Overview
SCIENTIFIC SCORE
Questionable
Based on 16 Researches
6.6
USERS' SCORE
Good
Based on 7 Reviews
8.2
Supplement Facts
Serving Size: 2 Soft Gels
Amount Per Serving
%DV
Calories
20
Total Fat
2 g
3%
Total Omega-3s♢
690 mg
†
EPA (Eicosapentaenoic Acid)
330 mg
†
DHA (Docosahexaenoic Acid)
220 mg
†
Top Medical Research Studies
7
We examined the effects of omega-3 supplementation on rheumatoid arthritis through a meta-analysis of 18 randomized controlled trials involving over 1,000 patients.
Our findings showed that omega-3 increased beneficial fatty acids and decreased triglyceride levels and tender joint counts.
However, while there were some reductions in inflammation markers, these changes weren't statistically significant, suggesting that omega-3 might not drastically alter disease activity overall.
Our findings showed that omega-3 increased beneficial fatty acids and decreased triglyceride levels and tender joint counts.
However, while there were some reductions in inflammation markers, these changes weren't statistically significant, suggesting that omega-3 might not drastically alter disease activity overall.
Read More
We conducted a systematic review of randomized placebo-controlled trials to investigate whether omega-3 fatty acids can benefit those with rheumatoid arthritis (RA). Our analysis of 23 studies found that while there were some signs of reduced pain and fewer tender and swollen joints, the effects were minimal and not clinically significant.
Additionally, we noted a small reduction in the intake of NSAIDs and c-reactive protein levels, but overall, the evidence quality was low. Thus, omega-3 supplementation appears to have limited effectiveness in managing RA symptoms.
Additionally, we noted a small reduction in the intake of NSAIDs and c-reactive protein levels, but overall, the evidence quality was low. Thus, omega-3 supplementation appears to have limited effectiveness in managing RA symptoms.
Read More
8
We examined the effects of omega-3 fatty acids on autoimmune diseases through a comprehensive review and a Mendelian randomization analysis. Our findings suggest that omega-3 fatty acids can help reduce disease activity and lower inflammation in rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE).
However, while the evidence is promising for RA, there was no consistent proof of omega-3s aiding other autoimmune conditions. Overall, further research is needed to build on our understanding of omega-3 fatty acids across various autoimmune diseases.
However, while the evidence is promising for RA, there was no consistent proof of omega-3s aiding other autoimmune conditions. Overall, further research is needed to build on our understanding of omega-3 fatty acids across various autoimmune diseases.
Read More
Most Useful Reviews
9
High efficacy
Great! Omega-3 fatty acids prevent osteoporosis, maintain healthy joints, and relieve pain during exacerbations. They effectively combat bone loss and reduce inflammation, addressing the symptoms of rheumatoid arthritis and slowing down the destruction of articular cartilage in arthrosis. The quality is excellent, the ingredients are natural, and the effectiveness is at its peak.
Read More
7.5
Reduces arthritis symptoms
High quality Omega-3 fatty acids prevent the onset of osteoporosis, maintain healthy joints, and alleviate pain during flare-ups. These fatty acids combat bone loss, reduce inflammation, and help diminish the symptoms of rheumatoid arthritis while slowing the destruction of articular cartilage in arthrosis.
Read More
7.5
Fights joint pain
Precoated Omega-3 fatty acids prevent the development of osteoporosis, maintain healthy joints, and relieve pain during flare-ups. They combat bone loss and relieve inflammation, assist in reducing the symptoms of rheumatoid arthritis, and slow down the destruction of articular cartilage with arthrosis.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 16 Researches
6.6
- All Researches
8
We examined the effects of omega-3 fatty acids on autoimmune diseases through a comprehensive review and a Mendelian randomization analysis. Our findings suggest that omega-3 fatty acids can help reduce disease activity and lower inflammation in rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE).
However, while the evidence is promising for RA, there was no consistent proof of omega-3s aiding other autoimmune conditions. Overall, further research is needed to build on our understanding of omega-3 fatty acids across various autoimmune diseases.
However, while the evidence is promising for RA, there was no consistent proof of omega-3s aiding other autoimmune conditions. Overall, further research is needed to build on our understanding of omega-3 fatty acids across various autoimmune diseases.
