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SCIENTIFIC SCORE
Possibly Effective
Based on 35 Researches
7.4
USERS' SCORE
Good
Based on 5 Reviews
8.9
Supplement Facts
Serving Size: 2 Soft Gels
Amount Per Serving
%DV
Calories
10
Total Fat
1 g
1%
Saturated Fat
0 g
0%
Trans Fat
0 g
†
Vitamin D3 (cholecalciferol)
10 mcg (400 IU)
67%
Total Omega-3s♦
830 mg
†
EPA (Eicosapentaenoic Acid)
205 mg
†
DHA (Docosahexaenoic Acid)
480 mg
†
Top Medical Research Studies
9.5
Eicosapentaenoic acid reduces migraines
A 12-week randomized double-blind clinical trial of eicosapentaenoic acid intervention in episodic migraine.
Direct investigation of EPA's impact
We conducted a 12-week study to explore how eicosapentaenoic acid (EPA) affects individuals suffering from episodic migraines. In our trial, 70 participants were randomly split into two groups—one received 2 grams of fish oil with 1.8 grams of pure EPA daily, while the other group got a placebo made of soybean oil.
The results were quite promising. Those taking EPA reported a significant reduction in the number of migraine days per month, averaging about 4.4 fewer days compared to just 0.6 fewer days in the placebo group. We also noticed a decline in the usage of medication to treat headache symptoms among those taking EPA.
Additionally, participants experienced less severe headaches and improved psychological wellbeing, as indicated by better scores in anxiety, depression, and overall quality of life measures. Notably, women seemed to benefit even more from EPA.
Overall, it appears that high-dose EPA can be an effective preventive treatment for episodic migraines, helping to ease frequency, severity, and even the emotional toll associated with chronic headaches. Importantly, the treatment was well tolerated, with no significant adverse effects reported.
The results were quite promising. Those taking EPA reported a significant reduction in the number of migraine days per month, averaging about 4.4 fewer days compared to just 0.6 fewer days in the placebo group. We also noticed a decline in the usage of medication to treat headache symptoms among those taking EPA.
Additionally, participants experienced less severe headaches and improved psychological wellbeing, as indicated by better scores in anxiety, depression, and overall quality of life measures. Notably, women seemed to benefit even more from EPA.
Overall, it appears that high-dose EPA can be an effective preventive treatment for episodic migraines, helping to ease frequency, severity, and even the emotional toll associated with chronic headaches. Importantly, the treatment was well tolerated, with no significant adverse effects reported.
Read More
9
Vitamin D3 aids migraine relief
Vitamin D3 might improve headache characteristics and protect against inflammation in migraine: a randomized clinical trial.
Directly examines vitamin D3 effects
We conducted a rigorous study to explore how vitamin D3 supplementation might influence headaches in people suffering from migraines. By utilizing a well-structured, placebo-controlled, double-blind design, we included 80 participants with episodic migraines, assigning them either a daily dose of vitamin D3 or a placebo for 12 weeks.
After the study, we observed significant improvements in those receiving vitamin D3. Participants reported fewer headache days each month, shorter headache durations, and less severe pain overall. They also used fewer pain relievers compared to those on placebo, showcasing the potential benefit of vitamin D3 in managing migraine symptoms.
Our findings suggest that vitamin D3 not only aids in reducing headache frequency but may also play a role in addressing inflammation, as evidenced by reduced levels of certain inflammatory markers in the blood. This highlights its possible therapeutic value for migraine sufferers, indicating that a daily dose could make a meaningful difference in their lives.
After the study, we observed significant improvements in those receiving vitamin D3. Participants reported fewer headache days each month, shorter headache durations, and less severe pain overall. They also used fewer pain relievers compared to those on placebo, showcasing the potential benefit of vitamin D3 in managing migraine symptoms.
Our findings suggest that vitamin D3 not only aids in reducing headache frequency but may also play a role in addressing inflammation, as evidenced by reduced levels of certain inflammatory markers in the blood. This highlights its possible therapeutic value for migraine sufferers, indicating that a daily dose could make a meaningful difference in their lives.
