' 
SCIENTIFIC SCORE
Possibly Effective
Based on 46 Researches
7.3
USERS' SCORE
Good
Based on 3 Reviews
8.7
Supplement Facts
Serving Size: 2 Soft Gels
Amount Per Serving
%DV
Calories
20
Total Fat
2 g
3%
Total Omega-3s♢
690 mg
†
EPA (Eicosapentaenoic Acid)
330 mg
†
DHA (Docosahexaenoic Acid)
220 mg
†
Top Medical Research Studies
8
Omega-3 benefits joint health in RA
Effects of omega-3 supplementation on lipid metabolism, inflammation, and disease activity in rheumatoid arthritis: a meta-analysis of randomized controlled trials.
Moderate relevance to treatment inquiry
We analyzed various trials to see how omega-3 fish oil affects rheumatoid arthritis (RA). Our research included 18 randomized controlled studies with 1,018 RA patients. The results showed omega-3 supplementation significantly increased beneficial omega-3 fatty acids, like EPA and DHA, and reduced triglycerides and tender joint count.
However, it didn't lead to significant changes in some inflammation markers and overall disease activity. While there are positive outcomes regarding certain symptoms, we found no remarkable evidence for its effectiveness in reducing inflammation levels.
However, it didn't lead to significant changes in some inflammation markers and overall disease activity. While there are positive outcomes regarding certain symptoms, we found no remarkable evidence for its effectiveness in reducing inflammation levels.
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8
Eicosapentaenoic acid aids arthritis
Effects of omega-3 supplementation on lipid metabolism, inflammation, and disease activity in rheumatoid arthritis: a meta-analysis of randomized controlled trials.
Directly improves arthritis symptoms
We explored the effects of eicosapentaenoic acid (EPA), a key component of omega-3 fatty acids, on patients with rheumatoid arthritis (RA). This analysis gathered data from eighteen randomized controlled trials involving over a thousand RA patients, ensuring a comprehensive look at its impact.
Our findings revealed that EPA supplementation significantly increased levels of both eicosapentaenoic acid and docosahexaenoic acid (DHA). Additionally, we noted a reduction in the omega-6 to omega-3 fatty acid ratio, which is beneficial for overall health.
Moreover, we observed that EPA led to a decrease in triglyceride levels and tender joint counts among RA patients. However, while there were slight decreases in markers of inflammation, such as erythrocyte sedimentation rate and C-reactive protein, these changes were not statistically significant.
Overall, our analysis supports the idea that EPA has positive effects on lipid profiles and joint tenderness for those with RA, although not all inflammatory markers showed significant improvement.
Our findings revealed that EPA supplementation significantly increased levels of both eicosapentaenoic acid and docosahexaenoic acid (DHA). Additionally, we noted a reduction in the omega-6 to omega-3 fatty acid ratio, which is beneficial for overall health.
Moreover, we observed that EPA led to a decrease in triglyceride levels and tender joint counts among RA patients. However, while there were slight decreases in markers of inflammation, such as erythrocyte sedimentation rate and C-reactive protein, these changes were not statistically significant.
Overall, our analysis supports the idea that EPA has positive effects on lipid profiles and joint tenderness for those with RA, although not all inflammatory markers showed significant improvement.
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9
DHA shows promise for osteoarthritis
DHA attenuates cartilage degeneration by mediating apoptosis and autophagy in human chondrocytes and rat models of osteoarthritis.
Highly relevant to arthritis treatments
We investigated how docosahexaenoic acid (DHA) impacts osteoarthritis (OA), which is a common joint disease in older adults. Using both human and rat models, we found that DHA can enhance chondrocyte (cartilage cells) growth while reducing cell death.
Moreover, DHA treatment thickened cartilage and lowered degeneration compared to untreated OA models. Additionally, it improved the overall health of chondrocytes by promoting autophagy, which helps recycle damaged cellular components. Our findings suggest that DHA could be a promising therapy for OA treatment.
Moreover, DHA treatment thickened cartilage and lowered degeneration compared to untreated OA models. Additionally, it improved the overall health of chondrocytes by promoting autophagy, which helps recycle damaged cellular components. Our findings suggest that DHA could be a promising therapy for OA treatment.
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Most Useful Reviews
8.8
Improved arthritic joint
Excellent! There is just a slight lemony aftertaste, which is not unpleasant. I've only been taking this for a short time, so I'm not sure yet about my cholesterol. However, within a few days, I noticed a significant improvement in my arthritic finger joint, which had been troublesome due to the cold winter weather. Despite the drastic changes in temperature, my joint feels fine. Additionally, I have experienced better energy levels and digestion. I take one in the morning and one before dinner, and I'm very pleased with the results!
Read More
9.5
Perfect for joint pain
The best omegas ever! If you're searching for relief from joint pain and arthritis, these are the ideal omegas for you.
