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SCIENTIFIC SCORE
Possibly Effective
Based on 45 Researches
7.5
USERS' SCORE
Good
Based on 1 Review
8.5
Supplement Facts
Serving Size: 2 Soft Gels
Amount Per Serving
%DV
Calories
10
Total Fat
1 g
1%
Saturated Fat
0 g
0%
Trans Fat
0 g
†
Vitamin D3 (cholecalciferol)
10 mcg (400 IU)
67%
Total Omega-3s♦
830 mg
†
EPA (Eicosapentaenoic Acid)
205 mg
†
DHA (Docosahexaenoic Acid)
480 mg
†
Top Medical Research Studies
8
Vitamin D3 improves asthma control
Vitamin D supplementation decrease asthma exacerbations in children: a systematic review and meta-analysis of randomized controlled trials.
High relevance for study topic
We explored the effectiveness of vitamin D3 in reducing asthma exacerbations among children through a systematic review and meta-analysis of randomized controlled trials. In our investigation, we analyzed data from ten studies, which included a total of 1,243 children with asthma. Among these, 631 received vitamin D3 supplementation while 612 were given a placebo.
Our pooled analysis revealed promising results: vitamin D3 supplementation significantly reduced the overall number of asthma exacerbations. Specifically, we found a risk ratio of 0.62, indicating a notable decrease in attacks. Notably, a subgroup analysis showed that children receiving the standard daily dose of vitamin D experienced an even more significant improvement, with a risk ratio of 0.41.
Overall, we concluded that vitamin D3 supplementation holds the potential to lower asthma exacerbations in children. This is particularly encouraging as it also correlates with improved lung function, measured through FEV1. Hence, vitamin D3 could be a valuable addition to asthma management for young patients.
Our pooled analysis revealed promising results: vitamin D3 supplementation significantly reduced the overall number of asthma exacerbations. Specifically, we found a risk ratio of 0.62, indicating a notable decrease in attacks. Notably, a subgroup analysis showed that children receiving the standard daily dose of vitamin D experienced an even more significant improvement, with a risk ratio of 0.41.
Overall, we concluded that vitamin D3 supplementation holds the potential to lower asthma exacerbations in children. This is particularly encouraging as it also correlates with improved lung function, measured through FEV1. Hence, vitamin D3 could be a valuable addition to asthma management for young patients.
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5
Vitamin D3 may aid asthma
A 12-week double-blind randomised controlled trial investigating the effect of dietary supplementation with 125 g/d vitamin D in adults with asthma.
Direct investigation of asthma treatment
We conducted a robust study to understand how vitamin D3 supplementation affects adults with asthma. Over 12 weeks, we closely monitored 32 participants with mild to moderate asthma. They were randomly assigned to receive either a daily supplement of 125 µg of vitamin D or a placebo, which allowed us to measure the real impact of vitamin D on lung function and asthma symptoms.
Our findings showed a slight improvement in lung function among those who received vitamin D compared to those on the placebo. Specifically, there was a modest increase in the ratio of forced expiratory volume (FEV) to forced vital capacity (FVC), indicating better lung mechanics. However, we didn’t observe any significant changes in asthma control scores or the inflammatory markers we measured.
It's worth noting that we found a meaningful association between initial vitamin D levels and markers of inflammation, suggesting that those with lower vitamin D might benefit more from supplementation. Overall, while vitamin D3 might not be a miracle solution, our results indicate it could be a helpful addition to current asthma management strategies, especially for those with low vitamin D levels.
Our findings showed a slight improvement in lung function among those who received vitamin D compared to those on the placebo. Specifically, there was a modest increase in the ratio of forced expiratory volume (FEV) to forced vital capacity (FVC), indicating better lung mechanics. However, we didn’t observe any significant changes in asthma control scores or the inflammatory markers we measured.
It's worth noting that we found a meaningful association between initial vitamin D levels and markers of inflammation, suggesting that those with lower vitamin D might benefit more from supplementation. Overall, while vitamin D3 might not be a miracle solution, our results indicate it could be a helpful addition to current asthma management strategies, especially for those with low vitamin D levels.