Read More
8
Vitamin D3 reduces migraine frequency
A randomized, double-blinded, placebo-controlled, parallel trial of vitamin D supplementation in adult patients with migraine.
Direct study on vitamin D3 effect.
We conducted a rigorous study to determine whether vitamin D3 supplementation could help improve the lives of adults suffering from migraines. Our approach involved a well-structured, randomized, double-blinded, placebo-controlled trial, which included 36 women and 12 men, aged between 18 to 65 years.
Participants underwent a 4-week baseline period before being randomly assigned to receive either 100 μg/day of D3 vitamin or a placebo for 24 weeks. Throughout the study, we kept track of migraine attacks and various symptoms through self-reported diaries, logging important details like the frequency and severity of their migraines.
Our findings were quite promising. Those taking D3 vitamin experienced fewer migraine days compared to those on the placebo, suggesting that vitamin D3 could serve as an effective preventative treatment for migraine management. However, we noted that further studies with larger sample sizes would be beneficial to solidify these claims and fully understand the potential role of vitamin D3 in migraine prevention.
Participants underwent a 4-week baseline period before being randomly assigned to receive either 100 μg/day of D3 vitamin or a placebo for 24 weeks. Throughout the study, we kept track of migraine attacks and various symptoms through self-reported diaries, logging important details like the frequency and severity of their migraines.
Our findings were quite promising. Those taking D3 vitamin experienced fewer migraine days compared to those on the placebo, suggesting that vitamin D3 could serve as an effective preventative treatment for migraine management. However, we noted that further studies with larger sample sizes would be beneficial to solidify these claims and fully understand the potential role of vitamin D3 in migraine prevention.
Read More
Most Useful Reviews
10
Headache relief
Very good supplement! I started taking fish oil during my second trimester after experiencing frequent headaches. Remarkably, within a month of taking it, I only had one headache! This really is a miracle for me. It's rather pricy, but it works well.
Read More
10
No allergic reactions
This is the only prenatal DHA vitamin that hasn't caused me any adverse reactions like headaches or rashes. I've taken it throughout my pregnancy and continue to do so while breastfeeding.
Read More
10
Headache cessation
Good quality product with fast delivery and secure packaging. The capsules are somewhat large, but I have no trouble swallowing them. I've noticed beneficial effects, especially with headaches and fatigue, after only ten days of use. My mood has improved significantly.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 35 Researches
7.4
9.5
Simvastatin plus vitamin D3 reduces migraines
Simvastatin and vitamin D for migraine prevention: A randomized, controlled trial.
Moderate relevance due to combination
We conducted a study to explore the effectiveness of simvastatin combined with vitamin D3 in preventing headaches for adults suffering from episodic migraines. The study involved 57 participants who were randomly assigned either the active treatment or a placebo for 24 weeks, following a 12-week baseline period.
Our findings revealed that those taking simvastatin and vitamin D3 experienced a meaningful reduction in the number of migraine days compared to those on the placebo. In fact, participants on the active treatment saw their migraine days decrease by an average of 8 days during the first 12 weeks, and 9 days during the subsequent weeks, with a statistically significant difference that supports the treatment's effectiveness.
It's also worth mentioning that 25% of the participants on simvastatin and vitamin D3 achieved at least a 50% reduction in migraine days at 12 weeks, which increased to 29% by 24 weeks. This is in stark contrast to just 3% of participants in the placebo group. Importantly, the occurrence of side effects was similar between the groups, suggesting that the treatment was well-tolerated.
Overall, we observed a promising potential for simvastatin and vitamin D3 as a preventative option for those grappling with chronic migraines, while also considering the broader health implications regarding vascular health.
Our findings revealed that those taking simvastatin and vitamin D3 experienced a meaningful reduction in the number of migraine days compared to those on the placebo. In fact, participants on the active treatment saw their migraine days decrease by an average of 8 days during the first 12 weeks, and 9 days during the subsequent weeks, with a statistically significant difference that supports the treatment's effectiveness.