Read More
9.5
Relieves arthritis
Amazing product! The quality is excellent and the ingredients are safe, lacking filler substances like titanium dioxide or maltodextrin. This supply lasts for three months with one pill daily. It helps lower cholesterol, promotes hair and nail health, and relieves arthritis symptoms. Suitable for anyone over 20, it's great for those who dislike fish as it compensates for their Omega-3 deficiency. Highly recommended!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 46 Researches
7.3
- All Researches
9
DHA shows promise for osteoarthritis
DHA attenuates cartilage degeneration by mediating apoptosis and autophagy in human chondrocytes and rat models of osteoarthritis.
Highly relevant to arthritis treatments
We investigated how docosahexaenoic acid (DHA) impacts osteoarthritis (OA), which is a common joint disease in older adults. Using both human and rat models, we found that DHA can enhance chondrocyte (cartilage cells) growth while reducing cell death.
Moreover, DHA treatment thickened cartilage and lowered degeneration compared to untreated OA models. Additionally, it improved the overall health of chondrocytes by promoting autophagy, which helps recycle damaged cellular components. Our findings suggest that DHA could be a promising therapy for OA treatment.
Moreover, DHA treatment thickened cartilage and lowered degeneration compared to untreated OA models. Additionally, it improved the overall health of chondrocytes by promoting autophagy, which helps recycle damaged cellular components. Our findings suggest that DHA could be a promising therapy for OA treatment.
Read More
9
l-Serine and EPA effective for pain
l-Serine and EPA Relieve Chronic Low-Back and Knee Pain in Adults: A Randomized, Double-Blind, Placebo-Controlled Trial.
Study relevant for arthritis pain
We conducted a study to examine the effects of eicosapentaenoic acid (EPA) combined with l-serine on individuals suffering from chronic low-back and knee pain. This was a randomized, double-blind, placebo-controlled trial, ensuring rigorous evaluation of the treatment's impact.
Over the course of 12 weeks, we assessed participants using well-structured questionnaires to measure their pain levels and overall experience. Our group comprised 120 adults who, despite enduring persistent pain for more than three months, showed promising results from the active treatment.
It appears that EPA, known for its anti-inflammatory properties, alongside l-serine, which supports nerve function, provided noticeable relief from pain. By the end of the study, many participants experienced significant improvements in their pain scores, suggesting that this combination could be a valuable option for those managing arthritis-related discomfort.
It's encouraging to see how l-serine and EPA can help enhance the quality of life for individuals struggling with painful conditions, reinforcing their importance as potential treatments for arthritis-related pain.
Over the course of 12 weeks, we assessed participants using well-structured questionnaires to measure their pain levels and overall experience. Our group comprised 120 adults who, despite enduring persistent pain for more than three months, showed promising results from the active treatment.
It appears that EPA, known for its anti-inflammatory properties, alongside l-serine, which supports nerve function, provided noticeable relief from pain. By the end of the study, many participants experienced significant improvements in their pain scores, suggesting that this combination could be a valuable option for those managing arthritis-related discomfort.
It's encouraging to see how l-serine and EPA can help enhance the quality of life for individuals struggling with painful conditions, reinforcing their importance as potential treatments for arthritis-related pain.
Read More
9
Eicosapentaenoic acid aids arthritis
Gelatin hydrogels with eicosapentaenoic acid can prevent osteoarthritis progression in vivo in a mouse model.
Relevant but partly complex findings
We investigated the impact of eicosapentaenoic acid (EPA) on osteoarthritis (OA) progression through an innovative approach involving gelatin hydrogels. In our study, we divided ten-week-old male mice into six different groups, each receiving various treatments after undergoing surgery that mimicked OA. This design allowed us to effectively compare the benefits of EPA delivered directly and through hydrogels.
Our findings revealed that when EPA was delivered in gelatin hydrogels, it significantly outperformed EPA injection alone in slowing down OA progression. Specifically, we measured several inflammatory markers and found that the group receiving the gelatin hydrogels exhibited lower levels of harmful proteins linked to inflammation and cartilage damage compared to those receiving just the EPA injections.
This suggests that the controlled release of EPA from these hydrogels can be a promising new strategy for treating OA. The potential benefits of gelatin hydrogels in enhancing the effectiveness of EPA treatment present a valuable insight for future therapeutic approaches addressing arthritis.
Our findings revealed that when EPA was delivered in gelatin hydrogels, it significantly outperformed EPA injection alone in slowing down OA progression. Specifically, we measured several inflammatory markers and found that the group receiving the gelatin hydrogels exhibited lower levels of harmful proteins linked to inflammation and cartilage damage compared to those receiving just the EPA injections.
This suggests that the controlled release of EPA from these hydrogels can be a promising new strategy for treating OA. The potential benefits of gelatin hydrogels in enhancing the effectiveness of EPA treatment present a valuable insight for future therapeutic approaches addressing arthritis.
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9
Docosahexaenoic acid reduces arthritis
Lipid mediators obtained from docosahexaenoic acid by soybean lipoxygenase attenuate RANKL-induced osteoclast differentiation and rheumatoid arthritis.
Moderate relevance of findings
We examined the effects of lipid mediators derived from docosahexaenoic acid (DHA) on arthritis, particularly focusing on rheumatoid arthritis (RA). The study utilized a model involving mice with collagen antibody-induced arthritis (CAIA) and RAW264.7 cells to investigate the role of these mediators in reducing inflammation and joint damage.
