type 2 diabetic mellitus patients: a double-blind randomized controlled trial. J Sci Food Agric. 2023;103:2970. doi:10.1002/jsfa.12346
- Gkiouras K, Grammatikopoulou MG, Myrogiannis I, Papamitsou T, Rigopoulou EI, et al. Efficacy of n-3 fatty acid supplementation on rheumatoid arthritis' disease activity indicators: a systematic review and meta-analysis of randomized placebo-controlled trials. Crit Rev Food Sci Nutr. 2024;64:16. doi:10.1080/10408398.2022.2104210
- Stonehouse W, Benassi-Evans B, Bednarz J, Vincent AD, Hall S, et al. Krill oil improved osteoarthritic knee pain in adults with mild to moderate knee osteoarthritis: a 6-month multicenter, randomized, double-blind, placebo-controlled trial. Am J Clin Nutr. 2022;116:672. doi:10.1093/ajcn/nqac125
- Eckert T, Jährling-Butkus M, Louton H, Burg-Roderfeld M, Zhang R, et al. Efficacy of Chondroprotective Food Supplements Based on Collagen Hydrolysate and Compounds Isolated from Marine Organisms. Mar Drugs. 2021;19. doi:10.3390/md19100542
- Ceotto BH, Figueroba SR, Ferreira LEN, Amorim KS, Sánchez JB, et al. The effect of association of aspirin and omega 3 in rat temporomandibular joint with induced arthritis. Ann Anat. 2022;239:151812. doi:10.1016/j.aanat.2021.151812
- Fan Z, Ross RP, Stanton C, Hou B, Zhao J, et al. CCFM1074 Alleviates Collagen-Induced Arthritis in Rats Balancing Treg/Th17 and Modulating the Metabolites and Gut Microbiota. Front Immunol. 2021;12:680073. doi:10.3389/fimmu.2021.680073
- Sasahara I, Yamamoto A, Takeshita M, Suga Y, Suzuki K, et al. l-Serine and EPA Relieve Chronic Low-Back and Knee Pain in Adults: A Randomized, Double-Blind, Placebo-Controlled Trial. J Nutr. 2020;150:2278. doi:10.1093/jn/nxaa156
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- Tsubosaka M, Kihara S, Hayashi S, Nagata J, Kuwahara T, et al. Gelatin hydrogels with eicosapentaenoic acid can prevent osteoarthritis progression in vivo in a mouse model. J Orthop Res. 2020;38:2157. doi:10.1002/jor.24688
- Gowler PRW, Arendt-Tranholm A, Turnbull J, Jha RR, Onion D, et al. Monocyte eukaryotic initiation factor 2 signaling differentiates 17-hydroxy-docosahexaenoic acid levels and pain. iScience. 2025;28:111862. doi:10.1016/j.isci.2025.111862
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- Yu H, Gong Z, Wang G, Cao R, Yin H, et al. DHA attenuates cartilage degeneration by mediating apoptosis and autophagy in human chondrocytes and rat models of osteoarthritis. In Vitro Cell Dev Biol Anim. 2023;59:455. doi:10.1007/s11626-023-00781-3
- Léger T, Brun A, Lanchais K, Rigaudière JP, Briat A, et al. Docosahexaenoic acid and etanercept could reduce functional and metabolic alterations during collagen-induced arthritis in rats without any synergistic effect. Life Sci. 2023;327:121826. doi:10.1016/j.lfs.2023.121826
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- Jeong M, Shin JI, Cho J, Jeon YJ, Kim JH, et al. DHA Induces Cell Death through the Production of ROS and the Upregulation of CHOP in Fibroblast-like Synovial Cells from Human Rheumatoid Arthritis Patients. Int J Mol Sci. 2023;24. doi:10.3390/ijms24021734
- Xie R, Zhang Y. Association between 19 dietary fatty acids intake and rheumatoid arthritis: Results of a nationwide survey. Prostaglandins Leukot Essent Fatty Acids. 2023;188:102530. doi:10.1016/j.plefa.2022.102530
- Feng L, Yang Z, Li Y, Hou N, Yang B, et al. Malat1 attenuated the rescuing effects of docosahexaenoic acid on osteoarthritis treatment via repressing its chondroprotective and chondrogenesis activities. Biomed Pharmacother. 2022;154:113608. doi:10.1016/j.biopha.2022.113608
- Oppedisano F, Bulotta RM, Maiuolo J, Gliozzi M, Musolino V, et al. The Role of Nutraceuticals in Osteoarthritis Prevention and Treatment: Focus on n-3 PUFAs. Oxid Med Cell Longev. 2021;2021:4878562. doi:10.1155/2021/4878562
- Chang CK, Chen PK, Chen CC, Chang SH, Chen CH, et al. Increased Levels of Omega-3 Fatty Acids and DHA Are Linked to Pain Reduction in Rheumatoid Arthritis Patients Treated with Janus Kinase Inhibitors. Nutrients. 2021;13. doi:10.3390/nu13093050
- Christmann U, Hancock CL, Poole CM, Emery AL, Poovey JR, et al. Dynamics of DHA and EPA supplementation: incorporation into equine plasma, synovial fluid, and surfactant glycerophosphocholines. Metabolomics. 2021;17:41. doi:10.1007/s11306-021-01792-5