Read More
8
Promising therapy for rheumatoid arthritis
We explored the impact of a lipid mediator derived from docosahexaenoic acid (DHA) on rheumatoid arthritis. In our study, the mediator showed promise in reducing inflammation in mice with collagen antibody-induced arthritis.
This treatment significantly decreased joint swelling and improved overall arthritis symptoms. Additionally, it lowered levels of harmful cytokines in the serum and boosted protective cytokines.
Our findings suggest that this lipid mediator could be a beneficial addition to rheumatoid arthritis therapy, potentially alleviating symptoms and repairing joint damage.
This treatment significantly decreased joint swelling and improved overall arthritis symptoms. Additionally, it lowered levels of harmful cytokines in the serum and boosted protective cytokines.
Our findings suggest that this lipid mediator could be a beneficial addition to rheumatoid arthritis therapy, potentially alleviating symptoms and repairing joint damage.
Read More
8
This study focused on how omega-3 and omega-6 fatty acids might influence disease activity in patients with early rheumatoid arthritis (RA). We examined the serum profiles of 669 patients and identified distinct fatty acid patterns.
Our findings revealed that a higher presence of omega-3 fatty acids was linked to lower disease activity after six months. Similarly, an omega-6 profile also showed reduced disease activity. These results suggest that incorporating these fatty acids could beneficially impact RA management.
Our findings revealed that a higher presence of omega-3 fatty acids was linked to lower disease activity after six months. Similarly, an omega-6 profile also showed reduced disease activity. These results suggest that incorporating these fatty acids could beneficially impact RA management.
Read More
8
We examined the potential benefits of omega-3 fatty acids on rheumatoid arthritis (RA) through a systematic review of 71 studies. Our findings suggest that a diet rich in these fatty acids may help reduce pain and disease activity in RA patients.
Consuming fish, a primary source of omega-3s, could also lower the incidence of RA. Given their anti-inflammatory properties, we believe that integrating omega-3s into treatment plans, alongside standard medications, could significantly enhance the quality of life for those living with RA.
Consuming fish, a primary source of omega-3s, could also lower the incidence of RA. Given their anti-inflammatory properties, we believe that integrating omega-3s into treatment plans, alongside standard medications, could significantly enhance the quality of life for those living with RA.
Read More
8
We explored the impact of omega-3 fatty acids on pain relief in rheumatoid arthritis (RA) patients treated with Janus kinase inhibitors (JAKi).
By analyzing lipid levels, we found that those on JAKi showed a significant increase in omega-3 fatty acids and docosahexaenoic acid (DHA).
Notably, 66.7% of these patients reported manageable pain after 24 weeks, and the reduction in pain correlated with the rise in DHA levels. This suggests that omega-3 fatty acids may play a key role in enhancing the pain-relief benefits of JAKi treatment.
By analyzing lipid levels, we found that those on JAKi showed a significant increase in omega-3 fatty acids and docosahexaenoic acid (DHA).
Notably, 66.7% of these patients reported manageable pain after 24 weeks, and the reduction in pain correlated with the rise in DHA levels. This suggests that omega-3 fatty acids may play a key role in enhancing the pain-relief benefits of JAKi treatment.
Read More
User Reviews
USERS' SCORE
Good
Based on 7 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
High efficacy
Great! Omega-3 fatty acids prevent osteoporosis, maintain healthy joints, and relieve pain during exacerbations. They effectively combat bone loss and reduce inflammation, addressing the symptoms of rheumatoid arthritis and slowing down the destruction of articular cartilage in arthrosis. The quality is excellent, the ingredients are natural, and the effectiveness is at its peak.
Read More
7.5
Reduces arthritis symptoms
High quality Omega-3 fatty acids prevent the onset of osteoporosis, maintain healthy joints, and alleviate pain during flare-ups. These fatty acids combat bone loss, reduce inflammation, and help diminish the symptoms of rheumatoid arthritis while slowing the destruction of articular cartilage in arthrosis.