It's also worth mentioning that 25% of the participants on simvastatin and vitamin D3 achieved at least a 50% reduction in migraine days at 12 weeks, which increased to 29% by 24 weeks. This is in stark contrast to just 3% of participants in the placebo group. Importantly, the occurrence of side effects was similar between the groups, suggesting that the treatment was well-tolerated.
Overall, we observed a promising potential for simvastatin and vitamin D3 as a preventative option for those grappling with chronic migraines, while also considering the broader health implications regarding vascular health.
Read More
9.5
Eicosapentaenoic acid reduces migraines
A 12-week randomized double-blind clinical trial of eicosapentaenoic acid intervention in episodic migraine.
Direct investigation of EPA's impact
We conducted a 12-week study to explore how eicosapentaenoic acid (EPA) affects individuals suffering from episodic migraines. In our trial, 70 participants were randomly split into two groups—one received 2 grams of fish oil with 1.8 grams of pure EPA daily, while the other group got a placebo made of soybean oil.
The results were quite promising. Those taking EPA reported a significant reduction in the number of migraine days per month, averaging about 4.4 fewer days compared to just 0.6 fewer days in the placebo group. We also noticed a decline in the usage of medication to treat headache symptoms among those taking EPA.
Additionally, participants experienced less severe headaches and improved psychological wellbeing, as indicated by better scores in anxiety, depression, and overall quality of life measures. Notably, women seemed to benefit even more from EPA.
Overall, it appears that high-dose EPA can be an effective preventive treatment for episodic migraines, helping to ease frequency, severity, and even the emotional toll associated with chronic headaches. Importantly, the treatment was well tolerated, with no significant adverse effects reported.
The results were quite promising. Those taking EPA reported a significant reduction in the number of migraine days per month, averaging about 4.4 fewer days compared to just 0.6 fewer days in the placebo group. We also noticed a decline in the usage of medication to treat headache symptoms among those taking EPA.
Additionally, participants experienced less severe headaches and improved psychological wellbeing, as indicated by better scores in anxiety, depression, and overall quality of life measures. Notably, women seemed to benefit even more from EPA.
Overall, it appears that high-dose EPA can be an effective preventive treatment for episodic migraines, helping to ease frequency, severity, and even the emotional toll associated with chronic headaches. Importantly, the treatment was well tolerated, with no significant adverse effects reported.
Read More
9.5
Omega-3s effectively reduce headaches
Targeted alteration of dietary n-3 and n-6 fatty acids for the treatment of chronic headaches: a randomized trial.
Dietary intervention impacts headaches
We conducted a clinical trial to see how dietary changes targeting omega-3 and omega-6 fatty acids could help people dealing with chronic headaches. Over 12 weeks, we divided participants into two groups: one that increased their omega-3 intake while reducing omega-6 and another that just focused on lowering omega-6.
Our findings were quite promising! Those in the group increasing their omega-3 levels experienced a greater reduction in headache severity and frequency compared to those simply lowering omega-6. Specifically, the high omega-3 group had a significant drop in both daily headache hours and pain impact, while altering levels of important headache-relief mediators in the body.
This suggests that increasing omega-3, particularly docosahexaenoic acid, can be an effective strategy for reducing headache symptoms and improving overall quality of life among chronic headache sufferers. These dietary adjustments could provide a new avenue for managing headaches more effectively.
Our findings were quite promising! Those in the group increasing their omega-3 levels experienced a greater reduction in headache severity and frequency compared to those simply lowering omega-6. Specifically, the high omega-3 group had a significant drop in both daily headache hours and pain impact, while altering levels of important headache-relief mediators in the body.
This suggests that increasing omega-3, particularly docosahexaenoic acid, can be an effective strategy for reducing headache symptoms and improving overall quality of life among chronic headache sufferers. These dietary adjustments could provide a new avenue for managing headaches more effectively.
Read More
9
Pediatric migraine treatment effectiveness
The Impact of Vitamin D Supplementation to Topiramate Therapy on Pediatric Migraine Prophylaxis.