The lipid mediators were produced by soybean lipoxygenase from DHA and included substances known for their anti-inflammatory properties. We found that these mediators significantly reduced symptoms in CAIA mice, evidenced by decreased paw swelling and reduced progression of arthritis. In the cellular studies, these mediators inhibited the formation of bone-resorbing cells called osteoclasts, while also downregulating key inflammatory markers.
Following treatment, there were notable improvements in serum cytokine levels, with a decrease in pro-inflammatory cytokines like TNF-α and IL-6, and an increase in the anti-inflammatory cytokine IL-10. Additionally, joint inflammation and damage were reduced, hinting at a complex relationship involving various signaling pathways.
These findings indicate that lipid mediators derived from DHA may offer a promising approach to alleviating symptoms of RA, though the precise individual contributions of DHA alone are difficult to isolate due to the presence of other components in the intervention.
The lipid mediators were produced by soybean lipoxygenase from DHA and included substances known for their anti-inflammatory properties. We found that these mediators significantly reduced symptoms in CAIA mice, evidenced by decreased paw swelling and reduced progression of arthritis. In the cellular studies, these mediators inhibited the formation of bone-resorbing cells called osteoclasts, while also downregulating key inflammatory markers.
Following treatment, there were notable improvements in serum cytokine levels, with a decrease in pro-inflammatory cytokines like TNF-α and IL-6, and an increase in the anti-inflammatory cytokine IL-10. Additionally, joint inflammation and damage were reduced, hinting at a complex relationship involving various signaling pathways.
These findings indicate that lipid mediators derived from DHA may offer a promising approach to alleviating symptoms of RA, though the precise individual contributions of DHA alone are difficult to isolate due to the presence of other components in the intervention.
Read More
9
DHA benefits osteoarthritis treatment
DHA attenuates cartilage degeneration by mediating apoptosis and autophagy in human chondrocytes and rat models of osteoarthritis.
High relevance to OA research
We set out to investigate how docosahexaenoic acid (DHA), a fatty acid known for its health benefits, can affect osteoarthritis (OA), a common degenerative joint disease, particularly among older adults. Using both human chondrocyte models stimulated by IL-1β and rat models created through surgical methods, we aimed to understand DHA's potential to impact chondrocyte behavior and cartilage health.
Our observations revealed that DHA significantly promotes the growth of chondrocytes while reducing cell death, which is a key concern in OA. Notably, we found an increase in autophagosomes—structures that help break down cellular waste—within cells treated with DHA, suggesting enhanced cell health.
In comparing groups, those treated with DHA exhibited healthier cartilage characterized by thickened tissue and a decrease in degeneration when compared to the untreated OA group. We also noted an increase in collagen production, vital for maintaining joint structure. The biochemical analysis indicated that DHA potentially exerts its effects by inhibiting certain pathways associated with cell growth and stress responses, thus enhancing chondrocyte proliferation and survival.
Overall, our findings contribute valuable insights into how DHA can be leveraged as a therapeutic approach for OA, emphasizing its role in protecting and restoring cartilage health.
Our observations revealed that DHA significantly promotes the growth of chondrocytes while reducing cell death, which is a key concern in OA. Notably, we found an increase in autophagosomes—structures that help break down cellular waste—within cells treated with DHA, suggesting enhanced cell health.
In comparing groups, those treated with DHA exhibited healthier cartilage characterized by thickened tissue and a decrease in degeneration when compared to the untreated OA group. We also noted an increase in collagen production, vital for maintaining joint structure. The biochemical analysis indicated that DHA potentially exerts its effects by inhibiting certain pathways associated with cell growth and stress responses, thus enhancing chondrocyte proliferation and survival.
Overall, our findings contribute valuable insights into how DHA can be leveraged as a therapeutic approach for OA, emphasizing its role in protecting and restoring cartilage health.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.7
- All Reviews
- Positive Reviews
- Negative Reviews
8.8
Improved arthritic joint
Excellent! There is just a slight lemony aftertaste, which is not unpleasant. I've only been taking this for a short time, so I'm not sure yet about my cholesterol. However, within a few days, I noticed a significant improvement in my arthritic finger joint, which had been troublesome due to the cold winter weather. Despite the drastic changes in temperature, my joint feels fine. Additionally, I have experienced better energy levels and digestion. I take one in the morning and one before dinner, and I'm very pleased with the results!
Read More
9.5
Perfect for joint pain
The best omegas ever! If you're searching for relief from joint pain and arthritis, these are the ideal omegas for you.
9.5
Relieves arthritis
Amazing product! The quality is excellent and the ingredients are safe, lacking filler substances like titanium dioxide or maltodextrin. This supply lasts for three months with one pill daily. It helps lower cholesterol, promotes hair and nail health, and relieves arthritis symptoms. Suitable for anyone over 20, it's great for those who dislike fish as it compensates for their Omega-3 deficiency. Highly recommended!
Read More