Read More
7.5
Fights joint pain
Precoated Omega-3 fatty acids prevent the development of osteoporosis, maintain healthy joints, and relieve pain during flare-ups. They combat bone loss and relieve inflammation, assist in reducing the symptoms of rheumatoid arthritis, and slow down the destruction of articular cartilage with arthrosis.
Read More
7.5
Promotes joint health
Omega-3 fatty acids support healthy joints and prevent osteoporosis. They lower inflammation and combat bone loss, relieving joint pain and reducing the symptoms of rheumatoid arthritis, while also slowing the destruction of articular cartilage in arthrosis.
Read More
7.5
Effective against arthritis
High quality Omega-3 fatty acids prevent osteoporosis, maintain healthy joints, and relieve pain during exacerbations. They fight bone loss and inflammation, help reduce the symptoms of rheumatoid arthritis, and slow the destruction of articular cartilage in arthrosis.
Read More
Frequently Asked Questions
9
High efficacy
Great! Omega-3 fatty acids prevent osteoporosis, maintain healthy joints, and relieve pain during exacerbations. They effectively combat bone loss and reduce inflammation, addressing the symptoms of rheumatoid arthritis and slowing down the destruction of articular cartilage in arthrosis. The quality is excellent, the ingredients are natural, and the effectiveness is at its peak.
7.5
Fights joint pain
Precoated Omega-3 fatty acids prevent the development of osteoporosis, maintain healthy joints, and relieve pain during flare-ups. They combat bone loss and relieve inflammation, assist in reducing the symptoms of rheumatoid arthritis, and slow down the destruction of articular cartilage with arthrosis.
7.5
Reduces arthritis symptoms
High quality Omega-3 fatty acids prevent the onset of osteoporosis, maintain healthy joints, and alleviate pain during flare-ups. These fatty acids combat bone loss, reduce inflammation, and help diminish the symptoms of rheumatoid arthritis while slowing the destruction of articular cartilage in arthrosis.
7.5
Promotes joint health
Omega-3 fatty acids support healthy joints and prevent osteoporosis. They lower inflammation and combat bone loss, relieving joint pain and reducing the symptoms of rheumatoid arthritis, while also slowing the destruction of articular cartilage in arthrosis.
7.5
Effective against arthritis
High quality Omega-3 fatty acids prevent osteoporosis, maintain healthy joints, and relieve pain during exacerbations. They fight bone loss and inflammation, help reduce the symptoms of rheumatoid arthritis, and slow the destruction of articular cartilage in arthrosis.
7.5
Natural ingredients
Triglyceride Omega-3 fatty acids prevent the development of osteoporosis, maintain healthy joints, and alleviate pain during exacerbations. They help combat bone loss and relieve inflammation, effectively reducing the symptoms of rheumatoid arthritis while slowing articular cartilage destruction in arthrosis.
7.5
Supports joint function
Omega-3 fatty acids prevent osteoporosis, maintain healthy joints, and help relieve pain during flare-ups. They combat bone loss and inflammation, assist in diminishing the symptoms of rheumatoid arthritis, and slow down the destruction of articular cartilage in arthrosis.
We conducted a systematic review of randomized placebo-controlled trials to investigate whether omega-3 fatty acids can benefit those with rheumatoid arthritis (RA). Our analysis of 23 studies found that while there were some signs of reduced pain and fewer tender and swollen joints, the effects were minimal and not clinically significant.
Additionally, we noted a small reduction in the intake of NSAIDs and c-reactive protein levels, but overall, the evidence quality was low. Thus, omega-3 supplementation appears to have limited effectiveness in managing RA symptoms.
Additionally, we noted a small reduction in the intake of NSAIDs and c-reactive protein levels, but overall, the evidence quality was low. Thus, omega-3 supplementation appears to have limited effectiveness in managing RA symptoms.
7
We assessed the relationship between omega-3 and omega-6 fatty acid intake and rheumatoid arthritis (RA) risk using data from over 50,000 participants in the NHANES study from 1999 to 2020.
By examining dietary recalls and questionnaire responses, we found a notable negative correlation. Specifically, higher intake of both n-3 and n-6 fatty acids was associated with lower odds of developing RA.
This suggests that including these fatty acids in our diet could potentially benefit those at risk for rheumatoid arthritis.