Limited vitamin D isolation effects
We aimed to explore the effects of vitamin D3 supplementation on headaches in children undergoing treatment with topiramate for migraines. In a carefully designed double-blind clinical trial, we involved children aged 5 to 14 years who were experiencing migraines. Participants were randomly divided into two groups: one received topiramate with vitamin D3 supplements, while the other received topiramate along with a placebo.
Over four months, we noted significant enhancements in the group taking vitamin D3. Specifically, this group showed a greater reduction in the frequency of headache attacks and overall migraine disability compared to the placebo group. We observed that 76% of children in the vitamin D3 group reported good responses to the treatment, compared to only 54% in the placebo group.
Importantly, while both groups experienced side effects, those in the vitamin D3 group reported fewer issues. Thus, we found vitamin D3 supplementation to be a well-tolerated and effective addition to topiramate therapy for managing pediatric migraines.
Over four months, we noted significant enhancements in the group taking vitamin D3. Specifically, this group showed a greater reduction in the frequency of headache attacks and overall migraine disability compared to the placebo group. We observed that 76% of children in the vitamin D3 group reported good responses to the treatment, compared to only 54% in the placebo group.
Importantly, while both groups experienced side effects, those in the vitamin D3 group reported fewer issues. Thus, we found vitamin D3 supplementation to be a well-tolerated and effective addition to topiramate therapy for managing pediatric migraines.
Read More
9
Giant Cell Arteritis Treatment Insights
A Case Report of Post COVID19 Giant Cell Arteritis and Polymyalgia Rheumatica With Visual Loss.
Moderate relevance to headache treatment
In exploring the treatment for headaches associated with post-COVID-19 giant cell arteritis and polymyalgia rheumatica, we observed that vitamin D3 was included alongside more traditional therapies. This was part of a comprehensive treatment approach that also involved pulse methylprednisolone and perineural injection therapy.
While the main focus of treatment appeared to be on corticosteroids and pain management strategies, the exact effect of vitamin D3 on headache relief remains unclear. Since the headaches notably persisted through early treatment stages and improved significantly after additional intervention, we can't conclusively state the efficacy of vitamin D3 in alleviating headache symptoms from this case alone.
It's worth noting that individual responses to treatments can vary widely, and further dedicated studies would be necessary to understand vitamin D3's specific role in headache management. For now, combining it with other treatments was part of a broader strategy to achieve recovery.
While the main focus of treatment appeared to be on corticosteroids and pain management strategies, the exact effect of vitamin D3 on headache relief remains unclear. Since the headaches notably persisted through early treatment stages and improved significantly after additional intervention, we can't conclusively state the efficacy of vitamin D3 in alleviating headache symptoms from this case alone.
It's worth noting that individual responses to treatments can vary widely, and further dedicated studies would be necessary to understand vitamin D3's specific role in headache management. For now, combining it with other treatments was part of a broader strategy to achieve recovery.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.9
10
Headache relief
Very good supplement! I started taking fish oil during my second trimester after experiencing frequent headaches. Remarkably, within a month of taking it, I only had one headache! This really is a miracle for me. It's rather pricy, but it works well.
10
No allergic reactions
This is the only prenatal DHA vitamin that hasn't caused me any adverse reactions like headaches or rashes. I've taken it throughout my pregnancy and continue to do so while breastfeeding.
10
Headache cessation
Good quality product with fast delivery and secure packaging. The capsules are somewhat large, but I have no trouble swallowing them. I've noticed beneficial effects, especially with headaches and fatigue, after only ten days of use. My mood has improved significantly.
8.8
Reduced headaches
I feel positive about this brand. Initially, I had unusual headaches, but they stopped. The capsules are easy to swallow, and there's no unpleasant smell or taste. The dosage in two capsules allows flexibility, making it easier to adjust as needed.
8.8
No issues reported
No headaches experienced! When they were made in summer, my capsules clumped together, but this delivery was fine and intact.