Read More
9
Vitamin D3 improves asthma symptoms
Vitamin D resolved human and experimental asthma via B lymphocyte-induced maturation protein 1 in T cells and innate lymphoid cells.
Direct effects on asthma management
We aimed to understand how vitamin D3 supplementation might affect asthma, particularly focusing on children and adults who struggle with this condition. By analyzing various groups and a controlled murine model, we investigated the immunomodulatory effects of vitamin D3 and discovered encouraging results.
Our findings indicated that individuals receiving vitamin D3 showed milder asthma symptoms and a decreased reliance on steroid medications. Notably, children and adults alike experienced better control over their asthma. Furthermore, we observed that vitamin D3 levels correlated with an increased expression of a protein called Blimp-1, which plays a vital role in immune response regulation.
In our animal studies, mice supplemented with vitamin D3 exhibited relief from asthma traits, including lower serum IgE levels and reduced airway mucus. Additionally, these mice showed enhanced production of the anti-inflammatory protein IL-10. The results suggest that vitamin D3 promotes a shift from pro-inflammatory states to anti-inflammatory responses, particularly through mechanisms involving Blimp-1 in lung cells.
Overall, we found that vitamin D3 not only eases asthma symptoms for humans but also improves immunity in experimental models. This positions vitamin D3 as a potential adjunctive treatment for managing asthma more effectively.
Our findings indicated that individuals receiving vitamin D3 showed milder asthma symptoms and a decreased reliance on steroid medications. Notably, children and adults alike experienced better control over their asthma. Furthermore, we observed that vitamin D3 levels correlated with an increased expression of a protein called Blimp-1, which plays a vital role in immune response regulation.
In our animal studies, mice supplemented with vitamin D3 exhibited relief from asthma traits, including lower serum IgE levels and reduced airway mucus. Additionally, these mice showed enhanced production of the anti-inflammatory protein IL-10. The results suggest that vitamin D3 promotes a shift from pro-inflammatory states to anti-inflammatory responses, particularly through mechanisms involving Blimp-1 in lung cells.
Overall, we found that vitamin D3 not only eases asthma symptoms for humans but also improves immunity in experimental models. This positions vitamin D3 as a potential adjunctive treatment for managing asthma more effectively.
Read More
Most Useful Reviews
8.8
Assisted asthma management
I ordered this for myself during my first trimester. It has significantly helped; I have asthma and really need to take omega. The effects are noticeable immediately, and the brand is reliable.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 45 Researches
7.5
9.5
DHA-derived lipid mediators aid asthma
Lipid mediators obtained from docosahexaenoic acid by soybean lipoxygenase alleviate ovalbumin‑induced allergic asthma in mice by reducing airway inflammation and oxidative stress.
Docosahexaenoic acid effects noted
We explored the potential of lipid mediators derived from docosahexaenoic acid (DHA) in treating allergic asthma using a well-established ovalbumin (OVA) model in mice. The treatment comprised a mix of lipid mediators, including 17S-monohydroxy DHA, resolvin D5, and protectin DX. Through this investigation, we aimed to better understand how these components could alleviate asthma symptoms.
Our findings indicated that administering these lipid mediators significantly reduced key features of allergic asthma. We observed a decrease in inflammatory cell infiltration, particularly in eosinophils, and a drop in the levels of inflammation-related cytokines. Furthermore, treatment with the lipid mediators helped mitigate airway remodeling and oxidative stress, indicating a return to near-normal conditions for the mice.
Notably, the lipid mediators led to a remarkable drop in inflammatory markers such as interleukin-6 and tumor necrosis factor-α, signaling a positive response. We also witnessed an improvement in the lung's oxidative stress status, as shown by increased antioxidant activities and reduced harmful substances.
Collectively, our study suggests that lipid mediators from DHA could represent a promising therapeutic avenue for asthma treatment, particularly by protecting lung tissues from inflammation and oxidative damage.
Our findings indicated that administering these lipid mediators significantly reduced key features of allergic asthma. We observed a decrease in inflammatory cell infiltration, particularly in eosinophils, and a drop in the levels of inflammation-related cytokines. Furthermore, treatment with the lipid mediators helped mitigate airway remodeling and oxidative stress, indicating a return to near-normal conditions for the mice.