By examining dietary recalls and questionnaire responses, we found a notable negative correlation. Specifically, higher intake of both n-3 and n-6 fatty acids was associated with lower odds of developing RA.
This suggests that including these fatty acids in our diet could potentially benefit those at risk for rheumatoid arthritis.
7
Fish oil supplements elevate mediators
We examined how over-the-counter fish oil supplements impact specialized pro-resolving mediators in individuals with and without rheumatoid arthritis (RA). Out of 104 participants, those taking fish oil displayed higher levels of beneficial fatty acids and their derivatives, regardless of their arthritis status.
This suggests that while fish oil may enhance certain mediators in the body, it does not necessarily lead to significant improvements specifically in RA-related inflammation. Interestingly, both RA and non-RA patients experienced similar benefits from supplementation.
This suggests that while fish oil may enhance certain mediators in the body, it does not necessarily lead to significant improvements specifically in RA-related inflammation. Interestingly, both RA and non-RA patients experienced similar benefits from supplementation.
8
We examined the potential benefits of omega-3 fatty acids on rheumatoid arthritis (RA) through a systematic review of 71 studies. Our findings suggest that a diet rich in these fatty acids may help reduce pain and disease activity in RA patients.
Consuming fish, a primary source of omega-3s, could also lower the incidence of RA. Given their anti-inflammatory properties, we believe that integrating omega-3s into treatment plans, alongside standard medications, could significantly enhance the quality of life for those living with RA.
Consuming fish, a primary source of omega-3s, could also lower the incidence of RA. Given their anti-inflammatory properties, we believe that integrating omega-3s into treatment plans, alongside standard medications, could significantly enhance the quality of life for those living with RA.
7
Omega-3 improves rheumatoid arthritis symptoms
We examined how oral supplementation with polyunsaturated fatty acids (PUFAs), particularly omega-3 from animal sources, affects rheumatoid arthritis (RA) symptoms.
The study involved 30 randomized controlled trials with 1,420 participants, revealing that patients taking over 2 grams of omega-3 daily experienced improvements in pain, joint swelling, and overall disease activity.
While omega-3 showed more significant benefits compared to vegetable sources, it’s essential to note that not all inflammatory rheumatic diseases responded the same way.
The study involved 30 randomized controlled trials with 1,420 participants, revealing that patients taking over 2 grams of omega-3 daily experienced improvements in pain, joint swelling, and overall disease activity.
While omega-3 showed more significant benefits compared to vegetable sources, it’s essential to note that not all inflammatory rheumatic diseases responded the same way.
7
We aimed to uncover how dietary factors, particularly omega 3-rich oily fish, influence the risk of rheumatoid arthritis (RA). Using a robust Mendelian randomization analysis, we assessed data from large genome-wide studies.
Our findings indicated that higher intake of oily fish is associated with a lower risk of RA, along with cereal consumption. However, we didn't find significant protective effects from other dietary factors. This suggests that RA patients and those at higher risk may benefit from dietary adjustments, especially with increased oily fish intake.
Our findings indicated that higher intake of oily fish is associated with a lower risk of RA, along with cereal consumption. However, we didn't find significant protective effects from other dietary factors. This suggests that RA patients and those at higher risk may benefit from dietary adjustments, especially with increased oily fish intake.
References
- Wang Y, Hu S, Zhang W, Zhang B, Yang Z. Dietary factors and rheumatoid arthritis: new perspectives from a Mendelian randomisation analysis. Br J Nutr. 2025;133:107. doi:10.1017/S0007114524002721
- Hong K, Hun M, Wu F, Mao J, Wang Y, et al. Association between Omega-3 fatty acids and autoimmune disease: Evidence from the umbrella review and Mendelian randomization analysis. Autoimmun Rev. 2024;23:103651. doi:10.1016/j.autrev.2024.103651
- Wang W, Xu Y, Zhou J, Zang Y. Effects of omega-3 supplementation on lipid metabolism, inflammation, and disease activity in rheumatoid arthritis: a meta-analysis of randomized controlled trials. Clin Rheumatol. 2024;43:2479. doi:10.1007/s10067-024-07040-0
- Kang T, Xi Y, Qian T, Lu S, Du M, et al. Exploring the link between dietary omega-3 and omega-6 fatty acid intake and rheumatoid arthritis risk: NHANES 1999-2020 study. Clin Exp Rheumatol. 2024;42:1720. doi:10.55563/clinexprheumatol/91tmfb
- Laevski AM, Doucet MR, Doucet MS, LeBlanc AA, Pineau PE, et al. Dietary omega-3 fatty acids modulate the production of platelet-derived microvesicles in an in vivo inflammatory arthritis model. Eur J Nutr. 2024;63:2221. doi:10.1007/s00394-024-03397-9
- Su Y, Han Y, Choi HS, Lee GY, Cho HW, et al. Lipid mediators obtained from docosahexaenoic acid by soybean lipoxygenase attenuate RANKL-induced osteoclast differentiation and rheumatoid arthritis. Biomed Pharmacother. 2024;171:116153. doi:10.1016/j.biopha.2024.116153
- Léger T, Brun A, Lanchais K, Rigaudière JP, Briat A, et al. Docosahexaenoic acid and etanercept could reduce functional and metabolic alterations during collagen-induced arthritis in rats without any synergistic effect. Life Sci. 2023;327:121826. doi:10.1016/j.lfs.2023.121826
- Marchand NE, Choi MY, Oakes EG, Cook NR, Stevens E, et al. Over-the-counter fish oil supplementation and pro-resolving and pro-inflammatory lipid mediators in rheumatoid arthritis. Prostaglandins Leukot Essent Fatty Acids. 2023;190:102542. doi:10.1016/j.plefa.2023.102542
- Gkiouras K, Grammatikopoulou MG, Myrogiannis I, Papamitsou T, Rigopoulou EI, et al. Efficacy of n-3 fatty acid supplementation on rheumatoid arthritis' disease activity indicators: a systematic review and meta-analysis of randomized placebo-controlled trials. Crit Rev Food Sci Nutr. 2024;64:16. doi:10.1080/10408398.2022.2104210
- Sigaux J, Bellicha A, Buscail C, Julia C, Flipo RM, et al. Serum Fatty Acid Profiles Are Associated with Disease Activity in Early Rheumatoid Arthritis: Results from the ESPOIR Cohort. Nutrients. 2022;14. doi:10.3390/nu14142947
- Sigaux J, Mathieu S, Nguyen Y, Sanchez P, Letarouilly JG, et al. Impact of type and dose of oral polyunsaturated fatty acid supplementation on disease activity in inflammatory rheumatic diseases: a systematic literature review and meta-analysis. Arthritis Res Ther. 2022;24:100. doi:10.1186/s13075-022-02781-2
- Tański W, Świątoniowska-Lonc N, Tabin M, Jankowska-Polańska B. The Relationship between Fatty Acids and the Development, Course and Treatment of Rheumatoid Arthritis. Nutrients. 2022;14. doi:10.3390/nu14051030
- Amjad S, Ahmad N, Afreen A, Ashraf S, Ahmed Z. Efficacy of Flaxseed and Fish Oils on Adults with Rheumatoid Arthritis. J Pak Med Assoc. 2022;72:22. doi:10.47391/JPMA.02-290
- Hahn J, Cook NR, Alexander EK, Friedman S, Walter J, et al. Vitamin D and marine omega 3 fatty acid supplementation and incident autoimmune disease: VITAL randomized controlled trial. BMJ. 2022;376:e066452. doi:10.1136/bmj-2021-066452
- Chang CK, Chen PK, Chen CC, Chang SH, Chen CH, et al. Increased Levels of Omega-3 Fatty Acids and DHA Are Linked to Pain Reduction in Rheumatoid Arthritis Patients Treated with Janus Kinase Inhibitors. Nutrients. 2021;13. doi:10.3390/nu13093050
- Kucharská J, Poništ S, Vančová O, Gvozdjáková A, Uličná O, et al. Treatment with coenzyme Q10, omega-3-polyunsaturated fatty acids and their combination improved bioenergetics and levels of coenzyme Q9 and Q10 in skeletal muscle mitochondria in experimental model of arthritis. Physiol Res. 2021;70:723.