Notably, the lipid mediators led to a remarkable drop in inflammatory markers such as interleukin-6 and tumor necrosis factor-α, signaling a positive response. We also witnessed an improvement in the lung's oxidative stress status, as shown by increased antioxidant activities and reduced harmful substances.
Collectively, our study suggests that lipid mediators from DHA could represent a promising therapeutic avenue for asthma treatment, particularly by protecting lung tissues from inflammation and oxidative damage.
Read More
9.5
LCPUFA supplementation's impact on asthma
A specific combined long-chain polyunsaturated fatty acid supplementation reverses fatty acid profile alterations in a mouse model of chronic asthma.
Combination therapy shows promise
We explored how chronic asthma affects the levels of specific long-chain polyunsaturated fatty acids (LCPUFAs) in the body and whether supplementation could help rebalance these levels. In our study, mice were sensitized to house dust mite extract to simulate allergic asthma and were then fed either a normal diet, eicosapentaenoic acid (EPA), or a specific combination of LCPUFAs, including docosahexaenoic acid (DHA), over a period of 24 days.
What we observed was quite intriguing. Allergic asthma indeed altered the fatty acid profiles in both blood and lung tissue of the mice. However, when we looked at the effects of our specific combination of n-3 and n-6 LCPUFAs, we found that it completely restored the altered profiles in lung tissue, unlike EPA alone. This suggests that a tailored combination of these fatty acids, which includes DHA, may be highly effective in managing the inflammatory processes associated with asthma.
Thus, our findings highlight the potential of combined LCPUFA supplementation as a meaningful approach to alleviate asthma-related inflammation and improve overall respiratory health.
What we observed was quite intriguing. Allergic asthma indeed altered the fatty acid profiles in both blood and lung tissue of the mice. However, when we looked at the effects of our specific combination of n-3 and n-6 LCPUFAs, we found that it completely restored the altered profiles in lung tissue, unlike EPA alone. This suggests that a tailored combination of these fatty acids, which includes DHA, may be highly effective in managing the inflammatory processes associated with asthma.
Thus, our findings highlight the potential of combined LCPUFA supplementation as a meaningful approach to alleviate asthma-related inflammation and improve overall respiratory health.
Read More
9
Combined effects on asthma treatment
A systematic pharmacological strategy-based to decode the synergistic mechanism of 7,4'-dihydroxyflavone in combination with vitamin D3 against asthma.
Moderate relevance due to limitations
We explored how vitamin D3 can play a role in asthma treatment, particularly when combined with 7,4'-dihydroxyflavone (74DHF). Our study took a systems pharmacology approach, which means we looked at how these two compounds might work together at a molecular level to combat asthma.
Through our analysis, we identified 47 overlapping targets, 20 core targets, and key pathways associated with asthma relief. We observed that this combination could help reduce inflammatory responses in immune cells and counteract changes in bronchial epithelial cells that contribute to asthma severity.
Although the potential benefits of vitamin D3 combined with 74DHF are promising, we must emphasize that the specific isolated effects of vitamin D3 alone were not assessed, making it challenging to determine its individual contribution. Nonetheless, this study highlights an innovative strategy for developing combination therapies in asthma management.
Through our analysis, we identified 47 overlapping targets, 20 core targets, and key pathways associated with asthma relief. We observed that this combination could help reduce inflammatory responses in immune cells and counteract changes in bronchial epithelial cells that contribute to asthma severity.
Although the potential benefits of vitamin D3 combined with 74DHF are promising, we must emphasize that the specific isolated effects of vitamin D3 alone were not assessed, making it challenging to determine its individual contribution. Nonetheless, this study highlights an innovative strategy for developing combination therapies in asthma management.
Read More
9
Vitamin D boosts asthma control
Vitamin D Oral Replacement in Children With Obesity Related Asthma: VDORA1 Randomized Clinical Trial.
Study highlights vitamin D importance
We aimed to uncover the right dosage of vitamin D that helps children with obesity-related asthma achieve healthy vitamin D levels. This was addressed through a two-part clinical trial involving children and adolescents with asthma and obesity.
In the first part of the study, we evaluated four different oral vitamin D regimens over 16 weeks. This helped us determine a safe dose that would elevate serum vitamin D levels to at least 40 ng/mL. Remarkably, while no participants receiving standard care reached the target level, a significant 50-72.7% of those taking our tested vitamin D doses did meet the goal.
The second part compared our chosen vitamin D replacement dose—which consisted of a 50,000 IU loading dose followed by 8,000 IU daily—to standard care over another 16-week period. This time, an impressive 78.6% of the children on the replacement dose achieved the desired vitamin D levels, while none of the standard care group did.
Throughout the study, we noted that the vitamin D treatment was safe, with no serious adverse events reported. This research opens up new insights into effectively treating vitamin D deficiencies in children struggling with both asthma and obesity, emphasizing the substantial role vitamin D may play in their overall health.
In the first part of the study, we evaluated four different oral vitamin D regimens over 16 weeks. This helped us determine a safe dose that would elevate serum vitamin D levels to at least 40 ng/mL. Remarkably, while no participants receiving standard care reached the target level, a significant 50-72.7% of those taking our tested vitamin D doses did meet the goal.
The second part compared our chosen vitamin D replacement dose—which consisted of a 50,000 IU loading dose followed by 8,000 IU daily—to standard care over another 16-week period. This time, an impressive 78.6% of the children on the replacement dose achieved the desired vitamin D levels, while none of the standard care group did.
Throughout the study, we noted that the vitamin D treatment was safe, with no serious adverse events reported. This research opens up new insights into effectively treating vitamin D deficiencies in children struggling with both asthma and obesity, emphasizing the substantial role vitamin D may play in their overall health.
Read More
9
Vitamin D3 improves asthma symptoms
Vitamin D resolved human and experimental asthma via B lymphocyte-induced maturation protein 1 in T cells and innate lymphoid cells.
Direct effects on asthma management
We aimed to understand how vitamin D3 supplementation might affect asthma, particularly focusing on children and adults who struggle with this condition. By analyzing various groups and a controlled murine model, we investigated the immunomodulatory effects of vitamin D3 and discovered encouraging results.
Our findings indicated that individuals receiving vitamin D3 showed milder asthma symptoms and a decreased reliance on steroid medications. Notably, children and adults alike experienced better control over their asthma. Furthermore, we observed that vitamin D3 levels correlated with an increased expression of a protein called Blimp-1, which plays a vital role in immune response regulation.
In our animal studies, mice supplemented with vitamin D3 exhibited relief from asthma traits, including lower serum IgE levels and reduced airway mucus. Additionally, these mice showed enhanced production of the anti-inflammatory protein IL-10. The results suggest that vitamin D3 promotes a shift from pro-inflammatory states to anti-inflammatory responses, particularly through mechanisms involving Blimp-1 in lung cells.
Overall, we found that vitamin D3 not only eases asthma symptoms for humans but also improves immunity in experimental models. This positions vitamin D3 as a potential adjunctive treatment for managing asthma more effectively.
Our findings indicated that individuals receiving vitamin D3 showed milder asthma symptoms and a decreased reliance on steroid medications. Notably, children and adults alike experienced better control over their asthma. Furthermore, we observed that vitamin D3 levels correlated with an increased expression of a protein called Blimp-1, which plays a vital role in immune response regulation.
In our animal studies, mice supplemented with vitamin D3 exhibited relief from asthma traits, including lower serum IgE levels and reduced airway mucus. Additionally, these mice showed enhanced production of the anti-inflammatory protein IL-10. The results suggest that vitamin D3 promotes a shift from pro-inflammatory states to anti-inflammatory responses, particularly through mechanisms involving Blimp-1 in lung cells.
Overall, we found that vitamin D3 not only eases asthma symptoms for humans but also improves immunity in experimental models. This positions vitamin D3 as a potential adjunctive treatment for managing asthma more effectively.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.5
8.8
Assisted asthma management
I ordered this for myself during my first trimester. It has significantly helped; I have asthma and really need to take omega. The effects are noticeable immediately, and the brand is reliable.
